Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. P... by Yashoda Tushar Maladkar, Veerappa Annasaheb Kothiwale

“…Lp(a) consists of one LDL particle containing apoB-100 and one molecule of a large, highly polymorphic glycoprotein known as apo (a). …”
Get full text

Thermal Treatment of Cerium Oxide and Its Properties: Adsorption Ability versus Degradation Efficiency by Pavel Janoš, Tomáš Hladík, Martin Kormunda, Jakub Ederer, Martin Šťastný

“…The >Ce–OH groups on the sorbent surface are responsible for the dye binding by the surface-complexation mechanism, and probably also for the nucleophilic cleavage of the P–O–aryl bond in the pesticide molecule.…”
Get full text

VEIKIANTIS GENOMAS - VISUMINIS POŽYMIS: DABARTIES ŽVILGSNIS Į GENETIKĄ by Jonas Rubikas

“…Genomics is based on the DNA - DNA or DNA - mRNA hybridization; the thousands of molecules of individual genes (or all genes of a genome) can be analysed. …”
Get full text

Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion by Aaron Babendreyer, Lisa Molls, Daniela Dreymueller, Stefan Uhlig, Andreas Ludwig

“…On endothelial cells, the transmembrane chemokine CX3CL1/fractalkine promotes vascular inflammation by functioning as a surface-expressed adhesion molecule and by becoming released as soluble chemoattractant for monocytic cells expressing the receptor CX3CR1. …”
Get full text

Electrochemical Behavior of Quinoxalin-2-one Derivatives at Mercury Electrodes and Its Analytical Use by Milan Zimpl, Jana Skopalova, David Jirovsky, Petr Bartak, Tomas Navratil, Jana Sedonikova, Milan Kotoucek

“…Pyrazine ring was found to be the main electroactive center undergoing a pH-dependent two-electron reduction process. The molecule protonization of nitrogen in the position 4 precedes the electron acceptance forming a semiquinone radical intermediate which is relatively stable in acidic solutions. …”
Get full text

15-Deoxy-Δ12,14-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction by Line Nilsson, Fredrik Palm, Rikke Nørregaard

“…Renal injury was aggravated by 15d-PGJ2 treatment as measured by kidney injury molecule-1 (KIM-1) and cortical caspase 3 content. …”
Get full text

Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…Over 6,000 compounds from small molecule drug repurposing libraries were subsequently screened in the assay developed, leading to identification of several promising in vitro hits.Using the assay developed and the identified hits opens avenues to investigate potential therapeutics for A-T.…”
Get full text

Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage–myofibroblast transition by Yueyuan Zhou, Zhilan Li, Shenyi Yu, Xuan Wang, Tingting Xie, Weiru Zhang

“…Iguratimod is a novel synthetic, small-molecule immunosuppressive agent used to treat rheumatoid arthritis. …”
Get full text

Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy by Xuexin Li, Xin Zhao, Zhengshan Qin, Jie Li, Bowen Sun, Li Liu

“…Abstract This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. …”
Get full text

Ultrafiltration operational conditions influence in the antibacterial activity of native and thermally treated lysozyme by de Espindola, Ariane, Miron, Simona M., Dutournié, Patrick, Ponche, Arnaud

“…Antibacterial activity after extreme stress factors is expected to decrease due to conformational changes in the protein molecule. It was observed that ultrafiltration can promote an activity decrease proportional to the applied transmembrane pressure of a non-treated lysozyme. …”
Get full text

Pyran-Squaraine as Photosensitizers for Dye-Sensitized Solar Cells: DFT/TDDFT Study of the Electronic Structures and Absorption Properties by Reda M. El-Shishtawy, Shaaban A. Elroby, Abdullah M. Asiri, Rifaat H. Hilal

“…Additionally, we performed natural bond orbital (NBO) analysis to investigate the role of charge delocalization and hyperconjugative interactions in the stability of the molecule.…”
Get full text

Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence by Shuying Zhu, Siyu Wu, Yanmin Liu, Zaibao Zhang, Huasong Zou

“…Results The PKC was determined to have a signal peptide, a START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) domain, and a GyrI-like small molecule binding domain. The expression of the PKC gene was induced in planta, as well as under stress by CuSO4 and SDS. …”
Get full text

Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration by Hiroki Nakamoto, Shunsuke Shichi, Chisato Shirakawa, Takuto Suzuki, Hidemitsu Kitamura, Akinobu Taketomi

“…We conclude that DGKα is a key molecule in the post-PH liver regeneration process and may have potential as a therapeutic target for the acceleration of liver regeneration.…”
Get full text

PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway by Chun-I Wang, Cheng-Yi Chen, Ting-Wen Chen, Chun-Chia Cheng, Shu-Wen Hong, Tsung-You Tsai, Kai-Ping Chang

“…In this study, we established a gene database related to OSCC recurrence and identified PSMA2 as a novel molecule influencing prognosis in OSCC patients. An independent Taiwanese cohort confirmed that elevated PSMA2 transcript levels were associated with poorer prognosis and contributed to the chemo- and radioresistance phenotype in OSCC. …”
Get full text

Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats by Marcela Alejandra Vazquez-Prieto, Cecilia Rodriguez Lanzi, Carina Lembo, Claudio Rómulo Galmarini, Roberto Miguel Miatello

“…At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). …”
Get full text

Identification and Characterization of Novel Perivascular Adventitial Cells in the Whole Mount Mesenteric Branch Artery Using Immunofluorescent Staining and Scanning Confocal Micro... by Chandra Somasundaram, Rahul K. Nath, Richard D. Bukoski, Debra I. Diz

“…A novel perivascular adventitial cell termed, adventitial neuronal somata (ANNIES) expressing the neural cell adhesion molecule (NCAM) and the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP), exists in the adult rat mesenteric branch artery (MBA) in situ. …”
Get full text

Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis by Thi Thanh Hoang Nguyen, Janardhan Prasad Bhattarai, Soo Joung Park, Seong Kyu Han

“…Taken together, our results indicate that taurine can be a target molecule for orofacial pain modulation through the activation of GlyRs and/or extrasynaptic GABAARs on the SG neurons.…”
Get full text

Studies of axially chiral atropisomers of an indole-substituted phthalonitrile derivative by Ayari, Sami, Elleuch, Haitham, Thebti, Amal, Ouzari, Hadda-Imene

“…Structural confirmation of the molecule was achieved using 1H, 13C NMR and mass spectroscopy. …”
Get full text

Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu by Natalia P. Rodina, Maksim I. Sulatsky, Anna I. Sulatskaya, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

“…However, these crowding agents can have a direct effect on the ThT molecule, and this effect must be taken into account. …”
Get full text

Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery by Francesco Maione, Antonio Parisi, Elisabetta Caiazzo, Silvana Morello, Fulvio D'Acquisto, Nicola Mascolo, Carla Cicala

“…Our findings indicate that IL-17A might be an important molecule at the interface between hemostasis and inflammation.…”
Get full text