Opioid-free versus opioid-based anesthesia in laparoscopic sleeve gastrectomy: a single-center, randomized, controlled trial by Hanane Barakat, Linda Gholmieh, Jessy Abou Nader, Vanda Yazbeck Karam, Obey Albaini, Mohamad El Helou, Rony Al Nawwar

“…Independent samples t-test or Mann–Whitney U test was used to assess for differences across the two groups. Results PACU morphine consumption, total postoperative morphine consumption, anti-emetic requirements up to 48 h after surgery, and pain levels after surgery were not statistically significantly different between OFA and OBA groups. …”
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Global cervical cancer elimination: quantifying the status, progress, and gaps by Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

“…The 10 countries with the highest annual opioid consumption (excluding methadone) for CC, in oral morphine equivalence per capita (2017), were all HICs. …”
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Bioactive Phytochemicals: Bioactivity, Sources, Preparations, and/or Modifications via Silver Tetrafluoroborate Mediation by Matthew C. Achilonu, Dennis O. Umesiobi

“…This review provides an overview of the biological activities, natural occurrences, and the silver tetrafluoroborate- (AgBF4-) mediated synthesis of proanthocyanidins, glycosides, N-heterocyclic alkaloid analogues (of pyrrole, morphine, quinoline, isoquinoline, and indole), furan analogues, and halocompounds. …”
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Pain in an osseous lymphoma. A case presentation. by José Julio Ojeda González, Evangelina Dávila Cabo de Villa, Alexis Guillén Sánchez

“…He was treated with analgesic through peridural via such as morphine, local anesthetic. Betametasone was used as anti-inflammatory having positive results. …”
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Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…<h4>Results</h4>In hot plate method, the highest pain inhibitory activity was found at a dose of 500 mg/kg of crude extract (3.37 ± 0.31 sec) which differed significantly (P < 0.01 and P < 0.001) with that of the standard drug morphine (6.47 ± 0.23 sec). The extract significantly prolonged reaction latency to thermal-induced pain in hotplate model. …”
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Managing Cancer Pain - Simple Rules, Major Benefits by Dwight E Moulin

“…Moderate pain requires the addition of a 'minor' opioid such as codeine (Step 2), and severe pain mandates the use of a major opioid analgesic such as morphine (Step 3). In this issue of Pain Research & Management, Gallagher et al (pages 188-194) highlight some of the barriers to adequate cancer pain management based on a cross-sectional survey of British Columbian physicians. …”
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Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Stu... by Haobin Peng, Jiajun Wen, Manli Chen, Zhengyuan Xia, Ying Jiang, Kaiqi Xie, Weitao Huang, Bangsheng Cui, Peixing Li, Yiwen Zhang, Xianping Wu

“…Pain scores at 12, 24, 36, 60, and 72 h post-block, rescue analgesia rate, time to first opioid, additional morphine consumption, and adverse events were assessed as the secondary outcomes. …”
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Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-expl... by Yanhua Zhao, Zhisheng Lu, Xuesong Song, Haihui Xie, Xungang Xiao, Guonian Wang, Qi Zhou, Qingmei Zhang, Liang Liu, Zhijian Lan, Ning Bai, Haiyan Wang, Zhihao Pan, Liang Dong, Xianzhong Lin, Gang Chen, Qinghui Wang, Jiangtao Dong, Jia Deng, Yongshan Nan, Jiaqiang Zhang, Xiaohua Zhou, Yanjuan Huang, Yongquan Chen, Huanzhong He, Ye Yang, Dengpan Yao, Jintai Jia, Shuan Jin, Yafeng Zhang, Zhonghui Luo, Jiangang Li, Linzhong Zhang, Fang Wang, Juehua Jing, Jiang Zhu, Lin Li, Guangda Wang, Huajing Guo, Qiang Wang, Diansan Su, Weifeng Yu, Xiyao Gu

“…In Phase II, 121 patients were divided into four groups to receive varying patient-controlled analgesia (PCA) doses of SHR8554 or morphine. Phase III involved 320 patients with similar groupings, including a placebo group. …”
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The Use of Opioids and Pain Medications in the Management of Postoperative Pain in Total Knee Arthroplasty Patients: A Retrospective Study by Ammar Almustafa, Asdghig Der-Boghossian, Abdel Majid Sheikh Taha

“…The postoperative pain scores and mean morphine equivalents (MME) were measured. These outcomes were assessed according to demographics, anesthesia, and analgesia used. …”
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The Current Consideration, Approach, and Management in Postcesarean Delivery Pain Control: A Narrative Review by L. Sangkum, T. Thamjamrassri, V. Arnuntasupakul, T. Chalacheewa

“…For a standard analgesic regimen, the use of long-acting neuraxial opioids (e.g., morphine) and adjunct drugs, such as scheduled acetaminophen and nonsteroidal anti-inflammatory drugs, is recommended unless contraindicated. …”
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Spinal NGF Restores Opioid Sensitivity in Neuropathic Rats: Possible Role of NGF as a Regulator of CCK-Induced Anti-Opioid Effects by Catherine M Cahill, Terence J Coderre

“…Recent evidence suggests that supplementation of spinal NGF restores morphine-induced antinociception in an animal model of neuropathic pain. …”
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Exploring the impact of xenobiotic drugs on forensic entomology for accurate post-mortem interval estimation by Sapna Jain, Jonathan J. Parrott, Gulnaz T. Javan

“…This systematic overview delves into the influence of drugs such as Morphine, heroin, Opiates, and cocaine on the variables affecting the use of forensically significant insects as evidence tools. …”
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Immobilisation and Epidural Anaesthesia in a Eurasian Lynx (Lynx lynx) Undergoing Pelvic Limb Orthopaedic Surgery by Sonia Campos, Pierre Picavet, Olivier Bertrand, Charlotte Sandersen, Alexandru Tutunaru

“…A sacrococcygeal epidural was performed before surgery using lidocaine (2 mg/kg) and morphine (0.1 mg/kg) to complement the ketamine–xylazine–isoflurane anaesthesia, which allows a low-end-tidal isoflurane concentration. …”
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Antinociceptive and Anti-Inflammatory Activities of Leaf Methanol Extract of Cotyledon orbiculata L. (Crassulaceae) by George J. Amabeoku, Joseph Kabatende

“…Paracetamol (300 mg/kg, i.p.) significantly inhibited the acetic acid-induced writhing in mice. Morphine (10 mg/kg, i.p.) significantly delayed the reaction time of mice to the thermal stimulation produced with hot plate. …”
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Pain catastrophizing is associated with high-dose opioids in patients with cancer pain by Simon van Rysewyk, Melanie Lovell, Paul Glare

“…At referral, most patients were on strong opioids, with many on high doses (>100 mg oral morphine equivalents (OME) per day). Despite higher doses of opioids, pain interference, depression, anxiety, self-efficacy, and catastrophizing scores were worse in patients with severe pain. …”
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An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray by Handong Ouyang, Shue Liu, Weian Zeng, Roy C. Levitt, Keith A. Candiotti, Shuanglin Hao

“…., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives of opium and other molecules that activate opioid receptors) induces dependence, which is associated with various specific behavioral and somatic signs after their withdrawal or after the administration of an opioid antagonist. …”
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Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado by Kelli Jo Welter, Mackenzie N. DeVine, Sharon E. Gordon, Gina Demasellis

“…The median number of rescue sedative boluses, morphine equivalents (MEs), and benzodiazepine equivalents (BZDE) significantly decreased 2 days after the first phenobarbital dose compared to the 2 days before the first phenobarbital dose. …”
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Methods of forensic examination of Nalbuphine by I. О. Besedina

“…It is emphasised that nalbuphine hydrochloride is a synthetic opioid analgesic, which is chemically similar to morphine and phenanthrene. In terms of pharmacological action, it belongs to the group of opioid receptor agonists-antagonists (pentazocine, buprenorphine, butorphanol). …”
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Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors by Milan Fedurco, Jana Gregorová, Kristýna Šebrlová, Jana Kantorová, Ondřej Peš, Roland Baur, Erwin Sigel, Eva Táborská

“…Interestingly, α1, α3, and α5 were not significantly affected by (R)-reticuline, 1,2-tetrahydroreticuline, codeine, and morphine—suspected (S)-reticuline metabolites in the rodent brain.…”
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Comparison of two bolus doses of dexmedetomidine for prophylaxis against postoperative nausea and vomiting in highly susceptible patients: A randomized controlled trial by Maha Mohamed Ismail Youssef, Amr Raafat Mahmoud Seif, Kareem Nagy Abbass Ahmed, Ghada Abo Bakr, Gihan Mohamed Obayah, Mohamed Ramadan Ahmed Mohamed

“…Results: PONV and postoperative morphine consumption were significantly reduced in group D75 compared to group D50 and in both Dex groups compared to group C. …”
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