Genetic diversity of Plasmodium falciparum reticulocyte binding protein homologue-5, which is a potential malaria vaccine candidate: baseline data from areas of varying malaria end... by Angelina J. Kisambale, Dativa Pereus, Salehe S. Mandai, Beatus M. Lyimo, Catherine Bakari, Gervas A. Chacha, Ruth B. Mbwambo, Ramadhan Moshi, Daniel A. Petro, Daniel P. Challe, Misago D. Seth, Rashid A. Madebe, Rule Budodo, Sijenunu Aaron, Daniel Mbwambo, Abdallah Lusasi, Stella Kajange, Samwel Lazaro, Ntuli Kapologwe, Celine I. Mandara, Deus S. Ishengoma

“…Plasmodium falciparum Reticulocyte Binding Protein Homologue 5 (Pfrh5) is a promising malaria vaccine candidate, given its limited polymorphism, its essential role in parasite survival, a lack of immune selection pressure and higher efficacy against multiple parasites strains. This study evaluated the genetic diversity of Pfrh5 gene among parasites from regions with varying malaria transmission intensities in Mainland Tanzania, to generate baseline data for this potential malaria vaccine candidate. …”
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PENGEMBANGAN INSTRUMEN PENILAIAN HASIL BELAJAR FISIKA BERORIENTASI HOTS (Higher Order Thinking Skills) PADA MATERI ELASTISITAS DAN HUKUM HOOKE by Dona Desilva, Indra Sakti, Rosane Medriati

“…The results of the research and the development showed that 1) The HOTS instrument design had the form of the question in multiple choice and essay, presentation of the questions in paper test, context of the question as outside the classroom (contextual), subject matter in Elasticity and Hooke's Law and indicators of the question in HOTS, 2) Validity test results by expert judgment and practitioners which was in the very valid category with a percentage of 97.14% for the material aspect, 98.33% for the construction aspect and 100% for the language aspect, and 3) The characteristics of HOTS instruments was referred to the HOTS indicator (at the cognitive level C4 or C5 or C6), used the Operational Verb (KKO) level C4 or C5 or C6, contextual and used stimulus (texts, images, tables).   …”
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Development of the DO₃SE-Crop model to assess ozone effects on crop phenology, biomass, and yield by P. Pande, S. Bland, N. Booth, J. Cook, Z. Feng, L. Emberson

“…The model structure allows scaling from the leaf to the canopy to allow for multiple leaf populations and canopy layers. The DO<span class="inline-formula">₃</span>SE-Crop model is calibrated and parameterised using O<span class="inline-formula">₃</span> fumigation data from Xiaoji, China, for the year 2008 and for an O<span class="inline-formula">₃</span>-tolerant and sensitive cultivar. …”
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Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Notably, in developing countries, the establishment of robust economic infrastructure is a pressing priority, serving as a cornerstone for overall growth and advancement across multiple economic sectors. However, the insufficient attention given to meeting financing requirements in this domain poses substantial challenges to economic progress. …”
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Biological characterization of novel Escherichia coli O157:H7 phages and their bacteriostatic effects in milk and pork by Qinghai Ren, Qinghai Ren, Qinghai Ren, Zhiwei Wang, Yichen Ge, Yucui Huang, Wei Zhang, Chunxue Liu, Yubao Li, Shengliang Cao

“…Two phages (vB_EcoP_SD2, vB_EcoP_SD6) of E. coli O157:H7 were isolated from slaughterhouse sewage and characterized for morphology, genomic composition, phage phylogenetic tree, optimal multiplicity of infection (MOI), one-step growth curve, thermal and pH stability and antibacterial efficacy. …”
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Establishment and Evaluation of a Rat Model of Non-Puerperal Mastitis by YIN Yulian, MA Lina, TU Siyuan, CHEN Ling, YE Meina, CHEN Hongfeng

“…After 7 days of injections, 200 μL of lactating SD rat milk was mixed with 200 μL of complete Freund's adjuvant to prepare an oil-in-water emulsion, which was administered by multiple subcutaneous injections into the back of the Wistar rats for the initial immunization. …”
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Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study by Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

“…We validated the NLR threshold of 5 from multiple previous studies in the data of this study, and patients with NLR > 5 also did not show a significant tendency towards the primary resistance group. …”
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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…Ursule Kalvaityte,1 Edvardas Bagdonas,1 Gailute Kirdaite,2 Asta Kausaite-Minkstimiene,3,4 Ilona Uzieliene,1 Almira Ramanaviciene,3,4 Anton Popov,3,4 Greta Butkiene,1,5 Vitalijus Karabanovas,1,5 Jaroslav Denkovskij,1 Ali Mobasheri,1,6– 8 Eiva Bernotiene1,9 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 2Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; 3Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 4NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Vilnius, LT-03225, Lithuania; 5Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, Vilnius, LT-08406, Lithuania; 6Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, 90014, Finland; 7World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, B-4000, Belgium; 8Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 9Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Vilnius, LT-10223, LithuaniaCorrespondence: Eiva Bernotiene, Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu G. 5, Vilnius, LT-08406, Lithuania, Tel +37068377130, Email eiva.bernotiene@imcentras.ltPurpose: For the diagnosis of various diseases, simultaneous sensitive detection of multiple biomarkers using low sample volumes is needed. …”
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Surgical treatment of small- and medium-sized primary macular holes with preservation of the internal limiting membrane in the papillomacular nerve fiber bundle area by N.M. Shilov, A.V. Tereshchenko, E.V. Erokhina, S.V. Novikov, A.A. Lugovaya, A.G. Kurguzova

“…Spectral optical coherence tomography showed multiple defects of the inner retinal layers in the perifovea of varying severity, corresponding to the area of ILM peeling and not involving the papillomacular area. …”
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Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…The analysis of the spatial pattern of river defense can improve the theoretical framework of the Great Wall defense system, thus fully integrating the multiple resource values of the Great Wall and the Yellow River. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…A positive HLA-B27 was associated with an earlier onset age, fewer cases of psoriasis, and a family history of ankylosing spondylitis. pSpA patients had a higher proportion of using conventional synthetic disease-modifying antirheumatic drugs(csDMARDs), biologic disease-modifying antirheumatic drugs(bDMARDs), and oral glucocorticoids, and they also more frequently used a combination of bDMARDs and csDMARDs(19.0% vs. 12.2%, P=0.009) or multiple csDMARDs(65.8% vs. 12.5%, P < 0.001). Compared to axSpA patients, pSpA1 patients(excluding psoriatic arthritis) did not show significant differences in the prevalence of psoriasis, uveitis, family history of psoriasis, or the use of bDMARDs, but the subgroup analysis of other variables was consistent with the results of pSpA patients.ConclusionspSpA patients tend to have a later onset of disease, a lower proportion of male and HLA-B27 positivity, more associated peripheral arthritis, dactylitis, psoriasis, and a more common family history of psoriasis. …”
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A cross-sectional study on the knowledge, attitude and practice of ICU nurses to ICU acquired weakness in grade-A tertiary hospitals in Beijing (北京市三甲医院ICU护士对ICU获得性衰弱的知信行现况调查及影响因素分... by KUANG Lu (旷璐), SHAO Xin (邵欣)

“…Results The scores of knowledge, attitude and practice of ICU nurses were (5. 21+-2. 03), (28. 64 +-4. 12) and (26. 06+- 7. 23) respectively. The results of multiple stepwise regression analysis showed that the influencing factors of knowledge about ICU-AW were professional titles and the educational level(R2=0. 062, △R2=0. 117); The influencing factors of attitude towards ICU-AW was self-evaluation of the degree of mastery of knowledge related to ICU-AW (R2=0. 062, △R2=0. 117); The influencing factors of practice of ICU-AW was working years (R2=0. 061, △R2=0. 102). …”
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Experimental study on freeze-thaw damage characteristics and mechanical properties of fractured rock mass of surface mine slope in cold region by Sen TIAN, Ying ZHAO, Hu SI, Chun ZHU, Quangui LI

“…There are numerous large-scale rock slopes in the surface mines of China, which are easily affected by multiple factors such as complex geological topography and natural, engineering disturbances, thereby resulting in frequent landslide disasters. …”
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Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000–2023): a systematic review and meta-analysis by Mozhgan Derakhshan-Sefidi, Fereshteh Eidy, Somayyeh Nadi-Ravandi, Sareh Bagheri-Josheghani, Maryam Mirfakhraei

“…Methods A comprehensive systematic search was conducted across multiple databases, including EMBASE, HINARI, MEDLINE, PubMed, Google Scholar, and the Cochrane Library. …”
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Epidemiology of hereditary eye disease in the populations of Russian Federation by V.V. Kadyshev, E.K. Ginter, S.I. Kutsev, Zh.G. Oganezova, R.A. Zinchenko

“…To confirm a certain type of inheritance of diseases from heterogeneous groups, the material was subjected to the multicomponent analysis used in multiple family registration. The rate of segregation was evaluated using the Weinberg proband method. …”
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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…To characterize the mechanism of tPA action in α-synuclein-mediated pathology in the SN and to identify possible therapeutic pathways, we performed RNA-seq analysis of the SN and used multiple transgenic mouse models. These included tPA deficient mice and two newly developed transgenic mice, a knock-in model expressing endogenous levels of proteolytically inactive tPA (tPA Ala-KI) and a second model overexpressing proteolytically inactive tPA (tPA Ala-BAC). …”
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plaTform fOr Urinary tract infection diagnostiC evAluatioN (TOUCAN): a protocol for a prospective diagnostic accuracy study of point-of-care testing in patients suspected of acute... by Thomas R Fanshawe, Philip J Turner, Gail N Hayward, Margaret Glogowska, Alastair D Hay, Michael Moore, Mark Lown, Christopher C Butler, Mandy Wootton, Mark H Wilcox, Jane Freeman, Nicola Kenealy, Valerie Tate, Owain Llion, Rebecca Lowe

“…To progress novel tests towards implementation, a diagnostic field study is required, to allow for parallel and sequential evaluation of multiple tests in a primary care population.Methods and analysis We will recruit participants assigned female at birth from primary care clinics in England who contact their clinic with symptoms of acute uncomplicated UTI. …”
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Orchard-Wide Visual Perception and Autonomous Operation of Fruit Picking Robots: A Review by CHEN Mingyou, LUO Lufeng, LIU Wei, WEI Huiling, WANG Jinhai, LU Qinghua, LUO Shaoming

“…Multi-view information fusion tackles the issue of occlusions by combining data from multiple cameras and sensors around the robot, providing a more comprehensive view of the environment and enabling more reliable sensing. …”
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Outcome Mapping as a Monitoring and Evaluation Tool for Livestock Value Chain Interventions: The Case of imGoats by Hailemichael Taye Beyene, Kees Swaans, Birgit Boogaard, Ramkumar Bendapudi, Saskia Hendrickx

“…Selection of M&E approach is dictated by the reality of multiple actors, relationships and perspectives in complex change processes. …”
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The Metempiricism of Margins: Professor Anthony Aṣiwaju and the Circumference of Knowledge by Toyin Falola

“…His Excellency, Ambassador Yai, made the remark that the Yoruba had always been diasporic, moving like a river, connecting multiple points, passing through valleys and plateaus, between mountains, across vegetation. …”
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