In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…Infectious agents such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have emerged in recent years causing epidemics with high mortality rates. The quick development of novel therapeutic compounds is required in the fight against such pathogenic agents. …”
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Association of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study by Jia Xu, Zhen Wang, Yun Wang, Xinran Chen, Lan Ma, Xiaochen Wang

“…The 30-day and 365-day mortality rates were 22.91% and 39.21%, respectively. …”
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Impact of regionalisation and case-volume on neonatal and perinatal mortality: an umbrella review by Jochen Schmitt, Stefanie Deckert, Mario Rüdiger, Felix Walther, Denise Bianca Küster, Anja Bieber, Jürgen Malzahn

“…In one SR, contradictory results of lower neonatal mortality rates were reported in hospitals with higher birth volumes.Conclusions Regionalised perinatal care seems to be a crucial care strategy to improve the survival of very low birth weight and preterm births. …”
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Voriconazole Pharmacokinetics Administered at 4 mg/kg IM and IV in Nursehound Sharks (<i>Scyliorhinus stellaris</i>) Under Human Care by Daniela Cañizares-Cooz, Daniel García-Párraga, Sonia Rubio-Langre, Teresa Encinas, Pablo Morón-Elorza

“…Fungal diseases, despite their low incidence in sharks and rays, are considered emerging diseases in this group of animals and can lead to high mortality rates despite treatment. The information available related to the treatment of fungal diseases in elasmobranchs is limited and is frequently based on the empirical knowledge provided by the professionals and clinicians working with these species. …”
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Selective and persistent toxicity of seven insecticides to five egg parasitoids of Spodoptera frugiperda by Hao-Ran Li, Cheng-Yang Li, Peng Dai, Lian-Sheng Zang, Nicolas Desneux, Wei Xu

“…. + luf. (3:1), MabrNPV, and Bt, the mortality rates of all tested parasitoid adults were below 25% (lunefuron lower than 10%). …”
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Analysis of the dynamics of transition from non-colonization to colonization and Staphylococcus aureus bacteremia in hemodialysis patients using Markov models. [version 3; peer rev... by Difariney González-Gómez, J Natalia Jiménez, Johanna M Vanegas, Daniela Montoya-Urrego

“…Background Hemodialysis patients are frequently colonized by Staphylococcus aureus, leading to severe infections with high mortality rates. However, little is known about transition from non-colonization to colonization or bacteremia over time. …”
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Knowledge and perception of stroke management practices among middle-aged residents of Otolo community in Nnewi North Local Government Area, Nigeria by Uchenna Prosper Okonkwo, Chidera Chibuikem Fortunate, Sochima Johnmark Obiekwe, Uchechukwu Martha Chukwuemeka, Christiana Nkiru Okafor, Augustine Asiduba Igwe, Jovita Ada Daniel

“…Abstract Background Stroke is a leading cause of morbidity and mortality globally, with Nigeria having one of the highest stroke mortality rates in Africa. The burden of stroke is particularly high in middle-aged individuals, who are often the primary breadwinners and caregivers in their families. …”
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Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis by Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C

“…Lingping Tan,1,2,&ast; Chi Zhang,1,2,&ast; Xiaoxing Kou,1– 3 Lu Zhao,4 Di Wu,1– 3 Jinyu Li,1,2 Chuanying Yu,1,2 Tansi Xu,1,2 Li Gao,1,2 Xueli Mao,1– 3 Chuanjiang Zhao1,2 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, People’s Republic of China; 3South China Center of Craniofacial Stem Cell Research, Guangzhou, People’s Republic of China; 4Department of Orthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuanjiang Zhao, Department of Periodontology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, People’s Republic of China, Email zhaochj@mail.sysu.edu.cn Xueli Mao, South China Center of Craniofacial Stem Cell Research, Guanghua School and Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China, Email maoxuel@mail.sysu.edu.cnIntroduction: Acute respiratory distress syndrome (ARDS) is a life-threatening type of acute lung injury (ALI) characterized by elevated mortality rates and long-term effects. To date, no pharmacological treatment has proven effective for ARDS. …”
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Burden trends and future predictions for hypertensive heart disease attributable to non-optimal temperatures in the older adults amidst climate change, 1990–2021 by Can Xu, Xinyu Nie, Rui Xu, Ge Han, Dongjin Wang

“…Additionally, male heat-related HHD mortality rates have shown a substantial increase over the past 30 years, whereas female rates have exhibited a comparatively modest decline.ConclusionAlthough cold remains the dominant non-optimal temperature factor, rising global temperatures suggest an increasing burden of heat-related HHD among the older adults. …”
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Utilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus by Chalairat Suk‐Ouichai, Mitchell M. Huang, Clayton Neill, Christopher K. Mehta, Ashley E. Ross, Shilajit D. Kundu, Kent T. Perry Jr, Duc T. Pham, Hiten D. Patel

“…Radical nephrectomy with thrombectomy is a standard treatment for patients with RCC and associated TT. Morbidity and mortality rates tend to correlate with aggressiveness of tumour and TT level. …”
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Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks by Sijia Lu, Yanbin Zhu, Yanbin Zhu, Xiaojuan Zhang, Yangji Cidan, Wangdui Basang, Kun Li

“…Weaning stress, along with dietary changes, can lead to a decline in physical fitness and immune function, making yaks more susceptible to diarrhea and resulting in high mortality rates during this period. Therefore, our study aimed to address this issue by incorporating traditional Chinese medicine (TCM) formulas into the diet of yaks during the weaning period.MethodsFollowing a dialectical analysis, three TCM formulas, mainly composed of Paeonia lactiflora, Coptis chinensis, and Dandelion, were identified for their anti-inflammatory, antioxidant, and immune enhancing potentials. …”
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Pattern and Predictors of Maternal Healthcare Services Utilization among Women of Reproductive Age in Lagos, Nigeria by Esther Oluwakemi Oluwole, Alero Ann Roberts, Ifeoma Peace Okafor, Victoria Oluwasola Yesufu

“…Background: The world still grapples with alarming maternal mortality rates, particularly in developing nations, including Nigeria. …”
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Measurement, determinants and outcomes of maternal care satisfaction in Nigeria: a systematic review by Jane E Hirst, Robyn Norton, Margaret Peden, Edward Mullins, Beatrice Wuraola Ope, Tavleen Wasan

“…Introduction Maternal mortality rates are unacceptably high in Nigeria. Understanding women’s satisfaction with the maternity health system is fundamental, as perceived quality of care is a determinant of service utilisation and improved birth outcomes.Objectives This systematic review aims to explore patients’ satisfaction with maternal healthcare in Nigeria, examining the measurement, determinants, and outcomes of satisfaction.Design A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.Data sources Searches were conducted in Embase, Maternity and Infant Care, Global Health, Ovid, Africa Journals Online, Cochrane Central Register of Controlled Trials, MEDLINE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus and Google Scholar, alongside citation searches of relevant studies.Eligibility criteria Original studies assessing patient satisfaction with maternal health services in Nigeria were included. …”
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Mixed-methods study assessing the accuracy of verbal autopsy and sociocultural determinants of infant mortality in Gujarat, India by Monika Patel, Bhavesh J. Khandhar, Niketkumar D. Satapara, M Yogesh, Samarth Rabadiya, Soumya Sharma

“…CONCLUSION: Enhancing antenatal care, skilled birth attendance, optimal breastfeeding, complementary feeding practices, addressing acute malnutrition, overcoming sociocultural barriers through community engagement, health system strengthening, and culturally sensitive interventions could potentially reduce infant mortality rates. While a verbal autopsy is practical for the cause of death determination in resource-limited settings, its effectiveness relies on addressing the identified challenges through policy measures focused on community participation, health system improvements, and culturally appropriate strategies.…”
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Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for... by Jiyauddin Khan, Priyanjana Ghosh, Urmi Bajpai, Kountay Dwivedi, Daman Saluja

“…Among various types, lung cancer is the most prevalent with high morbidity, while breast, colorectal, and pancreatic cancers also show high mortality rates. Cancer progression often involves disruption in cell cycle regulation and signaling pathways, with mutations in genes like TP53, EGFR, and K-RAS playing significant roles. …”
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A comparison of disseminated intravascular coagulation scoring systems and their performance to predict mortality in sepsis patients: A systematic review and meta-analysis. by Girum Tesfaye Kiya, Gemeda Abebe, Zeleke Mekonnen, Edosa Tadasa, Gedion Milkias, Elsah Tegene Asefa

“…The pooled proportion of cases diagnosed as positive using ISTH-DIC criteria, JAAM-DIC criteria, and SIC were 28% (95% CI: 24-34%), 55% (95% CI:42-70%), and 57% (95% CI: 52-78%), respectively. The pooled mortality rates were 44% (95% CI:33-53%), 37% (95% CI: 29-46%), and 35% (95% CI: 29-41%), respectively. …”
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Incidence and risk factors of postoperative delirium in elderly surgical patients 2023 by Efrem Fenta, Diriba Teshome, Simegnew Kibret, Metages Hunie, Abebe Tiruneh, Amsalu Belete, Amsalu Molla, Belayneh Dessie, Kumlachew Geta

“…Its presence leads to an increase in surgical morbidity and mortality rates, as well as a notable prolongation of hospital stays. …”
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Association between frailty, as measured by the FRAIL scale, and 1-year mortality in older patients undergoing hip fracture surgery by Shaohua Xi, Zhibin Wu, Jian Cui, Suran Yin, Shaozhi Xi, Chaoyang Liu

“…Postoperative complications and 1-year mortality rates were compared between these groups. The association of preoperative frailty with 1-year mortality and its predictive capability were assessed. …”
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Trends and contributors of complete continuum of maternal healthcare service utilization in Ethiopia: a multivariate decomposition analyses by Ayal Debie, Molla M. Wassie, Claire T. Roberts, Murthy N. Mittinty, Annabelle Wilson, Jacqueline H. Stephens

“…However, maternal mortality rates remain high in Ethiopia partly due to only a few women using a complete Continuum of Maternal Healthcare Services (CMHS). …”
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Association Between Artificial Liver Support System and Prognosis in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Cui K, Liu CH, Teng X, Chen F, Xu Y, Zhou S, Yang Q, Du L, Ma Y, Bai L

“…The 28-day, 60-day and 90-day transplant-free mortality rates were 25.6%, 35.8% and 38.9%, respectively. …”
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