Thresholds for Rural Public and Ecosystem Services: Integration into Rural Green Space Spatial Planning for Sustainable Development by Huiya Yang, Jiahui Zou, Chongxiao Wang, Renzhi Wu, Maroof Ali, Zhongde Huang, Hongchao Jiang, Fan Zhang, Yang Bai

“…The results are as follows (1) With the increase in RPSs, all ESs respond with a downward trend. (2) In addition to the negative linear relationship between education and social welfare services and ESs, the response thresholds of other RPSs and ESs were identified. (3) According to multiple density threshold analysis of each RPS’s response to ESs, four functional areas were obtained. …”
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Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya by Irene N. Ogali, Paul O. Okumu, Erick O. Mungube, Jacqueline K. Lichoti, Stephen Ogada, Grace K. Moraa, Bernard R. Agwanda, Sheila C. Ommeh

“…Histopathological findings in four-week-old SPF chicken challenged with the NDV isolates KE001, KE0811, and KE0698 showed multiple organ involvement at five days after infection with severe effects seen in lymphoid tissues and blood vessels. …”
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Paleoclimatic and paleoenvironmental constraints on organic matter enrichment in the Paleocene strata in the Lishui Sag, East China Sea Shelf Basin by Shiyan Yin, Chuang Lei, Jiaren Ye, Jingfu Wu, Yu Wang, Ying Zhang, Xiaoying Han

“…Using major and trace element analyses, this study investigated the impacts of paleoclimatic and paleoenvironmental variations on organic matter enrichment in the Paleocene Yueguifeng, Lingfeng, and Mingyuefeng formations in the Lishui Sag, East China Sea Shelf Basin. Multiple geochemical proxies suggest that during the deposition of the three formations, the paleoclimate evolved from a humid climate to an arid and then back to humid conditions, the paleosalinity conditions underwent brackish, saline, and fresh water sequentially, and the paleowater conditions shifted from relatively deep water to relatively shallow water and then to shallow water. …”
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Enhancing newborn screening sensitivity and specificity for missed NICCD using selected amino acids and acylcarnitines by Peiyao Wang, Lingwei Hu, Yuhe Chen, Duo Zhou, Shasha Zhu, Ting Zhang, Ziyan Cen, Qimin He, Benqing Wu, Xinwen Huang

“…Conclusions Combining multiple metabolic markers during NBS significantly improves sensitivity and specificity for detecting missed NICCD cases. …”
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Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled... by Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Reza Heidari, Ida Mohammadi, Mohsen Chamanara, Melika Hosseinpour, Alireza Zali, Reza Mosaed, Saeed Oraee-Yazdani

“…Similarly, pain frequency ( P = 0.002), mean ( P = 0.001), and worst ( P = 0.001) numeric rating scale (NRS) pain intensity scores showed significant reductions in the treatment group after 6 months compared with the control one. Based on multiple regression analysis controlled for potential confounders, significant associations between changes in all outcome measures over the study period and the treatment group were found. …”
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Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…Both groups will be presented with the same educational material and follow a standardised JC structure hosted by nominated moderators and medical faculty members.The primary outcome is the difference in participants’ knowledge acquisition and retention 7 days after the JCs evaluated using standardised multiple-choice questions. We will report secondarily on the feasibility and acceptability of the JCs using Likert scale questionnaires. …”
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Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Paul Dowling, Simone Marcone, Caitriona Scaife, Elaine M. Kenny, Michael Henry, Paula Meleady, Paul F. Ridgway, Finbar MacCarthy, Kevin C. Conlon, Barbara M. Ryan, Stephen G. Maher

“…Abstract Integration of multi-omic data for the purposes of biomarker discovery can provide novel and robust panels across multiple biological compartments. Appropriate analytical methods are key to ensuring accurate and meaningful outputs in the multi-omic setting. …”
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Candidiasis mucocutánea crónica, infecciones micobacterianas y rosácea en un adulto mexicano con aumento de la función en STAT1 by Valeria Valerio-Gómez, Uriel Pérez-Blanco, Guillermo Velázquez-Sámano, Andrea Aída Velasco-Medina, Antonio Albarrán, Itzel Yoselín Sánchez, Laura Berrón-Ruiz, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…El diagnóstico se corroboró con la secuenciación de múltiples genes asociados con errores innatos de la inmunidad. …”
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Multidimensional analysis and enhancement strategies for ecological environment quality at the county level under dual carbon goals: a case study of Shaanxi Province, China by Jianfeng Li, Jianfeng Li, Jianfeng Li, Yongxin Hu, Yongxin Hu, Jian Li, Liangyan Yang, Liangyan Yang, Jie Yan

“…The results indicate that: 1) From 2000 to 2020, the overall EEQ in Shaanxi Province showed a fluctuating upward trend, improving from a moderate level to a good level, although some counties experienced slight degradation from 2010 to 2020. 2) The spatial distribution of county-level EEQ displayed a “low-high-low-high” gradient from north to south, indicating superior ecological conditions in the southern and central-northern counties, while northern regions faced significant ecological challenges. 3) The future trend of EEQ in Shaanxi Province is expected to be one of continuous improvement, although attention must be paid to the ongoing degradation risks in highly urbanized areas. 4) The spatial differentiation of county-level EEQ is primarily driven by climate factors and influenced by the synergistic effects of multiple factors. For counties with varying levels of EEQ, it is essential to comprehensively consider the interactions between climate, topography, and human factors, and to implement tailored carbon sequestration enhancement strategies. …”
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Factors Associated with the Technical Success of Bilateral Endoscopic Metallic Stenting with Partial Stent-In-Stent Placement in Patients with Malignant Hilar Biliary Obstruction by Toshihiro Fujita, Shinichi Hashimoto, Shiroh Tanoue, Kengo Tsuneyoshi, Yoshitaka Nakamura, Makoto Hinokuchi, Hiromichi Iwaya, Shiho Arima, Yuji Iwashita, Fumisato Sasaki, Hiroki Taguchi, Shuji Kanmura, Akio Ido

“…Regarding complications, pancreatitis occurred in 5 patients (11%), cholangitis in 6 (13%), and cholecystitis in 1 (2%). A multiple logistic regression analysis identified the use of a SEMS with a delivery system<6.0 Fr as a factor associated with technical success (P=0.033; odds ratio, 10.769; 95% confidence interval, 1.205-96.212). …”
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High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study by Liang Zhang, Min Zhang, Ying Cui, Lixin Zhang, Guanrong Zhang, Qingyang Liu, Haike Guo, Qianli Meng, Siwen Zang, Chun-Han Lo, Yanlei Chen, Jin Zeng

“…After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. …”
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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…Objectives Platform trials were used successfully in adult populations during the COVID-19 pandemic. By testing multiple treatments within a single trial, platform trials can help identify the most effective treatments (and any interactions between treatments) for patients more quickly and with less burden for patients and their families. …”
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Identifying strokes in Nigerian children with sickle cell disease as part of clinical trials: training curriculum for healthcare professionals in low-income settings by Djamila L. Ghafuri, Halima Bello-Manga, Fenella J. Kirkham, Mariana Ciobanu, Edwin Trevathan, Edwin Trevathan, Mark Rodeghier, Michael R. DeBaun, Michael R. DeBaun, Lori C. Jordan

“…We successfully identified strategies for task shifting from a single pediatric neurologist in the region to multiple non-neurologist physicians.…”
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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…Molecular docking studies showed that 4896 − 4038 has a strong binding affinity to the active site of Mpro and forms key interactions, such as hydrogen bonds, carbon-hydrogen bonds, pi-sulfur, and multiple van der Waals and pi-pi stacked bonds. The binding energy was comparable to that of the reference drug X77, indicating potential efficacy. …”
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Deep learning captures the effect of epistasis in multifactorial diseases by Vladislav Perelygin, Alexey Kamelin, Alexey Kamelin, Nikita Syzrantsev, Layal Shaheen, Layal Shaheen, Anna Kim, Nikolay Plotnikov, Anna Ilinskaya, Valery Ilinsky, Alexander Rakitko, Alexander Rakitko, Maria Poptsova

“…The aim of the presented study is to explore the power of non-linear machine learning algorithms and deep learning models to predict the risk of multifactorial diseases with epistasis.MethodsSimulated data with 2- and 3-loci interactions and tested three different models of epistasis: additive, multiplicative and threshold, were generated using the GAMETES. …”
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Exploring urban-rural inequalities of maternal healthcare utilization in Bangladesh by A.T.M. Shariful Alam, Shorful Alam, Kashfia Mobasshira, S.M. Nuruzzaman Anik, Mohammad Nayeem Hasan, Muhammad Abdul Baker Chowdhury, Md Jamal Uddin

“…Descriptive statistics provide an overview of the factors, and multiple logistic regression analysis identifies important factors in MHCS. …”
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Disease-Related Knowledge, Stress, and Quality of Life of Parental Caregivers of Children with Cleft Lip and Palate in a Selected Hospital in Ho Chi Minh City, Vietnam by Phung Le Thi Kim, Leonora Collantes, Phuong Lam Hoai, An Phan Huynh, Nghia Le Trung, Tu Nguyen Thanh, Anh Nguyen Viet, Kieu Nguyen Thi Thanh, Truc Pham Thanh Luu, Phi Duong Nguyen

“…Descriptive statistics were used to summarize the data; Pearson's correlation coefficient and multiple linear regression were used to examine the relationships between knowledge, stress, and QoL. …”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…Here the archaeological data has made it possible to trace the presence, below the later domus, of buildings from the 2nd century BC, built behind the city walls and basing part of their southernmost rooms on the sequence of cisterns with multiple vaulted chambers. While it is true that the decision to install chambered cisterns to regulate the slope of the hillside may have served to enlarge the building spaces, it is equally plausible that their purpose was also to provide the city wall defences with water reserves to supply the militia in case of siege or fire, in accordance with a common practice in ancient urban design.The military value of some of these cisterns, however, lost its significance after the establishment of the colony, as did walled fortifications. …”
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Association of coronary revascularisation after physician-referred non-invasive diagnostic imaging tests with outcomes in patients with suspected coronary artery disease: a post ho... by Takao Kato, Moriaki Inoko, Naoya Matsumoto, Yukari Uemura, Masanao Naya, Mitsuru Momose, Satoshi Hida, Takao Yamauchi, Takatomo Nakajima, Eriko Suzuki, Tohru Shiga, Nagara Tamaki

“…Objective We aimed to evaluate the association of the prognostic impact of coronary revascularisation with physician-referred non-invasive diagnostic imaging tests (single photon emission CT (SPECT) vs coronary CT angiography) for coronary artery disease.Design A post hoc analysis of a subgroup from the patient cohort recruited for the Japanese Coronary-Angiography or Myocardial Imaging for Angina Pectoris Study.Setting Multiple centres in Japan.Participants From the data of 2780 patients with stable angina, enrolled prospectively between January 2006 and March 2008 in Japan, who had undergone physician-referred non-invasive imaging tests, 1205 patients with SPECT as an initial strategy and 625 with CT as an initial strategy were analysed. …”
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Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach by Jinling Tang, Zhirong Yang, Shanshan Wu, Feng Sha, Tengfei Lin, Di Liu, Meiling Cao, Yiwen Jiang, Weijie Cao, Fuxiao Li

“…Robust associations were found between multisite chronic pain and both IBS and coexisting disorders.Conclusions Our study identified a comprehensive array of potential modifiable factors and coexisting disorders associated with IBS, supported by genetic evidence, including genetic correlation and multiple MR analyses. The presence of multisite chronic pain may offer a promising avenue for the concurrent prevention of IBS and its coexisting disorders.…”
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