Preoperative anemia is associated with prolonged hospital stay and increased facility discharges after glioblastoma resection by Ahmad K. Almekkawi, Ammar Adenwalla, James P. Caruso, William H. Hicks, Benjamin Rail, Carlos A. Bagley, Jonathan D. Breshears, Tarek Y. El Ahmadieh, Tomas Garzon-Muvdi, Samuel A. Goldlust

“…On multivariate regression analysis, controlling for age, gender, and performance status, we observed trends suggesting anemic patients may have longer lengths of stay (t statistic = 3.23, p = 0.0015) and higher rates of discharge to inpatient facilities [OR 3.01 (1.09–8.13), p = 0.029], though these associations did not reach statistical significance after correction for multiple comparisons (Bonferroni-corrected significance threshold p < 0.01).ConclusionPreoperative anemia may be a useful pre-operative predictor of postsurgical GBM outcomes. …”
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Automatic detection of floating instream large wood in videos using deep learning by J. Aarnink, J. Aarnink, T. Beucler, T. Beucler, M. Vuaridel, V. Ruiz-Villanueva, V. Ruiz-Villanueva

“…We sampled data to represent different wood transport conditions, combining 20 datasets to yield thousands of instream wood images. We designed multiple scenarios using different data subsets with and without data augmentation. …”
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Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis by Xiaotong Yu, Xiaotong Yu, Chen Huang, Chen Huang, Yan Song, Yan Song, Chun Zhang, Chun Zhang, Debo You, Debo You, XuRan Dong, XuRan Dong, DeFu Wu, DeFu Wu, Alan Keith Meeker, Hao Feng, Yuqing Wang, Yuqing Wang

“…Background and aimsMultiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. …”
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Molecular characterization and lineage analysis of canine astrovirus strains from dogs with gastrointestinal disease in Ecuador based on ORF-2 gene analysis by Anthony Loor-Giler, Anthony Loor-Giler, Silvana Santander-Parra, Sara Castillo-Reyes, Martín Campos, Martín Campos, Renan Mena-Perez, Renan Mena-Perez, Santiago Prado-Chiriboga, Santiago Prado-Chiriboga, Luis Nunez, Luis Nunez

“…Given the high frequency of CaAstV infections in dogs with gastroenteritis and its high genetic variability, it emphasizes the need to implement routine diagnostic measures that include this pathogen as one of the main causes of the disease and a risk agent in case of multiple infections.…”
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Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review by Joshua P Vogel, Jack Williams, Tari Turner, Steve McDonald, Alexander John Eggleston, Annabel Richards, Elise Farrington, Wai Chung Tse, Ayeshini Sella Hewage

“…Objectives To identify and map all trials in maternal health conducted in low and middle-income countries (LMIC) over the 10-year period from 2010 to 2019, to identify geographical and thematic trends, as well as comparing to global causes of maternal death and preidentified priority areas.Design Systematic scoping review.Primary and secondary outcome measures Extracted data included location, study characteristics and whether trials corresponded to causes of mortality and identified research priority topics.Results We searched the Cochrane Central Register of Controlled Trials database, a combined registry of trials from multiple sources. Our search identified 7269 articles, 874 of which were included for analysis. …”
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Population dynamics and the role of protected areas in China’s milu deer (Elaphurus davidianus) rewilding by Zhibin Cheng, Yuanyuan Zhang, Wei Liu, ZhenyuZhong, Jiade Bai, Kun Cheng, Chengmiao Feng, Libo Wang, Yuming Zhang, Hongxin Yi, Qingyun Guo, Qingxun Zhang, Pan Zhang

“…Our studies indicate that long-term conservation in protected areas has played an irreplaceable role in the reconstruction and rejuvenation of wild populations of milu deer over the past 30 years, and multiple reintroductions are an effective way to quickly restore wild milu populations in China.…”
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Development and validation of a food-related quality of life questionnaire (CANUT-QVA) for cancer patients by Kenza Drareni, Catherine Mercier, Reisya Rizki Riantiningtyas, Anestis Dougkas, Benjamin Riche, Pascale Roux, Chantal Fingal, Hélène Labrosse, Fadila Farsi, David Dayde, Mélanie Roche, Julie Anne Nazare, Arnaud Fournel, Delphine Maucort-Boulch, Moustafa Bensafi, Véronique Mourier, Amandine Bruyas, Agnès Giboreau

“…Exploratory Factor Analysis (EFA) and multiple correspondence analysis were performed for both groups to determine construct and discriminant validity. …”
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Evaluation of Tissue Tropism and Horizontal Transmission of a Duck Enteritis Virus Vectored Vaccine in One-Day-Old Chicken by Yassin Abdulrahim, Yingying You, Linggou Wang, Zhixiang Bi, Lihua Xie, Saisai Chen, Benedikt B. Kaufer, Armando Mario Damiani, Kehe Huang, Jichun Wang

“…However, due to limitations in loading multiple foreign antigens into a single HVT vector, other viral vectors are urgently needed. …”
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Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study by Yudiyang Ma, Ying Hui, Linxi Tang, Jianing Wang, Meiqi Xing, Lei Zheng, Feipeng Cui, Shuohua Chen, Shouling Wu, Zhenchang Wang, Yaohua Tian

“…Given the limited evidence on the relationship between air pollution and CSVD, this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk. Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study, totaling 1216 participants. …”
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Chromosomal Abnormalities in Miscarriages and Maternal Age: New Insights from the Study of 7118 Cases by Anna A. Pendina, Mikhail I. Krapivin, Olga G. Chiryaeva, Lubov’ I. Petrova, Elizaveta P. Pashkova, Arina V. Golubeva, Andrei V. Tikhonov, Alla S. Koltsova, Ekaterina D. Trusova, Dmitrii A. Staroverov, Andrey S. Glotov, Olesya N. Bespalova, Olga A. Efimova

“…In contrast, the proportions of multiple aneuploidies and regular trisomies 13, 15, 18, 21, and 22 showed an upward trend with maternal aging. …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Additionally, SUMOylated TRPC1 activates the Nod-like receptor protein (NLRP) 3 signaling pathway in microglia and stimulates multiple CC-chemokine ligands and C-X-C motif ligand chemokines after MCAO/R. …”
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Predicting the exposure of mycophenolic acid in children with autoimmune diseases using a limited sampling strategy: A retrospective study by Ping Zheng, Ting Pan, Ya Gao, Juan Chen, Liren Li, Yan Chen, Dandan Fang, Xuechun Li, Fei Gao, Yilei Li

“…Abstract Mycophenolic acid (MPA) is commonly used to treat autoimmune diseases in children, and therapeutic drug monitoring is recommended to ensure adequate drug exposure. However, multiple blood sampling is required to calculate the area under the plasma concentration‐time curve (AUC), causing patient discomfort and waste of human and financial resources. …”
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Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study by Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong

“…A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were conducted to assess the heterogeneity, horizontal pleiotropy, and robustness of the MR findings. …”
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Health effects of mixed metal exposure on accelerating aging among the elderly population by Chuanli Yang, Jijun Zhang, Haohan Liu, Qin Hong, Yunhe Fan, Jie An, Haijia Zhang, Xiaobing Shen, Xiushan Dong

“…Background: Human exposure to heavy metals occurs through multiple pathways in daily life. However, the effects of mixed heavy metal exposure on accelerated aging in the elderly U.S. population remains unclear. …”
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The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation by Zhenlei Peng, Qiyu Jia, Junxiong Mao, Shijie Jiang, Qi Ma, Xiao Luo, Zhiguo An, Anqi Huang, Chuang Ma, Qizhong Yi

“…SCZ patients showed significant differences in markers compared to the HC group (P < 0.01). Multiple linear regression analysis revealed that decreased GSH and iron levels, along with elevated SOD levels, were significantly associated with the overall severity of psychiatric symptoms. …”
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Responsiveness and clinical utility of PROMIS instruments in pediatric Crohn's disease: insights from a longitudinal study by Sara Azevedo, Sara Azevedo, Maria Miguel Oliveira, Maria Miguel Oliveira, Paulo Nogueira, Paulo Nogueira, Paulo Nogueira, Ana Isabel Lopes, Ana Isabel Lopes

“…Globally, the study demonstrated significant and clinically relevant changes in multiple PROMIS measures, confirming their responsiveness to changes in disease activity.ConclusionPROMIS instruments are clinically useful in managing pediatric CD, providing valuable insights into global health and quality of life. …”
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Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)—Two-Year Follow-Up Study by Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Saeed Hesam

“…Then variables with P value < 0.2 were tested with a multivariate analysis, using backward-elimination multiple logistic regression. Results. Among 605 patients, 39 cases had DFU, so we followed up the remaining 566 patients without any present or history of DFU. …”
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Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy by Qianqian Yan, Zihao Zhao, Dongwei Liu, Jia Li, Shaokang Pan, Jiayu Duan, Zhangsuo Liu

“…Weighted gene co-expression network analysis (WGCNA) was implemented in the IBD dataset to identify the major immune infiltration modules, and the Boruta algorithm, RFE algorithm, and LASSO regression were applied to filter the cross-talk genes. Next, multiple machine learning models were applied to confirm the optimal cross-talk genes. …”
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Associations of substance use and positive coping behaviors with sleep quality during the COVID-19 pandemic by Jessica Laudie, Bethany L. Stangl, Tommy Gunawan, Tommy Gunawan, Melanie L. Schwandt, Cecilia Cheng, Amanda K. Gilmore, Amanda K. Gilmore, David Goldman, David Goldman, Vijay A. Ramchandani, Nancy Diazgranados, Jeremy W. Luk

“…., take care of body, make time to relax, connect with others, multiple healthy behaviors) were associated with better sleep quality domains.ConclusionsAUD history, substance use, and positive coping behaviors were correlated with sleep quality during the pandemic. …”
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Radiomics analysis of thoracic vertebral bone marrow microenvironment changes before bone metastasis of breast cancer based on chest CT by Hao-Nan Zhu, Yi-Fan Guo, YingMin Lin, Zhi-Chao Sun, Xi Zhu, YuanZhe Li

“…Radiomic features were extracted from the bone marrow of thoracic vertebrae on non-contrast chest CT scans. Multiple machine learning algorithms were utilized to construct various radiomics models for predicting the risk of bone metastasis, and the model with optimal performance was integrated with clinical features to develop a nomogram. …”
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