The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony-Forming Unit-Fibroblast Assay and the CD45lowCD271+ Phenotype by Payal Ganguly, Jehan J. El-Jawhari, Agata N. Burska, Frederique Ponchel, Peter V. Giannoudis, Elena A. Jones

“…No significant differences in the expression of selected adipogenic, osteogenic, stromal, and bone remodelling genes as well as CD295, CD146, CD106, and connexin 43 surface molecules were found in sorted CD45lowCD271+ MSCs from young and old donors (n=8 donors each). …”
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The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia by Kai Shen, Chenlu Yang, Jie Huang, Xiao Shuai, Ting Niu, Hongbing Ma

“…It is considered to result from a severe systemic inflammatory response mediated by increased expression of cytokines, chemokines, and adhesion molecules on differentiating blast cells. The kidney, as a vital organ rich in the capillary endothelium, could be targeted by differentiating blasts in DS. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer’s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Moreover, the relationship between hub biomarkers and immune infiltration was assessed using CIBERSORT, and the potential drugs or small molecules associated with the core biomarkers were identified via the DGIdb database.Results: MR analysis showed that KI may be a risk factor for AD. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…Cytokine IL-6 is involved in the development of endothelial dysfunction by regulating the expression of the VCAM1 and ICAM1 genes, encoding intercellular adhesion molecules. Prior to this work, no data on the association of essential arterial hypertension (EAH) with rs2228145 allelic variations of the IL6R gene have been reported. …”
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Study on the potential diagnostic value of metabolomics changes in different biological fluids for aspiration pneumonia by Lianghui Chen, Yazhen Chen, Fansen Lin, Jianbao Wang, Hongzhi Gao, Yuqi Liu

“…The area under curve (AUC) values showed that these molecules could serve as effective biomarkers for AP. …”
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Rapid fabrication and dissolution of pressed 58Ni/Mg matrix targets for 55Co production by Jonathan Siikanen, Stefan Milton, Klas Bratteby, Wilson Lin, Jonathan W. Engle, Emma Jussing, Thuy A. Tran

“…One promising option for imaging medium-sized molecules and peptides is ⁵⁵Co (T₁/₂ = 17.5 h, β⁺ = 76%), which enables imaging of new and already established tracers with blood circulation of several hours. …”
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The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis. by Yukai Luo, Shuang Zhou, Xiaojing Zhang, Yijian Lin, Jun Liu, Wenzhao Cheng, Yiming Zeng

“…The findings from the metabolomics analysis revealed that the metabolites exhibiting notable variances were primarily composed of Lipids and lipid-like molecules, Organoheterocyclic compounds, Organic acids and derivatives, and Benzenoids, indicating the potential of UC-MSCs to exert antifibrotic effects via these metabolic pathways.…”
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Exploring the antimicrobial and antioxidative potential of Leucas aspera (Willd.) link: Phytochemical screening, molecular docking, and HR-LC/MS profiling against SARS-CoV-2 protei... by Thavasiaanatham Seenivasan Shalini, Ragothaman Prathiviraj, Poomalai Senthilraja

“…Conclusion: Thus, our findings could serve as potential active molecules of L. aspera against this target protein. …”
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Use of Nanostructured Layered Double Hydroxides as Nanofilters in the Removal of Fe2+ and Ca2+ Ions from Oil Wells by Emmanuel K. Ephraim, Chinyere A. Anyama, Ayi A. Ayi, Jude C. Onwuka

“…In the infrared spectra, the characteristic absorption band for water molecules was observed in all the compounds. The XRD pattern showed that d012 and d104 peaks of M-Al-PO4 LDHs corresponding to interplanar spacing of 3.4804 and 2.5504 Å, respectively, shifted to higher 2θ values for the M-Al-PO4PF6 system, which indicates a decrease in the interlamellar spacing as PF6− was incorporated along with PO43− anion. …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

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Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…RNA sequencing results demonstrated an increased expression level of TP63 and its downstream genes (PERP, CDH3, and DLX5) compared with the controls, indicating an enrichment of cell adhesion molecules the differentially expressed genes in the patient. …”
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Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies by Atri Das, Swarnali Khan, Syamal Roy, Shantanabha Das

“…Studying the effectiveness of such phytochemicals against COVID-19 and identifying new plant-derived molecules with antiviral properties have been a focus since the SARS-CoV-2 outbreak. …”
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Density Functional Theory plus U Study of Methanol Adsorption and Decomposition on CuO Surfaces with Oxygen Vacancy by Lu Liu, Peng Gong, Guangcai Shao, Pengfei Liu, Junfeng Wang

“…The configurations and electronic structures of CH3OH and CH3O adsorbed on CuO(111) surfaces were analyzed. CH3OH molecules were preferentially adsorbed on Cu top sites with OMeOH atoms and H-O3C bonds formed simultaneously. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Finally, transcriptome analysis was utilized to identify potential key molecules and pathways.Results: In OA patients, the infiltration, activation, and differentiation of B cells in synovium and peripheral blood exhibited distinct characteristics. …”
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Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

“…Immune infiltration analysis further revealed the possible key role of COL1A1 and TNFRSF12A in regulating immune cell infiltration in osteoporosis and cartilage injury.Conclusion COL1A1 and TNFRSF12A as key regulatory molecules in osteoporosis and cartilage injury.…”
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Modulation of the Nernst Thermoelectrics by Regulating the Anomalous Hall and Nernst Angles by Meng Lyu, Junyan Liu, Jianlei Shen, Shen Zhang, Yang Liu, Jinying Yang, Yibo Wang, Yiting Feng, Binbin Wang, Hongxiang Wei, Enke Liu

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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…Tumor cells in MIBC displayed enhanced glycolytic activity and downregulation of chemokines and MHC-II molecules, reducing immune cell recruitment and facilitating immune evasion. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson&rsquo;s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…Hence, the aim of this study was to investigate if the function of CMV-specific cells of kidney transplant recipients could be restored by a modulation of costimulatory molecules. To address this question, lymphocytes of kidney transplant patients were stimulated with CMV-specific antigens and incubated with programmed death-ligand 1 (PD-L1), programmed cell death protein 1 (PD-1), or B- and T-lymphocyte attenuator (BTLA) antibodies. …”
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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…Many alternate molecular targets present themselves for PET imaging of neuroinflammation in vivo, including enzymes, intracellular signaling molecules as well as ionotropic, G-protein coupled, and immunoglobulin receptors. …”
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