Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation by Wenpei Chen, Xiaolan Yao, Chenghao Zhou, Ziyang Zhang, Gang Gui, Baoqin Lin

“…Moreover, DHK markedly reduced the serum levels of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1). Furthermore, DHK significantly downregulated protein expressions of VEGF and inducible NO synthase (iNOS) and mRNA expression of ICAM-1 in retinas. …”
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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…Stapled peptides, as the most promising therapeutic candidate for interfering with PPIs, have a higher degree of α-helicity, improved binding affinity, more resistance to proteolytic digestion, longer serum half-life, and enhanced cell permeability, which exhibits higher pharmacological activity compared with small molecule drugs and biologics. This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases.…”
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A paradigmatic approach to the topological measure of babesiosis drugs and estimating physical properties via QSPR analysis by Nadeem Ul Hassan Awan, Muhammad Usman Ghani, Sakeena Bibi, Syed Ajaz K. Kirmani, Manal Elzain Mohamed Abdalla

“…The chemical structure of a molecule is represented as a graph. Further research into topological indices' QSPR analysis revealed so as a substantial link with the physical characteristics of drugs utilized in the production of drugs to halt the disease. …”
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VEIKIANTIS GENOMAS - VISUMINIS POŽYMIS: DABARTIES ŽVILGSNIS Į GENETIKĄ by Jonas Rubikas

“…Genomics is based on the DNA - DNA or DNA - mRNA hybridization; the thousands of molecules of individual genes (or all genes of a genome) can be analysed. …”
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Clinical advances in antibody-drug conjugates for hematological malignancies by TANG Sijie, MI Jianqing

“…An antibody-drug conjugate (ADC) is a targeted therapeutic drug composed of a monoclonal antibody linked to a small-molecule cytotoxic drug via a linker. Once administered, ADCs bind to tumor-specific antigens, forming ADC-antigen complexes, which are internalized through endocytosis. …”
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The complete mitochondrial genome of Ophiocordyceps gracilis and its comparison with related species by Aifeire Abuduaini, Yuan-Bing Wang, Hui-Ying Zhou, Rui-Ping Kang, Ming-Liang Ding, Yu Jiang, Fei-Ya Suo, Luo-Dong Huang

“…As the second largest mitogenome reported in the family Ophiocordycipitaceae, the mitogenome of O. gracilis (voucher OG201301) is a circular DNA molecule of 134,288 bp that contains numerous introns and longer intergenomic regions. …”
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Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging by Zhongxiang Chen, Qian Li, Ying Wu, Jianyong Liu, Luntao Liu, Lichao Su, Rongrong Wu, Jibin Song

“…Thus, this study establishes a directly activatable NIR-II CL emission unimolecular skeleton, validating the scalability of this duplex NIR-II CL/FL imaging platform in bioactive molecule detection and disease diagnosis.…”
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Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation by Michiel G. H. Betjes, Willem Weimar, Nicolle H. R. Litjens

“…Proinflammatory CD4+ T cells without the costimulatory molecule CD28 (CD4+CD28null T cells) are expanded in patients with end-stage renal disease (ESRD) and associated with atherosclerotic vascular events (AVE). …”
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Propionate metabolism in Desulfurella acetivorans by Eugenio Pettinato, Thomas M. Steiner, Eric A. Cassens, Thomas Geisberger, Christian Seitz, Simone König, Wolfgang Eisenreich, Ivan A. Berg

“…The latter is directed to the tricarboxylic acid (TCA) cycle, where it is converted to oxaloacetate and condenses with acetyl-CoA (produced by decarboxylation of another oxaloacetate molecule) to form citrate, which is oxidized in the TCA cycle. …”
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Role of aquaporins in brain water transport and edema by Yuyuan Li, Yining Wang, Xingda Huang, Hao Zhang, Youfei Guan, Xiaoyan Zhang

“…Water serves as the primary substance in all living cells and is an essential molecule involved in numerous biological processes critical for maintaining homeostasis in the central nervous system (CNS). …”
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Plant thionins: structure, biological functions and potential use in biotechnology by T. I. Odintsova, M. P. Slezina, E. A. Istomina

“…The amphipathic thionin molecule resembles the Greek letter Г, in which the long arm is formed by two antiparallel α-helices, while the short one, by two parallel β-strands. …”
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The triterpenoid curcumene mediates the relative hydrophilicity of Bacillus subtilis spores by Stefany Castaldi, Giuliana Donadio, Ivana Staiano, Ezio Ricca, Rachele Isticato

“…Understanding the complexity of the spore surface and the specific molecules involved in its structure is an essential step for unraveling the mechanisms underlying the spore’s resistance to environmental assaults.…”
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Maximum Bleaching of Vegetable Oils by Acid-Activated Bentonite: Influence of Nanopore Radius by Müsęerref Önal, Yüksel Sarıkaya

“…Adsorption of a pigment onto a BE was found to depend not only on the physicochemical interaction between the pigment molecule and the BE surface, but also on the mean nanopore size.…”
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The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity by Jessica A. Klein, Julia D. Heidmann, Tomomi Kiyota, Aaron Fullerton, Kimberly A. Homan, Julia Y. Co

“…We employed distinct proliferative and differentiated organoid models of the small intestine to assess whether differentiation state alone can alter toxicity responses to small molecule compounds in cell viability assays. In doing so, we identified several examples of small molecules which elicit differential toxicity in proliferative and differentiated organoid models. …”
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Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity by Dongsheng Mao, Xiaochen Tang, Runchi Zhang, Song Hu, Hongquan Gou, Penghui Zhang, Wenxing Li, Qiuhui Pan, Bing Shen, Xiaoli Zhu

“…Through the implementation of this strategy, we can now map the expression and nuclear distribution of multiple site-specific RNA N6-methyladenosine (m6A) modifications at the single-molecule resolution level in single-cells, and reveal the previously unknown heterogeneity. …”
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Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Alter the Gut-Brain Communication by L. A. Ballsmider, A. C. Vaughn, M. David, A. Hajnal, P. M. Di Lorenzo, K. Czaja

“…Microglia activation was determined by quantifying changes in the fluorescent staining of hindbrain sections against an ionizing calcium adapter binding molecule 1 (Iba1). Reorganization of vagal afferents in the hindbrain was studied by fluorescent staining against isolectin 4 (IB4). …”
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Trogocytosis-mediated immune evasion in the tumor microenvironment by Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred L. M. Bothwell, Jae Hun Shin

“…Unlike phagocytosis, this transfer maintains the surface localization of transferred membrane molecules. For example, CD4 T cells engaging with antigen-presenting cells undergo trogocytosis, which facilitates the transfer of antigen-loaded major histocompatibility complex (MHC) class II molecules from antigen-presenting cells to CD4 T cells. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…The biological capacity of each molecule to inhibit bacterial strains exhibited variability in the evaluation of the compounds' in vitro antibacterial efficacy. …”
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Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report by Hannah Haile, Pavan S. Upadhyayula, Esma Karlovich, Michael B. Sisti, Brian J. A. Gill, Laura E. Donovan

“…This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM. …”
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CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo by Kirsten Buschmann, Lutz Koch, Natascha Braach, Hanna Mueller, David Frommhold, Johannes Poeschl, Peter Ruef

“…Flow chamber experiments, expression analysis, functional depletion, and knockout of key adhesion molecules gave mechanistic insight in involved pathways. …”
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