RamA upregulates the ATP-binding cassette transporter mlaFEDCB to mediate resistance to tetracycline-class antibiotics and the stability of membranes in Klebsiella pneumoniae by Xiaoyu Zhao, Yixin Zhang, Mohan Ju, Yang Yang, Haoqi Liu, Xiaohua Qin, Qingqing Xu, Min Hao

“…We identified a novel signal pathway in which RamA mediates multidrug resistance of K. pneumoniae, leading to new ideas for the development of novel antimicrobial therapeutics, therefore deserving further comprehensive study.IMPORTANCEMultidrug-resistant and extensively drug-resistant Klebsiella pneumoniae have emerged as significant global health concerns resulting in high mortality rates. Although previous research has investigated the maintenance of lipid asymmetry (Mla) pathway, the extent to which it mediates antimicrobial resistance in K. pneumoniae and the underlying upstream regulatory mechanisms remain unclear. …”
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Evaluation of multidrug resistance in the Gram-negative microbiome of cancer patients and the adverse effects of their metabolites on albino rats and epithelial or fibroblasts cell... by Mervat Morsy Abbas Ahmed El-Gendy, Huda Ahmed Alghamdi, Khaled G. Abdel-Wahhab, Nabila S. Hassan, Aya A. M. El-Bondkly, Mohammed Abdel-Wahab, Ayman A. Farghaly, Ahmed Mohamed Ahmed El-Bondkly

“…Abstract Background Cancer is a significant global health issue due to its high incidence and mortality rates. In recent years, the relationship between the human microbiota and cancer has garnered attention across various medical fields. …”
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Non-carbapenem-producing carbapenem-resistant Pseudomonas aeruginosa in children: Risk factors, molecular epidemiology, and resistance mechanism by Lijun Yin, Lu Lu, Leiyan He, Gangfeng Yan, Guoping Lu, Xiaowen Zhai, Chuanqing Wang

“…Finding: Multivariate analysis identified prolonged hospitalization (OR: 1.026; 95 % CI: 1.004–1.049; P = 0.023) and increased exposure to enzyme inhibitor complex preparations (OR: 3.165; 95 % confidence interval [CI]: 1.113–8.999; P = 0.031) as independent risk factors for CRPA healthcare-associated infections (HAIs). Mortality rates were significantly higher in the HAI group compared to the non-HAI group (19.1 % vs. 6.0 %, P = 0.021). …”
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Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients by Mostafa Hossam El Din Moawad, Talal Salem, Anas Alaaeldin, Youssef Elaraby, Peter D. Awad, Amr Ahmed Khalifa, Ahmed El Naggar, Khaled Ashraf Mohamed, Mohamed Elhalal, Mostafa Badr, Ramy Abdelnaby

“…In terms of safety outcomes, IVT has proven a safe profile, as there was no significant difference in intracranial hemorrhage (ICH) and mortality rates between the IVT and control groups with OR of 1.75 (95CI: 0.95, 3.23, p = 0.07) and 0.93 (95%CI: 0.77, 1.11, p = 0.41), respectively. …”
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Evaluating the effectiveness of handheld ultrasound in primary blast lung injury: a comprehensive study by Shifeng Shao, Zhengbin Wu, Jun Liu, Zhikang Liao, Yuan Yao, Liang Zhang, Yaoli Wang, Hui Zhao

“…Primary blast lung injury (PBLI) is associated with high morbidity and mortality rates, while early diagnostic methods are limited. …”
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Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella by María Guembe, Rama Hafian, Marta Díaz-Navarro, Andrés Visedo, Flavio De Maio, Fulvia Pimpinelli, Ilaria Cavallo, Mauro Truglio, Francesca Sivori, Enea Gino Di Domenico

“…Our findings highlight the pathogenicity of carbapenem-resistant K pneumoniae isolates, particularly the role of the ST661 that, despite being a rare lineage, harbors the blaVIM gene and is associated with high biofilm production and the highest mortality rates.…”
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Temporal trends, associated risk factors and longitudinal cardiovascular outcomes of body roundness among middle-aged and older Chinese adults: from the China Health and Retirement... by Ying-Yuan Gan, Yun-Dan Luo, Lu Zhai, Rong-Rui Huo, Xia Dai, Qian Liao

“…BackgroundObesity is a major global health issue, driving high morbidity and mortality rates. The body roundness index (BRI), which includes waist circumference, offers a more accurate measure of visceral and total body fat. …”
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Assessment of synergistic efficacy of carbaryl in combination with Cinnamomum cassia and Origanum vulgare essential oils against Dermanyssus gallinae by Zhonghao Wang, Kai Xu, Shuo Yin, Jing Liu, Jianhua Qin, Dehe Wang, Lijun Xu, Chuanwen Wang

“…The binary mixtures of C. cassia–carbaryl (2:8), O. vulgare–carbaryl (6:4), and C. cassia–O. vulgare (7:3) exhibited the most effective contact toxicity and achieved mite mortality rates of 60 %, 66.7 %, and 65.5 %, respectively, with poison ratios of 1.22, 1.25, and 1.24, respectively, indicating synergism. …”
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Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association by Mengjie Zhao, Ning Sun, Yurong Cheng, Wantong Zhang, Jinjin Ji, Qiuyan Li, Fang Lu, Weiliang Weng

“…Currently, no studies have investigated the relationship between HGI and mortality rates among MASLD patients. This study analyzed data from the National Health and Nutrition Examination Surveys (NHANES) covering 1999 to 2018, involving 8,257 adult patients diagnosed with MASLD. …”
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Respiratory and Rehabilitation Expert Consensus on Full-cycle Rehabilitation Assessment and Treatment for Elderly Patients with Chronic Obstructive Pulmonary Disease by CHEN Xin, JIA Jie, DING Yipeng, YE Xujun, DONG Anqin, HE Jing, LIAO Weijing, ZHENG Jieqiao, YU Binbin, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, FU Jianghong, WANG Siyuan, ZHANG Yangxian

“…Pulmonary rehabilitation can significantly improve patients' respiratory function and physical fitness, alleviate symptoms, and reduce hospitalization and mortality rates. However, the specific contents of pulmonary rehabilitation for elderly COPD patients differ depending on the stage of the disease. …”
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Early-life famine exposure and subsequent risk of chronic diseases in later adulthood: a population-based retrospective cohort study by Rui Zhao, Qi Zheng, Le-qin Chen

“…The sharp decline in fertility and mortality rates has accelerated population aging, contributing to an increase in the prevalence of chronic diseases. …”
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The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients by Zhen-Hao Yu, Gui-Xiang Tian, Yao-Dong Wang, Ting-Yan Liu, Peng Shi, Jia-Yun Ying, Wei-Ming Chen, Yu-Feng Zhou, Guo-Ping Lu, Cai-Yan Zhang

“…Abstract Background Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. …”
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Hepatorenal syndrome in decompensated portal hypertension by M.I. Tutchenko, M.S. Besedinskyi, S.A. Aslanian, I.V. Kluzko, D.V. Rudyk, S.L. Chub

“…The primary criterion for diagnosing hepatorenal syndrome is the control of diuresis and its daily decline, coupled with an increase in creatinine levels exceeding 30 mmol/l within 48 hours.Varicose bleeding, severe ascites accompanied by intra-abdominal hypertension, and spontaneous bacterial peritonitis serve both as triggering factors for hepatorenal syndrome development and increase mortality rates.…”
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Scrub typhus in pregnancy: A 10-year multicenter study in resource-limited settings in China. by Peilin Zhao, Tieyong Dong, Hongbin Lu, Rui Zhu, Shanshan Zhao, Wuqian Tao, Li Li, Chunmei Liu, Shuwei Pu, Ling Mo, Huanhuan Wang

“…<h4>Background</h4>Despite its association with high mortality rates and negative fetal outcomes, large-scale epidemiological studies on scrub typhus (ST) during pregnancy remain scarce.…”
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Prognosis and factors related to severe secondary hyperparathyroidism in long-term peritoneal dialysis patients by Yanmei Li, Xiaonan Feng, Na Chen, Shuhua Song, Min Yu, Yan Wang, Hongxia Zhang, Li Wang, Menghua Chen, Na Tian

“…The sSHPT group had significantly higher infection-related mortality rates than the non-sSHPT group (12.0% vs. 4.3%; p < .05), and sSHPT was associated with increased infection-related mortality. …”
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Assessing five-year trend and socio-demographic determinants of caesarean section delivery in Ghana by Alfred Kwesi Manyeh, Anthony Ofosu, Anthony Kolsabilik Kuug, Atsu Ayi, Comfort Dede Tetteh, Saviour Edem Vidzro, Christopher Tetteh Odopey, Angela Nana Esi Ackon, Evelyn Acquah, Desmond Klu, Mustapha Immurana, Maxwell Ayindenaba Dalaba, Hubert Amu

“…By implementing these strategies, Ghana can reduce C-sections by 20–30%, lower maternal morbidity and mortality rates, and improve newborn health outcomes. …”
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Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach by Luailik Madaniyah, Saidun Fiddaroini, Elok Kamilah Hayati, Moh. Farid Rahman, Akhmad Sabarudin

“…Cancer is a significant global health issue, with rising prevalence and mortality rates demanding urgent attention. The World Health Organization emphasizes the need for effective prevention, early detection, and treatment strategies to address this public health challenge. …”
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Thyroid cancer survival and prognostic factors in Yantai, China (2012–2022): a population-based study by Haiyun Liu, Shuxia Zhang, Xiaohui Liu, Qianqian Wang, Hongjie Zhang, Weihong Cui

“…Abstract Background Although thyroid cancer is associated with low mortality rates, significant racial disparities in thyroid cancer outcomes have not been adequately studied in Asia. …”
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Fatty acids from soybeans: compatibility with Panonychus citri (Acari: Tetranychidae) and its two predators☆ by Qayyoum Muhammad Asif, Khan Bilal Saeed, Song Zi-Wei, Yi Tian-Ci, Inayat Rehan, Akram Muhammad Irfan, Mobarak Syed Husne, Li Dun-Song

“…Soybean oil, with its lower mortality rates and sublethal effects on reproduction and behavior, is a strong candidate for integrated pest management strategies. …”
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Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) pose a significant challenge to global public health, characterized by high morbidity and mortality rates, particularly in immunocompromised patients. …”
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