Dual Wavelength RP-HPLC Method for Simultaneous Determination of Two Antispasmodic Drugs: An Application in Pharmaceutical and Human Serum by Najmul Hasan, Mathurot Chaiharn, Sauleha Khan, Hira Khalid, Nawab Sher, Farhan Ahmed Siddiqui, Muhammad Zain Siddiqui

“…Oxidation degraded the molecule drastically while there was not so much significant effect of other stress conditions. …”
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A Chromosomal-Level Genome of Dermatophagoides farinae, a Common Allergenic Mite Species by Rongxuan Hu, Haifeng Huang, Ying Zhou, Yanshan Liu, Yaning Ren, Yuanfen Liao, Cunyin Yuan, Xiaohong Gu, Yubao Cui

“…We achieved a chromosome-level assembly of D. farinae’s genome by integrating PacBio single-molecule real-time sequencing, Illumina paired-end sequencing, and Hi-C technology, followed by annotating allergens and mapping them to specific chromosomes. …”
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Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta. by Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Duncan Berger, Daniel R G Price, Sam Dougan, Dionysis Grigoriadis, Alan Tracey, Nancy Holroyd, Katie Bull, Hannah Rose Vineer, Mike J Glover, Eric R Morgan, Alasdair J Nisbet, Tom N McNeilly, Yvonne Bartley, Neil Sargison, Dave Bartley, Matt Berriman, James A Cotton, Eileen Devaney, Roz Laing, Stephen R Doyle

“…Assembly using PacBio long-reads and Hi-C long-molecule scaffolding together with manual curation resulted in a 573 Mb assembly (N50 = 84 Mb, total scaffolds = 1,286) with five autosomal and one sex-linked chromosomal-scale scaffolds consistent with its karyotype. …”
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Nano‐pyrite as a plant hormone regulator: Emulating seed hormopriming by Brijesh Kaler, Himanshi Jangir, Sabyasachi Sarkar, Jayprakash Sharma, Mainak Das

“…Recently, several nanomaterials have emerged as economical seed and root priming agents, with nanoiron pyrite standing out as a particularly promising molecule. The observed enhancement in germination of nano‐pyrite treated seeds across various plant species indicate a shared underlying mechanism. …”
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Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy by Aneta Cinakova, Diana Vavrincova-Yaghi, Peter Krenek, Jan Klimas, Eva Kralova

“…STZ-induced DN was demonstrated by the propagation of apoptotic (Bax, p53, Casp3) and oxidative reactions (Gp91phox, MnSOD) and disrupted nitric oxide signalling (eNOS, Hsp90, Cav1). Kidney damage molecule expression (Kim1, Nphs1) revealed a deceleration of kidney damage by pioglitazone and dapagliflozine monotherapies. …”
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Structural modeling of NAD+ binding modes to PARP-1 by N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko

“…The structure of complex of human poly (ADP-ribose) polymerase-1 with NAD+ can be a starting point for rational design of small molecule inhibitors based on NAD+ derivatives. Indeed there is no crystal structure of complex poly (ADP-ribose) polymerase-1 with nicotinamide adenine dinucleotide (NAD+) available yet. …”
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Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population by Hatice Gül Dursun, Hüseyin Osman Yılmaz, Recep Dursun, Sevsen Kulaksızoğlu

“…Cytotoxic T lymphocyte antigen-4 (CTLA-4) expressed only on activated T cells is an immunoregulatory molecule and plays a role in the pathogenesis of autoimmune disorders. …”
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Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation by Giuseppe Vassalli, Giuseppina Milano, Tiziano Moccetti

“…JNK and p38 MAPK activation contributes to myocardial IR injury after prolonged hypothermic storage. p38 MAPK inhibition improves cardiac function after cold storage, rewarming and reperfusion. Small-molecule p38 MAPK inhibitors have been tested clinically in patients with chronic inflammatory diseases, but not in transplanted patients, so far. …”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…We also critically evaluate recent advancements in the development of gelatinase inhibitors, including small molecule inhibitors, natural compounds, and novel therapeutic approaches like gene silencing techniques. …”
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Label-Free Glucose Detection Using Cantilever Sensor Technology Based on Gravimetric Detection Principles by Shuchen Hsieh, Shu-Ling Hsieh, Chiung-wen Hsieh, Po-Chiao Lin, Chun-Hsin Wu

“…The Con A/APS-modified probes were then used to detect glucose by monitoring shifts in the cantilever resonance frequency. To confirm the molecule-specific interaction, AFM topographical images were acquired of identically treated silicon substrates which indicated a specific attachment for glucose-Con A and not for galactose-Con A. …”
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PRKD2 as a novel target for targeting the diabetes–osteoporosis nexus by Rongjin Chen, Chenhui Yang, Hefang Xiao, Ao Yang, Changshun Chen, Fei Yang, Bo Peng, Bin Geng, Yayi Xia

“…In conclusion, our findings establish PRKD2 as a pivotal molecule in DMOP, offering fresh insights into its mechanisms and affirming its value as a therapeutic target.…”
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Photocatalytic Dynamic Membrane Containing Graphitic Carbon Nitride/Zirconium dioxide Nanocomposite for MB and CR Dye Removal under Household LED Lamp by Marjan Tanzifi, Mohsen Jahanshahi, Majid Peyravi, Soodabeh Khalili

“…In addition to improving dye molecule removal efficiency, adding the photocatalyst to the PES membrane also significantly increased water flux. …”
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Line List for the A2Π−X2Σ+ and the B2Σ+−X2Σ+ Band Systems of CaF by Léo Lavy, Peter F Bernath, Adam Pastorek

“…The spectral analysis of molecule-rich asymptotic giant branch (AGB) stars is challenging. …”
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DiffMAP-GP: Continuous 2D diffusion maps from particle trajectories without data binning using Gaussian processes by Vishesh Kumar, J. Shepard Bryan, IV, Alex Rojewski, Carlo Manzo, Steve Pressé

“…We analyze both synthetic data, where ground truth is known, as well as data drawn from live-cell single-molecule imaging of membrane proteins. The resulting tool provides an unsupervised method to rigorously map diffusion coefficients continuously across membranes without data binning.…”
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Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model by Sean P. Kessler, Dana R. Obery, Carol de la Motte

“…Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the chemically induced dextran sodium sulfate (DSS) experimental colitis model, we previously determined that changes in colon distribution of HA occur before inflammation. …”
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On the Primary Ionization Mechanism(s) in Matrix-Assisted Laser Desorption Ionization by Laura Molin, Roberta Seraglia, Zbigniew Czarnocki, Jan K. Maurin, Franciszek A. Pluciński, Pietro Traldi

“…A mechanism is proposed for the first step of ionization occurring in matrix-assisted laser desorption ionization, leading to protonated and deprotonated matrix (Ma) molecules ([Ma+H]+ and [Ma-H]- ions). It is based on observation that in solid state, for carboxyl-containing MALDI matrices, the molecules form strong hydrogen bonds and their carboxylic groups can act as both donors and acceptors. …”
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Hydrogen Peroxide Is Involved in Salicylic Acid-Elicited Rosmarinic Acid Production in Salvia miltiorrhiza Cell Cultures by Wenfang Hao, Hongbo Guo, Jingyi Zhang, Gege Hu, Yaqin Yao, Juane Dong

“…Hydrogen peroxide (H2O2) plays an important role as a key signaling molecule in response to various stimuli and is involved in the accumulation of secondary metabolites. …”
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Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling by Jianwen Wang, Ikuo Takahashi, Ko Kikuzato, Toshihiko Sakai, Zhangliang Zhu, Kai Jiang, Hidemitsu Nakamura, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa, Tadao Asami

“…Our experiments also demonstrate the binding affinity of triazole urea compounds are regulated by the structured water molecule networks. By fine-tuning this network, we successfully develop a more potent derivative of KK181N1. …”
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Prognostic signature and therapeutic drug identification for dilated cardiomyopathy based on necroptosis via bioinformatics and experimental validation by Han Yang, Zhenwei Wang, Yawei Xu, Yimei Du, Haibo Yang, Yang Lu

“…Notably, nTreg and iTreg cells were enriched in the high NRS group, while CD8 naive T cells and CD8 T cells positively correlated with NRS. Small molecule drugs fenofibrate, procyclidine, and tienilic acid emerged as potential therapeutic agents for high-risk patients, with fenofibrate showing efficacy in inhibiting DCM progression in an inflammatory animal model. …”
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Cinnamaldehyde impacts key cellular signaling pathways for induction of programmed cell death in high-grade and low-grade human glioma cells by Yoo Na Kim, Ketki Patil, S. Balakrishna Pai

“…Notably, the cell survival/death pivotal molecule Bcl-2 was impacted. These effects were observed in both the types of brain tumor cells studied: GBMs, represented by U251 cells (p53 mutated cell line) and LGGs represented by H4 cells. …”
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