Anticancer effects of 7,8-dihydromethysticin in human leukemia cells are mediated via cell-cycle dysregulation, inhibition of cell migration and invasion and targeting JAK/STAT pat... by Xiao Yi, Deng Taoran, Jiang Lijun, Wang Di

“…The 7,8-dihydromethysticin molecule also caused cell cycle arrest at G2/M-phase along with concentration-dependent inhibition of cyclin B1, D1 and E. …”
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Studies of the Adsorption of SO, H and O on a CrO Surface by an Electrical Conductivity Technique by Mahmoud M. Khader, Mahmoud M. Saleh, Ahmad M. Mohammad

“…The induction period may be regarded as the time necessary to create an oxygen vacancy, the activation energy for such a process being 21.1 kJ/mol. A hydrogen molecule is then adsorbed on to the oxygen vacancy possibly as a hydride ion, and leading to the initial increase in the conductivity. …”
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Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma by Zhuning Wang, Junqiao Yao, Tengyu Dong, Xing Niu

“…We also predicted several small molecule compounds (GSK461364, KX2-391, etc.) for treating this subset. …”
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By activating endothelium histone H4 mediates oleic acid-induced acute respiratory distress syndrome by Yanlin Zhang, Jingjin Tan, Yiran Zhao, Li Guan, Shuqiang Li

“…Conclusions: Histone H4 is a pro-inflammatory and pro-thrombotic molecule in OA-induced ARDS in mice.…”
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Effect of Electric Fields on the Mechanical Mechanism of Regorafenib–VEGFR2 Interaction to Enhance Inhibition of Hepatocellular Carcinoma by Yichen Tian, Fenghui Liao, Heng Sun, Yongrong Lei, Yuna Fu, Feng Xia, Jianhua Wang

“…We found that electric fields lead to an increase in the normal (adhesion) and transverse (friction) interaction forces between regorafenib and VEGFR2. In single molecule pair interactions, there are changes in specific and nonspecific forces. …”
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The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients by A. A. Turkina, M. V. Maevskaya, M. S. Zharkova, V. T. Ivashkin

“…With the severity of ascites, the native conformation index (DR), which characterizes the structural usefulness of the albumin molecule, decreased. Median DR for ascites stage I (IAC) was –1.69, II grade — –2.28, III grade — –2.42 (p < 0.05). …”
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hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation by Weijiang Liu, Fulin Yuan, Haitao Bai, Yuanlin Liu, Xue Li, Yang Wang, Yi Zhang

“…Collectively, these results reveal a new immunosuppressive molecule, Chi3l1, in hUC-MSCs in the treatment of aGvHD that regulates Th17 differentiation and inhibits STAT3 activation. …”
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Extracellular AMP Inhibits Pollen Tube Growth in <i>Picea meyeri</i> via Disrupted Calcium Gradient and Disorganized Microfilaments by Junhui Zhou, Haobo Yang, Yue Zhang, Yuan Cao, Yanping Jing

“…In mammalian cells, extracellular AMP functions as a signaling molecule by binding to adenosine A1 receptors, thereby activating various intracellular signaling pathways. …”
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CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies by Lena Gockeln, Florian Wirsdörfer, Verena Jendrossek

“…Furthermore, the CD73/adenosine pathway can also limit the immune-activating effects of cytotoxic therapies by degrading the pro-inflammatory danger molecule ATP, which is released into the tumor microenvironment and normal lung tissue upon therapy-induced cell damage. …”
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Melatonin and its physiological and therapeutic effects: A review by Stefanović Bojana V., Spasojević Nataša M., Ferizović Harisa N., Janković Milica D., Virijević Kristina M., Dronjak Slađana S.

“…Melatonin, an evolutionarily old molecule, is found in many living organisms. This neurohormone is known to control many physiological processes, including circadian rhythm, mood, and behavior. …”
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…The inhibition of GSK3β in FHIT-deficient cells suppressed the ATR/BRCA1/RAD51 axis in HRR signaling via two distinct pathways and suppressed DNA double-strand break repair, leading to the accumulation of DNA damage and apoptosis. Small molecule inhibitors of HRR, but not NHEJ or PARP, induced synthetic lethality in FHIT-deficient lung cancer cells. …”
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The Expression Regulation and Cancer-Promoting Roles of RACGAP1 by Jiacheng Lin, Yuhao Zhu, Zhaoping Lin, Jindong Yu, Xiaobing Lin, Weiyuan Lai, Beibei Tong, Liyan Xu, Enmin Li, Lin Long

“…However, studies increasingly suggest that overexpressed RACGAP1 activates Rac and RhoA in multiple cancers to mediate downstream oncogene overexpression by assisting in the nuclear translocation of signaling molecules and to promote cytokinesis by regulating the cytoskeleton or serving as a component of the central spindle. …”
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Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies by S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke

“…Adrenocorticotrophic hormone represents the parent molecule of the melanocortins; the first 13 amino acids of which (termed a-MSH) have been shown to be the most pharmacologically active region of the parent hormone. …”
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Comparative diagnostic performance of recombinant Tams1 protein based dot-ELISA in detecting tropical theileriosis in naturally infected cattle by Sanjhi Paliwal, Vikrant Sudan, Daya Shanker

“…With its minimal antigen requirement, Tams1 molecule based dot-ELISA is recommended as an effective tool for epidemiological studies and field surveys of BTT.…”
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Effect of Dissolution and Dispersion Conditions of VC-713 on the Hydrate Inhibition by Ren Wang, Huicui Sun, Jinsheng Sun, Yuanzhi Qu, Jie Zhang, Xiaomei Shi, Ling Zhang, Dongdong Guo

“…This is due to more complex skeleton structures formed by the hydrated VC-713 molecule. When the amount of VC-713 is 0.5 wt.%, the induction time, the formation rate, and the degree of supercooling of hydrate formation were extended, mitigated, and increased by 10.30%, 21.43%, and 17.80%, respectively, and changed to values of 8.75%, 14.29%, and 22.50%, respectively, for 1.0 wt.% VC-713.…”
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Identification of Potential Abnormal Methylation-Modified Genes in Coronary Artery Ectasia by Xiuchun Yang, Yijun Zong, Zhentian Zhang, Yan Zhao, Xueying Gao, Jie Zhang, Qian Hou, Renyi Li, Bing Xiao

“…Some signaling pathways were identified in patients with CAE, including cell adhesion molecule, O-glycan biosynthesis, and the renin–angiotensin system. …”
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Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy by R. Ortenberg, S. Sapoznik, D. Zippel, R. Shapira-Frommer, O. Itzhaki, A. Kubi, D. Zikich, M. J. Besser, J. Schachter, G. Markel

“…The expression of the CEACAM1 adhesion molecule on melanoma cells is a strong predictor of poor prognosis. …”
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The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites by Sujata B. Walunj, Geetanjali Mishra, Kylie M. Wagstaff, Swati Patankar, David A. Jans

“…We recently showed that the FDA-approved macrocyclic lactone ivermectin, as well as several other different small molecule inhibitors, can specifically bind to and inhibit <i>P. falciparum</i> and <i>T. gondii</i> IMPα functions, as well as limit parasite growth. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…This is provided by the benzodiazepine molecule binding and causing a conformational change to the chloride ion channel to cause hyperpolarization and thus inhibition of the central nervous system. …”
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Exploring RNA modifications in infectious non-coding circular RNAs by Pavel Vopalensky, Anton Škríba, Michela Chiumenti, Lucia Ďuričeková, Anna Šimonová, Ondřej Lukšan, Francesco di Serio, Beatriz Navarro, Hana Cahova

“…Although no modification was detected in ASBVd, CEVd contained approximately one m6A per RNA molecule. ONT sequencing predicted three m6A positions. …”
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