How energy determines spatial localisation and copy number of molecules in neurons by Cornelius Bergmann, Kanaan Mousaei, Silvio O. Rizzoli, Tatjana Tchumatchenko

“…We show that the drive to save energy determines transcript quantities and their location while acting differently on each molecular species depending on the length, longevity and other features of the respective molecule. We combined our own data and experimental reports from five other large-scale mRNA and proteomics screens, comprising more than ten thousand molecular species to reveal the underlying computational principles of molecular localisation. …”
Get full text

Hybrid Quantum Cycle Generative Adversarial Network for Small Molecule Generation by Matvei Anoshin, Asel Sagingalieva, Christopher Mansell, Dmitry Zhiganov, Vishal Shete, Markus Pflitsch, Alexey Melnikov

Get full text

Advantages of using biofilms to obtain high-value molecules by microbial biotransformations by Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa

“…Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties. …”
Get full text

Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance by Wenqiang Tian, Xu Wang, Yan Zhang, Ting Weng, Tlili Chaker, Xiaohan Chen, Qingke Kong, Deqiang Wang

Subjects: Get full text

Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. Furthermore, assembly of the immunological synapse leads to intracellular events that modulate and define the magnitude and characteristics of the T cell response. …”
Get full text

Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques by Li Zheng, Qingdan Ye, Mengmeng Wang, Fan Sun, Qiang Chen, Xiaoping Yu, Yufeng Wang, Pei Liang

Subjects: “…small molecule…”
Get full text

The Role of Key Molecules of Pyroptosis in Liver Damage of Rats With Exertional Heat Stroke by Lifang Lin, Jiaolong Zheng, Qingqing Lin, Fangze Cai, Dongliang Li

Get full text

Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds by René Gerardo Escobedo-González, Héctor Pérez Martínez, Ma. Inés Nicolás-Vázquez, Joel Martínez, Gabriela Gómez, Juan Nava Serrano, Vladimir Carranza Téllez, C. L. Vargas-Requena, René Miranda Ruvalcaba

“…The structural attribution of the target molecules was performed by typical spectroscopic procedures; moreover, the experimental and computed 1H and 13C NMR chemical shifts data, with previous acquisition of the corresponding minimum energetic structures, were in good agreement.…”
Get full text

Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. …”
Get full text

The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections by Fabio Morandi, Enrico Fainardi, Roberta Rizzo, Nathalie Rouas-Freiss

Get full text

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment by Anna Carbone, Rafael M. Couñago, Cristian O. Salas, Alessandra Moltalbano

Subjects: Get full text

Erratum to “Reverse Zagreb and Reverse Hyper-Zagreb Indices for Crystallographic Structure of Molecules” by Zhen Wang, Faryal Chaudhry, Maria Naseem, Adnan Asghar

Get full text

Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

Subjects: “…natural plant molecules…”
Get full text

The Role of Molecule Clustering by Hydrogen Bond in Hydrous Ethanol on Laminar Burning Velocity by I Made Suarta, I. N. G. Wardana, Nurkholis Hamidi, Widya Wijayanti

“…The role of hydrogen bond molecule clustering in laminar burning velocities was observed. …”
Get full text

Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses by Alessandra L. Morassutti, Carlos Graeff-Teixeira

“…As a mechanism of neutralizing these host defenses, A. cantonensis expresses different molecules with immunomodulatory properties that are excreted or secreted (ES). …”
Get full text

Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…The computational and experimental analysis performed allowed us to characterize the optimal conformation of the FA DD protein for the design of the small molecules that can bind in the region of amino acid residue Y25. …”
Get full text

Exploring the Capability of Mechanically Interlocked Molecules in Anion Recognition: A Computational Insight by Fábio J. Amorim, Giovanni F. Caramori

Get full text

Painlevé Analysis, Soliton Molecule, and Lump Solution of the Higher-Order Boussinesq Equation by Bo Ren

“…The multisoliton solutions of the higher-order Boussinesq equation are obtained by introducing dependent variable transformation. The soliton molecule and asymmetric soliton of the higher-order Boussinesq equation can be constructed by the velocity resonance mechanism. …”
Get full text

Investigation on small molecule-aptamer dissociation equilibria based on antisense displacement probe by Lei Wang, Lili Yao, Qihui Ma, Yu Mao, Hao Qu, Lei Zheng

Subjects: Get full text

An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…We have implemented an unbiased cell morphology-based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system. …”
Get full text