Matrine Attenuates COX-2 and ICAM-1 Expressions in Human Lung Epithelial Cells and Prevents Acute Lung Injury in LPS-Induced Mice by Chian-Jiun Liou, You-Rong Lai, Ya-Ling Chen, Yi-Hsien Chang, Zih-Ying Li, Wen-Chung Huang

“…Here we evaluated matrine’s suppressive effects on cyclooxygenase 2 (COX-2) and intercellular adhesion molecule-1 (ICAM-1) expressions in lipopolysaccharide- (LPS-) stimulated human lung epithelial A549 cells. …”
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Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study by Jichen Zhang, Jiancan Lu, Hongling Zhu, Xinglu Zhou, Xijuan Wei, Mingjun Gu

“…Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.…”
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Microglia Play a Major Role in Direct Viral-Induced Demyelination by Dhriti Chatterjee, Kaushiki Biswas, Soma Nag, S. G. Ramachandra, Jayasri Das Sarma

“…Current studies revealed that MHV infection is associated with the pronounced activation of microglia during acute inflammation, as evidenced by characteristic changes in cellular morphology and increased expression of microglia-specific proteins, Iba1 (ionized calcium-binding adaptor molecule 1), which is a macrophage/microglia-specific novel calcium-binding protein and involved in membrane ruffling and phagocytosis. …”
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Computational analysis of spliced leader trans-splicing in the regenerative flatworm <i>Macrostomum lignano</i> reveals its prevalence in conserved and stem cell related genes by K. V. Ustyantsev, E. V. Berezikov

“…One of the functions of SL trans-splicing is processing polycistronic pre-mRNA molecules transcribed from operons, when several genes are transcribed as one pre-mRNA molecule. …”
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Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy by Felicity J. Ashcroft, Asimina Bourboula, Nur Mahammad, Efrosini Barbayianni, Astrid J. Feuerherm, Thanh Thuy Nguyen, Daiki Hayashi, Maroula G. Kokotou, Konstantinos Alevizopoulos, Edward A. Dennis, George Kokotos, Berit Johansen

“…We identify a more potent and selective lead molecule, GK420 (AVX420), which we test in parallel with AVX235 and a structurally unrelated compound, AVX002 for inhibition of cell viability across a panel of cancer cell lines. …”
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

“…<h4>Methods and findings</h4>Here we show that three ECs in that study made at least seven robust CD8+ T cell responses directed against novel epitopes in Vif, Rev, and Nef restricted by the MHC class I molecule Mamu-B*08. Two of these Mamu-B*08-positive animals subsequently lost control of SIV replication. …”
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A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease by Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova

“…Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS. …”
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Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

“…Many of these altered sites are clustered within regulatory elements of differentially expressed genes, including the tumour suppressor gene cell adhesion molecule 1 (CADM1), which supresses epithelial cell growth and invasion. …”
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Inorganic polyphosphate and the stringent response coordinately control cell division and cell morphology in Escherichia coli by Christopher W. Hamm, Michael J. Gray

“…Escherichia coli also makes inorganic polyphosphate (polyP), an ancient molecule evolutionary conserved across most bacteria and other cells, in response to a variety of stress conditions, including amino acid starvation. …”
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Lc-ms-based untargeted metabolomics reveals potential mechanisms of histologic chronic inflammation promoting prostate hyperplasia. by Jiale Li, Beiwen Wu, Guorui Fan, Jie Huang, Zhiguo Li, Fenghong Cao

“…The mechanism by which histologic chronic inflammation promotes prostate hyperplasia was elucidated through the analysis of small molecule metabolites. These findings support the notion that chronic prostatitis may contribute to an increased risk of prostate hyperplasia.…”
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Evaluation of terminal blend rubberized asphalt incorporating high crumb rubber content by Yangquan Huang, Kun Long, Chi Qu, Chuanqi Yan, Changfa Ai, Shengxiong Zhou

“…Results show that the terminal blending process leads to CR particle breakdown and rubber molecule depolymerization, enhancing workability and stability up to a rubber dosage limit of approximately 40 %. …”
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Experimental assessment of the pyramidal energy on water. by Pedro Díaz Rebollido, Luis Carlos Silva Ayçaguer, Mikhail Benet Rodríguez

“…The effect of the pyramids didn't modify the conductivity neither the pH of the molecule of water. Our results suggest that pyramids do not produce any effect on water in relation with the two parameters studied. …”
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Molecular aspects of cell-penetrating peptides: key amino acids, membrane partners, and non-covalent interactions by Walrant, Astrid, Tazi, Farah, Khemaissa, Sonia, Sagan, Sandrine

“…Since the early 1990s, there has been considerable interest in cell-penetrating peptides (CPPs) capable of transporting various types of molecules in cells. These CPPs are endowed with the ability to cross the cell membrane by endocytosis and by other, as yet poorly understood, translocation pathways. …”
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Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells by Yan Li, Jingping Ge, Yuanyuan Yin, Ruowen Yang, Jie Kong, Jianping Gu

“…The expression of thrombus resolution markers, CD34 molecule (CD34) and matrix metallopeptidase 2 (MMP2), in the thrombi was measured by immunofluorescence staining. …”
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The Possible Role of Neutrophils in the Induction of Osteoclastogenesis by Carolyn G. J. Moonen, Teun J. de Vries, Patrick Rijkschroeff, Patrice E. Poubelle, Elena A. Nicu, Bruno G. Loos

“…The ligand of the receptor activator of NF-κB (RANKL) is a key molecule in the formation of osteoclasts, the key cells that cause the disease-associated alveolar bone resorption in periodontitis. …”
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Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation by Zhendong He, Nan Zheng, Xiu-Quan Guo, Gang-Gang Wang, Mingjian Lin

“…Dual luciferase assay and the transfection of hsa-miR-4741 mimics or inhibitor were used to investigate the targeted regulation of it to LILRB2.Results The combination of hsa-miR-4741 and LILRB2 showed higher accuracy in predicting the outcome of RDH (AUC = 0.9367), compared with a single molecule. Overexpression of hsa-miR-4741 enhanced TNF-α-induced oxidative stress and senescence, while LILRB2 overexpression had the opposite effect. …”
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Thermal ablation enhances immunotherapeutic effect of IP-001 on orthotopic liver cancer in a rat model by Yan Li, Samuel S.K. Lam, Chun Fung Wong, Tomas Hode, David Anderson, Robert C.G. Martin

“…IP-001, a synthesized molecule, is created by attaching galactose molecules to the free amino groups of partially deacetylated glucosamine polymers. …”
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The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. by Alexander M Cole, Dorothy L Patton, Lisa C Rohan, Amy L Cole, Yvonne Cosgrove-Sweeney, Nicole A Rogers, Deena Ratner, Alexandra B Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I Lehrer, Alan J Waring, Phalguni Gupta

“…The presence of antivirally active RC-101 after five days in vivo suggests that RC-101 would be an important molecule to develop further as a topical microbicide to prevent HIV-1 transmission.…”
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FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils by Peiyuan Li, Wenbin Ji, Baotong Zhang, Haowen Jia, Jinmiao Wang, Zhaonan Sun, Yifan Wang, Weiwei Wang, Feng Qi

“…Conclusion This study found that FPR1 might be an important molecule involved in neutrophils during acute rejection of kidney transplantation, explored the relationship between kidney transplantation and neutrophils, and provided potential treatment methods for clinical practice.…”
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The influence of exogenous melatonin treatment on quality, nutritional profile, and antioxidant system of fresh-cut carambola during cold storage by Farah Anum Mohd Yusof, Ezzat Mohamad Azman, Noranizan Mohd Adzahan, Noor Liyana Yusof

“…High hydrogen peroxide content during the initial storage may serve as a signalling molecule that upregulates the antioxidant system, resulting in fresh-cut carambola with better retention in quality and nutritional value. …”
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