Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice by Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo

“…These findings confirmed that conditional knockdown of hepatic PCSK9 attenuates liver inflammation following hyperlipidemia induction by modulating multiple signaling pathways; this suggests that targeting PCSK9 knockdown/inhibition with appropriate agents is useful not only for treating hyperlipidemia but also for ameliorating hyperlipidemia-induced liver inflammation.…”
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Experiences of general practitioners explaining central sensitisation to patients with persistent physical symptoms: a focus group study by Henriëtte E van der Horst, Johannes C van der Wouden, Berend Terluin, Annette H Blankenstein, Carine den Boer

“…They tailored the CS model to their patients’ needs and used multiple consultations to explain the model. The GPs reported that the use of the CS model seemed to improve the understanding and acceptance of the symptoms by the patients and seemed to reduce their need for more diagnostic tests. …”
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Evaluating Trends in Interior Design Strategies and Their Impact on the Emotional Experience of Older Adults by Lintong Li, Suhua Wang, Noranita Mansor, Athira Azmi, Jialing Xiang

“…The study introduces a dynamic feedback mechanism within the framework of the proposed architectural interior design strategy, highlighting the importance of employing multiple strategies that balance and complement each other in practical applications. …”
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Outdoor Education Coaches Competency Level Self-Assessment Model, Co-Curriculum Centres in Malaysia by Nurul Diyana Sanuddin, Omar Firdaus Mohd Said, Md Amin Md Taff, Jaffry Zakaria, Mohamed Azizul Mohamed Afandi, Adjullea James @ Noew

“…Results: Regression analysis revealed significant relationships across multiple competency sub-attributes: philosophy, history, and psychosocial aspects (R-square = .681, F (3,236) = 167.60, p = .000); hard skills such as safety, environment, and technical expertise (R-square = .865, F (6,233) = 249.77, p = .000); soft skills like teaching, facilitating, and organizing (R-square = .964, F (9,230) = 690.97, p = .001); and meta-skills encompassing leadership, communication, and decision-making (R-square = .970, F (12,227) = 14209.92, p = .001). …”
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Livestock Depredation and Pastoralist Attitudes towards Carnivore in the Landscape of Lions Associated with Gambella National Park, Abobo District, Western Ethiopia by Getahun Gedif Abie, Krishnagouda Shankargouda Goudar, Hussein Ibrahim, Gezahegn Getachew

“…Data analysis involved the utilization of multiple response analysis, Chi square test, Cramer’s V and Cohen’s Omega, Potential for Conflict Index2, and multinomial regression analysis. …”
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Impact Assessment of Grid-Connected Solar Photovoltaic Systems on Power Distribution Grid: A Case Study on a Highly Loaded Feeder in Ulaanbaatar Ger District by Turmandakh Bat-Orgil, Battuvshin Bayarkhuu, Bayasgalan Dugarjav, Insu Paek

“…Thus, it is necessary to assess the impact of solar PV systems on the power distribution grid in detail, even though there are multiple economic and environmental advantages associated with installing solar PV systems. …”
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Predicting the presence of tephra layers in lacustrine deposits using spectral gamma ray data: An example from Lake Chalco, Mexico City. by Mehrdad Sardar Abadi, Christian Zeeden, Arne Ulfers, Alex Susan Meyer, Thomas Wonik, Mexidrill team

“…The protocol involves identifying similarities between known tephra layers, analyzing differences in gamma-ray signals between tephra and non-tephra layers, and studying the composition of energy channels at various depths within the training dataset. Multiple linear regression models are used to predict the relationship between the composition of tephra layers as a dependent variable and the constituent energy channels of the gamma-ray signal as independent variables. …”
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Vision-Based Underwater Docking Guidance and Positioning: Enhancing Detection with YOLO-D by Tian Ni, Can Sima, Wenzhong Zhang, Junlin Wang, Jia Guo, Lindan Zhang

“…In addition, an underwater docking positioning algorithm leveraging multiple markers was implemented. Tests on an underwater docking markers dataset demonstrated that YOLO-D achieved a detection accuracy of mAP@0.5 to 94.5%, surpassing the baseline YOLOv11n with improvements of 1.5% in precision, 5% in recall, and 4.2% in mAP@0.5. …”
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Racial/ethnic differences in the associations between social support and cardiovascular morbidity and mortality in the Multi-Ethnic Study of Atherosclerosis (MESA) by Jeanean B. Naqvi, Taynara Formagini, Matthew A. Allison, Namratha R. Kandula, Jee Won Park, Britta A. Larsen

“…Racial/ethnic differences in perceived support (overall, emotional, informational, and instrumental) were tested using multiple regression with adjustments for demographic, socioeconomic, lifestyle/psychosocial, and clinical risk factors, and immigration history. …”
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El liderazgo y la inteligencia emocional: elementos clave para la formación de directivos de educación especial by Cinthia Verónica Domínguez Pineda, Jorge Luis Cruz Hernández, Josefa Bravo Moreno

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Quality Assurance System Using Statistical Process Control: An Implementation for Image Cytometry by David Chiu, Martial Guillaud, Dennis Cox, Michele Follen, Calum MacAulay

“…QA events were detected using the QA system. Multiple examples of event detection leading to correction of system malfunction are described in this report. …”
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Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence by Ashim Gupta, Nicola Maffulli

“…This review summarizes the outcomes of clinical studies involving APBOs to manage shoulder disorders. Methods Multiple databases (PubMed, Web of Science, Embase, and Scopus) were searched employing terms for APBOs and various shoulder disorders for articles published in the English language to September 11, 2024, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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Application of Flower Pollination Algorithm for Solving Complex Large-Scale Power System Restoration Problem Using PDFF Controllers by G. Ganesan Subramanian, Albert Alexander Stonier, Geno Peter, Vivekananda Ganji

“…Automatic Generation Control (AGC) in modern power systems is getting complex, due to intermittency in the output power of multiple sources along with considerable digressions in the loads and system parameters. …”
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Feasibility and Reliability of a Novel Game-Based Test of Neurological Function in Youth: The Equilibrium Test Battery by Heather A Shepherd, Cody R van Rassel, Amanda M Black, Robert F Graham, Keith Owen Yeates, Carolyn A Emery, Kathryn J Schneider

“…Test-retest reliability was examined using Bland Altman 95% limits of agreement and intraclass correlation coefficients comparing the first and second and second and third obtained scores. Reliability across multiple baseline assessments was also analyzed using intraclass correlations for the second to sixth and seventh to eleventh obtained scores…”
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Application of attenuated total reflection-Fourier transform infrared spectroscopy in semi-quantification of blood lipids and characterization of the metabolic syndrome. by Tz-Ping Gau, Jen-Hung Wen, I-Wei Lu, Pei-Yu Huang, Yao-Chang Lee, Wei-Po Lee, Hsiang-Chun Lee

“…This study used AI-assisted attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to identify MetS and precisely quantify multiple blood lipid levels with a blood sample of 0.5 µl and the assaying time is approximately 10 minutes.…”
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SViG: A Similarity-Thresholded Approach for Vision Graph Neural Networks by Ismael Elsharkawi, Hossam Sharara, Ahmed Rafea

“…Image representation in computer vision is a long-standing problem that has a significant impact on any machine learning model performance. There have been multiple attempts to tackle this problem that were introduced in the literature, starting from traditional Convolutional Neural Networks (CNNs) to Vision Transformers and MLP-Mixers that were more recently introduced to represent images as sequences. …”
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Reflexiones sobre el proyecto Auto-Demarcación y EtnoCartografía de las Tierras y Hábitats Jodï y Eñepa by Stanford Zent, Egleé L. Zent, Lucas Juae Mölö, Pablo Chonokó

“…In the second place, we analyze the ambiguity of the State in regards to Indian land rights recognition throughout the Bolivarian constitutional period, as reflected in various contradictions between written laws and legal practices, the separate actions and attitudes of different government agents at regional and national levels, the inconsistencies in the institutional authorities and application of norms established to promote the demarcation process, the legal lacunae or recurrent changes in the rules regarding the petition of land rights recognition, among other aspects that have impeded reaching the final goal of indigenous land demarcations: obtaining legal title or ownership rights over their lands. Third, the multiple realities of the map are evidenced by spatial-temporal polysemy, which have forced us to recognize the different ways of perceiving and experiencing space and time among non-western peoples, for example internalized in daily life yet externalized in symbolic representations at the same time. …”
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A Systematic Review on Serious Games in Attention Rehabilitation and Their Effects by Leila Shahmoradi, Fatemeh Mohammadian, Meysam Rahmani Katigari

“…There were (57%) casual, (23%) action, (10%) simulation, and (10%) multiple genres. Of the 47 tools used in the studies, 5 utilized cross-modal oddball attention tasks, 4 utilized game performance, 3 utilized the paced auditory serial additional test (PASAT), and the rest employed other tools. …”
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Acceptability of donor funding for clinical trials in the UK: a qualitative empirical ethics study using focus groups to elicit the views of research patient public involvement gro... by Simon Bowman, Heather Draper, Alexander Masters, Dominic Nutt, Kirstie Shearman

“…Other concerns discussed related to the acceptability of the donor securing a place on the trial including: whether this was an unfair distribution of benefits, disclosing the identity of the donor as the funder, protecting the donor from exploitation and funding a single study with multiple donors on the same terms. Some misgivings fell outside the usual REC purview: detrimental impact of donors of bad character, establishing the trustworthiness of the matching agency and its processes and optimising research funding and resources. …”
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Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms by Mohammad Mehdi Banoei, Abdulrazagh Hashemi Shahraki, Kayo Santos, Gregory Holt, Mehdi Mirsaeidi

“…<b>Background:</b> Sarcoidosis is a granulomatous disease affecting multiple organ systems and poses a diagnostic challenge due to its diverse clinical manifestations and absence of specific diagnostic tests. …”
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