Successful Pregnancy Using the NxStage Home Hemodialysis System by Yasmin Brahmbhatt, Arinze Ikeme, Navjyot Bhogal, Vincenzo Berghella

“…The NxStage System One uses low-volume dialysate and hence small and middle molecule clearance may differ compared to conventional therapies and affect pregnancy outcomes. …”
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Application of a macrocyclization strategy in kinase inhibitor development by Kun Xing, Shujun Li, Jinghuan Li, Dan Liu, Min Huang, Linxiang Zhao

“…By mid-2024 the Food and Drug Administration had approved 81 small-molecule kinase inhibitors targeting greater than 30 kinases, providing substantial clinical benefits for patients with cancer and other diseases. …”
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Biobased Polylactide Nanoparticles as Novel Gene Delivery Nanoplatforms: Can They Be Used for DNA Transport? by Farnaz Sadat Fattahi

“…Nanoparticles are some of the important examples of nano-materials for molecule delivery (drugs, growth factors and DNA) used in biomedical applications. …”
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P-Body Components, microRNA Regulation, and Synaptic Plasticity by Jens Hillebrand, Scott A. Barbee, Mani Ramaswami

“…While illuminating the function of this important RNA regulatory molecule, it also brings into focus a hypothesis of potentially broad significance. …”
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Modulation of nitric oxide synthase activity in macrophages by P. G. Jorens, K. E. Matthys, H. Bult

“…NO is a major effector molecule of the anti-microbial and cytotoxic activity of rodent macrophages against certain micro-organisms and tumour cells, respectively. …”
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NF-κB Inhibitory Activity of the Di-Hydroxy Derivative of Piperlongumine (PL-18) by Yael Schlichter Kadosh, Subramani Muthuraman, Ariel Kushmaro, Rajendran Saravana Kumar, Jacob Gopas

“…Altogether, our results suggest that PL-18 is a molecule of interest to be further developed to treat persistent infections with severe inflammation.…”
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Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…BackgroundSTING is a core signaling hub molecule in the innate immune system, involved in various diseases, including infectious diseases, autoimmune diseases, tumors, aging, organ fibrosis, and neurodegenerative diseases. …”
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A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes. by Victoria Gillan, Kerry O'Neill, Kirsty Maitland, Francis M Sverdrup, Eileen Devaney

“…Previous studies, conducted in vitro, have shown that inhibition of Hsp90 kills adult Brugia pahangi. As numerous small molecule inhibitors of Hsp90 have been developed for use in cancer chemotherapy, we tested the activity of several novel Hsp90 inhibitors in a fluorescence polarization assay and against microfilariae and adult worms of Brugia in vitro. …”
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Blood serum levels of E-cadherin in patients with colorectal cancer by Dariusz Cepowicz, Konrad Zaręba, Anna Pryczynicz, Tomasz Dawidziuk, Joanna Żurawska, Joanna Hołody-Zaręba, Mariusz Gryko, Bogusław Kędra

“…E-cadherin is an adhesion molecule, loss of function of which is suspected to influence both cancer progression and metastasis. …”
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Mechanism of action of 5-arninosalicylic acid by N. A. Punchard, S. M. Greenfield, R. P. H. Thompson

“…However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. …”
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Crystal structure and Hirshfeld surface analysis of the chalcone derivative (2E)-3-[4-(diphenylamino)phenyl]-1-[4-(prop-1-yn-2-yloxy)phenyl]prop-2-en-1-one by Sundarasamy Madhan, M. NizamMohideen, Vijayan Viswanathan, Devadasan Velmurugan

“…In the crystal structure of the title chalcone derivative, C30H23NO2, the molecule adopts an s-cis conformation with respect to the C=O and C=C bonds. …”
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Theoretical Study of the Chemical Properties and the Reaction Pathway of Decarbonylative Alkylative Esterification of Styrenes with Aliphatic Aldehydes by Meysam Madahi, Dadkhoda Ghazanfari, Sayed Ali Ahmadi

“…The localized orbital locator, electron location function analysis, and quantum theory of atoms in the molecule have been used to study the active sites for interactions between reactants. …”
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Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Hea... by Kauko K. Mäkinen

“…The occurrence of disturbances depends on consumer properties and on the molecular size and configuration of the polyol molecule. Adaptation may take place as a result of enzyme induction in the intestinal flora. …”
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A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography by Umesh M Ingle, Arvind M Lali

“…This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities.…”
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Impacts of Climate Change on the Plant Water Interactions by Turyasingura, Benson, Ayiga, Natal

“…Despite the fact that water is the most plentiful molecule on Earth's surface, water scarcity is the element that most severely limits global terrestrial plant production. …”
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Antimicrobial Stewardship in the Pediatric Emergency Department: An Observational Pre-Post Study by Erika Silvestro, Ilaria Mussinatto, Antonia Versace, Marco Denina, Giulia Pruccoli, Raffaella Marino, Giulia Mazzetti, Lorenzo Scaglione, Federico Vigna, Alessandra Macciotta, Silvia Garazzino, Claudia Bondone

“…The study’s team assigned a score to each prescription, regarding the appropriate molecule, dose, and duration of therapy, according to the diagnosis. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…The full-length 16S rRNA gene of the microbiota in each sample was sequenced using the PacBio single-molecule real-time sequencing platform, followed by clustering the sequences into operational taxonomic units (OTUs). …”
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Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome by Nadja Scherbakov, Marvin Szklarski, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Antje Meyer, Patricia Grabowski, Wolfram Doehner, Carmen Scheibenbogen

“…Further, there was no difference in soluble vascular cell adhesion molecule and soluble intercellular adhesion molecule levels. …”
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PCSK9 in T-cell function and the immune response by Yuying Wang, Xiaosheng Fang, Jiarui Liu, Xiao Lv, Kang Lu, Yingxue Lu, Yujie Jiang

“…Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) was first reported in 2003 and confirmed to be strongly associated with familial hypercholesterolemia. Small-molecule inhibitors targeting PCSK9 provide an effective and safe method for managing hypercholesterolemia and reducing the cardiovascular risk. …”
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