Accelerated enzyme engineering by machine-learning guided cell-free expression by Grant M. Landwehr, Jonathan W. Bogart, Carol Magalhaes, Eric G. Hammarlund, Ashty S. Karim, Michael C. Jewett

“…We use these data to build augmented ridge regression ML models for predicting amide synthetase variants capable of making 9 small molecule pharmaceuticals. Over these nine compounds, ML-predicted enzyme variants demonstrate 1.6- to 42-fold improved activity relative to the parent. …”
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MIKRORNA – MOLEKUL VERSATIL DALAM KANSER TIROID by Azliana Mohamad Yusof, Nurul-Syakima Ab Mutalib

“…Sebagai molekul pengawalatur (regulatory molecule), mikroRNA adalah calon kajian yang sesuai untuk penyelidikan kanser tiroid di mana landskap mutasi genomnya secara relatif lebih senyap berbanding kanser lain. …”
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Ethyl 4-[(2-hydroxyethyl)amino]-2-(4-methoxyphenyl)-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate by Fatin Nur Ain Abdul Rashid, Mohd Fazli Mohammat, Mohd Abdul Fatah Abdul Manan, Ayisy Amirul Afti Bakhtiar Afendy, David B. Cordes, Aidan P. McKay

“…In the crystal, the compound forms inversion dimers through O—H...O hydrogen bonds from the disordered hydroxyl group to either the hydroxyl or ester carbonyl O atom of the adjacent molecule.…”
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Simulated gastrointestinal digestion of milk caseins containing A1 β-casein does not lead to increased production of inflammatory proteins in intestinal epithelial cells in vitro w... by Alan Aitchison, Teagan S. Edwards, Andrew S. Day

“…No difference was found in the effects of the digestion products of each β-casein on gene expression of inflammatory markers interleukin (IL)-8, carcinoembryonic antigen-related cell adhesion molecule (CEACAM)6 or intestinal alkaline phosphatase (IAP). …”
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Pyridin-1-ium carboxyformate–2-chloroacetic acid (1/1) by Nurlana D. Sadikhova, Farida M. Muradova, Narmina A. Guliyeva, Khudayar I. Hasanov, Tahir A. Javadzade, Ennio Zangrando, Alebel N. Belay

“…The asymmetric unit of the title salt co-crystal, C5H6N+·C2HO4−·C2H3ClO2, comprises a pyridinium cation, a carboxyformate anion and a 2-chloroacetic acid molecule. In the crystal, the components are connected by hydrogen bonds within a one-dimensional chain in the a-axis direction which incorporates rather short, charge-assisted O—H...O hydrogen bonds; the pyridinium-NH group forms bifurcated N—H...…”
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Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway by Chao Chen, Qiwu Wang, Jiwen Liu

“…Results The highly expressed PCa-related molecule IGF-1R was down-regulated in CRPC cells after curcumin treatment, as determined by RT-qPCR and western blotting. …”
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EFFECT OF SECONDARY METABOLISMS OF THE TRICHODERMA HARZIANUM FUNGUS ON THE SECOND LARVAL STAGE OF THE MUSCA DOMESTICA L. by S. M. Hardan, Th. A. A. Muhsen

“…Decanol and carbonochloridic acid, and decyl ester were also significant at 11.80% each. The molecule benzenepropanamine, alpha-methyl had the lowest presence at 1.48%. …”
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CO2-philicity of crude oil constituents: A computational study by Lionel T. Fogang, Syed M.S. Hussain, Theis I. Solling

“…The present ab initio study has investigated the affinity of CO2 to various binding sites in molecules that consist of an aromatic ring with aliphatic substituents. …”
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FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN by Krishnakumar Kizhatil, Graham M. Clark, Daniel K. Sunderland, Aakriti Bhandari, Logan J. Horbal, Revathi Balasubramanian, Simon W. M. John

“…We hypothesize that mechano-responsive phosphorylation of the cell adhesion molecule VE-CADHERIN (CDH5) in SECs, by FYN and possibly other SRC family kinases, regulates adherens junction (AJ) permeability to AQH in response to IOP. …”
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Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease by Punithavathi Ranganathan, Riyaz Mohamed, Calpurnia Jayakumar, Ganesan Ramesh

“…The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration. …”
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Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway by Simon C. M. Kwok

“…Zinc protoporphyrin IX (ZnPP), a naturally occurring molecule formed in iron deficiency or lead poisoning, is a potent competitive inhibitor of heme oxygenase-1 (HO-1). …”
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The Diagnosis and Treatment of Branch Retinal Vein Occlusions: An Update by Diana-Maria Darabuş, Rodica Georgiana Dărăbuş, Mihnea Munteanu

“…Therapeutic interventions, including laser photocoagulation, anti-VEGF therapy, and intravitreal corticosteroids, are critically evaluated, emphasizing emerging treatments such as gene therapy, peptide-based agents, and small-molecule inhibitors. Despite advancements in management strategies, the recurrence of macular edema and treatment resistance remain significant challenges. …”
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Macroprolactinemia: Diagnostic, Clinical, and Pathogenic Significance by Akira Shimatsu, Naoki Hattori

“…The cross-reactivity of macroprolactin varies widely according to the immunoassay systems. The epitope on PRL molecule recognized by the autoantibodies is located close to the binding site for PRL receptors, which may explain that macroprolactin has a lower biological activity. …”
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Process Optimization for Biosingeing of 100% Cotton Terry Towel Fabric Using Box–Behnken Design by Aklilu Azanaw, Asnake Ketema

“…The treated fabric was analyzed using FTIR to know the unknown functional group and the chemical bonds on the fabric molecule. Testing of physical properties of the treated fabric was done and the result was comparable with other untreated fabrics. …”
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Biophysical and Structural Studies on the Capsid Protein of the Human Immunodeficiency Virus Type 1: A New Drug Target? by José L. Neira

“…In the second part of this review, I shall describe the structures of complexes of CAC with small molecules able to weaken its dimerization. Furthermore, interactions with other proteins and lipids are also described. …”
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Development of biomaterials for bone tissue engineering based on bile acids by Yongjun Liu, Xiaojie Liu, Chang Liu, Wenan Zhang, Ting Shi, Guanying Liu

“…Additionally, the combination of BA molecule with other biological materials can help overcome problems associated with limited local bone regeneration and maintain a defined release state for a long time. …”
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Update on New Antigens in the Pathogenesis of Membranous Nephropathy by Maurizio Salvadori, Aris Tsalouchos

“…Through these techniques, four new antigens were first detected, including neural epidermal growth factor 1 and semaphorin 3B in the so-called primary membranous nephropathy, and exostosin 1 and 2 and neural cell adhesion molecule 1 in lupus membranous nephropathy. The aim of this study is to describe the characteristics of the new antigens discovered and their association with other diseases. …”
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The Influence of the Chemical Structures of Chitosan and Acid Dye on the Adsorption Process by Hayet Ben Ali, Salma Besbes Hentati, Salem S. Al-Deyab, Mohamed Rzaigui, M'henni Mohamed Farouk

“…In addition, the best extent of decolorization is obtained for AR 183 that is the smallest molecule. Langmuir model represents the best fit of the experimental data, indicating monolayer coverage of chitosan outer surface. …”
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PatCID: an open-access dataset of chemical structures in patent documents by Lucas Morin, Valéry Weber, Gerhard Ingmar Meijer, Fisher Yu, Peter W. J. Staar

“…It enables users to search which molecules are displayed in which documents. PatCID contains 81M chemical-structure images and 14M unique chemical structures. …”
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Structure and Functions of Human Serum Albumin in Normal Conditions and in Patients with Liver Cirrhosis by A. A. Turkina, M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The conformational structure of the albumin molecule plays an important role in maintaining its non-oncotic functions. …”
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