Identification of progressive pulmonary fibrosis: consensus findings from a modified Delphi study by Athol U. Wells, Simon L. F. Walsh, Ayodeji Adegunsoye, Vincent Cottin, Sonye K. Danoff, Anand Devaraj, Kevin R. Flaherty, Peter M. George, Kerri A. Johannson, Martin Kolb, Yasuhiro Kondoh, Andrew G. Nicholson, Sara Tomassetti, Elizabeth R. Volkmann, Kevin K. Brown

“…Consensus was reached that progression on HRCT or a decline in FVC ≥ 10% from baseline is sufficient to determine progression, and that small declines in multiple endpoints indicates progression. Consensus was reached that a histological pattern of usual interstitial pneumonia (UIP) is a risk factor for progression of ILD, but that a biopsy to look for a UIP pattern should not be performed solely for prognostic reasons. …”
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Identification of Nontuberculous Mycobacteria in Patients with Pulmonary Diseases in Gyeongnam, Korea, Using Multiplex PCR and Multigene Sequence-Based Analysis by Min-Jeong Kim, Kyu-Min Kim, Jeong-Ih Shin, Jong-Hun Ha, Dong-Hae Lee, Jeong-Gyu Choi, Jin-Sik Park, Jung-Hyun Byun, Jung-Wan Yoo, Seokyong Eum, Myunghwan Jung, Seung Chul Baik, Woo Kon Lee, Hyung Lyun Kang, Min-Kyoung Shin

“…In particular, major mycobacterial strains with a high isolation frequency as well as coinfections with multiple species were diagnosed through two-step mPCR. …”
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Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early r... by Bong-Ki Hong, Sungyong You, Jung Gon Kim, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju, Wan-Uk Kim, Wan-Uk Kim, Ho-Youn Kim

“…IntroductionOur aim was to investigate the insufficiently understood differences in the immune system between anti-citrullinated peptide antibody (ACPA)-positive (ACPA+) and ACPA-negative (ACPA-) early rheumatoid arthritis (eRA) patients.MethodsWe performed multiple cytokine assays using sera from drug-naïve ACPA+ and ACPA- eRA patients. …”
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Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

“…The developed approach can simplify and broaden applications that require the cointroduction of multiple nucleotide modifications in HSPCs.…”
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A systematic review and mapping exercise to assess the content validity of patient-reported outcome measures for adults having reconstructive surgery of the lower limb by Jennie Lister, Sophie James, Hemant K. Sharma, Catherine Hewitt, Helen Fulbright, Heather Leggett, Catriona McDaid

“…Aims: Lower limb reconstruction (LLR) has a profound impact on patients, affecting multiple areas of their lives. Many patient-reported outcome measures (PROMs) are employed to assess these impacts; however, there are concerns that they do not adequately capture all outcomes important to patients, and may lack content validity in this context. …”
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Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus by Qiang Wei, Xiaomin Pu, Li Zhang, Yi Xu, Meifan Duan, Yuemei Wang

“…Placental DUSP9 mRNA levels in all 33 women correlated moderately with delivery gestational week (R=0.465, P=0.006), fasting plasma glucose (R=0.350, P=0.046), 1-hour postload plasma glucose (R=0.363, P = 0.038), and 2-hour postload plasma glucose (R=0.366, P=0.036), but not with maternal age, preconception body mass index, prenatal body mass index, or neonatal birth weight. Multiple linear regression analysis indicated that delivery gestational week was an influence factor of DUSP9 mRNA levels (β1=0.026, P<0.05). …”
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JWST-TST DREAMS: A Precise Water Abundance for Hot Jupiter WASP-17b from the NIRISS SOSS Transmission Spectrum by Dana R. Louie, Elijah Mullens, Lili Alderson, Ana Glidden, Nikole K. Lewis, Hannah R. Wakeford, Natasha E. Batalha, Knicole D. Colón, Amélie Gressier, Douglas Long, Michael Radica, Néstor Espinoza, Jayesh Goyal, Ryan J. MacDonald, Erin M. May, Sara Seager, Kevin B. Stevenson, Jeff A. Valenti, Natalie H. Allen, Caleb I. Cañas, Ryan C. Challener, David Grant, Jingcheng Huang, Zifan Lin, Daniel Valentine, Mark Clampin, Marshall Perrin, Laurent Pueyo, Roeland P. van der Marel, C. Matt Mountain

“…Our transmission spectrum shows multiple H _2 O absorption features and a flatter slope towards the optical than seen in previous HST observations. …”
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Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after s... by Derek C Angus, Jennifer Holder-Murray, Katherine Moll Reitz, Christopher W Seymour, Jennifer Vates, Melanie Quintana, Kert Viele, Michelle Detry, Michael Morowitz, Alison Morris, Barbara Methe, Jason Kennedy, Brian Zuckerbraun, Timothy D Girard, Oscar C Marroquin, Stephen Esper, Anne B Newman, Scott Berry, Matthew Neal

“…We describe a randomised, embedded, multifactorial, adaptative platform (REMAP) trial to investigate multiple perioperative interventions, the first of which is metformin and selected for its anti-inflammatory and anti-ageing properties beyond its traditional blood glucose control features.Methods and analysis Within a multihospital, single healthcare system, the Core Protocol for Strategies to Promote ResiliencY (SPRY) will be embedded within both the electronic health record (EHR) and the healthcare culture generating a continuously self-learning healthcare system. …”
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Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality by Emmerson C. F. de Farias, Luciana M. P. P. do Nascimento, Manoel J. C. Pavão Junior, Dalila C. A. Pavão, Ana P. S. Pinheiro, Andreza H. O. Pinheiro, Marília C. B. Alves, Kíssila M. M. M. Ferraro, Larisse F. Q. Aires, Luana G. Dias, Mayara M. M. Machado, Michaelle J. D. Serrão, Raphaella R. Gomes, Sara M. P. de Moraes, Gabriela C. L. Pontes, Railana D. F. P. Carvalho, Cristiane T. C. Silva, Carla M. A. das Neves, Joyce C. L. dos Santos, Adriana M. B. de Sousa, Leda L. da Silva, Mary L. F. M. F. de Mello, Patricia B. Carvalho, Renata de B. Braga, Kathia de O. Harada, Maria C. A. Justino, Iran B. Costa, Igor Brasil-Costa, Marta C. Monteiro, Gleice Clemente, Maria Teresa Terreri

“…BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a rare and severe post-COVID-19 complication with multiple phenotypes.ObjectivesThe aim of this study is to study inflammatory biomarkers (cytokines and oxidative stress) in critical MIS-C patients and to observe if there is association between these biomarkers and mortality.MethodsA single-center prospective study enrolled patients with MIS-C (with positive molecular test), aged between 1 month and 18 years of age. …”
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Morphological properties of two-dimensional and three-dimensional bedforms in open channel flow: A flume experiments study by Wenhong Cao, Xu Geng, Chunjing Liu, Lingfeng Zhang

“…A streamwise ridge is an important form located in the upstream area of the dunes stoss side, and they are symmetrically distributed on both sides. Multiple streamwise ridges divide the stoss side of the dunes into relatively independent movement areas, restricting the movement of sediment particles to specific regions. …”
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A novel, multi-component contingency management intervention in the context of a syndemic of drug-related harms in Glasgow, Scotland: First year of the ‘WAND’ initiative by S. Smith, K.M.A. Trayner, J. Campbell, A. McAuley, J. Craik, C. Hunter, S. Priyadarshi, S.J. Hutchinson

“…Conclusion: WAND was able to engage and re-engage large numbers of high-risk PWID with multiple harm reduction initiatives. These findings suggest contingency management could be a useful tool for harm reduction services.…”
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Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study by Mei-Ting Wei, Ying Wen, Zhu-Xia Zhang, Xiu-Ju Liu, Feng-Xiang Wei, Wei-Qiang Liu, Li Zhou, Ding-Yan Chen, Yao Yao

“…School-aged children are a particularly susceptible population to phthalate exposure, yet research examining the correlation between combined exposure to multiple phthalates and hematologic changes is limited. …”
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Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana by Boansi Adu Ababio, Gerheart Winfred Ashong, Thomas Peprah Agyekum, Blessed Adjei Yeboah, Marian Asantewah Nkansah, Jonathan Nartey Hogarh, Michael Kweku Commeh, Edward Ebow Kwaansa-Ansah, Kwabena Dabie, Felix Adulley, Eldad Boansi, Lorenda Sarbeng, Birago Adu Ababio, Maame Serwaa Boapea, Nana Kwabena Oduro Darko, Meshach Kojo Appiah

“…Furthermore, NO2 concentrations (3.65–12.15 µg m−3 ) surpassed the WHO threshold of 10 µg/m³ in multiple cities. Hazard indices indicated that PM2.5 and O3 pose significant non-carcinogenic health risks for younger age groups for a daily exposure duration of three hours and beyond. …”
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Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy by Huirong Nie, Shasha Lan, Huan Wang, Pei Xiang, Mengzhen Yan, Yang Fan, Wanqing Shen, Yijuan Li, Wen Tang, Zhiyun Yang, Yujian Liang, Yingqian Chen

“…The SMA patients showed changes in multiple small-world and network efficiency parameters. …”
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Mineralogical and geochemical characteristics of the third member of Palaeogene Dongying formation in the Nanpu Sag, Bohai Bay Basin: implications for controlling on organic matter... by Shiyan Yin, Shiyan Yin, Aidong Yao, Jianzhong Cheng, Chuang Lei, Zhaosheng Wang, Zhenguo Zhang, Ying Zhang, Yu Wang, Xiaoying Han, Zhigang Ma

“…Introduction and MethodsTo identify the unconventional shale oil exploration potential of the third member of the Palaeogene Dongying Formation (Ed3) in the Nanpu Sag, Bohai Bay Basin, variations in paleoclimate and paleoenvironment and their influence on organic matter accumulation were investigated through analyzing mineralogical and geochemical characteristics of forty-nine mudstone samples.ResultsResults show that the Ed3 mudstones exhibit strong heterogeneity with the organic carbon content ranging from 0.30% to 2.66%, petroleum potential yield ranging from 0.44 to 11.41 mg/g, and hydrogen index ranging from 57 to 466 mg/g TOC, which are dominated by mixed kerogen and low maturity to maturity. Multiple mineralogical and geochemical proxies suggest that the semi-humid to semi-arid paleoclimate during the Ed3 period governed the fluctuations of paleoenvironmental elements. …”
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Establishment and evaluation of a UPLC-MS/MS method for simultaneous determination of bongkrekic acid and dehydroacetic acid in rice noodles by Lingguo Zhao, Ronggui Lv, Ronggui Lv, Jiang Song, Xi Chen, Lei Lei, Weixian Zeng, Miaowen She, Miaowen She, Dabing Li, Xiaxia Yu, Zhanguo Liu, Xiao Wang, Yong Liu

“…Electrospray ionization negative ion mode (ESI-) was used for multiple reaction detection and external standard method was used for quantitative determination. …”
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Bell’s palsy misdiagnosis: characteristics of occult tumors causing facial paralysis by Eun-Jae Chung, Damir Matic, Kevin Fung, S. Danielle MacNeil, Anthony C. Nichols, Ruba Kiwan, KengYeow Tay, John Yoo

“…An irreversible, progressive pattern of facial paralysis combined with pain, multiple cranial neuropathies or history of skin cancer were predictable risk factors for occult tumors. …”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…Recanalization of complex CTOs is associated with high success rate and low complication rates when performed by high-volume CTO operators and after multiple reattempts.…”
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Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis by Mingyang Chen, Jing Lei, Zhenqiu Liu, Renjia Zhao, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Chen Suo, Xingdong Chen

“…Interactions between PRS and RDW on the multiplicative and additive scale were observed. Mendelian randomization provided suggestive evidence of a bi-directional causal relationship between RDW and RA. …”
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Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

“…The anthelminthic assays revealed the more polar fractions to be most active against Ascaridia galli embryos (BuOH | 68% ED | c = 500 µg/ml and EtOAc | 65% ED | c = 500 µg/ml) and Caenorhabditis elegans adult worms (BuOH | 49% WMT | c = 150 µg/ml and EtOAc | 74% WMT | c = 150 µg/ml) suggesting the fraction’s constituents possess dual anthelmintic activity against multiple life-cycle stages (i.e., eggs, worms) of helminths. …”
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