Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases by Dimitar G. Tonev, Silvia A. Lalova, Elena P. Petkova-Lungova, Nikolay V. Timenov, Gabriela M. Radeva, Todor G. Kundurzhiev

“…All patients received parenteral dexamethasone (4 mg or 8 mg daily, 1 hour before RT, followed by the same dose for the next 4 days) along with their background and breakthrough pain opioid intake (morphine equivalents) during their 5-day in-hospital stay. …”
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Lumbar Erector Spinae Plane Block for Total Hip Arthroplasty Comparing 24-Hour Opioid Requirements: A Randomized Controlled Study by Dahlia Townsend, Nasir Siddique, Atsumi Kimura, Yaacov Chein, Eli Kamara, John Pope, Mitchell Weiser, Singh Nair, Iyabo Muse

“…The median opioid requirement in the first 8 hours after surgery was higher in the control group (28 mg of oral morphine equivalents (OME) versus 5 mg of OME in the ESPB group) (p=0.013). …”
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Illicit drug use derived from wastewater-based epidemiology in Iran, their removal during wastewater treatment, and occurrence in receiving waters by Anvar Asadi, Shabnam Zarei, Nebile Daglioglu, Evsen Yavuz Guzel, Neda Ravankhah

“…Among the analytes measured, morphine and codeine exhibited the most prevalent occurrence and highest concentration levels in all the samples. …”
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Opioid Prescription Patterns for Discharged Patients from the Emergency Department by Justin Yanuck, Jonathan B. Lee, Soheil Saadat, Jila Rouhi, Ghadi Ghanem, Bharath Chakravarthy, Shalini Shah

“…The median total prescribed milligram morphine equivalent (MME) was highest for extremity fracture (75.0; IQR 54.0–100.0). …”
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Progress in Treatment of Temporomandibular Joint Disorder by Wei YANG, Minghua XIE, Yu CAI, Zhuoming CHEN

“…., the curative effect is remarkable; He-Ne laser therapy could activate the intracranial morphine peptide system, inhibit the release of pain causing substances; when the conservative treatment is ineffective, minimally invasive surgery under the arthroscope can be selected to release adhesion and improve spasm. …”
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Analgesic Quality Improvement in Paravertebral Blocks for Pediatric Nuss Procedure: An Exploratory Report on the Effects of Perineural Combined Glucocorticoids by Donham RN, Jin E, Caty MG, Thomas DA, Yuan C, Hollingsworth K, Zhang X, Yanez ND, Li J

“…The primary outcome studied was postoperative opioid consumption measured by oral morphine milligram equivalents (MME).Results: A total of 44 patients were included in the final analysis. …”
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Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study pr... by A Eden Evins, Ellie Grossman, Julia Jashinski, Aurora Quaye, Corinne Cather, Kevin Potter, David A Schoenfeld, Jodi M Gilman

“…Here we describe the protocol for a randomised trial of the effect of cannabis, when added to a behavioural pain management and prescription opioid taper support programme, on opioid utilisation, pain intensity and pain interference.Methods This is a pragmatic, single-blind, randomised, wait-list controlled trial that aims to enrol 250 adults taking prescription opioids at stable doses of ≥25 morphine milligram equivalents per day for chronic non-cancer pain who express interest in using cannabis to reduce their pain, their opioid dose or both. …”
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Parturient on Magnesium Infusion and Its Effectiveness as an Adjuvant Analgesic after Cesarean Delivery: A Retrospective Analysis by Tanmay H. Shah, Abby R. Rubenstein, Edward S. Kosik, Stephen W. Heimbach, Abhinava S. Madamangalam

“…The Mg group also received significantly less intravenous morphine equivalents than the control group (median 5.0 (IRQ: 0.0 – 10.0) vs. 9.3 (IRQ: 6.0 – 21.1); P = 0.001) during the first 24 h after cesarean delivery. …”
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Protocol of DEXPED trial: efficacy of intravenous dexamethasone, administered at the time of analgesic blocking of the lower limb, on postoperative pain in children: a randomised,... by Nathalie Thilly, Nicolas Vautrin, Yohann Bernard, François Wurtz, Claude Meistelman

“…The primary outcome is the total doses of opioid administered (in mg/kg of morphine equivalent) within 24 hours postoperatively. …”
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Study on the Analgesic Efficacy of Femoral Nerve Block for Post-Hip Arthroscopy Pain by Mengwen Xue, Li Zhang, Ruiping Bai, Rui An, Jiarui Li, Xin Shen

“…The main outcomes included dynamic and static visual analog scale (VAS) scores at various time points postoperatively, total intraoperative remifentanil consumption, and cumulative consumption of morphine within 24 h postoperatively. Secondary outcomes included total intraoperative dexmedetomidine consumption, RASMAY sedation scores, and patients’ satisfaction scores postoperatively. …”
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Impact of vitamin C on the reduction of opioid consumption for acute musculoskeletal pain: A double-blind randomized control pilot study. by Raoul Daoust, Jean Paquet, David Williamson, Vérilibe Huard, Caroline Arbour, Jeffrey J Perry, Marcel Émond, Simon Berthelot, Patrick Archambault, Dominique Rouleau, Judy Morris, Alexis Cournoyer

“…Participants were ≥18 years of age, treated in ED for MSK injuries present for ≤2 weeks, and discharged with a standardized opioid prescription of 20 morphine 5 mg tablets (M5T) and, at the clinician discretion, 28 tablets of naproxen 500 mg. …”
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Predictors of Acute Postsurgical Pain following Gastrointestinal Surgery: A Prospective Cohort Study by Qing-Ren Liu, Mu-Huo Ji, Yu-Chen Dai, Xing-Bing Sun, Cheng-Mao Zhou, Xiao-Dong Qiu, Jian-Jun Yang

“…Results. 112 patients (39.7%) reported a clinically meaningful pain during the first 24 hours postoperatively. Oral morphine milligram equivalent (MME) consumption (β 0.05, 95% CI 0.03–0.07, p<0.001), preoperative anxiety (β 0.12, 95% CI 0.08–0.15, p<0.001), and expected postsurgical pain intensity (β 0.12, 95% CI 0.06–0.18, p<0.001) were positively associated with APSP intensity. …”
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Use of Tramadol or Other Analgesics in Patients Treated in the Emergency Department as a Risk Factor for Opioid Use by Jorge Enrique Machado-Alba, Laura Sofía Serna-Echeverri, Luis Fernando Valladales-Restrepo, Manuel Enrique Machado-Duque, Andrés Gaviria-Mendoza

“…In the tramadol group, using more than 10 mg of morphine equivalents was associated with a greater use of new opioids (HR:1.47, 95%CI:1.12–1.93). …”
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Intercostal Nerve Cryoablation During Lobectomy for Postsurgical Pain: A Safe and Cost-Effective Intervention by Daniel L. Miller, Jacob Hutchins, Michael A. Ferguson, Yazid Barhoush, Emily Achter, John P. Kuckelman

“…After 90 days, postsurgery cryoablation patients had lower opioid prescription refills (27.3 vs. 36.9 morphine milligram equivalents, p = 0.03). Cryoablation patient costs trended less than non-cryoablation patients during index ($38,753 vs. $43,974, p = 0.10) and lower through 6 months (total costs, $65,703 vs. $74,304, p = 0.10). …”
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Peripheral Nerve Blocks Are Associated With Decreased Early Medical Complications, Dislocations, and Opioid Consumption Following Total Hip Arthroplasty by Brian P. McCormick, MD, Sean B. Sequeira, MD, Mark D. Hasenauer, MD, Robert P. McKinstry, MD, Frank R. Ebert, MD, Henry R. Boucher, MD

“…Total cost and perioperative opioid consumption in morphine milligram equivalents (MMEs) per day were also evaluated and compared between groups. …”
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Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis by Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS

“…Our primary outcome was postoperative patient-reported opioid consumption within 30 days of surgery in oral morphine equivalents (OME). Our primary exposure was frailty status defined by the modified frailty index (mFi-5) criteria. …”
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The use of strong analgesics for prehospital pain management in children in the region of Southern Denmark: a register-based study by Josefine Tvede Colding-Jørgensen, Gina Maj Graven Brandstrup, Vibe Maria Laden Nielsen, Josefine Gradman, Line Anker Bang Thybo, Peter Martin Hansen, Daniel Wittrock, Stig Nikolaj Fasmer Blomberg, Helle Collatz Christensen, Søren Mikkelsen

“…In one in seventeen of all prehospital contacts with children, fentanyl, alfentanil, morphine and/or s-ketamine was administered. Three-quarters of the doses of strong analgesics were administered to patients older than 10 years. …”
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Clinical and Economic Outcomes Associated With Use of Liposomal Bupivacaine Versus Standard of Care for Management of Postsurgical Pain in Pediatric Patients Undergoing Spine Surge... by Robert Tracy Ballock, John Seif, Ryan Goodwin, Jennifer H. Lin, Jessica Cirillo

“…Outcomes included in-hospital postsurgical opioid consumption (morphine milligram equivalents [MMEs]), opioid-related adverse events (ORAEs), LOS (days), and total hospital costs. …”
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Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review. by Mahima Joshi, Javed Muneer, Lawrence Mbuagbaw, Ipsita Goswami

“…The most frequently used pharmacological agents are opioids (Morphine, Fentanyl), benzodiazepine (Midazolam) and Alpha2 agonists (Dexmedetomidine). …”
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Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences by Muriel Javier, Escorial Mónica, Margarit César, Barrachina Jordi, Carvajal Cristian, Morales Domingo, Peiró Ana M.

“…Effectiveness (< 50 mg per day of morphine equivalent daily dose without any aberrant opioid use behaviour) and safety (number of side-effects) were analysed in relation to sex differences and pharmacogenetic markers impact [OPRM1 genotype (rs1799971) and CYP2D6 phenotypes]. …”
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