Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…Our approach involves a multi-omics analysis of IFI30 tumor immunological profile in the macrophage-mediated Tumor Microenvironment (TME), spanning various cancers and bolstered by rigorous co-culture laboratory work.ResultsIFI30 predominantly localizes in monocyte/macrophage populations, correlating strongly with immune cell infiltration. …”
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Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation by Alexey Ferapontov, Anders Mellemkjær, Helen M. McGettrick, Thomas Vorup-Jensen, Tue W. Kragstrup, Kristian Juul-Madsen

“…Here, we show evidence that sCD18 found in serum regulates release of the proinflammatory cytokine monocyte chemoattractant protein-1 (MCP-1/CCL2) from fibroblast-like synovial cells. …”
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MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models by Jianwei Lv, Yiran Huang, Shiguo Zhu, Ganggang Yang, Yujian Zhang, Jing Leng, Juanjie Bo, Dongming Liu

“…Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by overexpression of monocyte chemoattractant protein-1 (MCP-1) in bladder tissues and induction of mast cell (MC) degranulation. …”
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Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics by Han Yang, Xuanyu Wu, Xiang Xiao, Jiajing Chen, Xiaomin Yu, Wen Zhao, Fei Wang

“…Single cell analysis showed differences in CD14+ CD16+ monocytes, CD16+ monocytes and Granulocyte-monocyte progenito between the IPF group and the healthy control group. …”
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Highly Pathogenic Avian Influenza (HPAI) H5N1 virus in Finland in 2021–2023 – Genetic diversity of the viruses and infection kinetics in human dendritic cells by Eda Altan, Veera Avelin, Kirsi Aaltonen, Essi Korhonen, Larissa Laine, Erika Lindh, Ilkka Julkunen, Niina Tammiranta, Tiina Nokireki, Tuija Gadd, Laura Kakkola, Tarja Sironen, Pamela Österlund

“…The infection kinetics of the selected H5N1 isolates from wild pheasant and fox, and fur animals blue fox and white mink were examined in human monocyte-derived dendritic cells (moDCs) with H5N1 human isolate as a control. …”
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Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264... by Liping Liu, Hongxian Wu, Qunan Cao, Zhenzhen Guo, Anmin Ren, Qiuyan Dai

“…Pretreatment with U0126 significantly suppressed phosphorylation of ERK1/2 and further attenuated nicotine-induced activation of c-Jun and upregulation of MMP-2, MMP-9, monocyte chemotactic protein- (MCP-) 1, and regulated upon activation normal T cell expressed and secreted (RANTES). …”
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CD300E+ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients by Tao Yang, Yuan Zhang, Chujun Duan, Hui Liu, Dong Wang, Qingshan Liang, Xiao Chen, Jingchang Ma, Kun Cheng, Yong Chen, Ran Zhuang, Jikai Yin

“…We observed a similar phenomenon of liver regeneration in cirrhotic mice and further confirmed that CD300E+ monocyte-derived macrophages facilitated hepatocyte NAD+ synthesis via the secretion of NAMPT, which subsequently promoted hepatocyte proliferation. …”
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High-Mobility Group Box-1 Induces Decreased Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Retina by Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Abdullah S. Al-Kharashi, Dustan Kangave, Ghulam Mohammad

“…To test the hypothesis that brain-derived neurotrophic factor-(BDNF-) mediated neuroprotection is reduced by high-mobility group box-1 (HMGB1) in diabetic retina, paired vitreous and serum samples from 46 proliferative diabetic retinopathy and 34 nondiabetic patients were assayed for BDNF, HMGB1, soluble receptor for advanced glycation end products (sRAGE), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), and TBARS. …”
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Increasing Thai Catfish's Immunity (Pangasius hypophthalmus Fowler) Using Ascorbic Acid by , Ilmiah, D. Dana, F. H. Pasaribu, R. Affandi

“…The result of this experiment shown that feed with ascorbic acid of 2.000 mg/kg was elevated the cellular responses such as: leucocyte total (34.850 cels/mm3), differential of leucocyte (lymphocyte: 72,2%, monocyte: 8,0%, neutrophyl: 7,8%), phagocytic index (13%) and humoral response (titre antibody: 0.829 serum aglutination unit), which at the same time proves high level of survival rate against the artificial injection using A. hydrophila. …”
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The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study by Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen

“…Mediation analysis revealed that Systemic Inflammatory Response Index (SIRI), Monocyte-to-HDL ratio (MHR), and Neutrophil-to-Lymphocyte ratio (NLR) mediated 27.15%, 35.15%, and 16.55%, respectively, of the association between AVI and all-cause mortality.ConclusionAVI is positively associated with all-cause mortality in older adults with hypertension, and this association appears to be partially mediated by inflammatory parameters.…”
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Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer:... by Joachim G J V Aerts, Sjoerd H van der Burg, Martijn P Lolkema, Sai Ping Lau, Freek R van ’t Land, Marjolein Y V Homs, Casper H J van Eijck

“…This study will determine the safety of DC/anti-CD40 agonistic antibody combination treatment, and treatment-induced tumour-specific immunological responses.Methods and analysis In this open-label, single-centre (Erasmus Univsersity Medical Center, Rotterdam, Netherlands), single-arm, phase I dose finding study, adult patients with metastatic pancreatic cancer with progressive disease after FOLFIRINOX chemotherapy will receive monocyte-derived DCs loaded with an allogeneic tumour lysate in conjunction with a CD40 agonistic antibody. …”
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Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK by Naru Morita, Toshio Hosaka, Atsuko Kitahara, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Kazuto Takahashi, Toshiaki Tanaka, Takuma Kondo, Hitoshi Ishida

“…To elucidate the role of AMPK, in this study, we observed the effects of AMPK activation on monocyte chemoattractant protein-1 (MCP-1) release in mature 3T3-L1 adipocytes. …”
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Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice by Yangchen Dhondup, Ivar Sjaastad, Øystein Sandanger, Jan Magnus Aronsen, Muhammad Shakil Ahmed, Håvard Attramadal, Alexandra Vanessa Finsen, Lili Zhang, Trine Ranheim, Katrine Alfsnes, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge

“…Both HF groups displayed increased left atrium size, lung weight, fetal gene expressions, monocyte/macrophage infiltration, and fibrosis. However, there were no significant differences between the groups. …”
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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri

“…We investigated whether NAS TLRs can induce MK and PTN production by human iAPCs, namely monocytes, macrophages, MDDCs, myeloid dendritic cells (mDCs), and pDCs. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…We found that luteolin decreased the levels of interleukin- (IL-) 6, IL-8, soluble intercellular adhesion molecule-1 (sICAM-1), and monocyte chemoattractant protein-1 (MCP-1) and attenuated adherence of the human monocytic leukemia cell line THP-1 to IL-1β-stimulated ARPE-19 cells. …”
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Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell by Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan

“…Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. …”
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Evaluation of placental growth factor, Vitamin D, and systemic inflammatory index as predictive biomarkers for preeclampsia severity: a retrospective cohort study by Xiaoyan Han, Hua Yang

“…Data on demographic, clinical, and laboratory characteristics, including PlGF, Vitamin D, neutrophil, lymphocyte, and monocyte counts, were collected between 16 and 20 weeks of gestation. …”
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Clinical Comparative Study of Intravitreal Injection of Triamcinolone Acetonide and Aflibercept in the Treatment of Diabetic Retinopathy Cystoid Macular Edema by Yanxia Zhu, Jun Li, Songping Yu, Bangxun Mao, Jia Ying

“…The clinical curative effect, visual acuity, central subfield macular thickness (CSMT), macular volume, scores of quality of life, and levels of cytokines in aqueous humor (vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), human angiopoietin-like protein 4 (ANGPTL4)] at different time points (before and at 6 months after surgery) were compared between the two groups. …”
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Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study by Qiaoer Chen, Qiaoer Chen, Weiqi Wu, Lu Wang, Honghong Huang, Lingxing Wang

“…Patients with the parenchymal type were younger and had higher platelet-to-lymphocyte ratio (PLR) and lower lymphocyte-to-monocyte ratio (LMR). Overall, 126 (88.7%) patients completed anti-syphilitic treatment prior to discharge, with 111 (88.1%) showing poor outcomes.DiscussionAn elevated CSF protein level and the parenchymal type were associated with poor outcome. …”
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Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis? by Thomas Bertran, Patrick Brachet, Marjolaine Vareille-Delarbre, Julie Falenta, Annie Dosgilbert, Marie-Paule Vasson, Christiane Forestier, Arlette Tridon, Bertrand Evrard

“…We investigated the interactions between G. vaginalis and human monocyte-derived DCs using a wide range of bacterial concentrations (multiplicity of infection from 0.01 to 100), and the effects of this pathogen on PHA-induced lymphocyte proliferation. …”
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