Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae by Rama Raju Baadhe, Naveen Kumar Mekala, Sreenivasa Rao Parcha, Yalavarthy Prameela Devi

“…Our main objective was to overproduce amorpha 4-11-diene, which is a key precursor molecule of artemisinin (antimalarial drug) produced naturally in plant Artemisia annua through mevalonate pathway. …”
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Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization by Xiaoxuan Zhang, Meile Zhang, Yihao Li, Ping Deng

“…We then performed screening using shape and protein conformation ensembles, followed by a re-evaluation of the docking results with deep-learning-driven GNINA to identify the candidate molecule, STOCK7S-56165. Based on this, we applied a fragment-replacement strategy under electrostatic-surface-matching conditions to obtain Compd 26. …”
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Quinoline-Based Materials: Spectroscopic Investigations as well as DFT and TD-DFT Calculations by Mahmoud A. S. Sakr, Samy A. El-Daly, El-Zeiny M. Ebeid, Sadeq M. Al-Hazmy, Mohammed Hassan

“…Also, the influence of pH on the absorption spectra of the DDP molecule was studied. The molecular structures of these quinoline derivatives have been optimized via utilizing the B3LYP/6-31G (d) level of theory. …”
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Nanocomposite of electrochemically reduced graphene oxide and gold nanourchins for electrochemical DNA detection by Mostafa Azimzadeh, Zahra Aghili, Behrooz Jannat, Saeid Jafari, Saeed Rafizadeh Tafti, Navid Nasirizadeh

“…The specificity of the DNA hybridisation and the signalling molecule (haematoxylin) caused very high selectivity towards the target DNA than other non‐specific sequences.…”
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Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity by Manfred Kunz, Saleh M. Ibrahim

“…Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future.…”
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Towards a full understanding of water splitting in photosynthesis by James Barber

“…The latter is made available as reducing equivalents, ultimately destined to convert carbon dioxide to organic molecules. In PSII, the “hydrogen” reduces plastoquinone (PQ) to plastoquinol (PQH2). …”
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Effect of Processing Parameters on Performance of Spray-Deposited Organic Thin-Film Transistors by Jack W. Owen, Natalia A. Azarova, Marsha A. Loth, Markos Paradinas, Mariona Coll, Carmen Ocal, John E. Anthony, Oana D. Jurchescu

“…In this study, we fabricate OTFTs of soluble small-molecule organic semiconductors by spray-deposition and explore the effect of processing parameters on film morphology and device mobility. …”
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All-optical azimuthal trapping of dissipative Kerr multi-solitons for relative noise suppression by Pradyoth Shandilya, Shao-Chien Ou, Jordan Stone, Curtis Menyuk, Miro Erkintalo, Kartik Srinivasan, Grégory Moille

“…This method ensures repetition rate noise is independent of the number of solitons, making a multi-DKS state indistinguishable from a single-DKS state in that regard, akin to trapped-soliton molecule behavior. Supported by theoretical analysis and experimental demonstration in an integrated microresonator, this approach provides metrological capacity regardless of the number of cavity solitons, benefiting numerous DKS-based metrology applications.…”
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A Simplified Method of Microscopic Polarizability Tensor Differential of Hyper-Raman Spectroscopy Based on the Bond Additivity Model by Yuan Wang, Liping Huang

“…In this paper, we use the bond additivity model (BAM) combined with experimental corrections to address the carbon dioxide (CO2) molecule and present the simplified scheme for differentiation of hyper-Raman microscopic polarizability tensor elements β′i′j′k′. …”
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The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide by Ø. Rekdal, Z. Konopski, J. S. Svendsen, J.-O. Winberg, T. Espevik, B. Østerud

“…It is suggested that different domains of the TNFα molecule induce distinct biological effects.…”
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Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis by Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti

“…E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis. Lately, its pleiotropic role beyond barrier function, including its involvement in immune responses, has become more evident. …”
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Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae by Shiva Kumar Goud Gadila, John R. Caskey, Edward B. Breitschwerdt, Ricardo G. Maggi, Monica E. Embers

“…Downregulation included BadA, a well-characterized adhesin molecule, of critical importance for cell invasion. …”
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A Novel Metal-Organic Framework Composite, MIL-101(Cr)@MIP, as an Efficient Sorbent in Solid-Phase Extraction Coupling with HPLC for Tribenuron-Methyl Determination by Xinyuan Zheng, Junping Wang

“…The MIL@MIP was prepared by surface molecular-imprinting technique, specially using MIL-101 as core, TBM as template molecule, methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and azobisisobutyronitrile (AIBN) as initiator. …”
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Unbinding of alpha chain of hemoglobin in sickle and normal structures by Jhulan Powrel, Rajendra Prasad Koirala, Narayan Prasad Adhikari

“…Sickle cell disease, a genetic disorder, is caused by a mutation of glutamic acid into valine in β chain of hemoglobin at the sixth residue, resulting in structural change of the entire hemoglobin molecule into a sickle shape. We investigated the atomic level interaction between the α chain (chain A) and the remaining three chains to identify the structural modification in sickle hemoglobin using the molecular dynamics simulations. …”
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The molecular basis of Human FN3K mediated phosphorylation of glycated substrates by Ankur Garg, Kin Fan On, Yang Xiao, Elad Elkayam, Paolo Cifani, Yael David, Leemor Joshua-Tor

“…Our structural work provides the molecular basis for rational small molecule design targeting FN3K.…”
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Circulating Endothelial Microparticles in Diabetes Mellitus by A. F. Tramontano, R. Lyubarova, J. Tsiakos, T. Palaia, J. R. DeLeon, L. Ragolia

“…We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization. …”
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Quantitative Imaging of Cell-Permeable Magnetic Resonance Contrast Agents Using X-Ray Fluorescence by Paul J. Endres, Keith W. MacRenaris, Stefan Vogt, Matthew J. Allen, Thomas J. Meade

“…Specifically, we coupled Gd(III)–diethylenetriaminepentaacetic acid DTPA and Gd(III)–1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid with an 8–amino acid polyarginine oligomer and an amphipathic stilbene molecule, 4-amino-4'-( N,N -dimethylamino)stilbene. …”
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A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina by Gaia Ziraldo, Sara Cupini, Valentina Sesti, Emanuela Delfino, Guglielmo Lanzani, Chiara Bertarelli, Fabio Benfenati, Stefano Di Marco

“…The results indicate that Ziapin2 is a promising molecule for reinstating physiological visual responses in the late stages of retinal degeneration.…”
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Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness by Lijuan Deng, Lifang Zou, Chunhong Zhou, Fuqin Yang, Fen Ouyang, Yingru Zhu, Huihui Cao, Min Hu, Xiaoshen Zhang, Junshan Liu

“…Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. …”
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An HPLC-based Assay to Study the Activity of Cyclic Diadenosine Monophosphate (C-di-AMP) Synthase DisA from Mycobacterium smegmatis by Avisek Mahapa, Sudhanshu Gautam, Arti Rathore, Dipankar Chatterji

“…Because of its pivotal role in bacterial signaling and host immune response, this molecule has garnered significant interest from the pharmaceutical industry. …”
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