IgE-based analysis of sensitization and cross-reactivity to yellow mealworm and edible insect allergens before their widespread dietary introduction by Majsiak Emilia, Choina Magdalena, Gromek Weronika, Wykrota Julia, Kozłowska Danuta, Swadźba Jakub, Cukrowska Bożena, Kowal Krzysztof

“…The aim of this study was to assess the incidence of sensitization to TM before its introduction as a food ingredient in Poland, as well as checking the occurrence of co-sensitivity to TM and other invertebrate allergenic extracts and molecules. This analysis was performed using serum allergen-specific immunoglobulin E (sIgE) results in 6,173 individuals using the ALEX2 test to detect sensitivity to TM and other related allergens. …”
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Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes. by Ulrich F Prodjinotho, Charlotte von Horn, Alex Y Debrah, Linda Batsa Debrah, Anna Albers, Laura E Layland, Achim Hoerauf, Tomabu Adjobimey

“…Our findings suggest that quantitative and qualitative alterations in IgG4 molecules are associated with the different clinical phenotypes in LF endemic regions.…”
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Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation by Tao Huang, Longqian Wei, Huafu Zhou, Jun Liu

“…Therefore, there is an ongoing need to explore potential molecules and therapeutic strategies related to tumor immunity in ESCC. …”
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Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance by Yury O. Nunez Lopez, Gabriella Garufi, Magdalena Pasarica, Attila A. Seyhan

“…This study suggests a novel association between the elevated levels of miRNAs miR-24, miR-30d, and miR-146a (apparently coregulated) and the level of SFRP4 transcript in AbdAT of subjects with obesity and T2DM. These molecules might be part of a regulatory loop involved in AbdAT remodeling/adiposity and systemic insulin resistance. …”
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Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis by Yuanshan Cui, Zhongbao Zhou, Yumeng Chai, Yong Zhang

“…Gasdermin B (GSDMB) is part of the gasdermin (GSDM) family, and they use varying means of domain interactions in molecules to adjust their pore-forming and lipid-binding actions. …”
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Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles by Yuqi Song, Fengrui Liang, Weikun Tian, Erin Rayhill, Liping Ye, Xinghan Tian

“…This review highlights the therapeutic promise of MSC-exosomes especially focusing on the modulation of miRNA (one of bioactive molecules in MSC-EVs) profiles through various preconditioning strategies such as exposure to hypoxia, chemotherapeutic agents, inflammatory cytokines, and physical stimuli. …”
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Phenolic Compounds from Ocimum basilicum Revealed as Antibacterial by Experimental and Computational Screening-Based Studies against Oral Infections by Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia

“…In streptococcal, the ComA enzyme catalyzes the first step to produce signalling molecules in quorum sensing that influence biofilm formation. …”
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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…Results were categorized in four groups: MTBC species, animal models, soluble factors and innate pathways, and other molecules (metabolites and drugs). Mtb and M. bovis were the only species studied. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Reactive oxygen species serve as key signaling molecules in copper-induced neuroinflammation, with elevated levels activating several critical inflammatory pathways. …”
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Molecular Dynamics Study on Crystallization Patterns in Tunnel Drainage Pipes in Alkaline Geological Environments by Xiangge Chen, Jie Zhou, Xuefu Zhang, Wenbing Yu, Shiyang Liu, Hongyi Liu, Yuhan Xiao

“…Analysis of the adsorption properties predicted by the CaCO3-PVC MD model reveals that CaCO3 molecules attract each other and form many atomic clusters at approximately 0.11 nm from the PVC interface. …”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

“…To identify potential new antiviral molecules, a select group of compounds previously evaluated in clinical studies were tested against 12 different viruses. …”
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Author Correction: Ligand-tuning copper in coordination polymers for efficient electrochemical C–C coupling by Yu Yang, Cheng Zhang, Chengyi Zhang, Yaohui Shi, Jun Li, Bernt Johannessen, Yongxiang Liang, Shuzhen Zhang, Qiang Song, Haowei Zhang, Jialei Huang, Jingwen Ke, Lei Zhang, Qingqing Song, Jianrong Zeng, Ying Zhang, Zhigang Geng, Pu-Sheng Wang, Ziyun Wang, Jie Zeng, Fengwang Li

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Quantum chemical study of molecular properties of small branched-chain amino acids in water by Roman Boča, Žofia Rádiková, Juraj Štofko, Beata Vranovičová, Cyril Rajnák

“…B3LYP hybrid version of DFT was used for geometry optimization and a full vibrational analysis of neutral molecules, their cations and anions in the canonical and zwitterionic forms (6 forms for each species). …”
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Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia by Le Jie Lee, Norfarazieda Hassan, Siti Zuleha Idris, Suresh Kumar Subbiah, Heng Fong Seow, Norhafizah Mohtaruddin, Kian Meng Chang, Raudhawati Osman, Hishamshah Mohd Ibrahim, Sheila Nathan, Maha Abdullah

“…Targeted next-generation sequencing was conducted on 62 activating/inhibitory receptors, ligands, effector, and exhaustion molecules on T-ALL (6 males) and normal controls (NC) (4 males and 4 females). …”
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Hypoxic Wharton’s Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells by Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas, Ariff Bongso

“…Hypoxic hWJSC-CM also produced significantly greater expression of immunogenic cell death (ICD) hallmarks such as surface-bound calreticulin, HSP70, HSP90, and high mobility group binding 1 proteins and significantly decreased expression of the defense molecules CD47 and PD-L1. This study showed that the tumoricidal effect of hypoxic hWJSC-CM was superior to normoxic hWJSC-CM and should be the preferred choice of preparing hWJSC-CM for the induction of ICD on lymphoma cells.…”
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Identification of new nucleotide sequences of the <i>Glu-B1-1</i> gene encoding x-type glutenins in bread wheat by A. A. Galimova, B. R. Kuluev

“…Thus, we have found previously undescribed deletions and substitutions in the nucleotide sequences of the Glu-B1-1 gene for high-molecular-weight glutenins, which lead to changes in amino acid sequences in functionally important regions, namely, in the central domains of protein molecules. The identified mutations can be used for genotyping bread wheat cultivars.…”
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Activin A promoted the anti‐tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma by Liangchang Hu, Yu Zhao, Xuguang Zhang, Chunhui Ma

“…ActRIIA high CD8+ T cells highly express cytotoxic molecules and cytokines. And ActRIIA high CD8+ T cells not only expressed high levels of activation/co‐stimulatory markers CD69, CD278, and CD28, but also high levels of inhibitory markers CD366 and KLRG1. …”
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Biochemistry of the Thrombin-Like TLBpic and Its Purification from Bothrops pictus “Jergon de la Costa” (Reptilia: Viperidae) by Victor Ludgardo Álvarez Tohalino, Hugo Guillermo Jiménez Pacheco, Juan Raúl Jesús Zumaran Farfán, Pavel Kewin Delgado Sarmiento, Paulino Rodolfo Zegarra Panca

“…Within the simple substances, we have free amino acids, peptides, nucleotides, carbohydrates, lipids, and biogenic amines (organic molecules) as well as cations and anions (inorganic constituents). …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…These mechanisms include the expression of various surface molecules that mediate adhesion, motility, and phagocytosis of host cells, as well as the secretion of proteases and other factors that degrade host extracellular matrix and modulate host immune response. …”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…Circulating DBP is composed of unmodified and O-glycosylated molecules with the glycosylation degree being dependent on the allelic variants of the gene encoding DBP. …”
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