Coupling between topological edge state and defect mode-based biosensor using phononic crystal by Zaky A. Zaky, M. Al-Dossari, Ahmed S. Hendy, Yassine Bouazzi, Attia Boudjemline, Arafa H. Aly

“…Abstract A wealth of details regarding an individual’s state of health, like a person’s respiratory and metabolic functioning, can be studied by analyzing the volatile molecules and atoms in human exhaled breath. Besides, the salinity of seawater is a crucial factor in understanding its characteristics because any variation in the salinity of seawater represents the variations in the hydrological, biological, and chemical distributions. …”
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Direct conversion of peptides into diverse peptidomimetics using a transformer-based chemical language model by Atsushi Yoshimori, Jürgen Bajorath

“…A critically important aspect of the approach has been the generation of training data for effective learning that was guided by a quantitative measure of peptide-likeness such that the CLM could implicitly capture transitions from peptides or peptide-like molecules to compounds with reduced or eliminated peptide character. …”
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Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice by José Belizário, Luiz Vieira-Cordeiro, Sylvia Enns

“…Under stress conditions, cells in living tissue die by apoptosis or necrosis depending on the activation of the key molecules within a dying cell that either transduce cell survival or death signals that actively destroy the sentenced cell. …”
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ISU201 Enhances the Resolution of Airway Inflammation in a Mouse Model of an Acute Exacerbation of Asthma by Yuka Hiroshima, Linda Garthwaite, Kenneth Hsu, Hyouna Yoo, Sang-Ho Park, Carolyn L. Geczy, Rakesh K. Kumar, Cristan Herbert

“…ISU201 significantly reduced peak expression of mRNA for the chemokines Cxcl9 and Cxcl10, the adhesion molecules Icam1 and Vcam1, and the proinflammatory cytokines Il1b, Il12p40, and Csf1. …”
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Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. …”
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Predicting purification process fit of monoclonal antibodies using machine learning by Andrew Maier, Minjeong Cha, Sean Burgess, Amy Wang, Carlos Cuellar, Soo Kim, Neeraja Sundar Rajan, Josephine Neyyan, Rituparna Sengupta, Kelly O’Connor, Nicole Ott, Ambrose Williams

“…However, the work required for upstream protein expression and downstream purification development often conflicts with timeline pressures and material constraints, limiting the number of molecules and process conditions that can reasonably be assessed. …”
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Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review by Fardin Nabizadeh, Shadi Sheykhlou, Sara Mahmoodi, Elham Khalili, Rasa Zafari, Helia Hosseini

“…AD patients with psychosis, hallucinations, or delusions have significant differences in the volume and perfusion levels of various brain regions along with alterations in EEG waves and biological molecules compared to patients with only AD.…”
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Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis by Simona Ceccarelli, Cristina Nodale, Enrica Vescarelli, Paola Pontecorvi, Valeria Manganelli, Giovanni Casella, Maria Giuseppina Onesti, Maurizio Sorice, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese

“…Adipogenesis is regulated by a complex network of molecules, including fibroblast growth factors. Keratinocyte growth factor (KGF) has been previously reported to promote proliferation on rat preadipocytes, although the expression of its specific receptor, FGFR2-IIIb/KGFR, is not actually detected in mesenchymal cells. …”
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The Effects of Using Waste Engine Oil Bottom on Physical, Rheological Properties and Composite Modification Mechanism of SBS-Modified Asphalt by Yanbo Wang, Ailian Liu, Weixiang Ding, Fangping Rao, Jun Yuan, Zhihua Zhang, Zhen Xu, Chuanzhou Dong

“…Furthermore, WEOB promotes the polarity of SBS and forms graft product MAH-g-SBS with asphalt, thus inhibiting the thermal movement of asphalt molecules. On the contrary, light components have a good correlation with the surface roughness of modified asphalt; the results show that the modified asphalt has good rutting resistance.…”
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Arsenic Induces Continuous Inflammation and Regulates Th1/Th2/Th17/Treg Balance in Liver and Kidney In Vivo by Xiaoxu Duan, Guowei Xu, Jinlong Li, Nan Yan, Xin Li, Xuping Liu, Bing Li

“…Moreover, arsenic enhanced the expression of MAPK/Nrf2/NF-κB signaling molecules. In conclusion, the results of the study suggested that arsenic induces continuous immune-inflammatory responses in the liver and kidney.…”
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Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification by Wolfgang Giese, Jan Philipp Albrecht, Olya Oppenheim, Emir Bora Akmeriç, Julia Kraxner, Deborah Schmidt, Kyle Harrington, Holger Gerhardt

“…Abstract Cell polarity involves the asymmetric distribution of cellular components such as signalling molecules and organelles within a cell, alterations in cell morphology and cell-cell contacts. …”
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Corrosion Inhibition Effect of 4-(2-Diethylamino-Ethylsulfonyl)-Phthalonitrile and 4,5-Bis(Hexylsulfonyl)-Phthalonitrile by Esma Sezer, Belkis Ustamehmetoğlu, Zehra Altuntaş Bayır, Kerim Çoban, Ayfer Kalkan

“…Langmuir adsorption isotherm 𝐾ads was applied and Δ𝐺 values were obtained and found as 4.32×10−4, 1.17×10−4 and 9.2 kJ, 12.5 kJ for DAESPN and Bis-HSPN, respectively, which suggests the electrostatic interaction between charged metal surface and charged organic molecules.…”
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Autologous Microfragmented Adipose Tissue Reduces the Catabolic and Fibrosis Response in an In Vitro Model of Tendon Cell Inflammation by Marco Viganò, Gaia Lugano, Carlotta Perucca Orfei, Alessandra Menon, Enrico Ragni, Alessandra Colombini, Paola De Luca, Pietro Randelli, Laura de Girolamo

“…In this in vitro model of tendon cell inflammation, the paracrine action of μFAT, exerted by anti-inflammatory molecules and growth factors, was able to inhibit the expression of fibrosis and catabolic markers. …”
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NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling by Hui Li, Panpan Wang, Huijuan Chen, Yanyan Shao, Hui Luo

“…NEIL3 and TOP2A play key roles in EC progression through the WNT signaling pathway. Targeting these molecules may offer promising therapeutic strategies for EC. …”
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Recyclable Multifunctional PSOGs for Rapid Removal of Wastewater Pollutants (Oily and Dye) by Wannian Zhang, Yingquan Du, Zhigang Gao, Fang Yu, Yu‐Peng He

“…Partial 1H VT NMR, FTIR, and XRD experiments have shown that the main driving force for TBTC gelation and host–guest recognition originates from interaction hydrogen bonding, are TBTC specifically recognizes dye molecules through weak hydrogen bonding interactions and rapidly aggregates to form precipitates. …”
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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…Abstract RNA-based therapeutics highlighted novel approaches to target either coding or noncoding molecules for multiple diseases treatment. In breast cancer (BC), a multitude of deregulated long noncoding RNAs (lncRNAs) have been identified as potential therapeutic targets also in the context of antiestrogen resistance, and the RNA binding activity of the estrogen receptor α (ERα) points additional potential candidates to interfere with estrogenic signaling. …”
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Lignin alkali regulated interfacial polymerization towards ultra-selective and highly permeable nanofiltration membrane by Wentian Zhang, Shanshan Zhao, Haiyun Li, Cunxian Lai, Shangwei Zhang, Wu Wen, Chuyang Y. Tang, Fangang Meng

“…Various characterizations and molecular dynamics simulations revealed that LA can promote the diffusion and partition of aqueous phase monomer piperazine (PIP) molecules into organic phase and their uniform dispersion on substrate, accelerating the IP reaction and promoting greater interfacial instabilities, thus endowing formation of TFC NF membrane with an ultrathin, highly cross-linked, and crumpled PA layer. …”
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LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice by Annica Hedberg, Premasany Kanapathippillai, Ole Petter Rekvig, Kristin Andreassen Fenton

“…Splenocyte cell proliferation as thymidine incorporation and the expression of costimulatory molecules and cell activation markers were measured. …”
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Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4 by Bruno Pagano, Iolanda Fotticchia, Stefano De Tito, Carlo A. Mattia, Luciano Mayol, Ettore Novellino, Antonio Randazzo, Concetta Giancola

“…Quadruplex-prone sequences are found in many regions of human genome and in the telomeres of all eukaryotic organisms. Since small molecules that target G-quadruplexes have been found to be effective telomerase inhibitors, the identification of new specific ligands for G-quadruplexes is emerging as a promising approach to develop new anticancer drugs. …”
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Development of a photoacoustic acquisition system and their proof-of-concept for hemoglobin detection by Bruna Pinheiro, Vânia Pinto, Hugo Dinis, Michael Belsley, Susana Catarino, Graça Minas, Paulo Sousa

“…PA systems combine an illumination source to excite the sample molecules, with an ultrasound sensor to measure the generated ultrasonic waves, combining the advantages of optics and acoustic methodologies to safely acquire tridimensional signals and images at various depths.This work is focused on the design, implementation and test of an acquisition electronics circuit, based on the PA principle, for hemoglobin (Hb) detection, aiming towards a future integration within an OoC platform. …”
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