Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs by Melissa Runge-Morris, Thomas A. Kocarek

“…During phase II metabolism, a substrate is rendered more hydrophilic through the covalent attachment of an endogenous molecule. The cytosolic sulfotransferase (SULT) and UDP-glucuronosyltransferase (UGT) families of enzymes account for the majority of phase II metabolism in humans and animals. …”
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Surface Enhanced Raman Spectroscopy of Proteins: Implications in Drug Designing by Soumik Siddhanta, Chandrabhas Narayana

“…Since its first observation in 1977, SERS have been fast developing into an analytical tool for trace detection of molecular entities, particularly in the area of bio‐molecule sensing and characterization. Also, with the development of the ability to design a variety of plasmonic structures and to be able to control and tune their plasmonic properties, we have been able to use them as SERS substrates for probing complex materials. …”
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Micronutrients Considerations for Warm-Season Grass Systems in Florida by Jane C. Griffin, Joao Mauricio Buen Vendramini, Diane L. Rowland, Maria Lucia Silveira

“…An element can be considered essential for plant growth if a plant fails to complete its life cycle in the absence of the element, the elements action is specific and cannot be completely replaced by another element, it has a direct effect on the organism, or it is a constituent of a molecule that is known to be essential. The objective of this publication is to describe the role of micronutrients in warm-season grass production. …”
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Psychrophilic Enzymes: From Folding to Function and Biotechnology by Georges Feller

“…In these naturally evolved enzymes, the optimization to low temperature activity is reached via destabilization of the structures bearing the active site or by destabilization of the whole molecule. This involves a reduction in the number and strength of all types of weak interactions or the disappearance of stability factors, resulting in improved dynamics of active site residues in the cold. …”
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Role of Electrostatic Effects in the Pure Component and Binary Adsorption of Ethylene and Ethane in Cu-Tricarboxylate Metal-Organic Frameworks by Timothy M. Nicholson, Suresh K. Bhatia

“…The interaction of ethane and ethylene with a Cu-tricarboxylate complex was investigated, showing that at low loadings the lighter molecule has a higher binding energy as a result of interaction with framework Cu and H-bonding with basic framework oxygen atoms. …”
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Synthesis and Thermotropic Properties of Some New Schiff Bases, N-[4-(4-n-Alkanoyloxybenzoyloxy)-2-Hydroxybenzylidene]-4-Cyano-, 4-Hydroxy-, 4-Thio- and 4-Nitroanilines by Sie-Tiong Ha, Guan-Yeow Yeap, Peng-Lim Boey

“…A series of elongated Schiff base esters containing three aromatic rings with hexadecanoyl chain as one of the terminal group and various R substituents (R = CN, OH, SH, and NO2) at the other end of molecule were prepared, and their structures were confirmed via physical measurement. …”
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PHOTOLYSIS OF ASCORBIC ACID IN AQUEOUS SOLUTION:A KINETIC STUDY by Iqbal Ahmad

“…The k–pH profile for the photolysis in the acid range is represented by a sigmoid curve indicating the gradual ionization of the molecule (AH2) to ascorbyl anion (AH– ). Ascorbic acid shows maximum stability around pH 5–6 due to the lowest rate of oxidation reduction of the mono–anion form. …”
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Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling by Melanie A. Simpson

“…Hyaluronan (HA) is a critical component of cell and tissue matrices and an important signaling molecule. The enzymes that synthesize and process HA, as well as the HA receptors through which the signaling properties of HA are transmitted, have been identified in extracellular vesicles and implicated in context-specific processes associated with health and disease. …”
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Study of Millimeter-Wave Rotational Spectra of Phosphorus Trifluoride in Ground,v2 = 1 and v4 = 1 States by Masoud Motamedi, Tahere Zohrevand

“…The millimeter-wave rotational spectra of the ground and excited vibrational states v2 =1 and v4 =1 of the symmetric top molecule, PF3, have been analyzed again. The B0 = 7819.9907(13) MHz, DJ = 7.84984(41) kHz, DJk = -11.7644 (11) kHz, HJ = 15.678 (36) mHz, HJk = -66.46 (12) mHz and HkJ = 87.42 (15) mHz have been determined for ground state. …”
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Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems by Abdolhossien Massoudi, Mohsen Adeli, Leila Khosravi far

“…Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…The μ-opioid receptor (OPRM1) was expressed in THP-1 monocytes, macrophages, HASMCs, HUVECs, and human aortic endothelial cells. β-Endorphin significantly increased THP-1 monocyte adhesion to HUVECs and induced upregulation of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin via nuclear factor-κB (NF-κB) and p38 phosphorylation in HUVECs. β-Endorphin significantly increased HUVEC proliferation and enhanced oxidized low-density lipoprotein-induced foam cell formation in macrophages. β-Endorphin also significantly shifted the macrophage phenotype to proinflammatory M1 rather than anti-inflammatory M2 via NF-κB phosphorylation during monocyte-macrophage differentiation and increased migration and apoptosis in association with c-jun-N-terminal kinase, p38, and NF-κB phosphorylation in HASMCs. …”
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Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway by Yingfu Chen, Burong Feng, Ye Yuan, Juan Hu, Wei Zhao, Huiwei Jiang, Wen Li, Ziyi Fan, Zhimin Du

“…In addition, vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM-1) protein expressions were also inhibited by AE. …”
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Differential impact of TIM-3 ligands on NK cell function by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert L Ferris, Tullia C Bruno, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lawrence P Kane, Pragati Upadhyay, Jennifer L Anderson, Onyedikachi Victor Onyekachi, Lidia M R B Arantes

“…Background The transmembrane protein T-cell immunoglobulin and mucin-domain containing molecule 3 (TIM-3) is an immune checkpoint receptor that is expressed by a variety of leukocyte subsets, particularly in the tumor microenvironment. …”
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Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production by Guangqiang Wei, Daodian Wang, Daodian Wang, Teng Wang, Gao Wang, Yunmei Chai, Yufang Li, Minhui Mei, Hao Wang, Aixiang Huang

“…Furthermore, L. fermentum A51 possesses adhesion, acid tolerance, bile salt tolerance, and heat tolerance genes (srtA, tuf, Bsh, nhaC, Ntn, cfa), antioxidant (nrfA, npr, nox2, tps), antibacterial genes (Idh and Dld) EPS synthesis-related genes (glf, epsG, gtf, Wzz, Wzx, Wzy), and signal molecule A1-2 synthesis-related genes (luxS, pfs). …”
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Multi-task aquatic toxicity prediction model based on multi-level features fusion by Xin Yang, Jianqiang Sun, Bingyu Jin, Yuer Lu, Jinyan Cheng, Jiaju Jiang, Qi Zhao, Jianwei Shuai

“…Methods: The model integrates molecular fingerprints and molecule graphs to characterize molecules, enabling the simultaneous prediction of acute toxicity for the same organic compound across four distinct fish species. …”
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Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics by Chelsea Jenkins, Jenny Kan, Maureen E. Hoatlin

“…Inhibiting the FA pathway in ATM deficient cells can be achieved with small molecule inhibitors, suggesting that new cancer therapeutics could be developed by identifying FA pathway inhibitors to treat cancers that contain defects that are synthetic lethal with FA.…”
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E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration by Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu

“…Ubiquitin protein ligase E3 is the most critical molecule in the UPS system. Dysregulation of the UPS system is associated with many conditions. …”
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Synthesis, Structural, Spectroscopic, and Hirshfeld Surface Analysis, and DFT Investigation of Benzaldehyde Semicarbazone by N. Sudha, S. Anbuselvi, Sudhakar Jyothula, A. Thiruppathi, B. Vijayakumar, Kartikeya Parmar, G. Puthilibai, Leevesh Kumar

“…A Hirshfeld analysis was used to study the interactions between molecules. A series of UV-visible, photoluminescence, and VCD spectroscopic experiments were used to verify the optical characteristics of the material. …”
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Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression. …”
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C-Reactive Protein (CRP) and Autoimmune Disease: Facts and Conjectures by Alexander J. Szalai

“…In this article we review and update the evidence generated in CRPtg by our group and in vitro by others' that indicates CRP is more than just an antimicrobial molecule and convenient marker of inflammation - rather, it protects against autoimmunity. …”
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