Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities by Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan

“…We also discussed the recent update on small-molecule inhibitors and PROTACs and their progress in preclinical and clinical trials.…”
Get full text

Modelling random antibody adsorption and immunoassay activity by D. Mackey, E. Kelly, R. Nooney

“…One of the primary considerations in immunoassay design is optimizingthe concentrationof capture antibodyin order to achieve maximal antigen binding and, subsequently, improved sensitivityand limit of detection.Many immunoassay technologies involve immobilizationof theantibody to solid surfaces.Antibodies are large molecules in whichthe position and accessibility of the antigen-binding sitedepend on their orientation and packing density. …”
Get full text

Synthesis of Well-Defined Three-Arm Star-Branched Polystyrene through Arm-First Coupling Approach by Atom Transfer Radical Polymerization by Syed Shahabuddin, Fatem Hamime Ismail, Sharifah Mohamad, Norazilawati Muhamad Sarih

“…The end-functionalized polymer is then coupled using 1,1,1-tris(4-hydroxyphenyl)ethane, a trifunctional core molecule, to give well-defined triple-arm star-branched polystyrene.…”
Get full text

Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography by Vittoria Delbono, Christopher P. Larch, Katrina Carol Newlands, Shona Rhydderch, Thomas Craven Baddeley, John Mervyn David Storey

“…Formaldehyde is a small, volatile molecule with a weak chromophore (the carbonyl group), and its direct analysis by GC-FID and HPLC-UV is difficult. …”
Get full text

Subdiffusion Equation with Fractional Caputo Time Derivative with Respect to Another Function in Modeling Superdiffusion by Tadeusz Kosztołowicz

“…Superdiffusion is usually defined as a random walk process of a molecule, in which the time evolution of the mean-squared displacement, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi>σ</mi><mn>2</mn></msup></semantics></math></inline-formula>, of the molecule is a power function of time, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mi>σ</mi><mn>2</mn></msup><mrow><mo>(</mo><mi>t</mi><mo>)</mo></mrow><mo>∼</mo><msup><mi>t</mi><mrow><mn>2</mn><mo>/</mo><mi>γ</mi></mrow></msup></mrow></semantics></math></inline-formula>, with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>γ</mi><mo>∈</mo><mo>(</mo><mn>1</mn><mo>,</mo><mn>2</mn><mo>)</mo></mrow></semantics></math></inline-formula>. …”
Get full text

RETRACTED ARTICLE: Synthesis of silver nanoparticles using Plantago lanceolata extract and assessing their antibacterial and antioxidant activities by Muhammad Zahir Shah, Zheng-Hui Guan, Ala Ud Din, Amjad Ali, Ata Ur Rehman, Kashif Jan, Shah Faisal, Shah Saud, Muhammad Adnan, Fazli Wahid, Saud Alamri, Manzer H. Siddiqui, Shamsher Ali, Wajid Nasim, Hafiz Mohkum Hammad, Shah Fahad

Get full text

Non-small Cell Lung Cancer Cell Line PC-9 Drug-resistant Mutant Cell Line 
Establishment and Validation of Their Sensitivity to EGFR Inhibitors by Tao HU, Yang LOU, Mingbo SU

“…This model aims to investigate the inhibitory effects of small-molecule EGFR-TKIs and to provide a cellular platform for developing a new generation of innovative drugs that target resistance associated with EGFR mutations. …”
Get full text

The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Conclusion: This study demonstrates that the Car molecule protects against I/R injury. Therefore, we contend that more experimental cohort investigations are needed to examine the impact of the Car molecule on preventing I/R injury.…”
Get full text

Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries by Javier Abello, Ying Yin, Yonghui Zhao, Josh Maurer, Jihui Lee, Cherokee Bodell, Jahmiera Richee, Abigail J. Clevenger, Zarek Burton, Megan E. Goeckel, Michelle Lin, Stephanie Grainger, Carmen M. Halabi, Shreya A. Raghavan, Rajan Sah, Amber N. Stratman

“…We supported the small molecule findings with in vivo genetic suppression of piezo1 and 2 in zebrafish, resulting in loss of transgelin+ vSMCs on the dorsal aorta. …”
Get full text

Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions by Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson, Gino van Heeke

“…These building blocks play an important role in the overall quality of the molecule and can influence many important aspects from potency and specificity to stability and half-life. …”
Get full text

Low Complexity, Low Probability Patterns and Consequences for Algorithmic Probability Applications by Mohammad Alaskandarani, Kamaludin Dingle

“…Here, we study this low complexity, low probability phenomenon by looking at example maps, namely a finite state transducer, natural time series data, RNA molecule structures, and polynomial curves. Some mechanisms causing low complexity, low probability behaviour are identified, and we argue this behaviour should be assumed as a default in the real-world algorithmic probability studies. …”
Get full text

Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. This review summarizes data from in vitro studies, animal models, and clinical trials that focus on the usage of melatonin in TBI.…”
Get full text

Semi-Empirical Predictions on the Structure and Properties of ent-Kaurenoic Acid and Derivatives by Jose Isagani B. Janairo, Gerardo C. Janairo, Derrick Ethelbhert C. YU

“…Results revealed that the molecule possess favourable attributes which renders it possible to be considered as a drug lead only that its very hydrophobic nature can result to poor bioavailabilty, low absorption and poor systemic circulation. …”
Get full text

Safety of Pegfilgrastim (Neulasta) in Patients with Sickle Cell Trait/Anemia by Pashtoon Murtaza Kasi, Mrinal M. Patnaik, Prema P. Peethambaram

“…Pegfilgrastim (Neulasta) is a recombinant filgrastim (human granulocyte colony-stimulating factor (G-CSF)) attached to a polyethylene glycol (PEG) molecule and is given as part of chemotherapy regimens that are associated with significant myelosuppression and risk for febrile neutropenia. …”
Get full text

Valency-Based Descriptors for Silicon Carbides, Bismuth(III) Iodide, and Dendrimers in Drug Applications by Qi-Zhao Li, Abaid ur Rehman Virk, Kashif Nazar, Imran Ahmed, Iskander Tlili

“…Dendrimers are repetitively branched molecules that are typically symmetric around the core and often adopt a spherical three-dimensional morphology. …”
Get full text

Photoredox reactions of environmental chromium by Piotr Mytych, Paweł Cieśla, Zofia Stasicka

“…Photoreduction of Cr(VI) proceeds through reductive quenching of chromate(VI) excited within UV-A by an alcohol molecule. Although HCrO4− is more susceptible to the quenching than the CrO42− ion, and oxygen favours the reverse reaction, the reduction can be easy noticeable at air-saturated natural waters. …”
Get full text

Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila. by Luis Garcia-Alonso

“…Fasciclin 2 (Drosophila NCAM) is a homophilic Cell Adhesion Molecule expressed at moderate levels in the proliferating epithelial cells of imaginal discs, where it engages EGFR in a cell autonomous auto-stimulatory loop that promotes growth along larval development. …”
Get full text

At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis by J. Layne Myhre, David B. Pilgrim

“…Unc45b has been proposed to act exclusively as an adaptor molecule, stabilizing interactions between Hsp90 and myosin; however, recent discoveries in zebrafish and C. elegans suggest the possibility of an earlier role for Unc45b during myofibrillogenesis. …”
Get full text

Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion by Shirin Kalyan, Anthony W. Chow

“…Here we show that the small pool of activated peripheral γδ T cells induces an early upregulation of CD40 on monocytes and the local release of High Mobility Group Box-1 (HMGB-1), the molecule designated as the late mediator of systemic inflammation. …”
Get full text

SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses by Hiroshi Takagi, Mitsutoshi Setou, Seiji Ito, Ikuko Yao

“…SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. …”
Get full text