FastContext: A tool for identification of adapters and other sequence patterns in next generation sequencing (NGS) data by E. Viesná, V. Fishman

“…NGS library preparation protocols may include steps with incorporation of various service sequences, such as sequencing adapters, primers, sample-, cell-, and molecule-specific barcodes. Despite a fairly high level of current knowledge, during the protocol development process researches often have to deal with various kinds of unexpected experiment outcomes, which result either from lack of information, lack of knowledge, or defects in reagent manufacturing. …”
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Allostery can convert binding free energies into concerted domain motions in enzymes by Nicole Stéphanie Galenkamp, Sarah Zernia, Yulan B. Van Oppen, Marco van den Noort, Andreas Milias-Argeitis, Giovanni Maglia

“…Here, we use single-molecule nanopore analysis to investigate the catalytic conformational changes of adenylate kinase (AK), an enzyme that catalyzes the interconversion of various adenosine phosphates (ATP, ADP, and AMP). …”
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An Emerging Role of Glucagon-Like Peptide-1 in Preventing Advanced-Glycation-End-Product-Mediated Damages in Diabetes by Alessandra Puddu, François Mach, Alessio Nencioni, Giorgio Luciano Viviani, Fabrizio Montecucco

“…These antidiabetic activities highlight GLP-1 as a potential therapeutic molecule in the clinical management of type 2 diabetes, (a disease characterized by progressive decline of beta-cell function and mass, increased insulin resistance, and final hyperglycemia). …”
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Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph by Dougald M. Monroe, Richard J. Jenny, Kevin E. Van Cott, Shelly Buhay, Laura L. Saward

“…Trenonacog alfa migrated as a single band on Coomassie-stained gels; activity assays were normal and showed <0.002 IU of activated factor IX (FIXa) per IU of FIX. The molecule has >97%  γ-carboxylation and underwent the appropriate structural change upon binding calcium ions. …”
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Alpha synuclein and inflammaging by Geneviève L. Putnam, Robert W. Maitta

“…The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). …”
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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…Nectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. …”
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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…High-mobility group box 1 (HMGB1), a nonhistone nuclear protein regulating gene expression, was rediscovered as an endogenous danger signal molecule to trigger inflammatory responses when released into extracellular milieu in the late 1990s. …”
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Antivirals and monoclonal antibody combination therapy in haematological patients in the omicron era by Serena Vita, Emanuela Giombini, Patrizia De Marco, Martina Rueca, Cesare Ernesto Maria Gruber, Alessia Beccacece, Laura Scorzolini, Valentina Mazzotta, Carmen Pinnetti, Priscilla Caputi, Daniele Focosi, Enrico Girardi, Andrea Antinori, Fabrizio Maggi, Alessandra D'Abramo, Emanuele Nicastri, Investigation Team Spallanzani COVID-19 case

“… Abstract: Im We describe here a single-center case series of 27 IC COVID-19 inpatients (mostly with haematological disorders) treated with a combined therapy based on tixagevimab/cilgavimab (T/C) plus small-molecule antivirals (AV), between April 1 2022 and November 30 2022.  …”
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Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review by Wesam Ahmed Nasif, Abeer Shaker El-Moursy Ali, Mohammed Hasan Mukhtar, Aali Marzouq H. Alhuzali, Yahya Ahmed Yahya Alnashri, Ziyad Ishaq Ahmed Gadah, Eyyad Adeeb A. Edrees, Hussam Abdulaziz Mabruk Albarakati, Hussam Saud Muhji Aloufi

“…A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. …”
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Expression of HGF and c-Met Proteins in Human Keratoconus Corneas by Jingjing You, Li Wen, Athena Roufas, Chris Hodge, Gerard Sutton, Michele C. Madigan

“…Recent genetic studies indicate that gene variants of an inflammation-related molecule, hepatocyte growth factor (HGF), are associated with an increased susceptibility for developing KC. …”
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Oxidative Thermolysis of Sulfobutyl-Ether-Beta-Cyclodextrin Sodium Salt: A Kinetic Study by Ionuț Ledeți, Claudia Temereancă, Amalia Ridichie, Adriana Ledeți, Denisa Laura Ivan, Gabriela Vlase, Titus Vlase, Carmen Tomoroga, Laura Sbârcea, Oana Suciu

“…As a derivative of beta-cyclodextrin, it is produced by introducing sulfobutyl ether groups into the beta-cyclodextrin molecule, which significantly increases its water solubility and decreases its toxicity compared to unmodified cyclodextrins. …”
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Direct visualization of peptide/MHC complexes at the surface and in the intracellular compartments of cells infected in vivo by Leishmania major. by Eric Muraille, Pierre Gounon, Julie Cazareth, Johan Hoebeke, Christoph Lippuner, Ana Davalos-Misslitz, Toni Aebischer, Sylviane Muller, Nicolas Glaichenhaus, Evelyne Mougneau

“…Altogether, our results suggest that peptides derived from Leishmania proteins are loaded onto Major Histocompatibility Complex class II molecules in the phagosomes of infected phagocytes. …”
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Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia malayi Wolbachia Surface Protein by Chantima Porksakorn, Surang Nuchprayoon, Kiwon Park, Alan L. Scott

“…However, the Wolbachia-derived molecules that are recognized by the innate immune system have not yet been identified. …”
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Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene by Alexey V. Kondyurin, Pourandokht Naseri, Jennifer M. R. Tilley, Neil J. Nosworthy, Marcela M. M. Bilek, David R. McKenzie

“…A high concentration of free radicals can give multiple covalent bonds to the protein molecule and destroy the native conformation and with it the catalytic activity. …”
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Mixed Ligand Complexes of N-Methyl-N-phenyl Dithiocarbamate: Synthesis, Characterisation, Antifungal Activity, and Solvent Extraction Studies of the Ligand by Anthony C. Ekennia, Damian C. Onwudiwe, Cyril Ume, Eno E. Ebenso

“…The infrared spectra showed that symmetrical bidentate coordination occurred with the dithiocarbamate moiety through the sulfur atoms, while neutral monodentate coordination occurred through the nitrogen atom for the pyridine molecule in the complexes. The electronic spectra, elemental analysis, and magnetic moment results proved that the complexes adopted octahedral geometry. …”
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The use of bacterial cellulose from kombucha to produce curcumin loaded Pickering emulsion with improved stability and antioxidant properties by Zhiyu Li, Wenxiu Hu, Jiajia Dong, Fidelis Azi, Xiao Xu, Chuanhai Tu, Sijie Tang, Mingsheng Dong

“…Curcumin is a bioactive molecule with limited industrial application because of its instability and poor solubility in water. …”
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VCAM-1 Promotes Angiogenesis of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Trauma-Induced Osteonecrosis of the Femoral Head by Regulating the Apelin/CCN2 Pathway by Yiming Shao, Lei Sun, Baodong Ma, Ranran Jin, Yueyao Ban, Ruibo Li, Jianfa Wang, Hongkai Lian, Han Yue

“…Vascular cell adhesion molecule 1 (VCAM-1) has been shown to have potent proangiogenic activity, but the role in angiogenesis of TI-ONFH is unclear. …”
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Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage by M. K. Sharief, M. Ciardi, M. A. Noori, E. J. Thompson, A. Salotti, F. Sorice, F. Rossi, A. Cirelli

“…Stimulation of endothelial cells by TNF-α induces the expression of intercellular adhesion molecule-1 (ICAM-1), which is an important early marker of immune activation and response. …”
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Pathogenic Process-Associated Transcriptome Analysis of Stemphylium lycopersici from Tomato by Dezhen Zhang, Wenjuan Chi, Cuicui Wang, Huijie Dai, Jintang Li, Chunlei Li, Fajun Li

“…The induction of genes associated with pectin degradation, adhesion, and colonization was notable during the early infection phase, whereas during the necrotrophic phase, some structural molecule activity-related genes were prominently induced. …”
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Bimolecular Complementation to Visualize Filovirus VP40-Host Complexes in Live Mammalian Cells: Toward the Identification of Budding Inhibitors by Yuliang Liu, Michael S. Lee, Mark A. Olson, Ronald N. Harty

“…In addition, we used the BiMC approach along with a VLP budding assay to test small molecule inhibitors identified by in silico screening for their ability to block eVP40 PTAP-mediated interactions with Tsg101 and subsequent budding of eVP40 VLPs. …”
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