Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…Considering the multifactorial nature of these diseases, medicinal plants could be a valuable therapeutic strategy as their phytoconstituents interact with multiple and relevant biological targets. In this context, Ilex paraguariensis emerges as a potential alternative to treat obesity and associated metabolic diseases since several studies have demonstrated its anti-inflammatory, anti-obesity and anti-diabetic effects. …”
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Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope <i>Helicobacter pylori</i> Vaccines in a BALB/c Mouse Model by Rita Amaral, Tomás Concha, Jorge Vítor, António J. Almeida, Cecília Calado, Lídia M. Gonçalves

“…<b>Methods</b>: In this study, new multi-epitope pDNA- and recombinant protein-based vaccines incorporating multiple <i>H. pylori</i> antigens were produced and encapsulated in chitosan nanoparticles for oral and intramuscular administration. …”
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A Lightweight Network for Ship Detection in SAR Images Based on Edge Feature Aware and Fusion by Yuming Li, Jin Liu, Xingye Li, Xiliang Zhang, Zhongdai Wu, Bing Han

“…To validate the superiority of our proposed method, we conduct extensive experiments on multiple public datasets, achieving average accuracy scores of 94.2&#x0025;, 97.6&#x0025;, and 97.7&#x0025; on the HRSID, SAR-Ship-Dataset, and SSDD, respectively, with a model parameter size of only 3.36 M, and the fastest processing time for a single frame is 7.2 ms.…”
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Integrating Sports Massage into Pre-training Routines Can Enhance Athletic Preparedness and Performance Capacity in Kabaddi Players by Muhammad Isnandar, Farid M. Alhumary, Krzykarist Krzykarist, Restin Zega, Reymond Benedith Hutajulu, Rachel Junika Abelia Putri, Martin Hofmeister

“…The intervention yielded statistically significant enhancements across multiple evaluated parameters. Muscle temperature exhibited an average increase of 2.3°C, while range of motion demonstrated a 12.5% improvement in hip flexibility; additionally, performance metrics revealed a 22% augmentation in defensive maneuver efficiency. …”
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A Population Analysis of 20 Exoplanets Observed from Optical to Near-infrared Wavelengths with the Hubble Space Telescope: Evidence for Widespread Stellar Contamination by Arianna Saba, Alexandra Thompson, Kai Hou Yip, Sushuang Ma, Angelos Tsiaras, Ahmed Faris Al-Refaie, Giovanna Tinetti

“…Across our target sample, we observe significant divergence among multiple observations conducted with the same STIS grating at various epochs, while we do not detect variations in the WFC3 data sets. …”
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The Association Between Periodontitis, Gingivitis, Tooth Loss and Stroke: An Umbrella Study with Meta-Analysis by Jad El Masri, Ahmad Al Malak, Diala El Masri, Maya Ghazi, Silva Al Boussi, Yasmina El Masri, Mohammad Hassoun, Maryam Tlayss, Pascale Salameh, Hassan Hosseini

“…Methods: PubMed, Cochrane, Scopus and Web of Science databases were searched for all meta-analyses assessing the effect of PD on CVA in accordance with Joanna Briggs Institute guidance for umbrella reviews in March 2024. Assessment of Multiple Systematic Reviews (AMSTAR) was used for quality assessment. …”
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The association between working hours and working type with non-alcoholic fatty liver disease: results from the NHANES 1999-2014 by Ruli Wang, Ningxi Wu, Huan Qu, Xiaowei Zheng, Haoyang Zhang, Lihong Zhu, Xiaolei Wang, Xiaodie Yao, Le Zhang

“…We employed the hepatic steatosis index (HSI) to evaluate NAFLD and examined the relationship between working hours or working type and hepatic steatosis using weighted multiple-variable regression models and restricted cubic spline (RCS) analysis. …”
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Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico by Victor Gonzalez-Uribe, MD, MSc, Luis A. Hernandez-Zarate, MD, Cesar F. Pozo Beltran, MD, Christian R. Alcocer-Arreguin, MD, Paola de Baro Alvarez, MD, MEd, Natalia Coello-Niembro, MD, Pablo Jimenez-Feria, MD, Zaira S. Mojica Gonzalez, MD, Carlos Andres Gomez-Nuñez, MD, Ricardo Martinez-Tenopala, MD, Martín R. Basile-Alvarez, MD, Berenice Velasco-Benhumea, MD, Roberto Fernandez-Soto, MD, Daniela E. García-Fajardo, MD, Herberth Perez-Avilés, MD, Cesar Pinto-Solis, MD, Luis A. Rios-Villalobos, MD, Roberto Ureña-Ortiz, MD, Leticia Lezama-Vazquez, MD, Patricio Acosta-Rodriguez-Bueno, MD, MSc, Blanca Estela Del Rio-Navarro, MD

“…Objectives: This study aimed to evaluate the current diagnostic and treatment practices for EoE in children across multiple centers in Mexico, identify common clinical presentations, and assess the role of IgG4 in EoE. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…We propose that in skeletal progenitors, LRP1 plays a critical role in formation and maturity of multiple bones and joints by regulating Wnt signalling, providing novel insights into the fundamental processes of morphogenesis and the emergence of skeletal pathologies.…”
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Radiopharmaceuticals and their applications in medicine by Siqi Zhang, Xingkai Wang, Xin Gao, Xueyao Chen, Linger Li, Guoqing Li, Can Liu, Yuan Miao, Rui Wang, Kuan Hu

“…Abstract Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases. Radiopharmaceutical therapy, which directly causes systematic and irreparable damage to targeted cells, has attracted increasing attention in the treatment of refractory diseases that are not sensitive to current therapies. …”
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Associations between Driving Status, Frequency of Transport use after Driving Cessation, and Social Frailty among Middle-Aged and Older Adults by Tatsuya Fukuei, Shoma Akaida, Yoshiaki Taniguchi, Daijo Shiratsuchi, Yuto Kiuchi, Mana Tateishi, Yukari Aishita, Ryota Kuratsu, Hyuma Makizako

“…The relationships between driving status, transport use, and social frailty were examined using multiple logistic regression. Results The current non-driver group and the transport non-user group were significant association with a higher social frailty. …”
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Identification of Candidate Genes for Green Rind Color in Watermelon by Wei Zhou, Licong Yi, Yunqiang Wang, Hongsheng Wang, Qingke Li, Na Wu, Zhaoyi Dai

“…Moreover, qRT-PCR analysis revealed that the transcription levels of multiple key genes in the chlorophyll (Chl) biosynthesis pathway were downregulated in the light-green rind relative to the green rind. …”
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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study by Peter Koch, Inke König, Johann Roider, Jan Tode, Konstantine Purtskhvanidze, Claus von der Burchard, Helge Sudkamp, Cristoph Ehlken, Moritz Moltmann, Britta Heimes, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Gereon Hüttmann

“…This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).Design Prospective single-arm diagnostic accuracy study.Setting Tertiary care centre (University Eye Clinic).Participants 46 patients with age-related macular degeneration.Interventions Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. …”
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Community case study: an academia-industry-government partnership that monitors and predicts outbreaks in Tri-County Detroit area since 2017 by Irene Xagoraraki, Liang Zhao, Yabing Li, Brijen Miyani, John Norton, James Broz, Andrew Kaye, Anna Mehrotra, Anil Gosine, Scott Withington, Stacey McFarlane, Russell A. Faust

“…The Tri-County Detroit Area (TCDA) is the 12th most populous metropolitan area in the United States with over three million people. Multiple communicable diseases are endemic in the TCDA. …”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…The drought monitoring performance of IMLDI was validated in the eastern parts of China, and three integrated drought indies composited by PCA, multiple linear regression, and gradient boosting method were also included for comparison. …”
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Strengthening the Resilience of Objective-Oriented Health System Reforms. Analysis of the Left-Turn in the Health Reform Proposals in Mexico (2019) and Colombia (2023) by Laura Flamand, Octavio Gómez-Dantés, Natalia Losada-Trujillo, Diana Pinto, Edson Serván-Mori, Diego Cerecero-García, Thomas Hone, Sumit Mazumdar

“…For long-term resilience, they also need multiple networks to secure them, including citizens well informed about their benefits, health workers with a sense of ownership, and legal protections.…”
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Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity by Bingjie Zhou, Reiko Ichikawa, Laurence D. Parnell, Sabrina E. Noel, Xiyuan Zhang, Shilpa N. Bhupathiraju, Caren E. Smith, Katherine L. Tucker, Jose M. Ordovas, Chao-Qiang Lai

“…Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing. Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI. …”
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Exploring the relationship between opium consumption and lipid profiles: A population-based study of 10,663 individuals in Southern Iran by Najibullah Baeradeh, Seyed Vahid Hosseini, Leila Moftakhar, Fatemeh Jafari, Masoumeh Ghoddusi Johari, Abbas Rezaianzadeh

“…LDL demonstrated correlation with BMI (r = 0.06, P = 0.0001) and physical activity (r = −0.034, P = 0.003), while HDL showed correlation with age (r = 0.062, P < 0.001), BMI (r = 0.061, P < 0.001), and physical activity (r = −0.017, P < 0.001). However, multiple linear regression indicated there was no significant relationship between opium use and lipid profiles (P > 0.05). …”
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Wetland elevation change following beneficial use of dredged material nourishment by Brian D. Harris, Aleksandra Ostojic, Lenore P. Tedesco, Keith VanDerSys, Susan Bailey, Justin L. Shawler, Navid H. Jafari, Monica Chasten

“…While there have been numerous demonstrations of BUDM in wetland environments, there is a limited understanding of the resultant spatial and temporal elevation response due to consolidation of the dredged material and underlying wetland foundation soils.MethodsTo address this, surface elevations were monitored following multiple BUDM nourishments on a back-bay island in New Jersey. …”
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Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors by Runi Hou, Lijian Xu, Maolin Yu, Zengmin Tang, Bin Zhou, Qiao Zhang, Na Li, Jianxiong Xu

“…To this end, a functional hydrogel of oxidized sodium alginate (OSA) crosslinked poly(acrylic acid-co-acrylamide) (P(AA-co-AM)) in the presence of BaTiO3 (BTO) nanoparticles was initially prepared and then immersed in FeCl3 solution to form OSA/P(AA-co-AM)/Fe3+-BTO (O/P/Fe-BTO) hydrogels. Due to the multiple interaction (such as dynamic Schiff base cross-linking bond, metal coordination and hydrogen bonding), along with the synergistic contributions of each component, the as-prepared O/P/Fe-BTO hydrogels displayed outstanding mechanical property (tensile stress of 2.14 MPa, tensile strain of 876 %, toughness of 9.96 MJ/m3), good conductivity (0.14 S/m) and excellent antibacterial activity. …”
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