Régulation, verrous technologiques et transition écologique : le cas des formaldéhydes by Nicolas Béfort

“…The present change towards the use of renewable resources is activating production regimes in which economic actors are trying to use as an opportunity the social contestation of toxic molecules. In this context, our aim is to analyze the use of formaldehyde, an emblematic and carcinogenic molecule widely used in the production of resins and adhesives.Starting with a review of the regulation literature analyzing innovation, we discuss here the 'evolutionist theory of environmental innovations' in order to highlight an analytical framework that aims to analyze from a historical perspective the dynamics of acquiring knowledge. …”
Get full text

Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression by Yan-jun Zhao, Wen-jing Yi, Xiao-jian Wan, Jun Wang, Tian-zhu Tao, Jin-bao Li, Jia-feng Wang, Xiao-ming Deng

“…Intercellular adhesion molecule-1 (ICAM-1) is a key adhesion molecule mediating neutrophil migration and infiltration during sepsis. …”
Get full text

NeuroEPO influence on the fetal heart in a placental insufficiency model of rats by Nìnive Nùñez Lòpez, Julito Dos Santos Dos Santos, Aida María Suàrez Aguiar, María Antonia Cruz García, Claudia Joffre Frías, Carmen Inés Morales Paneque, Laura López Marín

“…<br /><strong>Conclusions:</strong> the administration of this molecule improved fetal weight and allowed an adequate balance in the development of the fetal heart, perhaps due to the cytoprotective effects of this molecule.…”
Get full text

Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients’ Assessment by Radu-Stefan Miftode, Ionela-Lăcrămioara Şerban, Amalia-Stefana Timpau, Ionela-Larisa Miftode, Adriana Ion, Ana-Maria Buburuz, Alexandru-Dan Costache, Irina-Iuliana Costache

“…Multiple evidence revealed that syndecan-1 is also associated with tissue injury and may regulate inflammatory and regenerative responses, being considered a protective molecule that limits the inflammation and reduces cardiac remodelling and dysfunction after a myocardial infarction. …”
Get full text

Ezetimibe Improves Rosuvastatin Effects on Inflammation and Vascular Endothelial Function in Acute Coronary Syndrome Patients Undergoing PCI by Changqing Sun, Wuyang Zheng, Ling Liang, Zuheng Liu, Wenchao Sun, Rong Tang

“…Lipid profile, type II secretory phospholipase A2 (sPLA2-IIa), interleukin-1β (IL-1β), vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1) were measured at baseline and after 7 days. …”
Get full text

Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. …”
Get full text

Novel Organotin(IV) Schiff Base Complexes with Histidine Derivatives: Synthesis, Characterization, and Biological Activity by Ariadna Garza-Ortiz, Carlos Camacho-Camacho, Teresita Sainz-Espuñes, Irma Rojas-Oviedo, Luis Raúl Gutiérrez-Lucas, Atilano Gutierrez Carrillo, Marco A. Vera Ramirez

“…The spectroscopic evidence shows two types of structures: a trigonal bipyramidal stereochemistry with the tin atom coordinated to five donating atoms (two oxygen atoms, one nitrogen atom, and two carbon atoms belonging to the alkyl moieties), where one molecule of ligand is coordinated in a three dentate fashion. …”
Get full text

Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

“…Thus, our findings suggest B7-H6 as a potential molecule for glioma stem cell targeted immunotherapy.…”
Get full text

Near-infrared fluorogenic RNA for in vivo imaging and sensing by Zhenyin Chen, Wei Chen, Cun Xu, Haozhi Song, Xin Ji, Haodong Jiang, Hongtao Duan, Zehao Li, Wankai Gao, Tuoxin Yao, Zhongxuan Zhang, Liuqin He, Yulong Yin, Nanyang Yang, Wenjing Tian, Jiahui Wu, Xing Li

“…With Squash:DFQL-1T complexes, we generate RNA-based sensors for detecting non-coding RNAs and small molecule targets in living mammalian cells and in mice. …”
Get full text

High-Performance Liquid Chromatographic Ultraviolet Determination of Memantine Hydrochloride after In Vitro Transdermal Diffusion Studies by Sergio del Rio-Sancho, César E. Serna-Jiménez, M. Aracely Calatayud-Pascual, Cristina Balaguer-Fernández, Andrés Femenía-Font, Virginia Merino, Alicia López-Castellano

“…In order to analyze a molecule with no chromophoric groups that could be detected by a UV/visible detector, it was necessary to extract the drug and to perform a dansylation reaction that enabled the UV/visible detection of the derivatized molecule. …”
Get full text

Molecular dynamics and machine learning unlock possibilities in beauty design—A perspective by Yuzhi Xu, Haowei Ni, Fanyu Zhao, Qinhui Gao, Ziqing Zhao, Chia-Hua Chang, Yanran Huo, Shiyu Hu, Yike Zhang, Radu Grovu, Hermione He, John Z. H. Zhang, Yuanqing Wang

“…Computational molecular design—the endeavor to design molecules, with various missions, aided by machine learning and molecular dynamics approaches—has been widely applied to create valuable new molecular entities, from small molecule therapeutics to protein biologics. …”
Get full text

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model by Akiko Nishidate, Kana Takemoto, Yuki Imura, Mikako Murase, Ryu Yamanaka, Manami Kikuchi, Junpei Anan, Sayuka Kato, Airi Akatsuka, Sachiko Mochizuki, Yuzo Koda

“…The hPBMC mice exhibit elevated serum levels of creatine kinase and aspartate transaminase, markers of myositis, and increased expression levels of myositis-related genes, such as vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and serum amyloid A1, in muscle tissues. …”
Get full text

Use of Carbon Fibre Composite Molecular Sieves for Air Separation by Timothy D. Burchell, Omats O. Omatete, Nidia C. Gallego, Frederick S. Baker

“…Molecular-sieving effects in the composite were highlighted by the adsorption of carbon dioxide, a more sensitive probe molecule for the presence of micro-porosity in adsorbents. …”
Get full text

Adsorption Studies of the Effect of Thiosemicarbazides on the Corrosion of Steel in Phosphoric Acid by M.A. Ameer, E. Khamis, G. Al-Senani

“…It was found that the inhibitor molecule was adsorbed through more than one active centre and occupied more than one active site on the steel surface.…”
Get full text

Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors by Nicholas Young, James R. Van Brocklyn

“…Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to regulate cell proliferation, migration, cytoskeletal organization, and differentiation. …”
Get full text

The Deformation Mechanisms in Process of Crack Propagation for Alpha Titanium with Compounding Microdefects by Ying Sheng, Xiang-guo Zeng

“…Next, based on the conclusions above, the molecule dynamics analysis of three models of α-Ti with compounding microdefects was conducted and cross-scaly simulated. …”
Get full text

Update on the Use of Inhaled Nitric Oxide by Robert M Kacmarek

“…A literature review on nitric oxide would identify thousands of citations on the biological implications of this molecule. From the perspective of respiratory care, the effect inhaled nitric oxide has on pulmonary vasculature is the most intriguing. …”
Get full text

Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions by Sandip Patil, Xiaowen Chen, Feiqiu Wen

“…We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small-molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. …”
Get full text

Detection of Ammonia in Liquids Using Millimeter Wave Spectroscopy by Hilmi Ozturk, Hakki Nazli, Korkut Yegin, Mehmet Sezgin

“…The inversion of ammonia molecule results in split rotational spectral lines and transitions of these lines can be detected. …”
Get full text

Crystal structure of luliconazole by Anna Ben, Lilianna Chęcińska

“…The crystal structure of luliconazole {LCZ; C14H9Cl2N3S2; systematic name: (E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile} is reported. In the molecule of the title compound, the dithiolane ring adopts an envelope conformation, while the dichlorophenyl ring exhibits disorder. …”
Get full text