Specificity and tunability of efflux pumps: A new role for the proton gradient? by Matthew Gerry, Duncan Kirby, Boian S Alexandrov, Dvira Segal, Anton Zilman

“…It remains unclear how efflux pumps can maintain this broad spectrum specificity to diverse drug molecules while limiting the efflux of other cytoplasmic content. …”
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Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells by Zhiyv Niu, Shaun M. Goodyear, Mary R. Avarbock, Ralph L. Brinster

“…Inhibition of CXCR4 signaling using a small molecule inhibitor (AMD3100) during the critical window of homing also significantly lowered the efficiency of donor-derived SSCs to establish spermatogenic colonies in recipient mice; however, the self-renewal of SSCs was not affected by exposure to AMD3100. …”
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Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease by B. Vainerc, O. H. Nielsen

“…E-selectin (CD62E) is an endothelial specific glycoprotein belonging to the selectin family of adhesion molecules. Because a high expression of this molecule at intestinal mucosal surfaces in inflammatory bowel disease (IBD) has been described earlier, the aim was to assess serum levels of E-selectin (sE-selectin) and to correlate it to disease activity, and further to evaluate its chemotactic properties at physiological concentrations. …”
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Identification and validation of TSPAN13 as a novel temozolomide resistance-related gene prognostic biomarker in glioblastoma. by Haofei Wang, Zhen Liu, Zesheng Peng, Peng Lv, Peng Fu, Xiaobing Jiang

“…Additionally, we focused on the molecule TSPAN13, whose role in GBM is not well understood. …”
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Ligands of CD6: roles in the pathogenesis and treatment of cancer by Mikel Gurrea-Rubio, Feng Lin, Max S. Wicha, Yang Mao-Draayer, David A. Fox

“…An additional cell surface molecule (CD44) is being studied as a potential third ligand of CD6. …”
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Live imaging of paracrine signaling: Advances in visualization and tracking techniques by Eriko Deguchi, Michiyuki Matsuda, Kenta Terai

“…Diffusion of paracrine factors has been studied using techniques such as fluorescence correlation spectroscopy (FCS), fluorescence recovery after photobleaching (FRAP), fluorescence decay after photoactivation (FDAP), and single-molecule tracking. Binding of paracrine factors to target cells has been visualized through various biosensors, including GPCR-activation-based (GRAB) sensors and Förster resonance energy transfer (FRET) probes for receptor tyrosine kinases. …”
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HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses by Mansaku Hirai, Khoir Amaliin, Jing Rin Huang, Salma Aktar, Yasuko Mori, Jun Arii

“…Human cytomegalovirus (HCMV) belongs to the other betaherpesvirus genus, Cytomegalovirus; its RNR inhibits nuclear factor-kappa B (NF-κB) signaling via interaction with the adaptor molecule RIPK1. However, the significance of enzymatically inactive RNR in roseoviruses is unclear. …”
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Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types by Leif R. Neitzel, Daniela T. Fuller, Jessica Cornell, Samantha Rea, Carolina de Aguiar Ferreira, Charles H. Williams, Charles C. Hong

“…Previously, using ogremorphin (OGM), a small molecule inhibitor of GPR68, an extracellular proton sensing receptor, we demonstrated that GPR68 is a key pro-survival pathway in glioblastoma cells. …”
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Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells by Sonia Martínez-Herrero, Ignacio M. Larráyoz, Laura Ochoa-Callejero, Josune García-Sanmartín, Alfredo Martínez

“…Postnatal neurogenesis is subjected to tight regulation by many growth factors, cell signals, and transcription factors. An emerging molecule involved in this process is adrenomedullin (AM). …”
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Excited states of mono- and biruthenium(II) complexes adsorbed on nanocrystalline titanium dioxide studied by electroabsorption spectroscopy by Daniel Pelczarski, Błażej Gierczyk, Maciej Zalas, Malgorzata Makowska-Janusik, Waldemar Stampor

“…Due to the difficulties arising from standard analysis based on Liptay formalism, we have for the first time successfully reproduced the EA spectra of the Ru/TiO2 systems using the time-dependent density functional (TDDFT) calculations, incorporating into the Hamiltonian a term describing the interaction of a molecule with the local electric field it experiences from the TiO2 structure and the neighboring Ru complex molecules, without additional assumptions about the lineshape of the EA signal. …”
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Potential of cumin essential oil as inhibitor of deamination during ensiling process: A meta-analysis and in-silico approach by Susanto Irwan, Mahendra Fachrur R., Rahmadani Mardiah, Ridwan Roni, Jayanegara Anuraga

“…However, computer simulations showed that the α-hederin molecule compound was the most effective ligand tested as a deamination inhibitor. …”
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Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction by Line Lisbeth Olesen, Thomas Vauvert F. Hviid

“…The immune system is activated in LVSD, and the immunomodulatory molecule human leukocyte antigen-G (HLA-G) may be involved. …”
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Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…The EGFR signalling pathway plays a critical role in the development and progression of oral cancer, making it an attractive therapeutic target. Small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting EGFR have shown promise in preclinical studies and clinical trials. …”
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The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure by Zhenhua Wang, Zhaoling Cai, Markus W. Ferrari, Yilong Liu, Chengyi Li, Tianzhang Zhang, Guorong Lyu

“…The gut microbiota is simplified by the disease, and serum small-molecule metabolites evidently change in elderly patients with CHF. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…Further analyses showed that Cldn11 knockout impaired Sertoli cell polarization, localization of stem cell factor (SCF) (a key molecule for maintaining differentiating spermatogonia) to the basal compartment of seminiferous tubules, and also proliferation of differentiating spermatogonia. …”
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Experimental Characterization, Computational Investigation, and Structure-propertyeactivity Relationship Studies of Nickel Ferrite Nanostructures by Ali Ben Ahmed

“…Additionally, the theoretical background of nickel ferrite was carved out using Density Functional Theory (DFT) by evaluating the electronic structure through the Frontier Molecular Orbital, Molecular Electrostatic Potential, Milliken charge distribution, Density of state spectrum, and nonlinear optical parameters embedded within the nickel ferrite molecule. Based on all these results, nickel ferrite can be considered as a multifunctional material.…”
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MultiChem: predicting chemical properties using multi-view graph attention network by Heesang Moon, Mina Rho

“…We evaluated our model on nine MoleculeNet datasets, encompassing both classification and regression tasks, and compared its performance with state-of-the-art methods. …”
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THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes proliferation and migration. by Marie Klimontova, Han Zhang, Francisco Campos-Laborie, Natalie Webster, Byron Andrews, Kimberley Chung Kim Chung, Ryan Hili, Tony Kouzarides, Andrew J Bannister

“…Moreover, depletion of THUMPD3 selectively and preferentially affects the alternative splicing of ECM and cell adhesion molecule encoding transcripts, as well as those encoding neurodevelopmental proteins. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Besides, the activation of cGAS-STING signaling enhanced the expression of type I IFN and its downstream molecule PD-L1 through the TBK1-IRF3 pathway. Importantly, a high level mtDNA and PD-L1 were present in EVs derived from IL6-induced EC cells; these vesicles were shown to be able to induce T cell apoptosis. …”
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A data-driven group retrosynthesis planning model inspired by neurosymbolic programming by Xuefeng Zhang, Haowei Lin, Muhan Zhang, Yuan Zhou, Jianzhu Ma

“…However, current methods often treat each molecule independently, missing the opportunity to utilize shared synthesis patterns and repeat pathways, which may contribute from known synthesis routes to newly emerging, similar molecules, a notable challenge with AI-generated small molecules. …”
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