Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients by Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto

“…Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. …”
Get full text

Operationalizing goal setting as an outcome measure in trials involving patients with frailty, multimorbidity or complexity by Emma Tenison, Katherine Lloyd, Yoav Ben-Shlomo, Emily J. Henderson

“…We needed a meaningful outcome measure which could capture effects across multiple symptoms and domains; be suitable across the spectrum of disease stage/phenotype, including for participants with multimorbidity and/or cognitive impairment. …”
Get full text

Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae by Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil

“…However, no apparent heat tolerance benefit was observed from single or combined mutations in these genes, supporting the hypothesis that thermotolerance is mediated by multiple interacting mechanisms. In this context, all evolved clones exhibited altered sterol profiles, with differences observed between respiratory‐competent and ‐deficient strains. …”
Get full text

Using machine learning models to plan HIV services: Emerging opportunities in design, implementation and evaluation by T Dzinamarira, E Mbunge, I Chingombe, D F Cuadros, E Moyo, I Chitungo, G Murewanhema, B Muchemwa, G Rwibasira, O Mugurungi, G Musuka, H Herrera

“…Considerable progress has been made to reduce the impact of HIV/AIDS in the past years through successful multiple HIV/AIDS prevention and treatment interventions. …”
Get full text

Extended homogeneous field correction method based on oblique projection in OPM-MEG by Fulong Wang, Fuzhi Cao, Yujie Ma, Ruochen Zhao, Ruonan Wang, Nan An, Min Xiang, Dawei Wang, Xiaolin Ning

“…The spatiotemporal extended homogeneous field correction (teHFC) method uses multiple orthogonal projections to suppress disturbances. …”
Get full text

Electrogastrogram-based detection of cybersickness with the application of wavelet transformation and machine learning: A case study by Ilija V. Tanasković, Nenad B. Popović, Jaka J. Sodnik, Sašo J. Tomažič, Nadica S. Miljković

“…Furthermore, recovery signs appear approximately 8 minutes after the first VR experience supporting the idea of conducting multiple sessions the same day i.e., intensive VR-based training. …”
Get full text

Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress by Alexandre Champroux, Mitra Sadat-Shirazi, Xuan Chen, Jonathan Hacker, Yongjie Yang, Larry A. Feig

“…We showed previously that exposure of male mice to chronic social instability (CSI) stress results in elevated anxiety and reduced sociability specifically in their female offspring across multiple generations because it reduces miR-34c levels in sperm of stressed males and their unstressed male offspring. …”
Get full text

Pursuit on the plane by objects moving away from the trajectory of defending object, with simulation of detection area by A. А. Dubanov, T. V. Ausheev

“…The task is to implement a dynamic model of multiple group pursuit, where each object has its own tasks, which implements the chase method. …”
Get full text

Clinical Research Network: JHCRN Infrastructure and Lessons Learned by Rahul Kashyap, Gayane Yenokyan, Robert Joyner, Melissa Gerstenhaber, Mary Alderfer, Erika Siegrist, Joan Moore, Channing J. Paller, Hanan Aboumatar, James J. Potter, Stanley Watkins Jr, John E. Niederhuber, Daniel E. Ford, Adrian Dobs

“…In conclusion, the CRN, as an academic–community partnership, provides an infrastructure for multiple disease studies, shared risk, and increased investigator and volunteer engagement.…”
Get full text

Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway by Yiyang Wang, Baoshuai Bai, Yanzhu Hu, Haoming Wang, Ningyuan Liu, Yibo Li, Pei Li, Guangdong Zhou, Qiang Zhou

“…Established studies proved that hydrostatic pressure had multiple effects on the biological behavior of the intervertebral disc (IVD). …”
Get full text

Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery by Yonghe Chen, Dan Liu, Jian Xiao, Jun Xiang, Aihong Liu, Shi Chen, Junjie Liu, Xiansheng Hu, Junsheng Peng

“…To identify clinical parameters that are associated with the survival of AGC patients after NAC and radical surgery and to establish a nomogram integrating multiple factors to predict survival. Methods. We reviewed the medical profiles of 215 AGC patients who received NAC and radical resection, and clinical parameters concerning NAC, surgery, pathological findings, and adjuvant chemotherapy were analyzed using a Cox regression model to determine their impact on survival. …”
Get full text

The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil by Rhayra B. Dias, João A. M. Guimarães, Marco B. Cury, Leonardo R. Rocha, Elaine S. da Costa, Liebert P. Nogueira, Camila Hochman-Mendez, Anneliese Fortuna-Costa, Anna Karoline F. Silva, Karin S. Cunha, Sergio A. L. de Souza, Maria Eugênia L. Duarte, Rafaela C. Sartore, Danielle C. Bonfim

“…In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. …”
Get full text

Implementation of patient-centred care: which organisational determinants matter from decision maker’s perspective? Results from a qualitative interview study across various health... by Lena Ansmann, Holger Pfaff, Kira Isabel Hower, Vera Vennedey, Hendrik Ansgar Hillen, Ludwig Kuntz, Stephanie Stock

“…Our qualitative study examines determinants of PCC implementation from decision makers’ perspectives across diverse HSCOs.Design Qualitative study of n=24 participants in n=20 semistructured face-to-face interviews conducted from August 2017 to May 2018.Setting and participants Decision makers were recruited from multiple HSCOs in the region of the city of Cologne, Germany, based on a maximum variation sampling strategy varying by HSCOs types.Outcomes The qualitative interviews were analysed using an inductive and deductive approach according to qualitative content analysis. …”
Get full text

Global, regional, and national lifetime risk of developing and dying from lung cancer in 2022: A population-based study in 185 countries by Meng Li, Xin Wen, Xin Liang, Mengwen Liu, Li Zhang, Rongshou Zheng, Jing Ni

“…The lifetime risks of lung cancer development and death were estimated using adjustment for multiple primary cancers (AMP) method. The lung cancer risks in countries or regions worldwide were compared by region and the Human Development Index (HDI). …”
Get full text

Plasma Concentrations of Benzylpenicillin and Cloxacillin in Infective Endocarditis—With Special Reference to Delayed Hypersensitivity Reactions by Malin Hägglund, Ulrika Snygg-Martin, Lars Olaison, Michael Stofkoper, Bert Ove Larsson, Magnus Brink

“…Kidney function could explain, at best, 54% of the variation, and a multiple regression model including kidney function, body mass index, age, and albumin explained up to 68% of the variation for benzylpenicillin. …”
Get full text

Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis by Allysson Cramer, Bruno Cabral de Lima Oliveira, Paulo Gaio Leite, David Henrique Rodrigues, Fatima Brant, Lisia Esper, Pollyana Maria Oliveira Pimentel, Rafael Machado Rezende, Milene Alvarenga Rachid, Antonio Lucio Teixeira, Ana Maria Caetano Faria, Mauro Martins Teixeira, Fabiana Simão Machado

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). …”
Get full text

Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera) by Andrea Becchimanzi, Giovanna De Leva, Rosanna Mattossovich, Serena Camerini, Marialuisa Casella, Giovanni Jesu, Ilaria Di Lelio, Sabrina Di Giorgi, Joachim R. de Miranda, Anna Valenti, Silvia Gigliotti, Francesco Pennacchio

“…Among the co-immunoprecipitated proteins, one of the most interesting was arginine kinase (ArgK), a conserved protein playing multiple roles both in physiological and pathological processes and stress response in general. …”
Get full text

Modelling the seasonal dynamics of Aedes albopictus populations using a spatio-temporal stacked machine learning model by Daniele Da Re, Giovanni Marini, Carmelo Bonannella, Fabrizio Laurini, Mattia Manica, Nikoleta Anicic, Alessandro Albieri, Paola Angelini, Daniele Arnoldi, Federica Bertola, Beniamino Caputo, Claudio De Liberato, Alessandra della Torre, Eleonora Flacio, Alessandra Franceschini, Francesco Gradoni, Përparim Kadriaj, Valeria Lencioni, Irene Del Lesto, Francesco La Russa, Riccardo Paolo Lia, Fabrizio Montarsi, Domenico Otranto, Gregory L’Ambert, Annapaola Rizzoli, Pasquale Rombolà, Federico Romiti, Gionata Stancher, Alessandra Torina, Enkelejda Velo, Chiara Virgillito, Fabiana Zandonai, Roberto Rosà

“…Stacked ensemble modelling incorporates predictions from multiple base learners or models as inputs for a meta-learner. …”
Get full text

The correlation of the forkhead transcription factor foxo1 expression and histopathological pancreatic lesions in dogs by Firas M. Abed, Ahmed N. Abduljawaad, Omar A. Al-Mahmood, Karam H. Yehia, Hana Kh. Ismail

“…Among the 14 samples, degenerative changes, congestion, edema, coagulative and fat necrosis, as well as inflammation were detected in some samples. Multiple lesions, including fibrosis, hyperplasia, and atrophy, were observed in other samples. …”
Get full text

Sugarcane waste products as source of phytotoxic compounds for agriculture by Dandara A. Luz, Anne C. C. Gomes, Naomi K. Simas, Otavio A. Heringer, Wanderson Romão, Betina P. O. Lovatti, Rodrigo Scherer, Paulo R. Filgueiras, Ricardo M. Kuster

“…Correlation between chemical and biological methods was performed through chemometric analysis and multiple linear regression. Results From vinasse, dichloromethane (VDiCl) and ethyl acetate (VAcOEt) samples were the most phytotoxic fractions at the concentrations of 500 mg L-1 and 250 mg L-1. …”
Get full text