Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients by Yuqing Qu, Haoming Li, Xianling Wang, Yulong Chen, Qinghua Guo, Yu Pei, Jin Du, Jingtao Dou, Jianming Ba, Zhaohui Lv, Yiming Mu

“…Nine patients were diagnosed with multiple endocrine neoplasia type 1 (MEN1) in which all the associated functional PanNENs were insulinomas. …”
Get full text

Mechanism of Mongolian Medicine Batri-7 on Salmonella Enteritis by Yang D, Chen S, Borijihan H, Aoqier A, Sarula S, Siqin S, Manda M, Temuqile T, Baigude H

“…Simultaneously, the Minimum Inhibitory Concentration of BT-7 was evaluated against bacterial by microbroth dilution method, BT-7 regulation of Salmonella typhimurium gene was performed by RNA-Seq methods and verified by qRT-PCR.Results: In the LC-MS/MS assay, negative and positive-ion modes are identified for 511 and 699 compounds from BT-7, respectively. Of them, we found multiple antibacterial and anti inflammation compounds including chrysin, oroxylin A and luteolin. …”
Get full text

OUR EXPERIENCE IN TREATMENT OF ENTEROATMOSPHERIC FISTULAS FORMED AS A RESULT OF MINE-EXPLOSIVE INJURY by Kyrylo Parkhomenko, Anastasia Drozdova, Kostiantyn Prokopenko, Ivan Parkhomenko

“…The study shows that only 4 (23.5%) patients had isolated intestinal injury, the other 13 (76.5%) had combined and multiple injuries. All 13 patients (except for the intestinal injury) had shrapnel wounds and penetrating injuries to the limbs, of which 4 had a traumatic hemopneumothorax, 4 had kidney and retroperitoneal injury, 3 had liver injury, and 2 had pancreas and retroperitoneal injury. , in 2 - injury of the spleen, in 1 - violation of the integrity of the pelvic bones. …”
Get full text

Phytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment by Zhao H, Bao S, Chen S, Yang Q, Lou K, Gai Y, Lin J, Liu C, Liu H, Zhang C, Yang R

“…Phy-Mast-M could inhibit 4T1 cells growth through multiple channels, including arresting cell growth cycle and disturbing mitochondrial membrane integrity. …”
Get full text

Evolution and effectiveness of bilateral and multilateral development assistance for health: a mixed-methods review of trends and strategic shifts (1990–2022) by Yan Luo, Ying Chen, Beibei Yuan, Ming Xu, Shuduo Zhou, Zhijie Zheng, Siwei Xie, Sijin Du, Yuxin Huang

“…While associations between DAH and improvements in certain health outcomes were observed, establishing causality is challenging due to multiple influencing factors. The COVID-19 pandemic underscored the importance of robust health systems. …”
Get full text

Promotive effect of cancer-testis antigen CT57 on proliferation, invasion, migration and epithelial-mesenchymal transition of liver cancer cells by LUO Lange, ZHENG Chao, LEI Ming

“…Results·Bioinformatics analysis of multiple tumors and corresponding normal tissues in The Cancer Genome Atlas Program (TCGA) database showed that CT57 was highly expressed in most tumor tissues, including liver cancer, and the expression level of CT57 was significantly correlated with the prognosis of liver cancer patients. …”
Get full text

PlaceField2BVec: A bionic geospatial location encoding method for hierarchical temporal memory model by Zugang Chen, Shaohua Wang, Kai Wu, Guoqing Li, Jing Li, Jian Wang

“…The place field was represented by the summation of four Gaussian functions, allowing it to be stretched or divided into multiple fields as the geospatial space expanded. Then we created an HTM and devised an experiment that simulated rats moving on tables of varying sizes. …”
Get full text

Prolonged pain-to-balloon time still impairs midterm left ventricular function following STEMI by Dominik Felbel, Sabrina Fackler, Rachel Michalke, Michael Paukovitsch, Matthias Gröger, Mirjam Keßler, Nicoleta Nita, Yannick Teumer, Leonhard Schneider, Armin Imhof, Dominik Buckert, Wolfgang Rottbauer, Sinisa Markovic

“…Pain-to-balloon time was divided into quartiles (Q) [0-111, 112–159, 160–246 and 247–784 min]. Multiple logistic regression analysis identified independent predictors of reduced LVEF < 50% at 1-year FU. …”
Get full text

Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…This stimulation of artemisinin by consortia and ART7 emerged from the up-regulation of major structural genes like CYP7AV1, DXS1, HMGR, DXR1, FPS, ADS, ADH2, SQC, ALDH, HMGS, ADH1, and ISPH while down-regulation of SQS, that enabled the metabolic flux flowed toward artemisinin biosynthesis and were able to disrupt the restricted enzymatic stages in the artemisinin biosynthesis pathway; besides, TFs such as bZIP, AP2, C3H, ARF, E2F, MYB, WRKY, MYC, and ERF modulate gene expression, and these proved as possible candidates for studying adaptation to multiple stress and their mechanisms. In summary, our study reflects the potential of the endophytic consortium for strengthening one endophyte's functional vulnerability with another to gain maximum artemisinin yield and plant tolerance against various stresses via regulating essential metabolic pathway genes.…”
Get full text

Modeling control strategies for concurrent epidemics of seasonal and pandemic H1N1 influenza by Olivia Prosper, Omar Saucedo, Doria Thompson, Griselle Torres-Garcia, Xiaohong Wang, Carlos Castillo-Chavez

“…Optimal social distancing policies alone can be as effective as the combination of multiple policies, reducing the total number of influenza cases by more than 99% within a single outbreak, an unrealistic but theoretically possible outcome for isolated populations with limited resources.…”
Get full text

Identifying community-driven priority questions in acoustic backscatter research by Vincent Lecours, Benjamin Misiuk, Benjamin Misiuk, Felix Butschek, Felix Butschek, Philippe Blondel, Giacomo Montereale-Gavazzi, Vanessa L. Lucieer, Chris McGonigle

“…DiscussionAll eight themes are represented in the top 10 priority questions, underscoring the need for contributions to backscatter research from multiple perspectives to advance the field. The ranking of priority questions encourages collaboration within the community and will serve as a roadmap for backscatter research programs over the next decade.…”
Get full text

Diversity in mitotic DNA repair efficiencies between commercial inbred maize lines and native Central American purple landraces by Carlos Víquez-Zamora, Sergio Castro-Pacheco, María Viñas, Pablo Bolaños-Villegas

“…The kinase gene ZeaATM1 was amplified and sequenced in B73, Mo17, P1 and P2. Multiple sequence alignment of DNA and aminoacid sequences was performed using ClustalW. …”
Get full text

The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“… Introduction: Peripheral vision has been reported to be functional in team sports when monitoring the movements of multiple players (Vater et al., 2019). Expert soccer players for example report to use their peripheral vision in 3 vs. 3 football situations (Vater et al., 2019). …”
Get full text

Comparison of integrated versus parallel continuous renal replacement therapy combined with veno-venous extracorporeal membrane oxygenation in patients with COVID-19 ARDS by Kristina Schönfelder, Felix Helmenstein, Frank Herbstreit, Johanna Reinold, Andreas Kribben, Michael Jahn, Justa Friebus-Kardash

“…Abstract Introduction Acute kidney injury (AKI) is a common complication of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) in patients receiving extracorporeal membrane oxygenation (ECMO) support, leading to requirement of continuous renal replacement therapy (CRRT) in 70% of ECMO patients. …”
Get full text

The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Jianpi Huashi Tongluo Prescription - Xinfeng Capsule (XFC), a traditional Chinese medicine formulation comprising multiple herbal ingredients, is widely used clinically for the treatment of RA. …”
Get full text

Estado nutricional y niveles de actividad física en adolescentes de instituciones educativas públicas y privadas by María V Arias-Silva, Valentina Pedreros-Lemuz, Angie L Rodríguez-Perdomo, Raúl A González-Lozano, Jorge A Ramos-Castaneda

“…Introducción: La obesidad y la inactividad física en adolescentes se asocia con múltiples enfermedades y bajo rendimiento escolar. …”
Get full text

Simultaneous Changes in Astigmatism with Noncycloplegia Refraction and Ocular Biometry in Chinese Primary Schoolchildren by Yaoyao Lin, Dandan Jiang, Chunchun Li, Xiao Chang, Balamurali Vasudevan, Xiaoqiong Huang, Wenzhe Zhou, Lei Qin, Yanyan Chen

“…Ninety-two (8.1%) non-CSA children developed CSA. In multiple regression, after adjusting for age, gender, baseline cylinder refraction, and axis, children who had longer baseline ALs (>23.58 mm; odds ratio (OR) = 5.19, 95% confidence interval (CI): 2.72–9.90) and longer baseline AL/CRC ratio (>2.99, OR = 4.99, 95% CI: 2.37–10.51) were more likely to develop CSA after two years. …”
Get full text

Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modeling by Han Zhang, Jiaxing Dai, Qiuqiao Mu, Xiaojiang Zhao, Ziao Lin, Ziao Lin, Kai Wang, Meng Wang, Meng Wang, Daqiang Sun

“…The model’s performance was validated across multiple external datasets. We also examined differences between high and low-risk groups in terms of pathway enrichment, mutation information, tumor microenvironment(TME), and immunotherapy efficacy. …”
Get full text

Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes by Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

“…We built multivariate multiple linear regression models sequentially adjusted for socio-demographic, lifestyle, and clinical covariates. …”
Get full text

Sensorimotor Robotic Measures of tDCS- and HD-tDCS-Enhanced Motor Learning in Children by Lauran Cole, Sean P. Dukelow, Adrianna Giuffre, Alberto Nettel-Aguirre, Megan J. Metzler, Adam Kirton

“…Compared to sham, both tDCS and HD-tDCS demonstrated enhanced motor learning with medium effect sizes. At baseline, multiple KINARM measures correlated with PPT performance. …”
Get full text