Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections by Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin

“…However, the role of TLS in immune response and the molecules that drive its formation remain uncertain. …”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

“…However, the translation of these non-natural molecules into successful therapeutics can be hampered by developability challenges. …”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. …”
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Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri by Jean-Paul Vernot, Ana María Perdomo-Arciniegas, Luis Alberto Pérez-Quintero, Diego Fernando Martínez

“…Importantly, hTip-CSKH could be identified in heavy lipid rafts membrane fractions, a compartment where important T-cell signalling molecules (LAT, Ras, and Lck) are present during T-cell activation. …”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

“…In this review, we discuss the range of ubiquitin-independent proteasome pathways, focusing on substrate identification and targeting, regulatory molecules and adaptors, proteasome activators and alternative caps, and diverse proteasome complexes including the 20S proteasome, the neuronal membrane proteasome, the immunoproteasome, extracellular proteasomes, and hybrid proteasomes. …”
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Electrocatalytic and Photocatalytic N₂ Fixation Using Carbon Catalysts by Changchun Xu, Hongli Su, Shuaifei Zhao, Azadeh Nilghaz, Kunning Tang, Luxiang Ma, Zhuo Zou

“…The primary challenges for NF are the natural inertia of nitrogenous molecules and the competitive hydrogen evolution reaction (HER). …”
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Effect of irrigation with magnetized and ionized water on yield, nutrient uptake and water-use efficiency of winter wheat in Xinjiang, China by Xinyue Chen, Kai Zhang, Xiaopeng Gao, Xin Ai, Guoyue Chen, Xiaomeng Guo, Chengcheng Wu, Lu Zhang

“…Magnetization can alter hydrogen bonds among water molecules, leading to changes in water physicochemical properties, and ionization can use frequencies to break down polymers for better solubility. …”
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Kinetics of Supercritical CO₂ Extraction from Burrito (<i>Aloysia polystachya</i>) Leaves and Sucupira-Preta (<i>Bowdichia virgilioides</i>) Seeds by Gabrielle Vaz Vieira, Michel Rubens dos Reis Souza, Carlos Toshiyuki Hiranobe, José Eduardo Goncalves, Cristiane Mengue Feniman Moritz, Otávio Akira Sakai, Leila Maria Sotocorno e Silva, Michael Jones da Silva, Erivaldo Antônio da Silva, Renivaldo José dos Santos, Edson Antônio da Silva, Lucio Cardozo-Filho, Leandro Ferreira-Pinto

“…Despite their relatively low yields, the extracts contained a diverse range of chemical compounds, including fatty acids (oleic, linoleic, and palmitic acids), squalene, β-carotene, vitamin E, and other bioactive molecules with antioxidant, anti-inflammatory, and immunomodulatory properties. …”
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Development and Evaluation of Amlodipine-Polymer Nanocomposites Using Response Surface Methodology by Zain Alabden Ghanim Ahmed, Samer Hasan Hussein-Al-Ali, Ibrahim Abdel Aziz Ibrahim, Mike Kh. Haddad, Dalia Khalil Ali, Anwar Mahmoud Hussein, Ahmad Adnan Abu Sharar

“…In addition, the disappearance of drug peaks indicates that the drug was incorporated between the polymer molecules and was amorphous in behavior. The FTIR for the nanocomposite shows the functional group of the drug, which indicates the incorporation of Amlop into the nanocomposite. …”
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Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura by Jue Xie, Yan Liu, Lei Wang, Guoxiang Ruan, Huiming Yuan, Hong Fang, Jianyong Wu, Dawei Cui

“…Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.…”
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Cricket Flour and Pullulan Microparticle Formation via Electro-Blow Spinning as a New Method for the Protection of Antioxidant Compounds from Fruit Extracts by Sabina I. Wilkanowicz, Keara T. Saud

“…These findings indicate EBS to be a successful technique for the encapsulation of bioactive molecules, and cricket flour to be a new potential encapsulating material candidate that proves best when using a copolymer, such as pullulan.…”
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Detection of early relapse in multiple myeloma patients by Tereza Růžičková, Monika Vlachová, Lukáš Pečinka, Monika Brychtová, Marek Večeřa, Lenka Radová, Simona Ševčíková, Marie Jarošová, Josef Havel, Luděk Pour, Sabina Ševčíková

“…It is currently not possible to predict when relapse will occur; numerous studies investigating the dysregulation of non-coding RNA molecules in cancer suggest that microRNAs could be good markers of relapse. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Dietary phytochemicals, mostly flavonoids but also tetraterpenoids, organosulfur compounds, and isothiocyanates, represent biologically active molecules found in vegetables, fruits, medicinal plants, and beverages. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Adipocytokines are pleiotropic molecules, mainly released by white adipose tissue and immune cells. …”
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Distribution of (1,3)(1,4)-β-D-Glucans in Grains of Polish Oat Cultivars and Lines (Avena sativa L.) – Short Report by Sykut-Domańska Emilia, Rzedzicki Zbigniew, Zarzycki Piotr, Sobota Aldona, Błaszczak Wioletta

“…It is important not only to focus on increasing the content of β-glucans, but also to investigate molecules distribution in the seed. It was also demonstrated that Dukat cultivar was characterised by an especially valuable triple aleurone layer, which makes this cultivar predestined for further breeding studies as an extremely valuable carrier of genetic information.…”
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Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

“…CiPSCs, reprogrammed via small molecules, enable personalized islet therapies with promising clinical outcomes, as demonstrated in T1D patients. …”
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Lipid and Bile Acid Dysmetabolism in Crohn’s Disease by Koji Uchiyama, Hisashi Kishi, Wataru Komatsu, Masanori Nagao, Shuji Ohhira, Gen Kobashi

“…The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. …”
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Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review by Jesús Miguel Magaña Cerino, Héctor Arturo Peniche Pavía, Axel Tiessen, Carmen Magdalena Gurrola Díaz

“…These diseases are mainly associated with oxidative stress, which is characterized by a redox cell imbalance produced due to pro-oxidant molecules accumulation, inducing irreversible damages. …”
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Electrochemical sensors for the detection of immune checkpoint related proteins and their role in cancer companion diagnostics by Louise Barnaby, Andrew G. Watts, Pedro Estrela

“…Many methods such as enhancing an electrode surface with high conductivity materials or increasing the measured electrochemical signal via signal amplifying molecules have been investigated with promising results. …”
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Screening of SIRT2 inhibitors from natural product databases using computer-aided drug design and molecular dynamics simulation by Tianyi Liu, Hongli Yin, Xue Dong, Qingyang Hu, Xuejiao Hu, Wenxin Yan, Huanhuan Wang, Zhong Li

“…Applying computer aided drug design techniques to identify potential drug molecules from natural products holds profound significance for drug research.…”
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