Airborne Escherichia coli bacteria biosynthesize lipids in response to aerosolization stress by Brooke L. Smith, Meiyi Zhang, Maria D. King

“…Further analysis of the repairs the E. coli cells seemed to enact after short-term aerosolization revealed that the repair molecules were likely lipid-containing droplets that perfectly countered the air pressure impacting the E. coli cells. …”
Get full text

Chronic Inflammation as a Link between Periodontitis and Carcinogenesis by Anilei Hoare, Cristopher Soto, Victoria Rojas-Celis, Denisse Bravo

“…Such pathways are activated either by mono- or polymicrobial infections, resulting in an increase in the expression of proinflammatory molecules such as IL-6, IL-8, IL-1β, and TNF-α. In addition, it has been shown that several periodontitis-associated species induce the expression of genes related to cell proliferation, cell cycle, apoptosis, transport, and immune and inflammatory responses. …”
Get full text

Metabolites Profiling of Manilkara mabokeensis Aubrév Bark and Investigation of Biological Activities by Xavier Worowounga, Rami Rahmani, Armel-Frederic Namkona, Sylvie Cazaux, Jean-Laurent Syssa-Magalé, Hubert Matondo, Jalloul Bouajila

“…For HPLC analysis, 3,4-dihydroxy-benzoic acid methyl ester showed the highest concentration with 61.8 mg/g of dry residue (dr) among other identified molecules. Manilkara mabokeensis Aubrév bark MeOH extract showed a good anti-15-lipoxygenase (anti-15-LOX) and anti-acetylcholinesterase (anti-AChE) activities of 65.8 and 71.0%, respectively, while it exhibited a moderate antixanthine oxidase (anti-XOD) activity (41.5%) at 50 μg/mL. …”
Get full text

Adipose-Derived Stem Cells in Bone Tissue Engineering: Useful Tools with New Applications by Gabriele Storti, Maria Giovanna Scioli, Bong-Sung Kim, Augusto Orlandi, Valerio Cervelli

“…Together with an advantageous proliferative and differentiative profile, they also offer a high paracrine activity through the secretion of several bioactive molecules (such as growth factors and miRNAs) via a sustained exosomal release which can exert efficient conditioning on the surrounding microenvironment. …”
Get full text

Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…Gene expression of CD70 and CD27 was increased in AA lesions and was associated with disease severity and activity. Thus, both molecules can be a predictor of AA severity and activity. …”
Get full text

Absorption spectra of Nitrazine Yellow indicator. Experimental data and quantum chemical evaluations by Inna Khristenko, Volodymyr Ivanov

“…In the first variant of calculations, the LanL2DZ basis set (and corresponding pseudopotential) is used for all atoms within the molecules. In the second variant, the LanL2DZ basis set is applied exclusively to Na and S atoms, while the standard valence double-zeta split basis set 6-31+G(d,p) is utilized for the remaining elements (H, C, N, O). …”
Get full text

Synthesis and crystal structure of piperidinyl propanenitrile towards the preparation of piperidine based bioactive films for drug delivery applications by Reham A. Mohamed-Ezzat, Mohamed S. Hasanin, Benson M. Kariuki, Sawsan Dacrory

“…The films could also help maintain interaction with tissue to ensure the controlled release of therapeutic molecules. Thus, they are promising in developing drug delivery systems essential in the pharmaceutical industry. …”
Get full text

Biochemical blood parameters and level of endogenous intoxication in cows suffering from hepatopathies under heat stress by E. V. Kuzminova, E. N. Rud, M. P. Semenenko, A. A. Abramov

“…The study of the endogenous intoxication level dynamics in cattle during the development of heat stress, showed that in both groups the concentrations of middle molecules (ММ) increased relative to the background data: in the first group (healthy cows) MM 237 – by 11.8%,  MM 254 – by 14.4%,  MM 280 – by 16.9%; in the second group (cattle with liver pathology)  MM 237 – by 16.9%,  MM 254 – by 20.3%,  MM 280 – by 33%. …”
Get full text

CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer. by Qilu Fang, Qichuan Fang, Rui Cheng, Tingting Feng, Wenxiu Xin

“…Western blot and immunofluorescence analysis were used to assess key regulatory molecules. The cells were subjected to treatments involving ferroptosis inhibition, AMPK inhibition, or Foxo3 inhibition, followed by CAPE administration to assess cell proliferation, apoptosis, and ferroptosis. …”
Get full text

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties by Carlos Coll-Díez, Ana Marcela Giudici, Alberto Potenza, José Manuel González-Ros, José Antonio Poveda

“…Nonetheless, the SF conformation can be modified by different effector molecules. Such conformational plasticity opposes selectivity, as the SF departs from the “induced-fit” conformation required for K+ recognition. …”
Get full text

Cell Surface Proteins for Enrichment and In Vitro Characterization of Human Pluripotent Stem Cell-Derived Myogenic Progenitors by Sin-Ruow Tey, Madison Mueller, Megan Reilly, Colton Switalski, Samantha Robertson, Mariko Sakanaka-Yokoyama, Masatoshi Suzuki

“…Taken together, these cell surface proteins are not only useful markers to identify unique cellular populations in human PSC-derived myogenic progenitors but also functionally important molecules that can provide valuable insight into human myogenesis.…”
Get full text

Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application by Xiaoping Leng, Jianjun Wang, Andrew Carson, Xucai Chen, Huili Fu, Susanne Ottoboni, William R. Wagner, Flordeliza S. Villanueva

“…Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus “ischemic memory” biomarkers for recent cardiac ischemia. …”
Get full text

Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…It is recommended that the pure compounds from these extracts be isolated for further bioactivity tests and structural elucidation for consideration as lead molecules in drug discovery. In addition, the genes responsible for the enhanced bioactivity in these isolates can be characterized and bioengineered for pharmaceutical application.…”
Get full text

Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis by Zhihong Hu, Xixi Hou, Yongjing Ren, Ziyuan Wu, Dong Yan, Hong Chen, Lan Wang

Get full text

Snail Shells Adsorbent for Copper Removal from Aqueous Solutions and the Production of Valuable Compounds by Redouane Ouafi, Meryem Asri, Anass Omor, Mustapha Taleb, Zakia Rais

Get full text

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Dysregulation of both IL-1β and its related pathways is involved in inflammatory/autoimmune disorders and in a wide range of other diseases. Identifying molecules modulating their expression is a crucial need to develop new therapeutic agents. …”
Get full text

Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity by Mansi Shah, Bhanubhai Suhagia, Sunita Goswami, Sneha Sagar, Arpit Patwari

“…The discovery of new molecules is the need of the hour and several research groups worldwide are contributing to fight this scare. …”
Get full text

The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation by Naniek Widyaningrum, Chintiana Nindya Putri, Thendi Abdul Arief, Nada Aini Sofa, Monica Virdaus

“…It can be harnessed as a serum formulation featuring small molecules, facilitating deeper skin penetration, efficient delivery of highly concentrated active agents, and expedited resolution of skin issues. …”
Get full text

Research on the molecular dynamics of coalbed methane diffusion and adsorption in reservoir pores under different factors by Xuefan Wang, Jianwei Zhong, Ziyang Zhang, Xu Zeng, Rui Shen, Ze Deng, Nan Wang

“…In this study, we developed a theory based on the basic geological characteristics of coal beds and the adsorption state of CBM, focusing on the transition state of adsorption gas diffusion of surface diffusion gas molecules. We explored the impact of various factors on the diffusion coefficients and adsorption capacity of CBM, elucidating the underlying reasons for variations in CBM adsorption and diffusion through molecular dynamics simulations. …”
Get full text

Activating Transcription Factor 5 Promotes Tumorigenic Capability in Cervical Cancer Through the Wnt/β-Catenin Signaling Pathway by Shi F, Wei Y, Huang Y, Yao D

“…Furthermore, the downregulation of ATF5 led to the suppression of Wnt3a and β-catenin expression, which are key molecules in the Wnt/β-catenin signaling pathway.Conclusion: ATF5 promotes tumorigenic capability in cervical cancer through the Wnt/β-catenin signaling pathway. …”
Get full text