Pathway and molecular mechanisms for malachite green biodegradation in Exiguobacterium sp. MG2. by Ji'ai Wang, Feng Gao, Zhongzhong Liu, Min Qiao, Xuemei Niu, Ke-Qin Zhang, Xiaowei Huang

“…However, due to its negative impact on the environment and carcinogenic effects to mammalian cells, there is a significant interest in developing microbial agents to degrade this type of recalcitrant molecules. Here, an Exiguobacterium sp. MG2 was isolated from a river in Yunnan Province of China as one of the best malachite green degraders. …”
Get full text

Base-Catalyzed Polymerization of a Substituted Methylenebicyclo[3.3.1]nonane by Sujeet Kumar Thakur, Seera Raviteja, Tayur N. Guru Row, Sambasivan Venkat Eswaran

“…Only in very recent years, it has been recognized that these are relatively small molecules which masquerade as supramolecular structures. …”
Get full text

Neurocranial Pharmacodialysis Device for subarachnoid hemorrhage treatment—a perspective by Nandor Ludvig

“…The RESULTS showed the following four facts: (1) high-grade SAH requiring decompressive craniectomy readily offers, as the last step of the neurosurgical procedure, the safe closure of the opened cranium with the NPD while leaving the efficacy of the decompressive intervention intact. (2) The neurocranially attached NPD can automatically execute, as long as it is necessary, subarachnoid polypharmacy to prevent post-SAH vasospasm, reduce the risk of rebleeding, and provide neuroprotection in delayed cerebral ischemia (DCI), bypassing the blood-brain barrier (BBB) via connected subarachnoid strips. (3) These effects of drug delivery can be optimized with NPD-controlled long-term cleaning of the CSF and drainage of cellular debris, hydrocephalus, and interstitial edema accompanied by the subarachnoid dialysis of potentially neurotoxic extracellular molecules. (4) Safety and efficacy of these NPD operations are monitored, and possible epileptiform EEG is detected, via the wireless EEG system of the device. …”
Get full text

Mussel-inspired thermo-switchable underwater adhesive based on a Janus hydrogel by Hiroya Abe, Daichi Yoshihara, Soichiro Tottori, Matsuhiko Nishizawa

“…Herein, we present a Janus hydrogel adhesive that can reversibly switch its adhesion strength, which is controlled by temperature, using a thermoresponsive polymer and mussel-inspired molecules. This thermoswitchable adhesive (TSA) hydrogel displays both strong adhesion and gentle detachment with an over 1000-fold gap in underwater adhesion strength onto glass, titanium, aluminum, and Teflon substrates when exposed to temperatures above and below the lower critical solution temperature (LCST). …”
Get full text

Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis by Christopher Robinson, Cynthia Pham, Alec M. Zamarripa, Chase S. Dugay, Christopher A. Lee, Amnon A. Berger, Avi Landman, Elyse M. Cornett, Hisham Kassem, Alan D. Kaye, Ivan Urits, Omar Viswanath, Latha Ganti

“… # Results Recently, novel therapeutic options emerged in the form of groundbreaking drugs, Patisiran and Inotersen, small interfering RNA molecules that target TTR and reduce the production of this protein. …”
Get full text

Fine-tuning SLE treatment: the potential of selective TYK2 inhibition by Yoshiya Tanaka, Shingo Nakayamada, Yurie Satoh-Kanda

“…Multiple cytokines activate JAK/TYK2, and multiple JAK/TYK2 molecules are simultaneously activated by a single cytokine. …”
Get full text

miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…It is predicted that over 30% of mRNAs are regulated by miRNAs. Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness. …”
Get full text

FiberO for an automated quantitative analysis of fibers orientation and organization in biological fibrous tissues by Asier Muñoz, Anxhela Docaj, Julen Fernandez, Alessandra Carriero

“…In disease conditions, alterations in the primary components of these fibers, such as type I collagen molecules in bone, tendons, and ligaments, assembly into a disorganized fibers architecture generating a weak and/or brittle material. …”
Get full text

New strategies to enhance the efficiency and precision of drug discovery by Qi An, Liang Huang, Chuan Wang, Dongmei Wang, Yalan Tu

“…To demonstrate the utility of these methodologies, we highlight exemplary small molecules discovered in the past decade, along with a summary of marketed drugs and investigational new drugs that exemplify their clinical impact. …”
Get full text

Targeting HER2 in Nuclear Medicine for Imaging and Therapy by Adriana V. F. Massicano PhD, Bernadette V. Marquez-Nostra PhD, Suzanne E. Lapi PhD

“…Several antibodies and small molecules against HER2 have been labeled with different radioisotopes for nuclear imaging and/or therapy. …”
Get full text

The role of acetylation and deacetylation in cancer metabolism by Cuicui Wang, Xiaoxin Ma

“…In this complex regulatory network, acetylation and deacetylation, which are important post‐translational modifications, regulate key molecules and processes related to metabolic reprogramming by affecting protein function and stability. …”
Get full text

The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation by Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

“…Scorpion stings may be life-threatening since their venoms are comprised of a wide range of toxins and other bioactive molecules, such as enzymes. At the same time, scorpion envenomation may increase matrix metalloproteases (MMPs) levels, which enhance proteolytic tissue destruction by venom. …”
Get full text

The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation by James N. Cobley, Panagiotis N. Chatzinikolaou, Cameron A. Schmidt

“…This conjecture posits that highly oxidised proteoforms, molecules bearing multiple oxidised cysteines, are central to redox regulation. …”
Get full text

Aqueous Nanofluid as a Two-Phase Coolant for PWR by Pavel N. Alekseev, Yury M. Semchenkov, Alexander L. Shimkevich

“…The dense ones have helical hydrogen bonds and the nondense ones are tetrahedral clusters with ice-like hydrogen bonds of water molecules. Helical ordering of protons in the dense water clusters can participate in coherent vibrations. …”
Get full text

Comparative genomics of large mitochondria in placozoans. by Ana Y Signorovitch, Leo W Buss, Stephen L Dellaporta

“…All three mitochondrial genomes were found to be very large, 32- to 37-kb, circular molecules, having the typical 12 respiratory chain genes, 24 tRNAs, rnS, and rnL. …”
Get full text

The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions by C. Brizuela, George T.-J. Huang, A. Diogenes, T. Botero, M. Khoury

“…It will also provide overall information on the emerging technologies in biological and synthetic matrices, biomaterials, and signaling molecules, recent advances in stem cell therapy, and updated experimental results. …”
Get full text

Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation by Yoshikazu Nakaoka, Issei Komuro

“…In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules. Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP. …”
Get full text

Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain in Vivo Fluorescence Imaging by Abedelnasser Abulrob, Eric Brunette, Jacqueline Slinn, Ewa Baumann, Danica Stanimirovic

“…The area differential between the BBB disruption for small and large molecules could potentially be useful as a surrogate imaging marker for assessing perinfarct tissues to which neuroprotective therapies of appropriate sizes could be delivered.…”
Get full text

Diffusion rate determines balance between extinction and proliferationin birth-death processes by Hilla Behar, Alexandra Agranovich, Yoram Louzoun

“…We here study spatially extended catalyst induced growth processes.This type of process exists in multiple domains of biology, rangingfrom ecology (nutrients and growth), through immunology (antigensand lymphocytes) to molecular biology (signaling molecules initiatingsignaling cascades). Such systems often exhibit an extinction-proliferationtransition, where varying some parameters can lead to either extinctionor survival of the reactants.…”
Get full text

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis by Kakali Ghoshal, Maitree Bhattacharyya

“…Dynamic platelets bear distinct morphology, where α and dense granule are actively involved in secretion of molecules like GPIIb , IIIa, fibrinogen, vWf, catecholamines, serotonin, calcium, ATP, ADP, and so forth, which are involved in aggregation. …”
Get full text