Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment by Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba

“…Chemokines were initially identified as bioactive substances, which control the trafficking of inflammatory cells including granulocytes and monocytes/macrophages. Moreover, chemokines have profound impacts on other types of cells associated with inflammatory responses, such as endothelial cells and fibroblasts. …”
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Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential by Alba Soledad Aquino-Domínguez, María de los Ángeles Romero-Tlalolini, Honorio Torres-Aguilar, Juan Carlos Rodríguez-Alba, Lucia Lourdes Martínez-Martínez, Francisco Javier Sánchez-Peña, María Teresa Hernández-Huerta, Jesús Elizarrarás-Rivas, Gabriela Tapia-Pastrana, Melisa Gómez-López, Elsa Cruz-Martínez, Uriel Eleazar Hernández-Corrales, Sergio Roberto Aguilar-Ruiz

“…Using BPI at concentrations typical of colostrum, we observed that it reduces the growth of two distinct <i>E. coli</i> strains, enhances the uptake of these bacteria by monocytes, and suppresses the secretion of the proinflammatory cytokine interleukin (IL)-8 in infected intestinal cells. …”
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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

“…We identify a role for LECs as a source of extracellular 25-HC in tumors inhibiting PPAR-γ in intra-tumoral macrophages and monocytes, preventing their immunosuppressive function and instead promoting their conversion into proinflammatory myeloid cells that support effector T cell functions. …”
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The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide by Ø. Rekdal, Z. Konopski, J. S. Svendsen, J.-O. Winberg, T. Espevik, B. Østerud

“…The synthetic TNFα 36–62, similar to TNFα, had chemotactic effects on both PMN and monocytes. The chemotactic activity of the TNFα 36–62 peptide on PMN, was inhibited by Htr-7b, Utr-1 and soluble p55 receptor, which shows that the peptide possessed the ability to induce chemotaxis through the TNF receptors. …”
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Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…We compared TCR-specific promoters of distinct origin in lentiviral vectors, that is, Vβ6.7, delta, luria, and Vβ5.1 to evaluate TCR gene expression in human primary peripheral blood monocytes and T cell line HSB2. Vectors containing Vβ 6.7 promoter were found to be optimal for expression in PBMCs, and they maintained expression of the transduced TCRs for up to 7 weeks. …”
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Pruritic Vesicular Eruption on the Lower Legs in a Diabetic Female by Hassan Riad, Hamda Al Ansari, Khaled Mansour, Haya Al Mannai, Hussein Al Sada, Samya Abu Shaikha, Sharifa Al Dosari

“…Biopsy showed epidermal separation secondary to keratinocyte necrosis and minimal monocytic, perivascular infiltrate. Direct immunofluorescence was negative for intraepidermal and subepidremal deposition of immunoglobulin. …”
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Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation by Wen Zeng, Hanjun Dai, Ming Yan, Xiaojun Cai, Hong Luo, Min Ke, Zeming Liu

“…Furthermore, we show that this FOXO3A activation is responsible for the DAC-induced differentiation of SKM-1 cells into monocytes, as well as for SKM-1 cell cycle arrest, apoptosis, and autophagy. …”
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Pitfalls in Diagnosis: JMML versus KMT2A Rearranged Juvenile AML by Liesbeth Vanheeswijck, Sanjay Tewari, Robin Dowse, Nicola Potter, Jelena Jovanovic, Caroline L. Furness, Elsje Van Rijswijk

“…This case highlights the challenges of diagnosing KMT2A-rearranged monocytic AML and the importance of careful morphological assessment in partnership with cytogenetic and molecular diagnostics to distinguish between KMT2A-rearranged AML and JMML. …”
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Multifaceted roles of ninjurin1 in immunity, cell death, and disease by Lili Zhu, Yunfei Xu, Yunfei Xu

“…It is initially characterized to promote nerve regeneration and mediate the transendothelial transport of monocytes/macrophages associated with neuroinflammation. …”
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Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis by Alina A. Alshevskaya, Julia A. Lopatnikova, Nadezhda S. Shkaruba, Oksana A. Chumasova, Aleksey E. Sizikov, Aleksander V. Karaulov, Vladimir A. Kozlov, Sergey V. Sennikov

“…The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. …”
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A comparative study on the some haematological parameters of sakız, karayaka and crossbred of sakız x karayaka ci sheep by Şevket Arıkan, Arzu Yiğit, Halil Akçapınar, Nurgül Zengin, Umut Taşdemir

“…Blood samples obtained from the animals were analysed for erythrocyte (RBC) and leucocyte (WBC) numbers, haemoglobin concentrations (Hb). haematocnt values (PCV), sedimentation rates and percentages ot lymphocytes, neutrophyls, monocytes, eosinophyls and ba-sophyls. Mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were also calculated. …”
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CD4 expression controls epidermal stem cell balance by Nadine Brandes, Heidi Hahn, Anja Uhmann

“…Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed on murine K5+ keratinocytes. …”
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Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids by Scott J. Thomson, Ara Askari, David Bishop-Bailey

“…In particular, numerous studies have demonstrated that potentiation of EET activity using different methods can inhibit inflammatory gene expression and signalling pathways in endothelial cells and monocytes and in models of cardiovascular diseases. …”
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Differential Effects of Alpha-Particle Radiation and X-Irradiation on Genes Associated with Apoptosis by Vinita Chauhan, Matthew Howland, Jeremy Chen, Barbara Kutzner, Ruth C. Wilkins

“…This study examined differential effects of alpha-(α-) particle radiation and X-rays on apoptosis and associated changes in gene expression. Human monocytic cells were exposed to α-particle radiation and X-rays from 0 to 1.5 Gy. …”
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Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo by Constance Schmelzer, Mitsuaki Kitano, Gerald Rimbach, Petra Niklowitz, Thomas Menke, Kazunori Hosoe, Frank Döring

“…Preincubation of human monocytic THP-1 cells with ubiquinol-10 reduced the LPS-induced expression level of miR-146a to 78.9 ± 13.22%. …”
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Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist? by Gregory R. Tintinger, Charles Feldman, Annette J. Theron, Ronald Anderson

“…These novel activities enable montelukast to target eosinophils, monocytes, and, in particular, the corticosteroid-insensitive neutrophil, suggesting that this agent may have a broader spectrum of anti-inflammatory activities than originally thought. …”
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Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer by Jinlong Tian, Yanlei Li, Yu Tong, Yuan Zhang, Tingxiao Zhao, Yao Kang, Qing Bi

“…There were significant correlations between UCK2 and T cells, monocytes, mast cells, and macrophages. Moreover, as expected, the immune checkpoint human leucocyte antigen (HLA) was found to be negatively related to UCK2. …”
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A Novel Approach for Objective Assessment of White Blood Cells Using Computational Vision Algorithms by Cesar Mauricio Rodríguez Barrero, Lyle Alberto Romero Gabalan, Edgar Eduardo Roa Guerrero

“…Finally, the results obtained with the validation through the coefficient of determination showed an overall accuracy of 97.9% in the classification of the white blood cells per individual, while the precision in the classification by type of cell evidenced results in 93.4% for lymphocytes, 97.37% for monocytes, 79.5% for neutrophils, 73.07% for eosinophils, and a 100% in basophils with respect to the professional. …”
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The effect of ginseng on some hematological parameters in rats fed cholesterol-rich diet by Deniz Uluışık, Ercan Keskin

“…In these blood samples, red and white blood cells, hemoglobin, hematocrit, granulocytes, lymphocytes, monocytes, mean red cell volume , mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration were measured with hemacell counter.…”
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Modulation of nitric oxide synthase activity in macrophages by P. G. Jorens, K. E. Matthys, H. Bult

“…The NO synthesizing pathway has been demonstrated in human monocytes and other cells, but its role in host defence seems to be accessory. …”
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