Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…Consequently, targeting this enzyme is of particular interest in developing new drugs for the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).MethodsIn the present study, multiple computational tools were adopted to screen a microbial-based natural products database (NPAtlas) for potential inhibitors of the ATPase activity of MBT DNA gyrase.Results and discussionTwelve hits were initially identified as the top candidates based on their docking scores (ranging from −9.491 to −10.77 kcal/mol) and binding free energies (−60.37 to −73.21 kcal/mol). …”
Get full text

Clinical Epidemiology and Phenotypic Characteristics of Hidradenitis Suppurativa Disease in the Central Region of Saudi Arabia: Findings from a Cross-Sectional by Alotaibi H, Madani A, AlFada M, Alluhaybi A, Alsehli T, Almuhaideb Q, Alnasser S, Aldossari A, Barakeh M, AlKanaan R

“…Most patients (80.74%) had multiple affected sites. No significant associations were found between these factors and HS severity (p > 0.05).Conclusion: In conclusion, HS primarily affects young, unmarried Saudi female patients, many of whom are smokers and have comorbid conditions such as asthma and skin disorders. …”
Get full text

Application of a Multi‐Layer Artificial Neural Network in a 3‐D Global Electron Density Model Using the Long‐Term Observations of COSMIC, Fengyun‐3C, and Digisonde by Wang Li, Dongsheng Zhao, Changyong He, Yi Shen, Andong Hu, Kefei Zhang

“…However, it is still a challenging mission to develop a model with high predictability that captures the horizontal‐vertical features of ionospheric electrodynamics. In this study, multiple observations during 2005–2019 from space‐borne global navigation satellite system (GNSS) radio occultation (RO) systems (COSMIC and FY‐3C) and the Digisonde Global Ionosphere Radio Observatory are utilized to develop a completely global ionospheric three‐dimensional electron density model based on an artificial neural network, namely ANN‐TDD. …”
Get full text

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects by Sijie Zhang, Wenxuan Bian, Yan Wang, Min Shen, Yu Qian, Hao Dai, Shuai Zheng, Qi Fu, Kuanfeng Xu, Tao Yang, Hemin Jiang

“…Binary logistic regression was performed to evaluate the relationships between rs724030 in MTNR1B and prediabetes under the additive model. Additionally, multiple linear regression was utilized to investigate the associations between this variant and glycemic-related quantitative traits and lipid levels.ResultsWhile no association was observed between the rs724030 variant in MTNR1B and prediabetes risk in the overall cohort (P > 0.05), we found the G allele of this variant was associated with higher fasting and 30-minute plasma glucose levels, decreased Insulinogenic Index (IGI), and oral disposition index (DIo) (P = 0.009, 0.001, 0.001, and 0.007, respectively) in the normal glucose tolerance (NGT) individuals with normal BMI levels. …”
Get full text

Repeatability, reproducibility, and the effects of radiotherapy on radiomic features of lowfield MR-LINAC images of the prostate by Parker Anderson, Nesrin Dogan, John Chetley Ford, Kyle Padgett, Garrett Simpson, Radka Stoyanova, Matthew Charles Abramowitz, Alan Dal Pra, Rodrigo Delgadillo

“…Forty-three first and second order radiomic features extracted from these images were compared by calculating Lin’s concordance correlation coefficient (with Benjamini-Hochberg correction for multiple comparisons) between the modalities. FX1 and pMR images were correlated (p<0.05) for all but one RF. 12 RFs correlated between pMR and dT2 images. …”
Get full text

Effect of homemade peanut oil consumption during pregnancy on low birth weight and preterm birth outcomes: a cohort study in Southwestern China by Yanxu Zhong, Huan Lu, Yuyan Jiang, Minyan Rong, Xiangming Zhang, Tippawan Liabsuetrakul

“…The effect of homemade peanut oil exposure was analyzed using multiple logistic regression models using the directed acyclic graph (DAG) approach. …”
Get full text

Determination of the Antioxidant Capacity of Germinated and Yeast-Fermented Sweet and Bitter Lupin Seeds and Sprouts via Cyclic Voltammetry Compared to the Spectrophotometric and P... by Danuta Zielińska, Piotr Gulewicz, Małgorzata Kasprowicz-Potocka, Henryk Zieliński

“…Lord) are the most suitable for producing fermented sprouts with a high content of electroactive polar compounds able to scavenge multiple free radicals of biological and non-biological origin. …”
Get full text

Different DNA Loidy Patterns for the Differentiation of Common Subtypes of Renal Tumors by Guorong Li, Michèle Cottier, Odile Sabido, Anne Gentil-Perret, Claude Lambert, Christian Genin, Jacques Tostain

“…The diploid pattern was dominant in conventional and papillary RCCs. 10/13 (76.9%) of clear cell RCCs and 9/11 (81.8%) of papillary RCCs possessed a homogeneous DNA ploidy pattern while only 1/7 (14.3%) has a homogeneous DNA ploidy pattern. 6/7 chromophobe RCCs had multiple aneuploid stemlines. Conclusions: Flow cytometric analysis reveals that conventional and papillary RCCs are more homogeneous than chromophobe RCC. …”
Get full text

Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients by Jingxin He, Zhangkai Lian, Qianzhong Cao, Zhenzhen Liu, Charlotte Aimee Young, Xinyu Zhang, Danying Zheng, Guangming Jin

“…Data of refractive power, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) as well as ocular biometrics including AL, corneal curvature, white-to-white (WTW), and central corneal thickness (CCT) were collected at baseline and each follow-up visit. Multiple linear regression was performed to assess the potential associated factors for axial length growth in congenital ectopia lentis patients. …”
Get full text

Chemical and Noble Gas Isotope Compositions of Formation Gases from a 3 km Deep Scientific Borehole in the Koyna Seismogenic Zone, Western India by Nagaraju Podugu, Satrughna Mishra, Thomas Wiersberg, Sukanta Roy

“…The He-rich zones correlate well with the zones of anomalous physical and mechanical properties identified from geophysical logs and are characterized by high fracture density as revealed from borehole images, indicating that the borehole punctured multiple fracture zones. The helium concentrations are consistent with those previously observed over the surface fissures near Kadoli, suggesting a southward extension of the Donichawadi fault zone up to the KFD1 site and confirming that the fault zone is permeable even after 50 years of the 1967 Koyna earthquake. 3He/4He ratios of eleven gas samples fall between 0.426±0.022 and 0.912±0.059 Ra, with 4He/20Ne values between 0.3449±0.0091 and 0.751±0.020. …”
Get full text

Characterization and Biofilm Inhibition of Multidrug-Resistant Acinetobacter baumannii Isolates by Poonam Yadav, Sreska Shrestha, Deepak Basyal, Ananda Tiwari, Ranjit Sah, Anil Kumar Sah, Bishal Yadav, Mark Willcox, Shyam Kumar Mishra

“…Multidrug-resistant (MDR) Acinetobacter baumannii poses a significant therapeutic challenge due to its resistance to multiple antibiotics and its ability to form biofilm. …”
Get full text

Bankers' job stress, job performance, and job commitment trajectories during the COVID-19 pandemic by Sanjoy Kumar Roy, Md. Rahat Khan, Nazrul Islam Shanto

“…PURPOSE: The global COVID-19 pandemic has profoundly impacted multiple sectors across industries and regions, including medical services, financial institutions, and others. …”
Get full text

Response of the gut microbiome and metabolome to dietary fiber in healthy dogs by Amrisha Bhosle, Matthew I. Jackson, Aaron M. Walsh, Eric A. Franzosa, Dayakar V. Badri, Curtis Huttenhower

“…ABSTRACT Dietary fiber confers multiple health benefits originating from the expansion of beneficial gut microbial activity. …”
Get full text

Endocrine disruptor (17 β-estradiol) removal by poly pyrrole-based molecularly imprinted polymer: kinetic, isotherms and thermodynamic studies by Samaneh Mohebbi, Aram Dokht Khatibi, Davoud Balarak, Maryam Khashij, Edris Bazrafshan, Mohammad Mehralian

“…The MIP showed good reproducibility with only a slight decrease in removal efficiency after multiple absorption and reabsorption cycles. The adsorption of E2 by the MIP followed Langmuir adsorption isotherm and second-order adsorption kinetics. …”
Get full text

Implementation of a sexual health clinic in an oncology setting: patient and provider perspectives by Andrew G. Matthew, Taylor Incze, Elisa Stragapede, Steven Guirguis, Sarah E. Neil-Sztramko, Dean S. Elterman

“…This study further emphasizes the need for incorporating sexual healthcare in survivorship programs as well as the necessity of conducting thorough implementation research, involving multiple stakeholders, prior to launching new programs.…”
Get full text

Comparing Clean Water Act Section 316(b) Policy Options by John Kadvany

“…While various AEI options have been proposed over the years, none has been formalized through environmental regulations nor universally accepted. Using a multiple values approach from decision analysis, AEIs are characterized as measurement criteria for ecological impacts. …”
Get full text

Una aproximación a la geopolítica de las lenguas en el continente africano by Alfredo Portillo

“… La palabra geopolítica está asociada a rivalidades de poder en los territorios, y son múltiples los factores que dan lugar a éstas. A menudo se habla de geopolítica del agua, de los minerales, de las religiones e incluso de las lenguas. …”
Get full text

TEACHERS’ AND STUDENTS’ ATTITUDES TOWARDS THE USE OF ARTIFICIAL INTELLIGENCE: ALL-UKRAINIAN RESEARCH by Stanislav Dovgyi, Svitlana Babiichuk, Lidiia Davybida, Mariia Biletska

“… The steady rise of artificial intelligence (AI) across multiple domains, particularly education, marks a transformative period for the field. …”
Get full text

Self-representation: A review on Selfie Photos in Social Media According to Goffman's Dramaturgical Theory by Keyhan Valinejad

“…To describe and analyze the theoretical subjects, several original research articles and e-books were adopted.Findings: The individual and social identical patterns and the attempt to present a proper selfie in social media are more frequent, flexible, and even interactive compared to the real world due to the self-management nature of these environments.Conclusion: Social media has brought a new public space that enables multiple identities. According to Goffman's theory, uploading a selfie photo can be interpreted as a play, in which the subject consciously manipulates his/her characteristics even in a slight manner. …”
Get full text

Trends and critical points of Aspergillus contamination along Ethiopian chili postharvest value chain by Tariku Hunduma Tolera, Anteneh Tesfaye, Melaku Alemu

“…A total of 214 individual sample units composed of multiple subsamples consisting of aseptically picked matured red pods (PiPP), dried red pods (DPP), crushed chili (CP), unpacked (UpPPo), and packed chili powder (PaPPo) were randomly collected along the PVC from different major chili growing localities of Ethiopia during 2017/2018 main cropping season. …”
Get full text