Beyond averaging: A transformer approach to decoding event related brain potentials by Philipp Zelger, Manuel Arnold, Sonja Rossi, Josef Seebacher, Franz Muigg, Simone Graf, Antonio Rodríguez-Sánchez

“…Traditional methods involve averaging the EEG signal of multiple trials to extract valuable neural signals from the high noise content of EEG data. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Dysregulation of gut immune homeostasis was implicated in the pathogenesis of multiple autoimmune diseases, however, whether this homeostasis is disrupted in a lupus autoimmune background remains unclear. …”
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Complicated caries of permanent teeth in children: status of the problem and modern solution ways by N.S. Proshchenko, H.V. Sorochenko, O.I. Ostapko, O.M. Plyska, Yu.V. Trokhimets

“…The issue of improving dental care protocols for children with multiple (decompensated) and complicated caries of permanent teeth, their full rehabilitation is particularly relevant, especially in periods of social cataclysms (the COVID-19 pandemic, martial law, etc.). …”
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Immunological pathogenesis and treatment progress of adenovirus pneumonia in children by Yaowen Liang, Jie Wei, Jianjun Shen, Zihao Liang, Xiuchang Ma, Yuchen Du, Wenxian Qian, Hui Dong, Ping Huang, Apeng Chen, Changhua Yi

“…It has been found that immunocompromised children are highly susceptible to this pathogen, as it can swiftly evolve into severe pneumonia with multiple sequelae. Due to the lack of immunity in children, the body’s response mechanisms to innate and acquired immunity are specialized. …”
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations by Lucas Tricoli, Sunetra Sase, Julia L. Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife Roche, John Everett, Frederic Bushman, Peter Kurre, Rebecca Ahrens-Nicklas, Laura A. Adang, Adeline L. Vanderver, Stefano Rivella

“…In addition, our vectors achieved optimal transduction in mouse and human hematopoietic stem cells (HSCs) with minimal multiplicity of infection (MOI). Our top-performing vector (EA1) showed at least 4× more ARSA activity than the currently US and European Union (EU)-approved vector and a superior ability to secrete vesicle-associated ARSA, a critical modality to transfer functional enzymes from microglia to oligodendrocytes. …”
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Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion by Mehul Vora, Jonathan Dietz, Zachary Wing, Karen George, Jun Kelly Liu, Christopher Rongo, Cathy Savage-Dunn

“…In C. elegans, the BMP2/4 ortholog DBL-1 regulates multiple biological functions, including body size, via a canonical receptor-Smad signaling cascade. …”
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Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences by Pål Møller, Aysel Ahadova, Matthias Kloor, Toni T. Seppälä, John Burn, Saskia Haupt, Finlay Macrae, Mev Dominguez-Valentin, Gabriela Möslein, Annika Lindblom, Lone sunde, Ingrid Winship, Gabriel Capella, Kevin Monahan, Daniel D. Buchanan, D. Gareth Evans, Eivind Hovig, Julian R. Sampson

“…In path_APC carriers, second hits result in the development of multiple adenomas, with CRC typically emerging after an additional 20 years. …”
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Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact by Mohammad A. Jareebi, Saja A. Almraysi, Dhiyaa A. H. Otayf, Ghadeer A. Alneel, Areej H. Zughaibi, Sarah J. Mobarki, Imtenan A. Oberi, Hayam A. Alzahrani, Shatha A. Aldhowaihi, Zainab A. Alramadhan, Majed A. Ryani, Ahmed A. Bahri, Nuha H. Abutalib, Nada M. Makein, Ahmad Y. Alqassim

“…Descriptive and inferential statistics were utilized to evaluate the prevalence, severity, and associated symptoms of dysmenorrhea. Additionally, multiple logistic regression was employed to identify the determinants of dysmenorrhea within the sample. …”
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2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project by Lucia Billeci, Valentina Riva, Elena Capelli, Serena Grumi, Miriam Paola Pili, Maddalena Cassa, Eleonora Siri, Elisa Roberti, Renato Borgatti, Renato Borgatti, Livio Provenzi, Livio Provenzi

“…IntroductionVery preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. …”
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A Data-Driven Approach to Engineering Instruction: Exploring Learning Styles, Study Habits, and Machine Learning by Lauren Genith Isaza Dominguez, Antonio Robles-Gomez, Rafael Pastor-Vargas

“…Paired t-tests, Cohen’s effect size, and two-way ANOVA showed that aligning teaching methods with learning styles improved students’short-term exam scores and engagement. However, multiple regression analysis indicated that study habits (specifically time spent studying, frequency, and scores on a custom-developed study quality survey) were much stronger predictors of midterm and final exam performance. …”
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Mapping Susceptibility and Risk of Land Subsidence by Integrating InSAR and Hybrid Machine Learning Models: A Case Study in Xi'an, China by Chen Chen, Mimi Peng, Mahdi Motagh, Xinxin Guo, Mengdao Xing, Yinghui Quan

“…Then, subsidence risk map is obtained from the hazard and vulnerability assessment using the Analytic Hierarchy Process by combining multiple conditional factors. Remarkably, the results revealed that regions with the very high and high risk level of subsidence are 12.33 <inline-formula><tex-math notation="LaTeX">$\text{km}^{2}$</tex-math></inline-formula> and correspond to 1.34<inline-formula><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> of the total. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…This study aims to improve outcomes by molecular profiling of patients at relapse, then matching them with the best available drug based on their molecular profile, maximising the chances of patient benefit while simultaneously testing multiple novel drugs.Methods and analysis Low &amp; Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2) will be an international, phase 2, multicentre, open-label, biomarker-directed, umbrella clinical trial for recurrent isocitrate dehydrogenase mutant, histologically grade 2/3 gliomas. …”
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Association between serum testosterone changes and parameters of the metabolic syndrome by Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Norichika Ueda, Kentaro Takezawa, Hiroshi Kiuchi, Ayaka Tachi, Jiro Sakamoto, Toyofumi Abe, Go Tanigawa, Yasushi Miyagawa, Takashi Fujimoto, Norio Nonomura

“…We included 178 male subjects who visited our hospital multiple times between 2018 and 2023 for medical checkups for at least 3 years. …”
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Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Currently, a few studies have reported using a mixture of neoantigen peptides derived from multiple genetic mutation sites in the treatment of genomic unstable advanced solid malignancies. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Therefore, this study explores the association between SNPs in Bcl-2 and the structural, functional, protein-protein interactions (PPIs), drug binding and dynamic characteristics.MethodsComprehensive cross-validated bioinformatics tools and molecular dynamics (MD) simulations. Multiple sequence, genetic, structural and disease phenotype analyses were applied in this study.ResultsAnalysis revealed that out of 130 mutations, approximately 8.5% of these mutations were classified as pathogenic. …”
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Microclimate monitoring in commercial tomato (Solanum Lycopersicum L.) greenhouse production and its effect on plant growth, yield and fruit quality by Jakub Šalagovič, Dorien Vanhees, Pieter Verboven, Kristof Holsteens, Bert Verlinden, Marlies Huysmans, Bram Van de Poel, Bram Van de Poel, Bart Nicolaï, Bart Nicolaï, Bart Nicolaï

“…Large greenhouses typically rely only on one central weather station per compartment to steer their internal climate, ignoring possible microclimate conditions within the greenhouse itself.MethodsIn this study, we analysed spatial variation in temperature and vapour pressure deficit in a commercial tomato greenhouse setting for three consecutive years. Multiple sensors were placed within the crop canopy, which revealed microclimate gradients.Results and discussionDifferent microclimates were present throughout the year, with seasonal (spring – summer – autumn) and diurnal (day – night) variations in temperature (up to 3 °C, daily average) and vapour pressure deficit (up to 0.6 kPa, daily average). …”
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Seropositivity to tick-borne pathogens in nature management workers in the Netherlands by B.J.A. Hoeve-Bakker, G. Çelik, O.E. van den Berg, C.C. van den Wijngaard, A. Hofhuis, J.H.J. Reimerink, S.F.T. Thijsen, K. Kerkhof

“…In addition, the study examined coexposure to multiple TBPs and identified risk factors for B. burgdorferi s.l.- and A. phagocytophilum-seropositivity.The study included 525 nature management workers who donated serum and completed a questionnaire. …”
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Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…In the present study, by integrating comprehensive non-coding RNA-seq data from multiple cohorts of GBM patients, we identified that a series of miRNAs are frequently downregulated in GBM patients compared with the control samples. …”
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Genomic insights into a multidrug-resistant pandoraea apista clinical isolate carrying blaOXA-153 from China by Lirong Li, Yawen Zhang, Fang He, Ningjun wu

“…PA167 exhibited resistance to multiple antibiotics, including cephalosporins and carbapenems, and was susceptible only to sulfamethoxazole/trimethoprim. …”
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A Review on Performance Calculation and Design Methodologies for Horizontal-Axis Wind Turbine Blades by Rongyu Zha, Siyuan Wu, Chang Cai, Xiaohui Liu, Dian Wang, Chaoyi Peng, Xuebin Feng, Qiuhua Chen, Xiaohui Zhong, Qing’an Li

“…The paper also includes a refined review of extended areas such as aerodynamic add-ons and fatigue characteristics, which broadens the scope of the review to touch on multiple research areas and inspire further research. …”
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