Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia by Michaela Šiklová, Eva Krauzová, Barbora Svobodová, Jana Kračmerová, Marek Štěpán, Michal Koc, Vladimír Štich, Lenka Rossmeislová

“…In control subjects but not in FDR, the number of intermediate monocytes has declined in response to hyperinsulinemia. …”
Get full text

Low Lymphocyte-to-Monocyte Ratio as a Possible Predictor of an Unfavourable Clinical Outcome in Patients with Acute Ischemic Stroke after Mechanical Thrombectomy by Katarína Pinčáková, Georgi Krastev, Jozef Haring, Miroslav Mako, Viktória Mikulášková, Vladimír Bošák

“…Multivariate logistic regression analysis confirmed that the lymphocyte-to-monocyte ratio (LMR) was an independent predictor of unfavourable clinical outcome at 3 months (odds ratio=0.761, 95% confidence interval 0.625–0.928, and P=0.007). …”
Get full text

Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes by M. Ugur, M. Melli

“…LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)1H-tetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B4 (LTB4) receptor antagonist, inhibited the production of LTB4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B2 (TXB2). …”
Get full text

Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…Furthermore, these cells accumulated significantly in stage IV compared to stage III (p=0.006) and correlated negatively with overall survival (r=−0.471, p=0.002), lymphocyte to monocyte ratio (r=−0.446, p=0.004), and mean platelet volume to platelet count ratio (MPV/PC) (r=−0.464, p=0.003), patients with Mo‐MDSCs<13% had significantly better survival than those with Mo‐MDSCs≥13% (p=0.041). …”
Get full text

Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…Abstract Spinal cord injury (SCI) leads to permanent motor and sensory loss that is exacerbated by intraspinal inflammation and persists months to years after injury. After SCI, monocyte-derived macrophages (MDMs) infiltrate the lesion to aid in myelin-rich debris clearance. …”
Get full text

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing by Daisi Zheng, Xiaolong Li, Peicheng Wang, Qingmiao Zhu, Zhiyan Huang, Ting Zhao

“…The identified key targets are predominantly enriched in monocytes at the single-cell level, suggesting that classical monocytes may be crucial in linking inflammation and fatigue. …”
Get full text

Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis by Shih-Wei Wang, Tsun-Mei Lin, Chiou-Huey Wang, Hsiao-Han Liu, Jer-Yiing Houng

“…The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. …”
Get full text

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Conclusion The SARS-CoV-2-dependent alteration of the transcriptome of monocyte-derived macrophage (MDM)-infected cells can be linked to the chronological order of the variants’ appearance in the human population. …”
Get full text

Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…This was associated with an increased infiltration of macrophages, CXCR3 expressing CD8 T cells, and monocytic myeloid-derived suppressor cells (M-MDSCs) with a concomitant decrease in numbers of dendritic cells (DCs), in the AT of siglec-E KO fed HFD versus the WT HFD counterparts. …”
Get full text

The Intracellular Growth of M. tuberculosis Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients by Martha Torres, María Teresa Herrera, Guadalupe Fabián-San-Miguel, Yolanda Gonzalez

“…The intracellular growth of M. tuberculosis was evaluated by CFU counts at 0, 1, and 3 days in both monocytes from T2D patients and monocytes from healthy subjects cultured in HG. …”
Get full text

Peripheral Blood NMLR Can Predict 5-Year All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease by Li Y, Ge S, Liu J, Li R, Zhang R, Wang J, Pan J, Zhang Q, Zhang J, Zhang M

Subjects: Get full text

Diagnostic value of monocyte chemoattractant protein-1 (MCP-1) and lactate dehydrogenase (LDH) in malignant pleural effusion: A cross-sectional study by Iqbal Muhammad, Ngakan P. P. Putra, Ungky A. Setyawan, Nanik Setijowati

Get full text

Different Transcriptional Profiles of Human Monocyte-Derived Dendritic Cells Infected with Distinct Strains of Mycobacterium tuberculosis and Mycobacterium bovis Bacillus Calmette-Guérin by Nunzia Sanarico, Alessia Colone, Manuela Grassi, Viviana Speranza, Daniela Giovannini, Antonio Ciaramella, Vittorio Colizzi, Francesca Mariani

“…In order to analyze dendritic cells (DCs) activation following infection with different mycobacterial strains, we studied the expression profiles of 165 genes of human monocyte-derived DCs infected with H37Rv, a virulent Mycobacterium tuberculosis (MTB) laboratory strain, CMT97, a clinical MTB isolate, Mycobacterium bovis bacillus Calmette-Guérin (BCG), Aventis Pasteur, and BCG Japan, both employed as vaccine against tuberculosis. …”
Get full text

Comments on “Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease” by Mostafa Javanian, Mohammad Barary, Soheil Bakhshinasab, Soheil Ebrahimpour

Get full text

Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients by Shinwan Kany, Johann-Philipp Horstmann, Ramona Sturm, Katharina Mörs, Borna Relja

“…Reduced IL-1β secretion was paralleled by significantly lowered gene expression of NLRP3 in monocytes from TP compared to those of HV. Transfection of monocytes with NLRP3-encoding plasmid recovered the functionality of monocytes from TP regarding the IL-1β secretion. …”
Get full text

Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury by Yu Peng, Qiang Li, Lu Zhang, Ming Bai, Zheng Zhang

“…In this study, we tested the hypothesis that PPARα would decrease the expression of monocyte chemoattractant protein-1 and tissue factor, and inhibit neointimal formation in a murine double carotid artery injury model. …”
Get full text

Predictive value of monocyte-to-high-density lipoprotein-cholesterol ratio (MHR) for poor prognosis after intravenous thrombolytic therapy for acute ischaemic stroke by Yinglei Li, Lingyun Xi, Litao Li

Subjects: Get full text

A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients by Eleni-Kyriaki Vetsika, Filippos Koinis, Marianthi Gioulbasani, Despoina Aggouraki, Anna Koutoulaki, Eirini Skalidaki, Dimitris Mavroudis, Vassilis Georgoulias, Athanasios Kotsakis

“…Increased percentages of both monocytic-MDSCs’ subpopulations were inversely correlated to dendritic/monocyte levels (P≤0.04), while granulocytic-MDSCs were inversely correlated to CD4+ T cells (P=0.006). …”
Get full text

Contrasting Effects of Systemic Monocyte/Macrophage and CD4+ T Cell Depletion in a Reversible Ureteral Obstruction Mouse Model of Chronic Kidney Disease by Lee D. Chaves, Liby Mathew, Mohammed Shakaib, Anthony Chang, Richard J. Quigg, Tipu S. Puri

“…Treatment of C57BL/6 mice with liposomal clodronate to deplete monocyte/macrophages led to a relative protection from CKD as assessed by BUN values. …”
Get full text

The prognostic impact of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patients with advanced colorectal cancer treated with first-line chemotherapy by Magdalena Krakowska, Sylwia Dębska-Szmich, Rafał Czyżykowski, Anna Zadrożna-Nowak, Piotr Potemski

Subjects: Get full text