Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…Edaravone dexborneol (EDB) is known to target multiple pathways involved in fibrosis. Methods We constructed the CCH mouse models that were subjected to either PBS or EDB at different concentrations. …”
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Malignancy Risk and Related Factors of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance in Thyroid Fine Needle Aspiration by So-hyeon Hong, Hyejin Lee, Min-Sun Cho, Jee Eun Lee, Yeon-Ah Sung, Young Sun Hong

“…The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. …”
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Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy by Yishen Tian, Jingxuan Li, Na Yang, Yang Zhao, Jiancao Zuo, Hang Xiong, Yiwen Pan, Li Xiao, Min Su, Feng Han, Zhixu He, Rong Hu

“…Specifically, the cell preparation exerted its anti-tumor effects through multiple mechanisms: Firstly, the surface BTN2A2 antibodies effectively inhibited the proliferation of Tregs and MDSCs within the tumor microenvironment; Secondly, leveraging the T cell antigen receptors (TCRs) present in the blood T cells, which were similar to those of tumor-infiltrating lymphocytes, significantly enhanced their targeting and cytotoxic capabilities; Furthermore, the CMP component within the droplets effectively promoted the infiltration of T cells into tumor tissues. …”
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Dust Scattering Albedo at Millimeter Wavelengths in the TW Hya Disk by Tomohiro C. Yoshida, Hideko Nomura, Takashi Tsukagoshi, Kiyoaki Doi, Kenji Furuya, Akimasa Kataoka

“…We propose to break this degeneracy by using multiple optically thin molecular lines as a dust–albedo-independent thermometer. …”
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…Background: Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development of multiple diseases, including tumor. Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. …”
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A SARS‐CoV‐2 EG.5 mRNA vaccine induces a broad‐spectrum immune response in mice by Hongyu Wang, Qinhua Peng, Xinxian Dai, Zhifang Ying, Xiaohong Wu, Xinyu Liu, Hongshan Xu, Jia Li, Leitai Shi, Jingjing Liu, Yunpeng Wang, Danhua Zhao, Yanqiu Huang, Lihong Yang, Ren Yang, Guangzhi Yue, Yue Suo, Qiang Ye, Shouchun Cao, Yuhua Li

“…Compared with a single dose of 15 µg CoV072, two doses of 5 µg COV072 exhibited higher levels of pseudovirus neutralizing antibody (PNAb) and cross‐reactive IgG responses to multiple variants. Moreover, higher levels of neutralizing antibody (NAb) against live XBB and EG.5 variants were also induced. …”
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HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke by Chaoping Yu, Yang Huang, Jiangang Xie, Chujun Duan, Shanshou Liu, Wei Zhao, Yutong Wang, Ran Zhuang, Junjie Li, Wen Yin

“…EHS immune disorders can cause systemic inflammatory responses and multiple organ failure; however, the underlying mechanisms remain unclear. …”
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Optimizing planting management practices considering a suite of crop water footprint indicators —A case-study of the Fengjiashan Irrigation District by Yujie Yuan, Jichao Wang, Xuerui Gao, Kejing Huang, Xining Zhao

“…In the path of planting structure, it was necessary to reduce the area of multiple planting and increase the area of monocropping. …”
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Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). …”
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Ultra-flexible TiO2/SiO2 nanofiber membranes with layered structure for thermal insulation by Zhenfeng Guo, Ze Zhu, Xiaoqian Zhang, Ying Peng, Ziting Huang, Xinqiang Wang, Luyi Zhu, Yongshuai Xie, Guanghui Zhang, Benxue Liu, Dong Xu

“…A single-layer nanofiber membrane was composed of multiple layers of nanofibers. According to the principle of multi-level reflection, the multilayer structure had a better near-infrared reflection effect. …”
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Chasing the Beginning of Reionization in the JWST Era by Christopher Cain, Garett Lopez, Anson D’Aloisio, Julian B. Muñoz, Rolf A. Jansen, Rogier A. Windhorst, Nakul Gangolli

“…Not all probes agree with this conclusion, hinting at a possible lack of concordance arising from deficiencies in observations and/or theoretical modeling. Observations by multiple experiments (including JWST, Roman, and CMB-S4) in the coming years will establish a concordance picture of reionization's beginning or uncover such deficiencies.…”
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Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation by Mareen Braunstein, Martina Williamson, Thomas Kusmenkov, Jürgen Landes, Peter Biberthaler, Karl-Georg Kanz, Wolfgang Böcker, Viktoria Bogner

“…TNF-alpha, IL-8, IL-10, and IL-1ra mRNA levels were quantified by RT-qPCR and compared to multiple organ failure, 30-day survival, and the induction of therapeutic hypothermia (TH). …”
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Optimization of cultivation parameters for bovine respiratory syncytial virus strain Vologda/2019 by V. V. Kirpichenko, S. V. Kononova, I. N. Shumilova, A. A. Nesterov, M. V. Turkova, Ye. A. Bukhon, D. V. Romenskaya, A. V. Sprygin, B. L. Manin, O. P. Byadovskaya

“…It was determined that in case of multiplicity of inoculation of FBT and RBT cell cultures with the virus at 0.1 lg TCD50/cell and the use of 2% glutamine in the maintenance nutrient medium, as well as 2% horse or cattle blood serum, it is possible to obtain virus material with high cytopathic activity.…”
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Dynamic compressive characteristics of a green sandstone under coupled hydraulic-mechanical loading: Experiments and theoretical modeling by Bangbiao Wu, Geli Zhao, Ying Xu, Kaiwen Xia

“…The findings reveal that the dynamic behavior of rock specimens is significantly influenced by multiple factors, including the loading rate, confining stress, and pore pressure. …”
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A Novel Gridless Non-Uniform Linear Array Direction of Arrival Estimation Approach Based on the Improved Alternating Descent Conditional Gradient Algorithm for Automotive Radar Sys... by Mingxiao Shao, Yizhe Fan, Yan Zhang, Zhe Zhang, Jie Zhao, Bingchen Zhang

“…We compared the proposed algorithm with ANM, Iterative Shrinkage Thresholding (IST), and Multiple Signal Classification (MUSIC) algorithms. …”
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Mediation effects of subjective social status and personality traits between childhood nurturing experiences and depressive symptoms in adult volunteers by Yuki Nakagawa, Miki Ono, Chihiro Morishita, Mina Honyashiki, Yu Tamada, Yota Fujimura, Shinji Higashi, Naoki Hashimoto, Takeshi Inoue, Jiro Masuya

“…Methods A questionnaire survey was conducted on 404 adults. Multiple regression analysis and structural equation modeling were conducted using demographic information and scores for the Patient Health Questionnaire‐9, Parental Bonding Instrument, and NEO Five‐Factor Inventory. …”
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Plasma myeloperoxidase interactions with cadmium, lead, arsenic, and selenium and their impact on chronic kidney disease by Hsi-Hsien Chen, Ya-Li Huang, Chih-Yin Wu, Mei-Chieh Chen, Horng-Sheng Shiue, Sheng-Lun Hsu, Ying-Chin Lin, Yu-Mei Hsueh

“…High plasma MPO concentrations also showed multiplicative interactions with elevated blood Pb levels or low plasma Se concentrations, which increased the ORs for CKD (p-values = 0.005 and 0.009, respectively). …”
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Shortening of the telomere length during the transition period of dairy cows in relation to biological stress by Manon Dewulf, Osvaldo Bogado Pascottini, Stijn Heirbaut, Maya Meesters, Dries S. Martens, Tim S. Nawrot, Mingqi Zhang, X. P. Jing, Leen Vandaele, Veerle Fievez, Mieke Van Eetvelde, Geert Opsomer

“…Abstract Telomere length (TL) is a recognized biomarker for ageing in multiple species. In dairy cattle, the transition period is considered a very stressful period. …”
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Space Weather Forecasts of Ground Level Space Weather in the UK: Evaluating Performance and Limitations by A. W. Smith, I. J. Rae, C. Forsyth, J. C. Coxon, M.‐T. Walach, C. J. Lao, D. S. Bloomfield, S. A. Reddy, M. K. Coughlan, A. Keesee, S. Bentley

“…The model appears to capture multiple modes of magnetospheric activity, including substorms and viscous interactions, but poorly predicts impulsive phenomena (i.e., storm sudden commencements) and longer timescale coupling processes. …”
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Health Benefits Due to Reduction in Respirable Particulates during COVID-19 Lockdown in India by Anubha Goel, Pallavi Saxena, Saurabh Sonwani, Shubham Rathi, Ananya Srivastava, Akash Kumar Bharti, Supreme Jain, Shubhanshi Singh, Anuradha Shukla, Anju Srivastava

“…The health impacts of particle inhalation were quantified using the multiple-path particle dosimetry and AirQ+ models, which revealed that the most considerable improvement was during lockdown Phase 1. …”
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