Riesgo y vulnerabilidad de los profesionales de la salud ante la pandemia de COVID-19 by Diana L. Reartes-Peñafiel, Clara Juárez-Ramírez, Hortensia Reyes-Morales, Gaudencio Gutiérrez-Alba, José A. Muños-Hernández

“…It was developed in different phases during 2020-2021, using concurrent mixed methods and pursuing multiple objectives. This article reports findings from a qualitative section, derived from the analysis of a subsample of participants. …”
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Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Further MeRIP-seq and RIP-seq revealed 197 genes interacting with IGF2BP3, downregulated at mRNA and m6A levels after NC treatment, primarily associated with multiple metabolism-related pathways. Through intersection analysis, we pinpointed 30 potential metabolic target genes regulated by NC through IGF2BP3. …”
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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients by C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian

“…Non- confounding significant variables were included in a multiple regression model. Results. The study showed that all expressor donors genotyped as CYP3A5*1/*1 were of black African self-reported race and ethnicity. …”
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Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial by Ana Maria Ruiz-Leon, Rosa Casas, Sara Castro-Barquero, Sofia Alfaro-González, Petia Radeva, Emilio Sacanella, Francesc Casanovas-Garriga, Ainhoa Pérez-Gesalí, Ramon Estruch

“…Analysis of covariance was performed to evaluate changes at 6 and 12 weeks, adjusted for baseline levels of each variable. Multiple contrasts were corrected using a Bonferroni post hoc test. …”
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New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B by Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm

“…Pneumococci may evade host or vaccine-induced immunity as a result of variation in capsule structure mediated via multiple mechanisms, such as the loss or gain of O-acetylation. …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…This reduction was observed in all groups of the classification (Cochran-Armitage tests P < 0.001), ranging from -33.0% in Group 2a [nulliparous term cephalic singleton with forceps delivery] to -94.0% in Group 7 [multiple pregnancy]. The difference in overall prevalence of OASI between 2010 (0.7%) and 2021 (1.0%) was not statistically significant after adjustment (aRR 1.24, 95% CI 0.91 to 1.68). …”
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Patterns of beta-blocker use and dose optimization among ambulatory heart failure patients with reduced ejection fraction (HFrEF) attending public hospitals in Northeast Ethiopia:... by Minimize Hassen, Tsehaynesh Kebede Ebsa, Oumer Sada Muhammed, Tewodros Solomon, Mulat Belete Demessie, Teklehaimanot Fentie Wendie, Nuhamin Alemayehu Tesfaye, Mengistie Yirsaw Gobezie

“…Factors positively associated with beta-blocker use included Angiotensin Converting Enzyme Inhibitor use (AOR: 15.48, 95% CI: 2.11-113.54, p = 0.007), and taking multiple medications (AOR: 7.12, 95% CI: 1.54–33.02, p = 0.012), while ingestion of secondary prevention agents (AOR: 0.05, 95% CI: 0.01–0.98, p = 0.048) and male gender (AOR: 0.08, 95% CI: 0.01–0.47, p = 0.005) were negatively associated. …”
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Oncolytic influenza virus enhances killing effect of gemcitabine against pancreatic cancer cells by MENG Zihe, MENG Zihe, XU Yongru, DENG Zhaoda

“…CCK-8 assay was utilized to determine the impact of OvFlu-GM-CSF viruses ［multiplicities of infection （MOI）： 0， 0.1， 1.0， 3.0］ on the survival rate of pancreatic cancer cell lines （Panc02， PANC-1， SW1990， BxPC-3） and normal pancreatic ductal epithelial cells （HPDE6-C7） after treatment for 24， 48 or 72 h. …”
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Dealing with Complexity – Knowledge, design, and management of the built environment by Cesare Sposito, Francesca Scalisi

“…In this view, ‘complex’ should be brought back to its etymological meaning of ‘woven’ or ‘held together’, connecting different forms of knowledge in the virtuous circle of a body of knowledge articulated in a systemic view of the real world based on the principle of ‘co-evolution’ of social and ecological systems (of culture and nature) and the awareness that it determines; on the one hand, the interweaving of multiple causal chains (e.g., although the pandemic crisis is a health crisis it has also become a biological, ecological, economic, social, cultural and spiritual crisis) with interdependent effects, and on the other hand, effects that also retroact on causes since causality is circular. …”
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Prediction of slaughter weight with body components and liner body measurement of Hararge cattle at Haramaya University abattoir, Ethiopia by Takele Wolkaro, Yosef Tadesse, Mengistu Urge, Merga Bayisa

“…Simple (linear, quadratic) and multiple (linear, quadratic) regression models were used to explore the relationships between SW, and four linear body measurements. …”
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The association between controlling nutritional status and postoperative pulmonary complications in patients with colorectal cancer by Yafang Li, Chuang Nie, Na Li, Jieying Liang, Ning Su, Chunhua Yang

“…In addition, we assessed surgical outcomes including ICU admission, hospital stay, 1-year mortality and tumor-related mortality.ResultsThe incidence of PPCs was 9.0% (n = 230). Multiple regression showed that the higher the CONUT score, the higher the risk of PPCs (mild malnutrition group vs. normal nutrition group, OR: 1.61, 95% CI: 1.18–2.20, p = 0.003; moderate-to-severe malnutrition group vs. normal nutrition group, OR: 2.41, 95% CI: 1.51–3.84, p &lt; 0.001). …”
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Efficacy and safety of single and double catheter intrathecal drug delivery systems in patients with refractory neck and abdominal cancer pain by Qin Li, Huaiming Wang, Qiju Li, Maoxia Xu, Bo Zhong, Xin Hu, Jiang Zou, Pengjiu Feng, Aimin Zhang

“…Abstract Intrathecal drug delivery systems (IDDS) is a crucial for treating refractory cancer pain, but their effectiveness in patients with pain across multiple spinal segments is limited by the localized spread of pain relief medication. …”
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Nature and prevalence of long-term conditions in people with intellectual disability: retrospective longitudinal population-based study by Ashley Akbari, Navjot Kaur, Rania Kousovista, Gemma Lewin, Emeka Abakasanga, Rishika Shivamurthy, Georgina Cosma, Gyuchan Jun, Satheesh Gangadharan

“…Further work is required to translate the findings of this study into actionable insights. Clusters of multiple long-term conditions, trajectories, outcomes and risk factors should be explored to optimise the understanding and longitudinal care of individuals with intellectual disabilities and long-term conditions.…”
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Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experience... by Xiriaili Kadier, Kai Liu, Aierbanjiang Shali, Yimurang Hamiti, Sulong Wang, Xin Yang, Alimu Keremu, Aihemaitijiang Yusufu

“…Conclusion LCP used as a sequential external fixator following the distraction phase is an effective method for treating massive tibial bone defects caused by FRI and is also suitable for patients with scars and poor tissue conditions resulting from multiple previous debridement. Furthermore, this combined technique could be more beneficial in alleviating psychological burdens, supporting patients’ engagement in rehabilitation, and facilitating a return to normal life. …”
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Treating drug-resistant tuberculosis in an era of shorter regimens: Insights from rural South Africa by J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort

“…Therefore, by alleviating burdens on multiple stakeholders, a short regimen is likely to be favourable for rural patients, clinicians, and healthcare systems. …”
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CAMELS-IND: hydrometeorological time series and catchment attributes for 228 catchments in Peninsular India by N. K. Mangukiya, K. B. Kumar, P. Dey, S. Sharma, V. Bejagam, P. P. Mujumdar, P. P. Mujumdar, A. Sharma, A. Sharma

“…For each of these catchments, CAMELS-IND provides a catchment mean time series of meteorological forcings for 41 years (1980–2020) and 211 catchment attributes representing hydroclimatic and land cover characteristics extracted from multiple data sources (including ground-based observations, remote sensing-based products, and reanalyses datasets). …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…Depending on the strain examined and accessory genomic content present, conserved regulatory actions might be masked, thus investigation in multiple strains may be warranted.…”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…We present a pooled analysis from multiple cohorts of the phase 1/2 trial of patients with R/R AML who received combination olutasidenib and azacitidine therapy. …”
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Addressing Critical Mistakes in Administering Intravenous Medications at Omdurman Military Hospital, Khartoum, Sudan by Ahmed WAM, Abdelrahman AEHE, Mohamed AA, Mohammed IO, Mustafa AMA, Ahmed ZEE, Mohamed MMT, Alghamdi FAA, Elbashir AEE, Alkubati S, Al-Sowaidi A, Dinar NMAA, Obadi AA, Saleh KA

“…We observed 60 nurses responsible for intravenous drug preparation and administration using a pretested questionnaire and checklist on multiple occasions. The data was analyzed by SPSS and the descriptive and inferential statistics were applied.Results: Our findings reveal that 98% of the nurses reported a lack of formal training in IV drug preparation and administration. …”
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Application of online and offline blended teaching model combined with curriculum ideological and political education: Taking the course of clinical anesthesiology for example (线上线... by LI Jing (李静), FAN Xiaoying (范晓英), ZHANG Wanping (张万平), SU Yuqiang (苏玉强)

“…It is a comprehensive medical subject that covers a wide range of clinical medicine and involves multiple disciplines. A qualified anesthesiologist should not only have a solid theoretical and practical foundation, but also have a good professional ethics, humanistic quality and social responsibility. …”
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