Survey Report Analysis on Parasitic and Microbial Quality of Laboratory Animals in Sichuan Province, 2017-2023 by LIU Lida, CHEN Bing, XIE Na, LIU Li, ZHUANG Siqi, ZOU Yixing

“…Methods Sichuan Province has 31 licensed laboratory animal production units, with the main species including mice, rats, guinea pigs, rabbits, dogs, monkeys, and pigs. Sampling inspections and reports were conducted for units with laboratory animal production qualifications in accordance with current national and local standards for laboratory animal classification. …”
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The Inconsistency of the Algorithms of Jaro–Winkler and Needleman–Wunsch Applied to DNA Chain Similarity Results by Boris Melnikov

“…In this paper, we consider the distance matrices for the two mentioned algorithms, calculated for the mitochondrial DNA of 32 species of monkeys belonging to different genera. For them, 4960 triangles are formed in both matrices, and we calculate the values of the rank correlation between these sequences. …”
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Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake by James A. Edwards

“…A 52-week chronic oral study in Cynomolgus monkeys at doses of 0.2 and 20 mg/kg bw/day, mainly designed to assess accumulation and effects in primate eyes, showed no adverse effects. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…In vivo antitumour activity was assessed by establishing humanized mice bearing human MSLN-expressing MC38 (MC38/hMSLN) or CT26 (CT26/hMSLN) cells, and safety was further evaluated in cynomolgus monkeys. Results We generated two humanized anti-MSLN×4-1BB bsAbs (HK013-G1/G4) by fusing an anti-4-1BB scFv to the C-terminus of an anti-MSLN VHH with an intact Fc fragment from human IgG1 or IgG4. …”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Pharmacokinetic studies of the αvβ8 antibody were conducted in cynomolgus monkeys. Results Integrin αvβ8 is notably expressed in certain tumor types and tumor-infiltrating macrophages. …”
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Alu-Sc-mediated exonization generated a mitochondrial LKB1 gene variant found only in higher order primates by Ivan Tan, Sonia Chothani, Hong-Hwa Lim, Kong-Peng Lam

“…While putative exon 1b sequences are recognizable in most members of the primate family from New World Monkeys onwards, characteristically functional LKB1/STK11 exon 1b, with translation start and 5ʹ and 3ʹ splice sites, could only be found in greater apes and human, and interestingly, correlates with their increased body mass and longevity development.…”
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Dynamic tracking of objects in the macaque dorsomedial frontal cortex by Rishi Rajalingham, Hansem Sohn, Mehrdad Jazayeri

“…We find that neurons in the monkeys’ dorsomedial frontal cortex (DMFC) represent task-relevant information about the ball position in a multiplexed fashion. …”
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A PAF receptor antagonist inhibits acute airway inflammation and late-phase responses but not chronic airway inflammation and hyperresponsiveness in a primate model of asthma by R. H. Gundel, C. D. Wegner, H. O. Heuer, L. G. Letts

“…In contrast, a multiple dosing regime with WEB 2170 (once a day for 7 consecutive days) failed to reduce the chronic airway inflammation (eosinophilic) and associated airway hyperresponsiveness to inhaled methacholine that is characteristic of dual responder monkeys. Thus, we conclude that the generation of PAF following antigen inhalation contributes to the development of lipid mediators, acute airway inflammation and associated late-phase airway obstruction in dual responder primates; however, PAF does not play a significant role in the maintenance of chronic airway inflammation and associated airway hyperresponsiveness in this primate model.…”
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Temporal variation in black-caiman-nest predation in varzea of central Brazilian amazonia. by Kelly Torralvo, Robinson Botero-Arias, William E Magnusson

“…On the Amazon floodplain, the main predators of black caiman (Melanosuchus niger) eggs are jaguars (Panthera onca), tegu lizards (Tupinambis teguixim), capuchin monkeys (Sapajus macrocephalus) and humans (Homo sapiens). …”
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Analysis of Determinants of Economic Efficiency in Honey Production in Horo Guduru Zone, Ethiopia: Stochastic Dual Cost Frontier Model Approach by Tolesa Tesema, Megersa Adugna

“…Additionally, since farmers in the study area spend their time guarding the honey from damage by ants and monkeys, labor that utilizes technology must be made available in the study area.…”
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Capacités vocales des primates non humains, des Homo sapiens et des hominines fossiles : un état de la question by Marion Laporte, Amélie Vialet

“…In this context, Philip Lieberman demonstrated that the descent of the larynx is a necessary condition for language, explaining why monkeys and Neanderthals lack it. This proposition dominated for half a century, hindering research on the vocal production of non-human primates used as a model to address the capacities of fossil hominins. …”
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Prior Knowledge of Target Direction and Intended Movement Selection Improves Indirect Reaching Movement Decoding by Hongbao Li, Yaoyao Hao, Shaomin Zhang, Yiwen Wang, Weidong Chen, Xiaoxiang Zheng

“…In this study, spike activities were collected from the PMd of two monkeys when performing a delayed obstacle-avoidance task. …”
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This or not that: select and reject control of relational responding in rats using a blank comparison procedure with odor stimuli by Bobbie Faith Wolff, Mark Galizio, Katherine Bruce

“…This task has been used to study exclusion learning, mostly in humans and monkeys, and the present study extends the procedure to rats. …”
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Threat perception and behavioral reactivity in response to an acute stressor in infant rhesus macaques by Tara M. Mandalaywala, Sean P. Coyne

“…At approximately 5 months of age, free-ranging rhesus macaque infants on Cayo Santiago, Puerto Rico (N = 44) were briefly separated from their social group and underwent a maternal separation test, a validated stressor shown to induce anxiety in infant monkeys (Sánchez et al., 2001). We assessed their behavioral (Temperament Task) and cognitive (Threat perception/Vigilance for Threat task) reactivity. …”
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Corrigendum to “Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake” by James A. Edwards, Dirk Cremer

“…A 52-week chronic oral study in cynomolgus monkeys at doses of 0.2 and 20 mg/kg  bw/day, mainly designed to assess accumulation and effects in primate eyes, showed no adverse effects. …”
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Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors by Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge

“…Second, three methods of scaffold fixation, including adhesion after gas-liquid exchange (n=1), tamponade by hydrogel (n=1), and fixation by retinal tacks (n=4), were performed in rhesus monkeys. After one month, fundus photography and SD-OCT were performed to assess the outcomes, and histological examination was performed to evaluate proliferation. …”
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut by Xina Xiao, Meng Hu, Li Gao, Huan Yuan, Baochen Chong, Yu Liu, Rou Zhang, Yanqiu Gong, Dan Du, Yong Zhang, Hao Yang, Xiaohui Liu, Yan Zhang, Huiyuan Zhang, Heng Xu, Yi Zhao, Wenbo Meng, Dan Xie, Peng Lei, Shiqian Qi, Yong Peng, Tao Tan, Yang Yu, Hongbo Hu, Biao Dong, Lunzhi Dai

“…By developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), we shed light on Cys redox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys. Notably, the proteins modified by SOH and SSG were associated primarily with cell adhesion. …”
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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

“…We observed upregulated and downregulated metabolic status in CHIKV‐infected rhesus monkeys and mice, respectively. Additionally, we identified host factors such as S100 Calcium‐Binding Protein A8/A9 (S100A8/A9), Voltage‐Dependent Anion Channel 1/2 (VDAC1/2), Complement Component 3 (C3), Apoptosis‐Inducing Factor Mitochondria‐Associated 1 (AIFM1), Endothelial Cell‐Specific Chemotaxis Regulator (ECSCR), and Kininogen 1 (KNG1) that may contribute to CHIKV‐induced inflammation and hemorrhage. …”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…The mRNA treatment in monkeys produced 3N39v4 in sera, which inhibited the replication of the authentic viruses. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…Seeking to refine the vaccine antigenic target and achieve scalable manufacturing compatible with Good Manufacturing Practices, we mapped linear B-cell epitopes spanning the entire VirG protein sequence by probing the immune reactivity of 10-mer peptides (overlapping 4–8 aa) with sera from Shigella-infected rhesus monkeys. The surface-exposed VirG53 – 353 subregion of the passenger α-domain demonstrated the highest and strongest immunoreactivity. …”
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