Antiviral activity of an ACE2-Fc fusion protein against SARS-CoV-2 and its variants. by Ernesto Bermúdez-Abreut, Talia Fundora-Barrios, Diana Rosa Hernández Fernández, Enrique Noa Romero, Anitza Fraga-Quintero, Ana V Casadesús Pazos, Briandy Fernández-Marrero, Claudia A Plasencia Iglesias, Marilyn Clavel Pérez, Katya Sosa Aguiar, Belinda Sánchez-Ramírez, Tays Hernández

“…Our results suggest the potential of this molecule to be used in both therapeutic and preventive settings against current and emerging mutants that use ACE2 as a gateway to human cells.…”
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Optomechanical micro-rheology of complex fluids at ultra-high frequency by H. Neshasteh, I. Shlesinger, M. Ravaro, M. Gély, G. Jourdan, S. Hentz, I. Favero

“…A shear elastic response appears at the highest frequencies, whose value allows determining the volume of a single liquid molecule. UHF optomechanical micro-rheology provides direct mechanical access to the fast molecular dynamics in a liquid, in a quantitative manner and within a sub-millisecond measurement time.…”
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miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart by Wanling Xuan, Lei Wang, Meifeng Xu, Neal L. Weintraub, Muhammad Ashraf

“…Cardiac progenitor cells (CPCs) induction by ISX-9, a small molecule possessing antioxidant, prosurvival, and regenerative properties, represents an attractive potential approach for cell-based cardiac regenerative therapy. …”
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In Situ Raman Spectroscopy for Early Corrosion Detection in Coated AA2024-T3 by Adrienne K. Delluva, Ronald L. Cook, Matt Peppel, Sami Diaz, Rhia M. Martin, Vinh T. Nguyen, Jeannine E. Elliott, Joshua R. Biller

“…Here we describe the synthesis and evaluation of a molecular corrosion sensor that can be applied in situ in aerospace coatings, then used to detect corrosion after the coating has been applied. A pH-sensitive molecule, 4-mercaptopyridin (4-MP), is attached to a gold nanoparticle to allow surface-enhanced Raman-scattering (SERS) for signal amplification. …”
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N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19 by Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson

“…N-acetylcysteine (NAC) and other sulfur donors contribute to the inorganic sulfate pool, the rate-limiting molecule in sulfation. NAC is not only a precursor to glutathione but also converts to hydrogen sulfide, inorganic sulfate, taurine, Coenzyme A, and albumin. …”
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FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking by Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

“…These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic targets for both small molecule-based and structure-based approaches. Protein language models (pLMs) have recently emerged as powerful tools for capturing physicochemical and functional protein features but have yet to be trained on fusion oncoprotein sequences. …”
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Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs by Xiang Zhang, Yulian Yin, Qiuting Yu, Xinlin Chen, Yiqin Cheng

“…In this paper, we classify them into three categories: monoclonal antibodies (mAbs), small-molecule tyrosine kinase inhibitors (TKIs), and antibody-drug conjugate (ADCs). …”
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Study on Surface-Enhanced Raman Scattering Substrate Based on Titanium Oxide Nanorods Coated with Gold Nanoparticles by Xiaodong Wang, Xiulan Cheng, Xufeng Yu, Xueling Quan

“…Rhodamine 6G (R6G) was chosen as the probe molecule to study the SERS performance of the substrates. …”
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Single-cell transcriptomics unveils multifaceted immune heterogeneity in early-onset versus late-onset cervical cancer by Qian Chen, Dongfeng Deng, Hong Zhu, Shan Li

“…Epithelial cells in EOCC exhibited a notable dual immunological phenotype, characterized by immune-suppressive properties driven by elevated CXCL production, alongside immune-stimulatory features linked to heightened HLA molecule expression. CD4 + and CD8 + T cells in LOCC demonstrated a heightened activation state, while NK cells exhibited diminished cytotoxicity. …”
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Proteolytic Processing of CD44 and Its Implications in Cancer by Priscila Anhel Medrano-González, Osmar Rivera-Ramírez, Luis Felipe Montaño, Erika P. Rendón-Huerta

“…Modifications in its structure contribute differently to the activity of this molecule. One modification that has provoked interest is the consecutive cleavage of the CD44 extracellular ectodomain by enzymes that belong mainly to the family of metalloproteases. …”
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Pushing the boundaries for fuel discovery with a multiview features fusion approach by Dehai Zhang, Di Zhao, Jiashu Liang, Yu Ma, Zheng Chen

“…This method uses the eight graph neural networks models as the basis of the multichannel network coordinator to extract the compound's molecular feature; also the functional groups in the compound are embedded with molecule weight as functional groups feature, and finally, combining the molecular view with the functional groups view for the prediction of compound flash point (FP). …”
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Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…Here the discovery of a small molecule that activates the production and secretion of fibroblast growth factor 21 (FGF21) is reported. …”
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Crystal and Molecular Structure of Bis(2,2-diphenyl-N-(di-n-propylcarbamothioyl) acetamido)copper(II) Complex by Hakan Arslan, Ulrich Flörke, Demet Sezgin Mansuroglu

“…This coordination has a slightly distorted square-planar geometry (O1-Cu1-O2: 86.48(11)°, O1-Cu1-S1: 93.85(9)°, O2-Cu1-S2: 94.20(9)° and S1-Cu1-S2: 91.21(4)°). The title molecule shows a cis-arrangement and C–O, C–S and C–N bond lengths of the complex suggest considerable electronic delocalization in the chelate rings.…”
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Proteomic Analysis Reveals Growth Inhibition of Coriolus versicolor by Methanol Extracts of Cinnamomum camphora Xylem by Quan Li, Xiangyang Li, Hui Lin

“…A total of 18.8% were mapped to small-molecule metabolic processes, 12.5% to cellular amino acid metabolic processes, and 10.9% to cellular nitrogen compound metabolic processes. …”
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Synthesis and Interface Activity of a Series of Carboxylic Quaternary Ammonium Surfactants in Hydraulic Fracturing by Shixin Dai, Yufei Gong, Feng Wang, Pan Hu

“…The critical micelle concentration (CMC) and surface tension at the CMC (γCMC) increase as increasing methylene segments in the anions, the maximum surface excess concentration (Γmax), and minimum area per molecule (Amin) present an opposite trend with the increase of methylene segments. …”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…With EGFR having four homologues: EGFR1, EGFR2, EGFR3, and EGFR4, in-depth understanding of EGFR biology led to the discovery of small-molecule inhibitors and antibodies against this receptor. …”
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Maxwellian Eye Fixation during Natural Scene Perception by Jean Duchesne, Vincent Bouvier, Julien Guillemé, Olivier A. Coubard

“…For each participant, the probability density function (PDF) of eye movement amplitude during fixation obeyed the law established by Maxwell for describing molecule velocity in gas. Only the mean amplitude of eye movements varied with expertise, which was lower in experts than novice participants. …”
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Development of Nanozyme-Labeled Biomimetic Immunoassay for Determination of Sulfadiazine Residue in Foods by Jingbo He, Li Zhang, Longhua Xu, Feifan Kong, Zhixiang Xu

“…In the present study, a molecularly imprinted polymer (MIP) that could selectively recognize sulfadiazine (SDZ) was prepared using SDZ as the template molecule and methacrylic acid as the functional monomer. …”
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A phenomenological model of non-genomic variability of luminescent bacterial cells by S. I. Bartsev

“…Since in the process of division all cells go through the stage of release of all regulatory molecules from the DNA molecule, the resulting distributions can be attributed not only to luciferase, but also to other proteins of constitutive (and not only) synthesis.…”
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N-Oxalylglycine-Conjugated Hyaluronic Acid as a Macromolecular Prodrug for Therapeutic Angiogenesis by Andrew H. DeMaria, Jeoung Soo Lee, Ken Webb

“…However, achieving therapeutic doses of bioactive small molecules in target tissues remains challenging. In this paper, we report the synthesis and characterization of a new macromolecular prodrug composed of the pro-angiogenic small molecule N-oxalylglycine conjugated to hyaluronic acid (HA-NOG). …”
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