Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…We also discovered that BATF expression could activate multiple immune-related pathways, altering the proportions of CD8+T cells and NK cells, suggesting that BATF may be a regulator of immune cell infiltration. …”
Get full text

Age-related differences of subjective visual vertical perception in adults—a functional near-infrared spectroscopy study by Jun Lu, Jun Lu, Xiang Gong, Meng-Huan Wang, Ruo-Xin Zhao, Yu-Chen Wang, Ying-Ying Shen, Rong Cao, Guang-Xu Xu, Guang-Xu Xu

“…Neuroimaging data, adjusted for multiple comparisons using the false discovery rate, reveal activation of the right supramarginal gyrus (SMG) and the left dorsolateral superior frontal gyrus (SFGdor) in both age groups during SVV tasks. …”
Get full text

Comparative Analysis of Tillage Indices and Machine Learning Algorithms for Maize Residue Cover Prediction by Jian Li, Kewen Shao, Jia Du, Kaishan Song, Weilin Yu, Zhengwei Liang, Weijian Zhang, Jie Qin, Kaizeng Zhuo, Cangming Zhang, Yu Han, Yiwei Zhang, Bingrun Sui

“…This study demonstrates that the stacking ensemble learning model significantly improves the predictive performance by leveraging the strengths of multiple base models and accurately monitoring the spatial distribution of MRC.…”
Get full text

Prompt-based three-dimensional tooth segmentation method based on pre-trained SAM(基于预训练SAM的提示式三维牙齿分割方法) by 刘复昌(LIU Fuchang), 蔡煜晨(CAI Yuchen), 缪永伟(MIAO Yongwei), 范然(FAN Ran)

“…Then, the three-dimensional dental models were projected onto multiple two-dimensional views, and the SAM network was utilized for image segmentation. …”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Results Given the precious value of human donor eyes for studying multiple ocular cell types, we validated a co-isolation protocol of both human NCMs and retinal pigment epithelial (RPE) cells from a single eye. …”
Get full text

Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Abstract Background Meat originating from the spent hen is an important source of poultry meat production; however, multiple factors cause the decline in the meat quality of spent hens. …”
Get full text

Genome-Wide Characterization and Expression Analysis of the HD-ZIP Gene Family in Response to Salt Stress in Pepper by Zhongrong Zhang, Ranran Zhu, Xuehua Ji, Hui Ji Li, Hui Lv, Hai Ying Zhang

“…The phylogenetic tree divided CaHD-ZIP into 4 subfamilies; 40 CaHD-ZIP genes were located on different chromosomes, and all of them contained the motif 1; two pairs of CaHD-ZIP parallel genes of six paralogism genes were fragment duplications which occurred in 58.28~88.24 million years ago. There were multiple pressure-related action elements upstream of the start codon of the HD-Z-IP family. …”
Get full text

Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…Patients with low PLK-1 expression were older than patients with high PLK-1 expression (64 (49–71) years vs. 49 (42–67) years, <i>p</i> = 0.016). Multiple logistic regression confirmed that age is a significant predictor of PLK-1 expression, independent of the covariates (<i>p</i> = 0.036). …”
Get full text

Global digital elevation model (GDEM) product generation by correcting ASTER GDEM elevation with ICESat-2 altimeter data by B. Li, B. Li, B. Li, B. Li, H. Xie, H. Xie, S. Liu, Z. Ye, Z. Hong, Q. Weng, Q. Weng, Q. Weng, Y. Sun, Q. Xu, X. Tong

“…We used a high-accuracy global elevation control point dataset and multiple high-accuracy local DEMs as the validation data for a comprehensive assessment at the global scale. …”
Get full text

Intensified conditioning containing decitabine versus standard myeloablative conditioning for adult patients with KMT2A-rearranged leukemia: a multicenter retrospective study by Zhongli Hu, Zinan Feng, Shiqi Liu, Hai He, Ying Dong, Zhiping Fan, Yiqing Li, Fen Huang, Na Xu, Can Liu, Yunxin Zeng, Ping Zhu, Ren Lin, Hua Jin, Xiong Zhang, Ruijuan Sun, Qifa Liu, Li Xuan

“…Subgroup analysis showed that the relapse rate of intensified conditioning was lower than that of standard conditioning in multiple subgroups, including different leukemia types, disease status at transplantation, high-risk cytogenetics and Bu-based regimens. …”
Get full text

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors by Chrystal Paulos, Mary Jo Turk, Megen C Wittling, Yina H Huang, Asmaa O Mohamed, David Tyler Boone, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm

“…Background Responsiveness to chimeric antigen receptor (CAR) T cell therapy correlates with CAR T cell expansion and persistence in vivo. Multiple strategies improve persistence by increasing stem-like properties or sustaining CAR T cell activity with combination therapies. …”
Get full text

Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive B... by Ming Zhai, Peipei Luan, Yefei Shi, Bo Li, Jianhua Kang, Fan Hu, Mingjie Li, Lei Du, Donglei Zhou, Weixia Jian, Wenhui Peng

“…DEGs mainly participated in the process of multiple immune cells’ infiltration. In protein-protein interaction network, we identified CSF1R, C1QC, and TYROBP as hub genes. …”
Get full text

Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…Different members of the pre-CTXΦ and CTXΦ families are distinguished by the sequence of the transcriptional repressor-coding gene <i>rstR</i>. Multiple <i>rstR</i> alleles can coexist within a single strain, demonstrating the diverse structure and complex genomic integration patterns of CTXΦ/pre-CTXΦ prophage on the chromosome. …”
Get full text

Predictors of specialist care referrals (SCR) following emergency department review or hospital admission in adults with previous acute COVID-19: a prospective UK cohort study by Anita Saigal, Songyuan Xiao, Owais Siddique, Prasheena Naran, Heba M Bintalib, Camila Nagoda Niklewicz, George Seligmann, Sindhu Bhaarrati Naidu, Amar J Shah, Chibueze Ogbonnaya, John R Hurst, Marc Ci Lipman, Swapna Mandal

“…Participants had either confirmed laboratory-positive SARS-CoV-2 infection or clinically suspected acute COVID-19 and were offered post-COVID clinical follow-up at approximately six weeks after their ED attendance or inpatient discharge, to assess ongoing symptoms and support recovery. Multiple logistic regression determined associations with specialist care referrals (SCR) to respiratory, cardiology, physiotherapy (including chest physiotherapy), and mental health services. …”
Get full text

RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis by Rebecca P. Duncan, Gina R. Lewin, Daniel M. Cornforth, Frances L. Diggle, Ananya Kapur, Dina A. Moustafa, Yasmin Hilliam, Jennifer M. Bomberger, Marvin Whiteley, Joanna B. Goldberg

“…For example, generating RNA sequencing (RNA-seq) data includes multiple steps where variance can be introduced. Thus, it is unclear if RNA-seq data from different sources can be validly compared. …”
Get full text

Quality of Life and Related Factors in Discharged Patients with COVID-19 by Jinzhuo HU, Wenhuan WU, Jinwen SUN, Wei ZHANG, Shu CHENG, Zicheng GAO, Jinghua QIAN

“…The correlation between the quality of life of patients and anxiety, depression and dyspnea and the related factors were analyzed.Results:A total of 57 questionnaires were distributed, and three duplicate and invalid questionnaires were eliminated, 54 valid questionnaires were obtained, with an effective questionnaire of 94.74%.①Quality of life of discharged patients with COVID-19: the physical component summary (PCS) scores and mental component summary (MCS) scores were (37.02±12.32) and (38.46±14.42) respectively; there were 3 cases (5.56%), 45 cases (83.33%), 5 cases (9.26%), and 1 case (1.85%) with dyspnea grade 0 to 3 respectively; 19 cases (35.19%) had an anxiety state (SAS≥50), and 19 cases (35.19%) had an anxiety state (SDS≥53). ②Comparison of quality of life of COVID-19 patients with different characteristics: patients with different disease types showed statistically significant differences in the SF-12V2 PCS(<italic>P</italic>&lt; 0.05). ③Correlation analysis between quality of life, anxiety, depression and dyspnea: Pearson's correlation indicated that, anxiety (<italic>r</italic>=-0.34, <italic>P</italic>=0.011) and dyspnea (<italic>r</italic>=-0.39, <italic>P</italic>=0.003) were negatively correlated with the PCS scores, anxiety (<italic>r</italic>=-0.46, <italic>P</italic>=0.001) and depression (<italic>r</italic>=-0.40, <italic>P</italic>=0.002) were negatively correlated with the MCS scores.④Analysis of influencing factors on the quality of life of COVID-19 patients: multiple linear regression indicated that, sex (β=8.27), depression (β=-0.34) and severity of illness (β=-11.68) were significant predictors of the SF-12V2 PCS scores (<italic>P</italic>&lt; 0.05). …”
Get full text

Leveraging machine learning to uncover multi-pathogen infection dynamics across co-distributed frog families by Daniele L. F. Wiley, Kadie N. Omlor, Ariadna S. Torres López, Celina M. Eberle, Anna E. Savage, Matthew S. Atkinson, Lisa N. Barrow

“…Furthermore, sampling across broad taxonomic and geographic scales to evaluate these factors poses logistical challenges, and interpreting the roles of multiple potentially correlated variables is difficult with traditional statistical approaches. …”
Get full text

Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. Multiple linear regression, linear mixed effects models, and causal mediation analyses bootstrapped 10,000 iterations were used to investigate the underlying associations among β2M and CSF biomarkers at baseline and during a longitudinal visit. …”
Get full text

Faktor Risiko Terjadinya Ulkus Diabetikum pada Pasien Diabetes Mellitus yang Dirawat Jalan dan Inap di RSUP Dr. M. Djamil dan RSI Ibnu Sina Padang by Rizky Loviana Roza, Rudy Afriant, Zulkarnain Edward

“…Meanwhile, the results of multiple logistic regression statistical tests that the old DM, neuropathy, PAD, history of trauma, and foot care a risk factor for diabetic ulcers. …”
Get full text

Development and Validation of Multiplex-PCR Assay for <i>β-Carotene hydroxylase</i> and <i>γ-Tocopherol methyl transferase</i> Genes Governing Enhanced Multivitamins in Maize for I... by Munegowda Manoj Gowda, Vignesh Muthusamy, Rashmi Chhabra, Hriipulou Duo, Saikat Pal, Nisrita Gain, Ashvinkumar Katral, Ravindra K. Kasana, Rajkumar U. Zunjare, Firoz Hossain

“…However, due to back-to-back breeding seasons, the time required for genotyping individually for each target gene in large backcross populations becomes a constraint for advancing the generations. Additionally, multiple PCR assays for various genes increase the required costs and resources. …”
Get full text