Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…This study was designed to investigate the expression variation of IL-10 in the multiple sites including cortex, hippocampus, and lung tissues of neonatal hypoxic-ischemic (HI) rats and explore the crucial role of IL-10 in alleviating HI brain damage. …”
Get full text

Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus by Dian-dian Zhao, Pei-lin Jiao, Jing-jia Yu, Xiao-jing Wang, Lin Zhao, Yan Xuan, Li-hao Sun, Bei Tao, Wei-qing Wang, Guang Ning, Jian-min Liu, Hong-yan Zhao

“…Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p<0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r=0.322), body mass index (BMI) (r=0.331), Ca (r=0.179), and Cr (r=0.239) (p<0.001) and were also positively associated with the concentrations of PTH (r=0.10, p<0.05). …”
Get full text

Fosab, but not fosaa, plays important role in learning and memory in fish—insights from zebrafish gene knockout study by Qiuling Wang, Qiuling Wang, Qiuling Wang, Lixin Zhang, Lixin Zhang, Lixin Zhang, Chenyuan Zhu, Chenyuan Zhu, Chenyuan Zhu, Ke Lu, Ke Lu, Ke Lu, Jiaqi Wu, Jiaqi Wu, Jiaqi Wu, Xu-Fang Liang, Xu-Fang Liang, Xu-Fang Liang

“…Additionally, the phylogenetic and multiple amino acid alignment results indicated that fish fosab has a higher identity with mammals Fos.Discussion: By integrating the above results, we found that fosab, but not fosaa, may possess a learning and memory function in fish. …”
Get full text

Critical appraisal and comparison of recommendations of clinical practice guidelines for treatment of schizophrenia in children and adolescents: a methodological survey protocol by Cristiane de Cássia Bergamaschi, Silvio Barberato-Filho, Izabela Fulone, Maíra Ramos Alves, Flávia Blaseck Sorrilha, Rejane Coan Ferretti Mayer, Daniela Oliveira de Melo, Luciane Lopes

“…The aim of this study will be to assess the quality of the development of CPGs for the treatment and management of schizophrenia in children and adolescents over time using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to compare the recommendations and interventions described in these documents.Methods and analysis CPGs will be identified using a prospective protocol through a systematic search of multiple databases (Medline, Embase, Health Systems Evidence, Epistemonikos, Lilacs, etc) and guideline websites from 2004 to December 2020. …”
Get full text

Progress Analysis and Development Prospects of Soil Ecological and Environmental Effects of Interlayer Construction by JIA Zhenjiang, WU Yangyang, LI Wangcheng, MA Dongxiang, CHEN Jihong, GAO Susu, NIU Xiaoxiao, XU Tianyuan

“…Within the framework of the dual carbon development pattern and multiple strategic overlapping context, the focus and direction of future research will be on innovating and technologically transforming new interlayer materials based on the efficient utilization of solid waste resources.…”
Get full text

Liquid biopsy - a review by WERONIKA RUTKOWSKA-KAWALEC, Karolina Michalczuk, Dariusz Fabian, Marek Kurowski, Elżbieta Leszczyńska-Knaga, Natalia Jakubczyk, Paweł Moczydłowski, Monika Ryglewicz, Anna Gliwa, Karolina Kuczapska

“…Machine learning enhances cfDNA analysis by integrating multiple markers, improving accuracy in distinguishing cancerous from precancerous states. …”
Get full text

Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…Considering its low toxicity profile, LDRT presents a compelling case for application across multiple lesions, augmenting the antitumor immune response in poly-metastatic disease scenarios. …”
Get full text

Multiscale Attention Feature Fusion Based on Improved Transformer for Hyperspectral Image and LiDAR Data Classification by Aili Wang, Guilong Lei, Shiyu Dai, Haibin Wu, Yuji Iwahori

“…With the uninterrupted evolution of remote sensing data, the list of available data sources has expanded, effectively utilizing useful information from multiple sources for better land surface observation, which has become an intriguing and challenging problem. …”
Get full text

Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…Participants will receive a 14-day treatment alongside routine medications and will be monitored at multiple time points: days 1, 3, 5, 7, 14, 30, 60, and 90. …”
Get full text

Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach by Sivapriya Dayakar, Anitha Pandi, Chandra Pandi, Paramasivam Arumugam, Vijayashree Priyadharsini Jayaseelan

“…The present study aims to demonstrate the association between the genetic alterations observed in the PIK3CA gene network and its role in establishing breast cancer.Method: In the present observational study, we used multiple tools (STRING, cBioportal, PANTHER, and UALCAN) to demonstrate the genetic alterations in the Breast Cancer Dataset (TCGA, Firehose Legacy). …”
Get full text

Large-Scale Experimental Validation of Real-Time Monitoring in Underground Gas Storage Wells Using Distributed Fiber Optic Sensing by Linqing Luo, Diana Abdulhameed, Gang Tao, Tianchen Xu, Jiangnan Wang, David Xu, Kenichi Soga, Yuxin Wu

“…Underground gas storage (UGS) is essential for balancing the natural gas supply and demand, but faces multiple risk factors, including well deformation and gas leaks. …”
Get full text

COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study by Jackie A Cassell, Laura J Hughes, Elizabeth Ford, Priyamvada Paudyal, Kavian Kulasabanathan, Jo Armes, Rebecca Sharp, Saliha Majeed-Hajaj, Emily Skinner, Naresh Khapangi Magar, Debbie Isobel Keeling

“…Participants highlighted the need for information in multiple formats and languages, and discussed the importance of culturally appropriate avenues, such as community centres and religious sites, for information dissemination.Conclusion This study, undertaken during the COVID-19 pandemic, provides insight into how health information can be optimised for ethnic minority older adults in terms of content, format and cultural relevance. …”
Get full text

Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study by Jinghua Li, Difei Wang, Yanyan Mao, Wuxia Zhang, Qianxi Zhu, Jun Liu, Jing Du, Weijin Zhou, Weijin Zhou, Fen Wang, Min Li

“…Latent Profile Analysis revealed three dietary patterns: “high-carbohydrate diet” (HCD), “low-carbohydrate diet” (LND), and “moderate nutrient diet” (MND). Multiple logistic regression indicated that pregnant women preferring Mala flavor were more likely to follow an HCD and had a higher risk of excessive GWG. …”
Get full text

Genome-Wide Association Analysis of Boar Semen Traits Based on Computer-Assisted Semen Analysis and Flow Cytometry by Xiyan Yang, Jingkun Nie, Yaxuan Zhang, Suqing Wang, Xiaoping Zhu, Zhili Li, Yunxiang Zhao, Xiuguo Shang

“…Additionally, trait heritability was estimated using single- and multiple-trait PBLUP models, yielding 0.19, 0.29, 0.13, 0.18, 0.11, and 0.14 heritability for MOT, DEN, ABN, MMP, AIR, and ROS, respectively. …”
Get full text

Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard by Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

“…Over the past decade, the development of nanomaterials (NMs) has surged, highlighting their potential benefits across multiple industries. However, concerns regarding human and environmental exposure remain significant. …”
Get full text

Assessing the Causal Effect of Circulating Protein‐To‐Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma by Qiuyuan Yue, Xiaoxia Li, Xiaoye Wan, Xi Lin, Yueming Li, Mingwei Zhang, Shaohua Xu

“…However, among the significant protein pairs, only one circulating protein, TDRKH (odds ratio: 0.5964, 95% CI: 0.4196–0.8476), was causally associated with HCC. Conclusion Using multiple datasets and methods, eight protein–protein pairs were identified as having causal associations with HCC. …”
Get full text

The association of agricultural and non-agricultural work on the healthy ageing of older adults in Japan: A 6-year longitudinal study from the Japan Gerontological evaluation study by Hiroki Takeuchi, Kazushige Ide, Hequn Wang, Motoki Tamura, Katsunori Kondo

“…Logistic and modified Poisson regression analyses were employed after imputing missing values.Results: Incidence ranged from 2.6 % (dementia) to 17.3 % (any level of functional disability). Post-multiple imputation analysis showed significantly lower odds ratios and risk ratios for dementia, functional disability, loss of healthy life expectancy, and death among non-agricultural and agricultural workers compared to retirees. …”
Get full text

Artificial intelligence-based approaches for multi-station modelling of dissolve oxygen in river by G. Elkiran, V. Nourani, S.I. Abba, J. Abdullahi

“…ABSTRACT: In this study, adaptive neuro-fuzzy inference system, and feed forward neural network as two artificial intelligence-based models along with conventional multiple linear regression model were used to predict the multi-station modelling of dissolve oxygen concentration at the downstream of Mathura City in India. …”
Get full text

Retrospectively understanding the multifaceted interplay of COVID-19 outbreak, air pollution, and sociodemographic factors through explainable AI by Mohmmed Talib, Kripabandhu Ghosh, Gopala Krishna Darbha

“…Furthermore, the stacked ensemble model consistently outperformed its base models, demonstrating the benefits of combining multiple models. Additionally, the XAI analysis identified NO2 as a key driver of COVID-19 cases and mortalities, while PM10 was found to be particularly influential on mortalities. …”
Get full text

A multi‐tagged SAR ocean image dataset identifying atmospheric boundary layer structure in winter tradewind conditions by Chen Wang, Justin E. Stopa, Doug Vandemark, Ralph Foster, Alex Ayet, Alexis Mouche, Bertrand Chapron, Peter Sadowski

“…Each image is tagged with one or multiple phenomena by five experts. This strategy extends the TenGeoP‐SARwv by identifying coexisting phenomena within a single SAR image and by the addition of mixed roll/cell states and cold pools. …”
Get full text