Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model. by Emily L Errante, Joseph Yunga Tigre, Ericka A Schaeffer, Meredith C Costello, Andrew J Kloehn, Aiko Puerto, Aisha Khan, Yelena Pressman, Risset Silvera, Francisco J Sanchez, Brian R Noga, W Dalton Dietrich, Allan D Levi, S Shelby Burks

“…Exosomes, which carry cellular signaling molecules, can be secreted by SCs and have shown promise in PNI. …”
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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
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Analysis of Natural Aging Behavior of Asphalt Binder in Cold and Arid Region by Shanglin Song, Meichen Liang, Fujin Hou, Honggang Gao, Yufeng Bi, Haixing Zhang, Meng Guo

“…The molecular weight of asphalt binder was increased, and the internal molecules of asphalt binder were subjected to large internal friction resistance in the process of movement. …”
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Characterization of Various Honey Samples from Different Regions of Morocco Using Physicochemical Parameters, Minerals Content, Antioxidant Properties, and Honey-Specific Protein P... by Badiaa Lyoussi, Meryem Bakour, Redouan El-Haskoury, Hamada Imtara, Christophe Hano, Katarína Bíliková

“…In this work, we evaluated the good quality, authenticity, and content in bioactive molecules of twenty-two Moroccan honey from different botanical origins and geographical areas. …”
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Unconventional hexagonal open Prussian blue analog structures by Jinwen Yin, Jing Wang, Mingzi Sun, Yajie Yang, Jia Lyu, Lei Wang, Xinglong Dong, Chenliang Ye, Haibo Bao, Jun Guo, Bo Chen, Xichen Zhou, Li Zhai, Zijian Li, Zhen He, Qinxin Luo, Xiang Meng, Yangbo Ma, Jingwen Zhou, Pengyi Lu, Yunhao Wang, Wenxin Niu, Zijian Zheng, Yu Han, Daliang Zhang, Shibo Xi, Ye Yuan, Bolong Huang, Peng Guo, Zhanxi Fan

“…Significantly, H-CuCo exhibits much superior gas uptake capacity over C-CuCo toward carbon dioxide and small hydrocarbon molecules. Mechanism studies reveal that unsaturated Cu sites with planar quadrilateral configurations in H-CuCo enhance the gas adsorption performance.…”
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RNA Interference Targeting Snail Inhibits the Transforming Growth Factor β2-Induced Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells by Ping Li, Jiaona Jing, Jianyan Hu, Tiejun Li, Yuncheng Sun, Huaijin Guan

“…TGFβ2 treatment of cultured human epithelial cell line (HLEB3) upregulated the expression of Snail and the EMT relevant molecules such as vimentin and α-SMA but downregulated the expression of keratin and E-cadherin. …”
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Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling by Da-Wei Yeh, Li-Rung Huang, Ya-Wen Chen, Chi-Ying F. Huang, Tsung-Hsien Chuang

“…Toll-like receptors (TLRs) activate NF-κB-mediated inflammatory responses when stimulated by carcinogenic microbes and endogenous molecules released from cells killed during cancer treatment. …”
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Analysis of doxorubicin and fullerenol in rat serum by micellar electrokinetic capillary chromatography by Injac Rade, Sertić Miranda, Glavač Nina Kočevar

“…The proposed MEKC procedure was fully validated and applied for the deter mination of Dox and Frl in Wistar rats after intra pe ritoneal administration of both molecules.…”
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Construction of functional covalent organic framework films by modulator and solvent induced polymerization by Xuerong Li, Xingyue Ji, Xinglong Zhang, Xinyi Chen, Hongfeng Li, Suoying Zhang, Fengwei Huo, Weina Zhang

“…By introducing functional molecules such as fluorescence, chirality and catalyst during the nucleation process, versatile functional covalent organic framework films can be easily fabricated, which endow them with broader application prospects.…”
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Mitogenomic Phylogenetic Analyses Reveal New Insights into the Taxonomy and Evolution of Parnassiinae Swallowtail Butterflies (Lepidoptera: Papilionidae) by Lu Song, Xiaoxiao Chen, Xiushan Li, Raul Narciso C. Guedes, Youssef Dewer, Suqin Shang, Jingjiang Zhou

“…Both mitogenomes are circular, double-stranded molecules, measuring 15,377 bp and 15,348 bp in length, each encoding 37 standard mitochondrial genes: 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes, and an A + T-rich control region. …”
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Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation by Chad M. Teven, Xing Liu, Ning Hu, Ni Tang, Stephanie H. Kim, Enyi Huang, Ke Yang, Mi Li, Jian-Li Gao, Hong Liu, Ryan B. Natale, Gaurav Luther, Qing Luo, Linyuan Wang, Richard Rames, Yang Bi, Jinyong Luo, Hue H. Luu, Rex C. Haydon, Russell R. Reid, Tong-Chuan He

“…While various signaling molecules important to MSC differentiation have been identified, our complete understanding of this process is lacking. …”
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Thio-modified trianglimines, a novel group of chiral macrocyclic compounds of high structural dynamics by Natalia Prusinowska, Agnieszka Czapik, Joanna Szymkowiak, Marcin Kwit

“…In the crystal lattice, around the macrocycle having bulky SCPh3 groups, a space filled with solvent is formed; however, the macrocycle’s internal cavity is closed and unavailable for guest molecules. Titration of the solutions of basic SBn-substituted imine and amine macrocycles by AgOTf results in significant changes in the ECD spectra, confirming possible binding interactions between macrocycle and metal cations.…”
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Monitoring of milk rennet coagulation: Chemical and physical perspective using Raman spectroscopy by Leonardo Sibono, Stefania Tronci, Martin Aage Barsøe Hedegaard, Massimiliano Errico, Massimiliano Grosso

“…For the first time, the response of the Raman sensor was also used to assess the dynamic evolution of signal intensity for every individual Raman shift in order to identify which chemical bonds and molecules are significantly involved in the renneting process. …”
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Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…There are 23 platforms available to generate 62 BsAbs which can be further divided into IgG-like ones and fragment-based ones, and more than 50 molecules are undergoing clinical trials currently. …”
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Application of Metabolomics in Thyroid Cancer Research by Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

“…Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. …”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. …”
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Using Improved XGBoost Algorithm to Obtain Modified Atmospheric Refractive Index by Yanbo Mai, Zheng Sheng, Hanqing Shi, Qixiang Liao

“…Atmospheric refraction is a special meteorological phenomenon mainly caused by gas molecules and aerosol particles in the atmosphere, which can change the propagation direction of electromagnetic waves in the atmospheric environment. …”
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Determination of FMDV 146S particle concentration by spectrometric method during viral RNA quantification by M. I. Doronin, D. V. Mikhalishin, V. A. Starikov, D. A. Lozovoy, Yu. S. El’kina, A. V. Borisov

“…It is an inexpensive, easy-to-perform method allowing for determination of FMDV 146S particle concentration in the non-inactivated culture suspension. 146S particle concentration was found to depend on the number of RNA molecules extracted from virions after their strain-specific immune capture and quantitatively detected by the spectrometric method. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Oxysterols are naturally occurring molecules that play important role in various metabolic and inflammatory processes and their levels are elevated in patients suffering from obesity and diabetes. 25-Hydroxycholesterol (25-OHC) is produced in cells from cholesterol by the enzyme cholesterol 25-hydroxylase (Ch25h) and is involved in lipid metabolism, inflammatory processes, and cell proliferation. …”
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Numerical Simulation of Low-Permeability Reservoirs with considering the Dynamic Boundary Layer Effect by Chuanzhi Cui, Yingfei Sui, Xiangzhi Cheng, Yinzhu Ye, Zhen Wang

“…Surface active components, salt component, and polar molecules in the fluid may adsorb on the solid surface and form the boundary layer during low-speed flow in a porous medium, which will influence the flowing law in the porous medium. …”
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