Identifying optimal substrate classes of membrane transporters. by Andreas Denger, Volkhard Helms

“…Membrane transporters are responsible for moving a wide variety of molecules across biological membranes, making them integral to key biological pathways in all organisms. …”
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Freeze-Drying Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts: A Comparative Study Using Different Polymers as Encapsulants by Firza Rajasa Gunawan, Siti Mariyah Ulfa, Anna Safitri

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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

“…<b>Methods</b>: Model development was performed using published studies in mice leveraging the PK-Sim^® standard implementation for large molecules with added implementations of ASGPR-mediated liver disposition and downstream target effects. …”
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A Smart Chatbot for Interactive Management in Beta Thalassemia Patients by Alma Mohammed Alturaiki, Haneen Reda Banjar, Ahmed Salleh Barefah, Salwa Abdulrahman Alnajjar, Salwa Hindawi

“…Background. β-thalassemia is an inherited blood disorder that affects the production of hemoglobin molecules owing to the reduction or absence of beta chains. …”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…MSC-Exos contain a variety of bioactive proteins (growth factors, immunoregulatory molecules, cytokines, and chemokines) lipids, and microRNAs (miRNAs) which affect viability, proliferation, phenotype, and function of eye-infiltrated immune cells. …”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. Race is significantly associated with CRP levels and CVD risks. …”
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Circulating levels of osteoprotegerin and sRANKL and the effect of methotrexate in patients with rheumatoid arthritis by Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir

“…Background: Receptor activator of nuclear factor κβ ligand (RANKL) and osteoprotegerin (OPG) are pivotal molecules involved in osteoclast activation and resorption. …”
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Endothelial calcium dynamics elicited by ATP release from red blood cells by Ananta Kumar Nayak, Sovan Lal Das, Chaouqi Misbah

“…Subsequently, these liberated ATP molecules initiate a crucial interaction with endothelial cells (ECs), thereby setting off a cascade involving the release of calcium ions (Ca $$^{2+}$$ 2 + ). …”
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Mechanisms of liver fibrosis in metabolic syndrome by Wajahat Mehal

“…In metabolic syndrome, there is little evidence that metabolite changes such as high levels of glucose and free fatty acids are directly inducing HSC transdifferentiation, however, metabolite changes may lead to reductions in immunomodulatory and hepatoprotective molecules such as lipoxins, resolvins and Interleukin (IL)-22. …”
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Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study by Ezhil Arasan Ramanan, Sailatha Ravi, K. R. Radha Anbu, Margaret Michael

“…Inositol and associated molecules display inhibitory properties against 5-α reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. …”
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Divergent Cotton leaf curl Multan betasatellite and three different alphasatellite species associated with cotton leaf curl disease outbreak in Northwest India. by Kajal Kumar Biswas, Nenavath Balram, Marimuthu Elangovan, Supratik Palchoudhury, Utpal Kumar Bhattacharyya, Halima Khatoon, Shilpi Aggarwal, Shruti Godara, Pradeep Kumar, Satish Kumar Sain, Rupesh Arora, Sibnarayan Datta

“…The present study indicated that the betasatellite and alphasatellite molecules associated with CLCuD-begomovirus complex in Northwest India are genetically diverse.…”
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QSPR Analysis of Some Alzheimer’s Compounds via Topological Indices and Regression Models by Muhammad Shoaib Sardar, Khalil Hadi Hakami

“…The objective of this study is to examine the efficacy of descriptors in correlating the physicochemical features of molecules associated with Alzheimer’s disease. We will use the computational method to calculate degree-related, distance-related, and eccentricity-based topological indices for any chemical graph. …”
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Thermodynamic Molecular Switch in Sequence-Specific Hydrophobic Interaction: Two Computational Models Compared by Paul Chun

“…The Planck-Benzinger method is the best known for evaluating the innate temperature-invariant enthalpy, ΔH°(T0), and provides for better understanding of the heat of reaction for biological molecules.…”
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Protective Effect of the Ethanol Extract from Hericium erinaceus Against Ethanol-Induced Gastric Ulcers by Guoying Lv, Xiaoya Song, Zuofang Zhang

“…The RNA-seq results suggest that EEH indirectly protects the gastric tissue from injury by regulating the cell cycle and biological functions, up-regulating several signal molecules, or activating several proteasome functions. …”
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STUDYING HOW DIESEL ENGINE ADDITIVES USING SILVER OXIDE (Ag2O) NANOPARTICLES AFFECT THE ENVIRONMENT by CIHAN BAYINDIRLI, MEHMET CELIK

“…In experiments, nano additive improved the thermal conductivity, mass dissipation and heat transfer of the test fuels, and resulted in reducing of CO emissions as it provided a higher oxidation rate of hydrocarbon molecules. Due to the improvement in the combustion reaction, CO2 emission increased with product of complete combustion. …”
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Identification and Validation of TEAD Family’s Prognostic Effects and Immune Microenvironment Regulations in Glioma by Zhengyuan Huo, Shaorui Gu, Zheng Bian, Wenli Wang, Zhifeng Jiang

“…The TEA domain transcription factor (TEAD) family proteins are the ultimate effector molecules of the Hippo pathway. However, their expression and function in gliomas have not been further studied. …”
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Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract by Mohamed Amine El-Hajjaji, Kawtar Fikri-Benbrahim, Najoua Soulo, Ghizlane Nouioura, Hassan Laaroussi, Pedro Ferreira-Santos, Badiaa Lyoussi, Zineb Benziane Ouaritini

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Modulation of first-passage time for bursty gene expression via random signals by Qiuying Li, Lifang Huang, Jianshe Yu

“…The stochastic nature of cell-specific signal molecules (such as transcription factor, ribosome, etc.) and the intrinsic stochastic nature of gene expression process result in cell-to-cell variations at protein levels. …”
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Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics by Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka

“…The chemical composition of these fractions was determined using LC-HRESIMS/MS and compared to inactive fractions of the same polarity in order to identify the unique bioactive molecules. The molecular networks constructed using the GNPS platform revealed that fraction 06104_D contained mass clusters primarily composed of chlorins, lipids, and terpenoids, while fraction 03283_B contained xanthophylls, peptides, and terpenoids. …”
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Frustrated Lewis pairs on nanoparticles for colloidal catalysis: dream or reality? by Carenco, Sophie

“…The FLPs represent a major advance over the past 20 years for the catalytic activation of small molecules (H2, CO, CO2, etc.) under mild conditions. …”
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