The association between cognitive impairment and oral health or oral hygiene behaviors among multiethnic older adults in Western China: a cross-sectional multicenter study by Yuqing Xie, Xin Xia, Xin Tian, Yuexia Hu, Yun Li, Xiao Tan, Wenwen Wu, Birong Dong, Yanyan Wang

“…Oral health and oral hygiene behaviors were evaluated through an oral examination and a self-made questionnaire, whereas cognitive condition was assessed via the Chinese version of the Short Portable Mental Status Questionnaire (SPMSQ). Three multiple regression models were used to examine the associations between cognitive impairment and oral health or oral hygiene behaviors, with adjustments for relevant variables. …”
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Assessing favipiravir impact on SARS-CoV-2 transmission within households: Insights from a multi-center study (FaviPrev) by Taweegrit Siripongboonsitti, Marisa Muadchimkaew, Kriangkrai Tawinprai, Ornisa Issaranon, Wichuda Meepholkij, Pureepat Arttawejkul, Apiradee Vararungzarit, Onwalee Dhissayakamol, Wilaiporn Preeyachit, Kamonwan Soonklang, Nithi Mahanonda

“…Methods: A retrospective study conducted from April 2021 to May 2022 across multiple centers in Thailand compared 892 individuals treated with favipiravir to 84 who received standard treatment among mild to moderate COVID-19 index patients. …”
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Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database by Bojing Wang, Shu Huang, Shu Huang, Shiqi Li, Yaqi Deng, Ziyan Li, Yizhou Wang, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaohong Wang, Xiaowei Tang

“…Autoimmune hepatitis and drug-induced liver injury both presented positive signals across multiple statin drugs. Notably, atorvastatin had the most significant signal strength in cholestatic pruritus and bilirubin conjugation abnormal. …”
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Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a system... by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

“…Background and purpose2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) exhibits a dualistic pharmacological profile, acting as both a hepatoprotective and hepatotoxic agent, which is intricately linked to its interaction with multiple signaling pathways and its stereoisomeric forms, namely, cis-SG and trans-SG. …”
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SAlexNet: Superimposed AlexNet using residual attention mechanism for accurate and efficient automatic primary brain tumor detection and classification by Qurat-ul-ain Chaudhary, Shahzad Ahmad Qureshi, Touseef Sadiq, Anila Usman, Ambreen Khawar, Syed Taimoor Hussain Shah, Aziz ul Rehman

“…In this work, we propose Superimposed AlexNet (SAlexNet-1 and its extension SAlexNet-2) to detect the malignancy of primary brain tumors (Glioma, Meningioma, and Pituitary) by incorporating three enhancements: (1) fusing Hybrid Attention Mechanism (HAM), (2) dense feature extraction by replacing initial convolution 11 × 11 layer with multiple convolution 3 × 3 layers for extra non-linearity alleviating parameter burden, and (3) pretraining the encoder path on a correlated dataset via semi-transfer learning (STL) enhancing model performance. …”
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Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model by Aarti C. Bhat, Aarti C. Bhat, Aarti C. Bhat, Andrew Fenelon, Andrew Fenelon, Andrew Fenelon, David M. Almeida, David M. Almeida, David M. Almeida

“…This review adapts existing stress process models to propose a conceptual model illustrating potential pathways linking the specific stressor of housing insecurity to physiological and epigenetic manifestations of stress among aging adults.MethodsThis narrative review examines literature across multiple fields, including public health, psychology, and sociology. …”
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Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults by Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…We used a multi-stage cluster random sampling method to recruit participants from seven districts in Hangzhou. Multiple regression was used to analyze the relationship between chronic diseases, sleep difficulty and HRQoL. …”
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Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques by Tiewei Li, Ning Chen, Zhengan Liu, Zhiming Shan, Geng Dong, Junmei Yang, Minglu Qi

“…The proportion of NCP/MP was significantly increased from 27.0% in the hsCRP<1.25 mg/L group to 42.7% in the hsCRP>2.70 mg/L group in older adults. Multiple logistic regression analysis showed that hsCRP was an independent risk factor for the presence of NCP/MP (odds ratio OR=1.093, 95% CI 1.032–1.157, P=0.001) only in older adults. …”
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HfC–HfO2 modified high/superhigh temperature thermal protection coating for superior hot corrosion resistance and antioxidation performance by Zhiyun Ye, Shuqi Wang, Shuang Yu, Xinrui Zhao, Yongchun Zou, Guoliang Chen, Lei Wen, Lina Zhao, Guangxi Zhang, Yaming Wang, Jiahu Ouyang, Dechang Jia, Yu Zhou

“…This improvement is attributed to the formation of a robust Hf-rich skeleton provided by the deposited HfC–HfO2 layer, which can accelerate the formation of a highly stable corroded layer/oxide scale. In addition, multiple stress release mechanisms of the composite coating at high temperatures also provide substantial contributions to long-term service. …”
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NMR Studies on the Structure of Yeast Sis1 and the Dynamics of Its Interaction with Ssa1-EEVD by Carolina O. Matos, Glaucia M. S. Pinheiro, Icaro P. Caruso, Gisele C. Amorim, Fabio C. L. Almeida, Carlos H. I. Ramos

“…Our experimental findings provide evidence supporting the interaction of EEVD with the client protein at multiple sites and essential insights into the mechanistic cycle of class B JDPs.…”
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Productivity of selection numbers of perennial ryegrass (Lolium perenne L.) in the nursery of competitive variety testing by Volodymyr Oleksiak, Lesia Baistruk-Hlodan, Oleg Stasiv, Hryhorij Konyk

“…The promising numbers PFZ 02082 and PFZ 02514 for hayfield and pasture use were identified, which will be submitted to the State Scientific and Technical Expertise after multiplication…”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…In this study, we analyzed the efficacy of a Phase Ia-cleared, orally bioavailable dual ALK and focal adhesion kinase (FAK) inhibitor, ESK440, in multiple preclinical NB models. ESK440 potently inhibited proliferation of NB cell lines, with increased sensitivity in cell lines harboring ALK aberrations. …”
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The correlation and predictive value of Hb, RDW and their association for short-term and long-term mortality in patients with acute aortic dissection by Peng Hou, Peng Hou, Lin Xia, Fangran Xin, Boxuan Sun, Guoxin Zhang, Liming Yu, Huishan Wang

“…Using adjusted Cox regression and Kaplan-Meier survival curve analyses, we assessed the relationship between Hb, RDW and their association at admission and mortality at multiple post-discharge intervals (30 days, 90 days, 1 year, and 5 years) among patients with AAD. …”
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Risk Factors of Small Intestine Cancer: An Epidemiological Analysis and Their Role in Early Diagnosis - A Literature Review by Paweł Miklis, Michał Pniak, Maciej Mawlichanów, Adrian Różycki, Marta Wojtczak, Krzysztof Szerej, Aleksandra Ciesielska, Natalia Myśliwiec, Aleksandra Sieradzka, Alicja Kot

“…Genetic conditions such as Lynch syndrome, Familial Adenomatous Polyposis (FAP), Peutz-Jeghers syndrome (PJS), and Multiple Endocrine Neoplasia (MEN1) significantly increase the risk. …”
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Evidence to practice – lessons learnt in developing an implementation strategy for an online digital health intervention (Eczema Care Online) by Laura Howells, Kim S. Thomas, Miriam Santer, Ingrid Muller, Kate Greenwell, Amanda Roberts, Hywel C. Williams, Jane Harvey, Stephanie J. Lax, Natasha K. Rogers, Tracey H. Sach, Sandra Lawton, Mary Steele, Katy Sivyer, Julie Hooper, Amina Ahmed, Sylvia Wilczynska, Sinead Langan, Paul Leighton

“…Key lessons in developing an implementation strategy include 1) start implementation work early 2) maintain flexibility to explore multiple routes to implementation 3) use secondary data sources 4) balance theory with practicalities 5) consider longer-term maintenance beyond the life of the research project. …”
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Global Insights from Patients, Providers, and Staff on Challenges and Solutions in Managing Neovascular Age-Related Macular Degeneration by Anat Loewenstein, Michelle Sylvanowicz, Winfried M. Amoaku, Tariq Aslam, Chui Ming Gemmy Cheung, Bora Eldem, Robert P. Finger, Richard P. Gale, Laurent Kodjikian, Adrian Koh, Jean-François Korobelnik, Xiaofeng Lin, Paul Mitchell, Moira Murphy, Mali Okada, Ian Pearce, Francisco J. Rodriguez, Jude Stern, S. James Talks, David T. Wong, Tien Yin Wong, Focke Ziemssen, Jane Barratt

“…Surveys comprised a series of single/multiple-response questions completed anonymously. …”
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Wastewater-based analysis of antimicrobial resistance at UK airports: Evaluating the potential opportunities and challenges by Margaret E. Knight, Kata Farkas, Matthew Wade, Gordon Webster, Daniel A. Pass, William Perry, Peter Kille, Andrew Singer, Davey L. Jones

“…This study provides the first comprehensive investigation of AMR in wastewater from both aircraft and terminals across multiple international airports. Our results highlight aircraft wastewater as a potential route for cross-border AMR transmission and a valuable tool for global AMR surveillance. …”
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Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis by Xiaohui Meng, Xiaohui Meng, Li Sheng, Yongqing You, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Funing Wang, Ziren Zhou, Ziren Zhou, Yun Shan, Meixiao Sheng

“…Network pharmacological analysis indicated that multiple QXHZF compounds contributed to improving PF by modulating various targets and pathways. …”
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A novel open-source cultivation system helps establish the first full cycle chemosynthetic symbiosis model system involving the giant ciliate Zoothamnium niveum by P. E. Contarini, E. Emboule, P. Jean-Louis, T. Woyke, S. V. Date, O. Gros, J-M. Volland, J-M. Volland, J-M. Volland

“…For the first time, starting from single cells, we successfully cultivated the symbiosis in flow-through chambers for 20 days, spanning multiple generations of colonies that remained symbiotic. …”
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Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy? by Gloria P. Vergara-Diaz, Stefano Sapienza, Jean-François Daneault, Eric Fabara, Catherine Adans-Dester, Giacomo Severini, Vincent C. K. Cheung, Carmen Echevarría Ruiz de Vargas, Donna Nimec, Paolo Bonato

“…Participants who demonstrated the most substantial improvements in clinical scores following RGT exhibited multiple changes in the muscle synergies. However, no statistically significant correlations were identified at the group level. …”
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