Virtual screening and molecular docking of Indonesian phytoconstituents as potential inhibitors of peroxisome proliferator-activated receptor gamma in polycystic ovary syndrome by Tunjungseto Arif, Iffatunnisa Fakhriyah, Pratiwi Intan Winta, Alif Azzam Muhyiddin Afrizal, Ahsan Fadhil, Santoso Budi

“…Precision medicine and targeted therapy have emerged as practical therapeutic approaches, focusing on specific molecules/pathways to minimize side effects and improve outcomes. …”
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Quantitative Understanding of the Adsorption Equilibria of Acetone on Mesoporous Silica MSU-H in Supercritical CO2 by Ikuo Ushiki, Mizuki Hironaka

“…Mesoporous silica, such as MSU-H, is a promising adsorbent due to its strong interactions with polar molecules. In this study, we quantitatively evaluated the adsorption equilibrium of acetone on MSU-H type mesoporous silica in supercritical CO2 at T = (333–353) K and P = (10.0–15.0) MPa using a fixed-bed adsorption system. …”
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In Vivo Quantitative Measurement of Arthritis Activity Based on Hydrophobically Modified Glycol Chitosan in Inflammatory Arthritis: More Active than Passive Accumulation by Kyeong Soon Park, Jin Hee Kang, Keum Hee Sa, Hee Beom Koo, Hyun Jung Cho, Eon Jeong Nam, In Chan Youn, Kwang Meyung Kim, In San Kim, Ick Chan Kwon, Kui Won Choi, Young Mo Kang

“…Activated macrophages expressing Mac-1 molecules effectively phagocytosed HGC-Cy5.5, which formed spherical nanoparticles under physiologic conditions. …”
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CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells by Die Hu, Brigitte L. Thériault, Vida Talebian, Laurent Hoffer, Julie Owen, Justin Lim, Benjamin J. Blencowe, Evelyne Lima-Fernandes, Punit Saraon, Richard Marcellus, Rima Al-awar

“…CDC40 mutation analysis suggests that it may be difficult to disrupt key interactions using small molecules within a large complex. Our results demonstrate that CDC40 is essential for lung cancer cell growth, and that its inhibition may represent a viable therapeutic strategy for lung cancer.…”
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Elucidating governing factors of PFAS removal by polyamide membranes using machine learning and molecular simulations by Nohyeong Jeong, Shinyun Park, Subhamoy Mahajan, Ji Zhou, Jens Blotevogel, Ying Li, Tiezheng Tong, Yongsheng Chen

“…The examination of the impacts of chemical structure involves interpreting the multimodal transformer model incorporated with simplified molecular input line entry system strings through heat maps, providing a visual representation of the attention score assigned to each atom of PFAS molecules. Both ML interpretation methods highlight the dominance of electrostatic interaction in governing PFAS transport across polyamide membranes. …”
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Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery by Manuela Kudlova, Pavel Kunes, Martina Kolackova, Vladimir Lonsky, Jiri Mandak, Ctirad Andrys, Karolina Jankovicova, Jan Krejsek

“…The levels of LBP and sCD14 are elevated in cardiac surgical patients being similar in both groups. These molecules are not produced as acute phase proteins in these patients.…”
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Machine learning-assisted quantitative prediction of thermal decomposition temperatures of energetic materials and their thermal stability analysis by Zhi-xiang Zhang, Yi-lin Cao, Chao Chen, Lin-yuan Wen, Yi-ding Ma, Bo-zhou Wang, Ying-zhe Liu

“…The SHapley Additive exPlanations (SHAP) analysis indicated that descriptors such as BCUT2D, PEOE_VSA, MolLog_P, and TPSA played a significant role, demonstrating that the thermal decomposition process is influenced by multiple factors relating to the composition, electron distribution, chemical bond properties, and substituent type of molecules. Additionally, descriptors such as Carbon_contents and Oxygen_Balance proposed for characterizing EMs showed strong linear correlations with thermal decomposition temperatures. …”
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Human platelet lysate: a potential therapeutic for intracerebral hemorrhage by Dachang Qiu, Lin Wang, Lanlan Wang, Yongfei Dong

“…Additionally, we summarize the bioactive molecules present in HPL and their potential therapeutic effects in ICH. …”
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IL-10 and ARG-1 Concentrations in Bone Marrow and Peripheral Blood of Metastatic Neuroblastoma Patients Do Not Associate with Clinical Outcome by Fabio Morandi, Michela Croce, Giuliana Cangemi, Sebastiano Barco, Valentina Rigo, Barbara Carlini, Loredana Amoroso, Vito Pistoia, Silvano Ferrini, Maria Valeria Corrias

“…The expression of the immunosuppressive molecules IL-10 and arginase 1 (ARG-1), and of FOXP3 and CD163, as markers of regulatory T cells (Treg) and macrophages, respectively, was evaluated in bone marrow (BM) and peripheral blood (PB) samples collected at diagnosis from patients with metastatic neuroblastoma (NB). …”
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M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b by Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté

“…Moreover, mutations in two RNA binding proteins, TAR DNA binding protein 43 and fused in sarcoma, have raised the intriguing possibility that perturbations of RNA metabolism, including that of the small endogenous RNA molecules that repress target genes at the posttranscriptional level, that is, microRNAs, may contribute to disease pathogenesis. …”
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Hydrogen Storage Enhancement Attained by Fixation of Ti on MWNTs by J. J. Pérez-Bueno, M. L. Mendoza López, K. M. Brieño Enriquez, J. Ledesma García, L. A. Godínez Mora-Tovar, C. Angeles Chavez

“…Each titanium atom has the potential of hosting two hydrogen molecules and relinquishing them by heating. Nevertheless, nanotubes are difficult to handle due to electrostatic charge and agglomeration, and in this context, two routes were tested as procedures to spread and stick nanotubes on an electrode: (1) a functionalization capable of attaching gold was tested in two forms, as either using 4 nm particles or a flat gold electrode. …”
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Inverted Pyramid Nanostructures Coupled with a Sandwich Immunoassay for SERS Biomarker Detection by Wen-Huei Chang, Shao-Quan Zhang, Zi-Yi Yang, Chun-Hung Lin

“…The system employs a sandwich immunoassay configuration, with substrates functionalized with antibodies to capture HA molecules and 4-MBA-labeled SERS tags for detection. …”
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The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling by Maricica Pacurari, Ramzi Kafoury, Paul B. Tchounwou, Kenneth Ndebele

“…Inflammatory factors such as ICAM-1, VCAM-1, TNFα, IL-6, and CRP have key roles in mediating vascular inflammation and blocking RAAS negatively modulates the levels of these inflammatory molecules. Some of these inflammatory markers are clinically associated with CVD events. …”
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Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review by Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba

“…The purpose of this review is to provide the latest information regarding these noteworthy molecules and the reasoning behind their use in cosmetic formulations.…”
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TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance by Junwei Ge, Hongwei Jiang, Junjun Chen, Xuemin Chen, Yue Zhang, Liangrong Shi, Xiao Zheng, Jingting Jiang, Lujun Chen

“…Additionally, we analyzed clinical associations, prognostic values, and the correlation of these molecules. These insights advance our understanding of the molecular mechanisms driving HCC progression and underscore the intricate interplay between tumor cells and the stromal components of the TME.…”
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The Role of PDGFs and PDGFRs in Colorectal Cancer by Roberta M. Manzat Saplacan, Loredana Balacescu, Claudia Gherman, Romeo I. Chira, Anca Craiu, Petru A. Mircea, Cosmin Lisencu, Ovidiu Balacescu

“…Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge. …”
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Both Freshly Prepared and Frozen-Stored Amniotic Membrane Cells Express the Complement Inhibitor CD59 by Ágnes Füst, Éva Pállinger, Adrienn Stündl, Eszter Kovács, László Imre, Sára Tóth, János Németh

“…Therefore it is most important to study if cryopreservation of the membrane affects cell surface expression of the molecules. We measured cell surface expression of CD59, a membrane-bound complement inhibitor on the cells of freshly prepared and cryopreserved amniotic membrane. …”
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Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I by Yukitoshi Takahashi, Kazumi Matsuda, Yuko Kubota, Jiro Shimomura, Etsuko Yamasaki, Tatsuya Kudo, Katsuyuki Fukushima, Hitoshi Osaka, Noriyuki Akasaka, Atsushi Imamura, Shinji Yamada, Naomi Kondo, Tateki Fujiwara

“…Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). …”
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Systematic and Empirical Study of the Dependence of Polyphenol Recovery from Apricot Pomace on Temperature and Solvent Concentration Levels by Dina Cheaib, Nada El Darra, Hiba N. Rajha, Richard G. Maroun, Nicolas Louka

“…Apricot pomace extracts could therefore be used as natural bioactive molecules for many industrial applications.…”
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Adipose-Derived Mesenchymal Stem Cells Enhance Ovarian Cancer Growth and Metastasis by Increasing Thymosin Beta 4X-Linked Expression by Yijing Chu, Min You, Jingjing Zhang, Guoqiang Gao, Rendong Han, Wenqiang Luo, Tingting Liu, Jianxin Zuo, Fuling Wang

“…Thymosin beta 4 X-linked (TMSB4X) levels changed dramatically, and this protein was identified as one of the most important candidate molecules contributing to the tumour-promoting effects of ADSCs. …”
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