Small-molecule-induced ERBB4 activation to treat heart failure by Julie M. T. Cools, Bo K. Goovaerts, Eline Feyen, Siel Van den Bogaert, Yile Fu, Céline Civati, Jens Van fraeyenhove, Michiel R. L. Tubeeckx, Jasper Ott, Long Nguyen, Eike M. Wülfers, Benji Van Berlo, Antoine A. F. De Vries, Nele Vandersickel, Daniël A. Pijnappels, Dominique Audenaert, H. Llewelyn Roderick, Hans De Winter, Gilles W. De Keulenaer, Vincent F. M. Segers

“…We hypothesize that small-molecule activation of ERBB4 could protect against heart damage and fibrosis. …”
Get full text

Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. Furthermore, assembly of the immunological synapse leads to intracellular events that modulate and define the magnitude and characteristics of the T cell response. …”
Get full text

Development of a full field-of-view spectroscopic single-molecule fluorescence instrument with improved methods for calibration by Deqi Yi, Shangyuan Deng, Chuang Tan, Jie Ma

Subjects: “…single-molecule fluorescence spectroscopy…”
Get full text

Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques by Li Zheng, Qingdan Ye, Mengmeng Wang, Fan Sun, Qiang Chen, Xiaoping Yu, Yufeng Wang, Pei Liang

Subjects: “…small molecule…”
Get full text

The Role of Key Molecules of Pyroptosis in Liver Damage of Rats With Exertional Heat Stroke by Lifang Lin, Jiaolong Zheng, Qingqing Lin, Fangze Cai, Dongliang Li

Get full text

Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds by René Gerardo Escobedo-González, Héctor Pérez Martínez, Ma. Inés Nicolás-Vázquez, Joel Martínez, Gabriela Gómez, Juan Nava Serrano, Vladimir Carranza Téllez, C. L. Vargas-Requena, René Miranda Ruvalcaba

“…The structural attribution of the target molecules was performed by typical spectroscopic procedures; moreover, the experimental and computed 1H and 13C NMR chemical shifts data, with previous acquisition of the corresponding minimum energetic structures, were in good agreement.…”
Get full text

Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. …”
Get full text

Computational screening, synthesis and neuroprotective evaluation of small molecule for the treatment of alzheimer's disease by Nerlis Pajaro-Castro, Elkin Torres-Sierra, Edwar Cortes-Gonzalez, Margaret Paternina, Erwin Camacho, Pedro Blanco

“…RESULTS: Four candidate molecules showed strong binding affinity, ranging from -6.8 to -9.1 kcal/mol. …”
Get full text

The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections by Fabio Morandi, Enrico Fainardi, Roberta Rizzo, Nathalie Rouas-Freiss

Get full text

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment by Anna Carbone, Rafael M. Couñago, Cristian O. Salas, Alessandra Moltalbano

Subjects: Get full text

Disruption of biological membranes by hydrophobic molecules: a way to inhibit bacterial growth by Alejandra Gabriela Valdez-Lara, Ángela M. Jaramillo-Granada, Daniel Ortega-Zambrano, Eristeo García-Marquez, Jorge Alberto García-Fajardo, H. Mercado-Uribe, J. C. Ruiz-Suárez

“…We propose the utilization of hydrophobic molecules, namely, propofol (PFL) and cannabidiol (CBD), dissolved in nanodroplets of oil, to effectively strike the membrane of two well-known pathogens: Escherichia coli and Staphylococcus aureus. …”
Get full text

Adsorption of Organic Molecules in Water onto Carbon Spheres Nanostructured by Air Oxidation by Michio Inagaki, Midori Sakanishi

Get full text

Erratum to “Reverse Zagreb and Reverse Hyper-Zagreb Indices for Crystallographic Structure of Molecules” by Zhen Wang, Faryal Chaudhry, Maria Naseem, Adnan Asghar

Get full text

Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

Subjects: “…natural plant molecules…”
Get full text

The Role of Molecule Clustering by Hydrogen Bond in Hydrous Ethanol on Laminar Burning Velocity by I Made Suarta, I. N. G. Wardana, Nurkholis Hamidi, Widya Wijayanti

“…The role of hydrogen bond molecule clustering in laminar burning velocities was observed. …”
Get full text

Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses by Alessandra L. Morassutti, Carlos Graeff-Teixeira

“…As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). …”
Get full text

Theoretical-experimental correlation of Voc in isoindigo-based small molecules for photovoltaic applications by O. Javier Hernández-Ortiz, Mario Rodríguez, Rosa Angeles Vazquez-García, Karina Alemán Ayala, María Aurora Veloz Rodríguez, Arián Espinosa-Roa, José-Luis Maldonado

“…This work demonstrates the potential of isoindigo-based molecules for organic solar cells.…”
Get full text

Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…The computational and experimental analysis performed allowed us to characterize the optimal conformation of the FA DD protein for the design of the small molecules that can bind in the region of amino acid residue Y25. …”
Get full text

Exploring the Capability of Mechanically Interlocked Molecules in Anion Recognition: A Computational Insight by Fábio J. Amorim, Giovanni F. Caramori

Get full text

Citrate: a key signalling molecule and therapeutic target for bone remodeling disorder by Qichang Liu, Yuchuan Xue, Junzhe Guo, Lin Tao, Yue Zhu

Get full text