Suicide in Patients with Motor Neuron Disease by S. Bak, E. N. Stenager, E. Stenager, J. Boldsen, T. A. Smith

“…The aim of the present study was to assess, through an epidemiological study, whether suicide risk is increased in patients with motor neuron disease (MND). The study involved 116 patients with MND. …”
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Cervicothoracic Intradural Arachnoid Cyst Misdiagnosed as Motor Neuron Disease by P. G. Sämann, H. Himmerich, T. Merl, C. Erös, M. B. Müller, J. C. Tonn, B. Buchwald

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Delusion of Pregnancy in Frontotemporal Lobar Degeneration with Motor Neurone Disease (FTLD/MND) by A. J. Larner

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Rehabilitation of a patient with late motor neuron syndrome after electric shock by Tuba Tulay Koca, Nurhayat Koca

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Whole blood transcriptome profile identifies motor neurone disease RNA biomarker signatures by Sulev Kõks, Sulev Kõks, Karin Rallmann, Mari Muldmaa, Mari Muldmaa, Jack Price, Abigail L. Pfaff, Abigail L. Pfaff, Pille Taba

Subjects: “…motor neuron disease…”
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Gastrostomy uptake in motor neurone disease: a mixed-methods study of patients’ decision making by Natalie James, Emma Power, Anne Hogden, Julie Labra, Victoria M Flood

“…Objectives Gastrostomy decision making is a complicated, multifaceted process for people with motor neuron disease (MND). This study explored demographic and disease-related factors that may impact on gastrostomy uptake; and reasons why people with MND accepted or declined gastrostomy, with a focus on how perceptions of swallowing and nutrition may influence decision making.Design Prospective, cross sectional, mixed methods.Setting An Australian multidisciplinary, specialty MND Service.Participants 33 patients were recommended gastrostomy by the treating medical specialist. 16 of 33 were invited to participate in the prospective decision making study; of whom 10 provided informed consent.Primary and secondary outcome measures Demographic and disease-related factors contributing to uptake are described. …”
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Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases by Asako Otomo, Lei Pan, Shinji Hadano

“…Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of incurable motor neuron diseases (MNDs) characterized by a selective loss of upper and lower motor neurons in the brain and spinal cord. …”
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Analyzing Language Dysfunctions in Patients of Motor Neuron Disease and Their Psycho-Emotional Problems: A Case Study by Azeem Alphonce, Irfan Abbas, Riaz Riaz Ullah

“… Language dysfunctions and psycho-emotional problems in patients with motor neuron disease have been an underexplored area in the Pakistani context. …”
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A Case of Facial-Onset Sensory Motor Neuronopathy – A Rare Variant of Motor Neuron Disease by S Pramod Kumar, S Haritha, PR Sowmini, S Lakshmanan, S Sakthi Velayutham, K Malcolm Jeyaraj, V Kannan, R Viveka Saravanan, K Mugundhan

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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. …”
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Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): study protocol for a randomised controlled trial by David J. Berlowitz, Dominic Rowe, Mark E. Howard, Amanda Piper, Marnie Graco, Sabine Braat, Bhajan Singh, Tanara Viera Souza, Natasha Lannin, Alistair McLean, Abbey Sawyer, Kate A. Carey, Yasmin Ahamed, on behalf of the 3TLA Trial Group

Subjects: “…Motor neurone disease…”
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Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…Objective To confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.Design A nested case–control study.Setting 1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.Participants Baseline cohort included 16.8 million individuals aged 18 years and over without a diagnosis of MND at study entry and with more than 3 years of digitalised information available. …”
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Glymphatic dysfunction and neurodegeneration in ALS: Longitudinal insights from rNLS8 TDP-43 mice by Akram Zamani, Adam K. Walker, David K. Wright

Subjects: “…Motor neuron disease…”
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Anesthetic Challenges in Hirayama Disease Patients Undergoing Cervical Spine Surgery—A Case Series by Sreyashi Naskar, Soumya Chakrabarti, Dipanjan Dawn, Amita A. Pahari

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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

Subjects: “…motor neuron disease…”
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Staging model for amyotrophic lateral sclerosis in Singapore by Yuan Teck Tay, Josiah YH Chai, Kamilah Bte Shekh Jabin, Kexin Ang

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Barriers and enablers encountered by bereaved informal motor neuron disease (MND) caregivers when trying to access bereavement support: a qualitative cross-sectional thematic analysis of semistructured interviews with 6–36 months postbereavement informal MND caregivers in the UK by Laura Cramond, Liberty Braben, Deepsi Khatiwada, Belinda F Bradley, Suresh K. Chhetri

“…Background Caregivers of people with motor neuron disease (MND) face more negative consequences of caregiving than other terminal illnesses. …”
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Spinal muscular atrophy type 1 in the Caribbean: the first case report from the Dominican Republic by María Belén Martín-Sanz, Delvis Lucas-Muñoz, Manuel Colomé-Hidalgo, Manuel Colomé-Hidalgo

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An Overview of DNA Repair in Amyotrophic Lateral Sclerosis by Fabio Coppedè

“…Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death. …”
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Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment by Qing Liu, Ye Sun, Baodong He, Haodong Chen, Lijing Wang, Gaojie Wang, Kang Zhang, Ximeng Zhao, Xinzhe Zhang, Dongchao Shen, Xue Zhang, Liying Cui

“…This study examines the clinical features of ALS patients harboring the ANXA11 hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement. …”
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