The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathw... by Ning Chai, Tanja Stachon, Sabrina Häcker, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry

“…Our purpose was to assess the effect of rose bengal photodynamic therapy (RB-PDT) on the expression of pro-inflammatory cytokines and chemokines, as well as on extracellular matrix (ECM)-related molecules, in lipopolysaccharide (LPS)-induced inflammation of keratoconus human corneal fibroblasts (KC-HCFs). …”
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The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. by Colin M Fitzsimmons, Frances M Jones, Alex Stearn, Iain W Chalmers, Karl F Hoffmann, Jakub Wawrzyniak, Shona Wilson, Narcis B Kabatereine, David W Dunne

“…Located inside the tegument, the molecule belongs to a family of proteins from parasitic platyhelminths, the Tegument-Allergen-Like proteins (TALs). …”
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An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytom... by Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Ryu Watanabe, Tomonori Ishii, Hideo Harigae

“…Here, we present an overview of recent research in AECAs and their target molecules and discuss the principle and the application of SARF. …”
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…ABSTRACT Background This study aims to elucidate the expression pattern of SERPINE1, assess its prognostic significance, and explore potential therapeutic drugs targeting this molecule. Methods and Results In this study, we delved into the variations in gene mutation, methylation patterns, and expression levels of SERPINE1 in head and neck squamous cell carcinoma (HNSCC) and normal tissues, leveraging comprehensive analyses of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. …”
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Prediction of Pt, Ir, Ru, and Rh complexes light absorption in the therapeutic window for phototherapy using machine learning by V. Vigna, T. F. G. G. Cova, A. A. C. C. Pais, E. Sicilia

“…While ML models have been used to predict UV–vis properties of organic molecules, applying this to metal complexes is novel. …”
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Silk-engineered bioactive nanoparticles for targeted alleviation of acute inflammatory disease via macrophage reprogramming by Renfeng Liu, Erkang Zhao, Yejing Wang, Hua Zuo, Lanlan Li, Qingyou Xia, Huawei He

“…Consistently, in murine models of acute lung and kidney injury, TPSN outperforms the small-molecule antioxidant NAC, exhibiting superior therapeutic efficacy. …”
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Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells by Markus Bergqvist, Kyong-Su Park, Nasibeh Karimi, Lijuan Yu, Cecilia Lässer, Jan Lötvall

“…This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercellular adhesion molecule-1 (ICAM-1). To target these cells, we overexpress the ICAM-1 binding receptor “lymphocyte function-associated antigen-1” (LFA-1) in HEK293F cells, by sequential transfection of plasmids of the two LFA-1 subunits, ITGAL and ITGB2 (CD11a and CD18). …”
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The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory by Andrea Henriques-Pons, Natália Vacani-Martins, Carina de Lima Pereira dos Santos, Marcelo Meuser-Batista

“…In the liver, the vascular anatomy is a game changer, as about 80% of the blood that percolates the organ arrives from the hepatic portal vein, draining blood rich in molecules from the intestinal flora. This 24/7 exposure to high amounts of pathogen-associated molecular pattern (PAMPs) molecules results in hepatic immunological tolerance. …”
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Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages by Laura Hyväri, Miina Ojansivu, Miia Juntunen, Kimmo Kartasalo, Susanna Miettinen, Sari Vanhatupa

“…Inhibition of these kinases with specific small molecule inhibitors diminished osteogenesis, while inhibition of FAK and ROCK activity led to elevation of adipogenic marker genes AP2 and LEP and lipid accumulation implicating adipogenesis. …”
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Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer by Tanya Tripathi, Apoorva Chaudhary, Divya Janjua, Udit Joshi, Nikita Aggarwal, Chetkar Chandra Keshavam, Alok Chandra Bharti

“…This unique characteristic suggests its potential to be used as an adjunct molecule in combination with existing treatment to enhance the efficacy of chemo/radiotherapy for treating CaCx. …”
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Immunolipid magnetic bead-based circulating tumor cell sorting: a novel approach for pathological staging of colorectal cancer by Qingyan Deng, Weidong Li, Yueming Huang, Haitao Wang, Xinhao Zhou, Zhifen Guan, Bohao Cheng, Yao Wang

“…ObjectiveThis study aimed to assess whether circulating tumor cells (CTCs) from colorectal cancer (CRC) could be used as an alternative to tissue samples for genetic mutation testing, overcoming the challenge of difficult tumor tissue acquisition.MethodsWe developed an immunolipid magnetic bead (IMB) system modified with antibodies against epithelial cell adhesion molecule (EpCAM) and vimentin to efficiently separate CTCs. …”
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Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai by Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa

“…The development of the first small-molecule inhibitor that targets its atypical substrate binding domain is a promising step that could eventually lead to patient benefit, and we would cover its discovery and ongoing efforts toward its use in clinic. …”
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The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level by Sara Farahi, Sara Hosseini, Hossein Ghanbarian, Seyed Mahmoud Hashemi, Mohammad Salehi, Samaneh Hosseini

“…The presence of MHC molecules on the surface of pluripotent stem cells was also checked by flow cytometry technique. …”
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A Simple Separation Method of the Protein and Polystyrene Bead-Labeled Protein for Enhancing the Performance of Fluorescent Sensor by Hye Jin Kim, Dong-Hoon Kang, Seung-Hoon Yang, Eunji Lee, Taewon Ha, Byung Chul Lee, Youngbaek Kim, Kyo Seon Hwang, Hyun-Joon Shin, Jinsik Kim

“…The separation between the protein and the PS beads was demonstrated by comparing the average intensity of fluorescence (AIF) by each molecule. Relative AIF was measured in various applying voltage and time conditions, and the conditions for allocating the PS beads into 15 μm hole were optimized at 80 mV and 15 min, respectively. …”
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High-entropy alloys catalyzing polymeric transformation of water pollutants with remarkably improved electron utilization efficiency by Ziwei Yao, Yidi Chen, Xiaodan Wang, Kunsheng Hu, Shiying Ren, Jinqiang Zhang, Zhao Song, Nanqi Ren, Xiaoguang Duan

“…The resulting PMS* complexes on HEAs possess a high redox potential, which drives spatially separated phenol oxidation on nitrogen-doped graphene support to form phenoxyl radicals, subsequently triggering the formation of high-molecule polymeric products via polymerization reactions. …”
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Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer: Role of Aflibercept by Guido Giordano, Antonio Febbraro, Michele Venditti, Serena Campidoglio, Nunzio Olivieri, Katia Raieta, Pietro Parcesepe, Giusy Carmen Imbriani, Andrea Remo, Massimo Pancione

“…Recently, the VELOUR study showed that addition of aflibercept to FOLFIRI regimen as a second-line therapy for mCRC improved significantly OS, PFS, and RR. This molecule represents a valid second-line therapeutic option and its peculiar ability to interfere with placental growth factor (PlGF)/vascular endothelial growth factor receptor 1 (VEGFR1) axis makes it effective in targeting angiogenesis, inflammatory cells and in overcoming resistances to anti-angiogenic first-line treatment. …”
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Comparison of AOPs Efficiencies on Phenolic Compounds Degradation by Lourdes Hurtado, Deysi Amado-Piña, Gabriela Roa-Morales, Ever Peralta-Reyes, Eduardo Martin del Campo, Reyna Natividad

“…Regarding 4-CP degradation, the complete disappearance of the molecule was achieved and the efficiency decreasing order was as follows: coupled electro-oxidation/ozonation > electro-Fenton-like process > photo-Fenton process > heterogeneous photocatalysis. …”
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Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters by Jui-Chi Kuo, Tsung-Rong Kuo, Fajar Rinawati, Erna Susilowati, Sucipto, Dyah Ika Krisnawati

“…Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is overexpressed in many cancer cells. …”
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Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCβI, PKCβII and PKCζ in human neutrophils by Xavier Siomboing, Bernard Gressier, Thierry Dine, Claude Brunet, Michel Luyckx, Michelene Cazin, Jean-Claude Cazin

“…The major difficulty is creating a specific molecule for one kinase. In this study, we test the action of Rho-kinase inhibitors (HA-1077 and Y-32885) on protein kinase C (PKC) in the respiratory burst in the human polymorphonuclear neutrophils. …”
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Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma by Wei An, Kai Zhang, Guangbing Li, Shunzhen Zheng, Yukun Cao, Jun Liu

“…Regrettably, the role and exact molecule mechanism of PDT is still incompletely clear in cholangiocarcinoma cells. …”
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